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Drug Metabolism and Pharmacokinetics最新文献

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Elacridar leads to a much more pronounced boost in dog absorption than expected based on available non-clinical and clinical observations 根据现有的非临床和临床观察结果，Elacridar 对狗吸收的促进作用比预期的要明显得多
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100987
Diane Ramsden, Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad
{"title":"Elacridar leads to a much more pronounced boost in dog absorption than expected based on available non-clinical and clinical observations","authors":"Diane Ramsden, Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad","doi":"10.1016/j.dmpk.2023.100987","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100987","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"11 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a renal OCT2/Mate biomarker (N1-methylnicotinamide) to enable the early clinical assessment of metformin drug interaction potential 利用肾脏 OCT2/Mate 生物标记物（N1-甲基烟酰胺）对二甲双胍药物相互作用潜力进行早期临床评估
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100985
Sumathy Mathialagan, A. David Rodrigues
{"title":"Use of a renal OCT2/Mate biomarker (N1-methylnicotinamide) to enable the early clinical assessment of metformin drug interaction potential","authors":"Sumathy Mathialagan, A. David Rodrigues","doi":"10.1016/j.dmpk.2023.100985","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100985","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"3 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers 评估 CACO-2 细胞单层基底膜上 OSTΑ/Β 转运体的活性
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100991
Emi Yamaguchi, A. David Rodrigues, Emi Kimoto
{"title":"Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers","authors":"Emi Yamaguchi, A. David Rodrigues, Emi Kimoto","doi":"10.1016/j.dmpk.2023.100991","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100991","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"20 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catabolites identification and quantification of antisense oligonucleotides by liquid chromatography - high resolution mass spectrometry (LC-HRMS) 利用液相色谱-高分辨质谱法（LC-HRMS）鉴定和定量反义寡核苷酸的代谢物
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100949
Xin Zhang, Khishig Tsogtbaatar, Mai Thayer, Ryan Takahashi
{"title":"Catabolites identification and quantification of antisense oligonucleotides by liquid chromatography - high resolution mass spectrometry (LC-HRMS)","authors":"Xin Zhang, Khishig Tsogtbaatar, Mai Thayer, Ryan Takahashi","doi":"10.1016/j.dmpk.2023.100949","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100949","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"46 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous metabolites change associated with pioglitazone administration in healthy male subjects 健康男性服用吡格列酮后的内源性代谢物变化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100968
Jihyun Kang, SeungHwan Lee, Kyung-Sang Yu, Joo-Youn Cho
{"title":"Endogenous metabolites change associated with pioglitazone administration in healthy male subjects","authors":"Jihyun Kang, SeungHwan Lee, Kyung-Sang Yu, Joo-Youn Cho","doi":"10.1016/j.dmpk.2023.100968","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100968","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"29 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiologically based pharmacokinetic modeling of adeno-associated viruses and the transgene product 腺相关病毒和转基因产物的生理学药代动力学建模
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100974
Shufang Liu, Ekram Chowdhury, Guy Meno-Tetang, Dhaval Shah
{"title":"Physiologically based pharmacokinetic modeling of adeno-associated viruses and the transgene product","authors":"Shufang Liu, Ekram Chowdhury, Guy Meno-Tetang, Dhaval Shah","doi":"10.1016/j.dmpk.2023.100974","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100974","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"53 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilization of target engagement in tissues measured by immunoaffinity LC-MS/MS for PBPK modeling of monoclonal antibody 利用免疫亲和力 LC-MS/MS 测定的组织中的目标参与度建立单克隆抗体的 PBPK 模型
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100972
Yutaro Hoshi, Yuki Oda, Junji Komaba, Yoshiyuki Yamaura
{"title":"Utilization of target engagement in tissues measured by immunoaffinity LC-MS/MS for PBPK modeling of monoclonal antibody","authors":"Yutaro Hoshi, Yuki Oda, Junji Komaba, Yoshiyuki Yamaura","doi":"10.1016/j.dmpk.2023.100972","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100972","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"253 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating cross-species differences of MDR1-mediated drug transport 调查 MDR1 介导的药物转运的跨物种差异
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100983
Csilla Temesszentandrasi-Ambrus, Krisztina Heredi-Szabo, Emoke Soskuti, Nora Szilvasy, Emese Kis, Zsuzsanna Gaborik
{"title":"Investigating cross-species differences of MDR1-mediated drug transport","authors":"Csilla Temesszentandrasi-Ambrus, Krisztina Heredi-Szabo, Emoke Soskuti, Nora Szilvasy, Emese Kis, Zsuzsanna Gaborik","doi":"10.1016/j.dmpk.2023.100983","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100983","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterization of human metabolites of the echinocandid drug rezafungin by microbial biotransformation 通过微生物生物转化合成棘白类药物雷沙芬净的人体代谢物并确定其特征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100942
Julia Shanu-Wilson, Ravi Manohar, Adriana Gomez, Richard Phipps, Jonathan Steele, Stephen Wrigley, Liam Evans, Frank Scheffler
{"title":"Synthesis and characterization of human metabolites of the echinocandid drug rezafungin by microbial biotransformation","authors":"Julia Shanu-Wilson, Ravi Manohar, Adriana Gomez, Richard Phipps, Jonathan Steele, Stephen Wrigley, Liam Evans, Frank Scheffler","doi":"10.1016/j.dmpk.2023.100942","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100942","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"21 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in PBPK modeling of phenolic drugs extensively metabolized by intestinal phase II enzyme 酚类药物经肠道二期酶广泛代谢的 PBPK 建模难题
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100977
Rashim Singh, Ming Hu, Lu Wang, Yifan Tu
{"title":"Challenges in PBPK modeling of phenolic drugs extensively metabolized by intestinal phase II enzyme","authors":"Rashim Singh, Ming Hu, Lu Wang, Yifan Tu","doi":"10.1016/j.dmpk.2023.100977","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100977","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"42 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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