Drug Metabolism and Pharmacokinetics最新文献_第10页

Validation of QPCR method to detect human cells in mouse and rat tissues 小鼠和大鼠组织中检测人细胞的QPCR方法的验证

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101143

Kuniyoshi Abe, Haruka Inoue, Yuka Torikai, Naoki Kaname, Seulgi Lee, Akiko Suzuki, Yukiko Arimura, Yurie Okawa, Tetsuya Yoshikawa

引用次数: 0

Why and when do i use PBPK modeling 为什么以及何时使用PBPK建模

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101060

Kunal Taskar

引用次数: 0

Species specificity and selection of animal models for drug oxygenations differently contributed by polymorphic human enzymes 多态酶对药物氧合作用的物种特异性和动物模型的选择

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101105

Hiroshi Yamazaki

引用次数: 0

Drug-induced gastrointestinal toxicity due to disruption of the interinfluence between serotonin and gut microbiota 5 -羟色胺与肠道微生物群之间相互影响的破坏引起的药物诱导胃肠道毒性

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101121

Suguru Asaji , Yuta Funai , Yuta Seki , Kotone Banba , Jun Hida , Ikumi Tamai , Yoshiyuki Shirasaka

引用次数: 0

Preclinical DDI risk assessment in drug discovery and development 药物发现和开发中的临床前DDI风险评估

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101080

Niresh Hariparsad

引用次数: 0

In vitro liver models for toxicological research 体外肝模型毒理学研究

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-03-13 DOI: 10.1016/j.dmpk.2025.101478

Ichiro Fukunaga , Takanori Takebe

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引用次数: 0

Review of finalized ICH M12 guideline on drug interaction studies 对ICH M12药物相互作用研究指南定稿的审查

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101079

Akihiro Ishiguro

引用次数: 0

A tale of preclinical insights into bile salt homeostasis disruption in DILI DILI患者胆盐稳态紊乱的临床前研究

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101108

Yurong Lai

引用次数: 0

Current status of Imaging Mass Spectrometry in drug discovery and development: A survey highlighting technical challenges and future directions 成像质谱在药物发现和开发中的现状：突出技术挑战和未来方向的调查

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.1016/j.dmpk.2025.101485

Yukari Tanaka , Hiroyuki Yokoi , Hidefumi Kaji , Yoko Urasaki , Masanobu Nishidate , Shin-ichiro Nitta , Kenichi Watanabe , Tomomi Ishida , Kouji Tanaka , Rika Komatsu , Kenji Yoshida , Kosuke Saito , Yoshiro Saito , Hiroshi Yamazaki

{"title":"Current status of Imaging Mass Spectrometry in drug discovery and development: A survey highlighting technical challenges and future directions","authors":"Yukari Tanaka , Hiroyuki Yokoi , Hidefumi Kaji , Yoko Urasaki , Masanobu Nishidate , Shin-ichiro Nitta , Kenichi Watanabe , Tomomi Ishida , Kouji Tanaka , Rika Komatsu , Kenji Yoshida , Kosuke Saito , Yoshiro Saito , Hiroshi Yamazaki","doi":"10.1016/j.dmpk.2025.101485","DOIUrl":"10.1016/j.dmpk.2025.101485","url":null,"abstract":"<div><div>Imaging mass spectrometry (IMS) is used in various fields of pharmaceutical research and development, including the targeted delivery of administered drugs, drug distribution in tissues, drug toxicity analysis, and disease mechanisms. However, IMS is a relatively new technology that requires further validation before being accepted by authorities for regulatory compliance of new drugs. In 2020, an international survey was conducted in collaboration with the Imaging Mass Spectrometry Society (IMSS) and the Japan Association for Imaging Mass Spectrometry (JAIMS) to understand the status of IMS and to identify problems with its application. The survey revealed technical challenges in sample preparation, quantitative analysis of drugs in tissues, and data acquisition. Based on the 2020 survey results, we recently conducted a further detailed survey and had discussions within the JAIMS aimed at translating the results into specific experimental procedures and proposing feasible standard methods. This survey involved detailed questions on five themes: sample collection and storage, tissue section preparation, sample preparation, data analysis (including quantitative analysis and data correction methods), and data reproducibility. The questions were answered by JAIMS members working for ten companies. To resolve technical issues identified by the survey, we propose some realistic approaches toward standardization.</div></div>","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"62 ","pages":"Article 101485"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of intracellular SLC46A3 in the cytosolic exposure and pharmacological effect of the payload of trastuzumab emtansine (ADC) 细胞内SLC46A3在曲妥珠单抗emtansine （ADC）有效负荷的胞质暴露和药理作用中的作用

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101095

Katsuhisa Inoue

引用次数: 0