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Construction of functional evaluation system for human BCRP-mediated biliary excretion using adeno-associated virus 用腺相关病毒构建bcrp介导的人胆道排泄功能评价体系
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101124
Shotaro Yoshino , Yusuke Masuo , Reiya Yamashita , Ken-ichi Fujita , Yukio Kato
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引用次数: 0
Regulatory acceptance of MPS - Consideration from context of USE MPS的监管接受-从使用背景考虑
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101097
Seiichi Ishida
{"title":"Regulatory acceptance of MPS - Consideration from context of USE","authors":"Seiichi Ishida","doi":"10.1016/j.dmpk.2025.101097","DOIUrl":"10.1016/j.dmpk.2025.101097","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101097"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of drug intestinal absorption and toxicity with the use of human/animal CRYPT-derived cultured intestinal cells 利用人/动物隐窝来源的培养肠细胞预测药物肠道吸收和毒性
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101098
Kazyua Maeda
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引用次数: 0
Defining the therapeutic window of BI-Specific T-cell engagers 定义bi特异性t细胞接合物的治疗窗口
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101087
Kip Conner
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引用次数: 0
Mechanistic multiple parameter optimization in drug discovery 药物发现中的机械多参数优化
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101089
Fabio Broccatelli
{"title":"Mechanistic multiple parameter optimization in drug discovery","authors":"Fabio Broccatelli","doi":"10.1016/j.dmpk.2025.101089","DOIUrl":"10.1016/j.dmpk.2025.101089","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101089"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exceeding 100% bioavailability in dog PK: Implication of CYP2D15 polymorphism 狗PK的生物利用度超过100%:CYP2D15多态性的含义
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101142
Richard Zang, Jianxia Shi, Jay Jain, Austin Li
{"title":"Exceeding 100% bioavailability in dog PK: Implication of CYP2D15 polymorphism","authors":"Richard Zang, Jianxia Shi, Jay Jain, Austin Li","doi":"10.1016/j.dmpk.2025.101142","DOIUrl":"10.1016/j.dmpk.2025.101142","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101142"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Title page 标题页
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/S1347-4367(25)00437-9
{"title":"Title page","authors":"","doi":"10.1016/S1347-4367(25)00437-9","DOIUrl":"10.1016/S1347-4367(25)00437-9","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101487"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro evaluation methods for hepatic and renal drug disposition and toxicity 肝脏和肾脏药物处置和毒性的体外评价方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101100
Hiroshi Arakawa
{"title":"In vitro evaluation methods for hepatic and renal drug disposition and toxicity","authors":"Hiroshi Arakawa","doi":"10.1016/j.dmpk.2025.101100","DOIUrl":"10.1016/j.dmpk.2025.101100","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101100"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro - In vivo extrapolation approaches for glucuronidated drugs: Promises and pitfalls 葡萄糖醛酸化药物的体外-体内外推方法：希望与缺陷
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101096
John O. Miners
{"title":"In vitro - In vivo extrapolation approaches for glucuronidated drugs: Promises and pitfalls","authors":"John O. Miners","doi":"10.1016/j.dmpk.2025.101096","DOIUrl":"10.1016/j.dmpk.2025.101096","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101096"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pegylated testosterone with enhanced pharmacokinetic properties in mice 聚乙二醇化睾酮增强小鼠药代动力学特性
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101125
Chae Bin Lee, Lukas Tenora, Mark C. Markowski, Barbara S. Slusher, Rana Rais
{"title":"Pegylated testosterone with enhanced pharmacokinetic properties in mice","authors":"Chae Bin Lee, Lukas Tenora, Mark C. Markowski, Barbara S. Slusher, Rana Rais","doi":"10.1016/j.dmpk.2025.101125","DOIUrl":"10.1016/j.dmpk.2025.101125","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101125"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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