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Drug Metabolism and Pharmacokinetics最新文献

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Rat and dog quad-culture liver chip models: Characterization and use to interrogate a potential flavin-containing monooxygenase-mediated, species-specific toxicity of a histamine receptor antagonist 大鼠和狗的四培养肝脏芯片模型：表征和用于询问潜在的含黄素单氧化酶介导的组胺受体拮抗剂的物种特异性毒性
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101099
David Stresser
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引用次数: 0
Targeted Protein Degraders (TPD): PK/PD translation from preclinical to clinical 靶向蛋白降解物（TPD）：从临床前到临床的PK/PD转化
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101085
Dapeng Chen
{"title":"Targeted Protein Degraders (TPD): PK/PD translation from preclinical to clinical","authors":"Dapeng Chen","doi":"10.1016/j.dmpk.2025.101085","DOIUrl":"10.1016/j.dmpk.2025.101085","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101085"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The regulatory roles of the lncRNA HNF1AOS1 in hepatic drug metabolism in mice lncRNA HNF1AOS1在小鼠肝脏药物代谢中的调控作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101153
Beshoy Armanios
{"title":"The regulatory roles of the lncRNA HNF1AOS1 in hepatic drug metabolism in mice","authors":"Beshoy Armanios","doi":"10.1016/j.dmpk.2025.101153","DOIUrl":"10.1016/j.dmpk.2025.101153","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101153"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a pharma[e]cological view of precision medicine 从制药生态学的角度看精准医疗
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101071
Peter Turnbaugh
{"title":"Towards a pharma[e]cological view of precision medicine","authors":"Peter Turnbaugh","doi":"10.1016/j.dmpk.2025.101071","DOIUrl":"10.1016/j.dmpk.2025.101071","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101071"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tips for bioanalytical method development of peptides, and their DDI risk evaluation 多肽生物分析方法发展提示及其DDI风险评估
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101075
Kosuke Saito
{"title":"Tips for bioanalytical method development of peptides, and their DDI risk evaluation","authors":"Kosuke Saito","doi":"10.1016/j.dmpk.2025.101075","DOIUrl":"10.1016/j.dmpk.2025.101075","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101075"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authenticity and adulteration of botanical natural products: Lessons from a decade of sourcing materials for scientific investigation 植物性天然产品的真实性和掺假：十年来为科学调查采购材料的经验教训
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101114
Nadja Cech
{"title":"Authenticity and adulteration of botanical natural products: Lessons from a decade of sourcing materials for scientific investigation","authors":"Nadja Cech","doi":"10.1016/j.dmpk.2025.101114","DOIUrl":"10.1016/j.dmpk.2025.101114","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101114"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of low CL compounds using chimeric mice with humanized liver 用人源化肝脏嵌合小鼠评价低CL化合物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101104
Hiroshi Suemizu
{"title":"Evaluation of low CL compounds using chimeric mice with humanized liver","authors":"Hiroshi Suemizu","doi":"10.1016/j.dmpk.2025.101104","DOIUrl":"10.1016/j.dmpk.2025.101104","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101104"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ontogeny and inter-individual variability of hydrolytic drug-metabolizing enzymes in human liver 人肝脏中水解药物代谢酶的个体发生和个体间变异
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101127
Dilip Singh , Deepak Ahire , Robert Jones , Bin Ma , Tian Yu , Bernard Murray , Bill Smith , Michael Zientek , Scott Heyward , Bhagwat Prasad
{"title":"The ontogeny and inter-individual variability of hydrolytic drug-metabolizing enzymes in human liver","authors":"Dilip Singh , Deepak Ahire , Robert Jones , Bin Ma , Tian Yu , Bernard Murray , Bill Smith , Michael Zientek , Scott Heyward , Bhagwat Prasad","doi":"10.1016/j.dmpk.2025.101127","DOIUrl":"10.1016/j.dmpk.2025.101127","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101127"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of pazopanib as an OATP1B1 substrate by competitive counterflow screeen 竞争性逆流筛选法鉴定帕唑帕尼为OATP1B1底物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101128
Kevin Huang, Thomas Drabison, Mike Boeckman, Alex Sparreboom, Shuiying Hu
{"title":"Identification of pazopanib as an OATP1B1 substrate by competitive counterflow screeen","authors":"Kevin Huang, Thomas Drabison, Mike Boeckman, Alex Sparreboom, Shuiying Hu","doi":"10.1016/j.dmpk.2025.101128","DOIUrl":"10.1016/j.dmpk.2025.101128","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101128"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of tyrosine kinases and inhibitors on SGLT1 activity 酪氨酸激酶和抑制剂对SGLT1活性的影响
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101122
Kshitee Sandeep Kharve, Aayush Shroff, Jeiyun Cao, Kyle Pasquariello
{"title":"Impact of tyrosine kinases and inhibitors on SGLT1 activity","authors":"Kshitee Sandeep Kharve, Aayush Shroff, Jeiyun Cao, Kyle Pasquariello","doi":"10.1016/j.dmpk.2025.101122","DOIUrl":"10.1016/j.dmpk.2025.101122","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101122"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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