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Drug Metabolism and Pharmacokinetics最新文献

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Targeted Protein Degraders (TPD): PK/PD translation from preclinical to clinical 靶向蛋白降解物（TPD）：从临床前到临床的PK/PD转化
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101085
Dapeng Chen
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引用次数: 0
Authenticity and adulteration of botanical natural products: Lessons from a decade of sourcing materials for scientific investigation 植物性天然产品的真实性和掺假：十年来为科学调查采购材料的经验教训
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101114
Nadja Cech
{"title":"Authenticity and adulteration of botanical natural products: Lessons from a decade of sourcing materials for scientific investigation","authors":"Nadja Cech","doi":"10.1016/j.dmpk.2025.101114","DOIUrl":"10.1016/j.dmpk.2025.101114","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101114"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucoadhesive hemi-porous Janus microparticles: Potential formulation to improve intestinal absorption for BCS Class 3 drugs 黏附半多孔Janus微颗粒：改善BCS 3类药物肠道吸收的潜在制剂
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101138
Akihiro Matsumoto , Satoshi Murao , Syou Maki , Masayuki Kaneda , Takeo Kitazawa , Tomoya Takashima , Masahiro Murakami
{"title":"Mucoadhesive hemi-porous Janus microparticles: Potential formulation to improve intestinal absorption for BCS Class 3 drugs","authors":"Akihiro Matsumoto , Satoshi Murao , Syou Maki , Masayuki Kaneda , Takeo Kitazawa , Tomoya Takashima , Masahiro Murakami","doi":"10.1016/j.dmpk.2025.101138","DOIUrl":"10.1016/j.dmpk.2025.101138","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101138"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of low CL compounds using chimeric mice with humanized liver 用人源化肝脏嵌合小鼠评价低CL化合物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101104
Hiroshi Suemizu
{"title":"Evaluation of low CL compounds using chimeric mice with humanized liver","authors":"Hiroshi Suemizu","doi":"10.1016/j.dmpk.2025.101104","DOIUrl":"10.1016/j.dmpk.2025.101104","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101104"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of tyrosine kinases and inhibitors on SGLT1 activity 酪氨酸激酶和抑制剂对SGLT1活性的影响
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101122
Kshitee Sandeep Kharve, Aayush Shroff, Jeiyun Cao, Kyle Pasquariello
{"title":"Impact of tyrosine kinases and inhibitors on SGLT1 activity","authors":"Kshitee Sandeep Kharve, Aayush Shroff, Jeiyun Cao, Kyle Pasquariello","doi":"10.1016/j.dmpk.2025.101122","DOIUrl":"10.1016/j.dmpk.2025.101122","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101122"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of functional evaluation system for human BCRP-mediated biliary excretion using adeno-associated virus 用腺相关病毒构建bcrp介导的人胆道排泄功能评价体系
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101124
Shotaro Yoshino , Yusuke Masuo , Reiya Yamashita , Ken-ichi Fujita , Yukio Kato
{"title":"Construction of functional evaluation system for human BCRP-mediated biliary excretion using adeno-associated virus","authors":"Shotaro Yoshino , Yusuke Masuo , Reiya Yamashita , Ken-ichi Fujita , Yukio Kato","doi":"10.1016/j.dmpk.2025.101124","DOIUrl":"10.1016/j.dmpk.2025.101124","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101124"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory acceptance of MPS - Consideration from context of USE MPS的监管接受-从使用背景考虑
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101097
Seiichi Ishida
{"title":"Regulatory acceptance of MPS - Consideration from context of USE","authors":"Seiichi Ishida","doi":"10.1016/j.dmpk.2025.101097","DOIUrl":"10.1016/j.dmpk.2025.101097","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101097"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of drug intestinal absorption and toxicity with the use of human/animal CRYPT-derived cultured intestinal cells 利用人/动物隐窝来源的培养肠细胞预测药物肠道吸收和毒性
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101098
Kazyua Maeda
{"title":"Prediction of drug intestinal absorption and toxicity with the use of human/animal CRYPT-derived cultured intestinal cells","authors":"Kazyua Maeda","doi":"10.1016/j.dmpk.2025.101098","DOIUrl":"10.1016/j.dmpk.2025.101098","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101098"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining the therapeutic window of BI-Specific T-cell engagers 定义bi特异性t细胞接合物的治疗窗口
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101087
Kip Conner
{"title":"Defining the therapeutic window of BI-Specific T-cell engagers","authors":"Kip Conner","doi":"10.1016/j.dmpk.2025.101087","DOIUrl":"10.1016/j.dmpk.2025.101087","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101087"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic multiple parameter optimization in drug discovery 药物发现中的机械多参数优化
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101089
Fabio Broccatelli
{"title":"Mechanistic multiple parameter optimization in drug discovery","authors":"Fabio Broccatelli","doi":"10.1016/j.dmpk.2025.101089","DOIUrl":"10.1016/j.dmpk.2025.101089","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101089"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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