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Drug Metabolism and Pharmacokinetics最新文献

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Effects of genetic polymorphisms of canine CYP2D15 on in vitro hepatic metabolism and in vivo pharmacokinetics of celecoxib, and the strategy for the accurate prediction of human pharmacokinetics 犬 CYP2D15 基因多态性对塞来昔布体外肝脏代谢和体内药代动力学的影响，以及准确预测人体药代动力学的策略
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100967
Miyuu Yanai, Kazutaka Sekiguchi, Yasuto Kido
{"title":"Effects of genetic polymorphisms of canine CYP2D15 on in vitro hepatic metabolism and in vivo pharmacokinetics of celecoxib, and the strategy for the accurate prediction of human pharmacokinetics","authors":"Miyuu Yanai, Kazutaka Sekiguchi, Yasuto Kido","doi":"10.1016/j.dmpk.2023.100967","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100967","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"128 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions of sutezolid and its active metabolite with human transporters 沙替佐利及其活性代谢物与人体转运体的相互作用
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100979
Upendra Argikar, Nathalie Rioux, Monicah Otieno
{"title":"Interactions of sutezolid and its active metabolite with human transporters","authors":"Upendra Argikar, Nathalie Rioux, Monicah Otieno","doi":"10.1016/j.dmpk.2023.100979","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100979","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches 通过实验和计算方法确定 UGT2B17 在药物和类固醇代谢中的杂交性和定量贡献
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100955
Deepak Ahire, Charles Mariasoosai, Siavosh Naji-Talakar, Senthil Natesan, Bhagwat Prasad
{"title":"Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches","authors":"Deepak Ahire, Charles Mariasoosai, Siavosh Naji-Talakar, Senthil Natesan, Bhagwat Prasad","doi":"10.1016/j.dmpk.2023.100955","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100955","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"40 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach to de-risk structural alerts in compound progression 在化合物进展过程中降低结构警报风险的方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100939
Charles Rotter, Heather Estrella, Takai Takafumi, Sean Zhu
{"title":"Approach to de-risk structural alerts in compound progression","authors":"Charles Rotter, Heather Estrella, Takai Takafumi, Sean Zhu","doi":"10.1016/j.dmpk.2023.100939","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100939","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"29 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of the relay method for low-turnover compounds in hepatocyte 建立肝细胞中低周转化合物的中继方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100947
Xiangling Wang, Haijuan Liu, Zhengu Xu, Yi Tao, Liang Shen, Genfu Chen
{"title":"Establishment of the relay method for low-turnover compounds in hepatocyte","authors":"Xiangling Wang, Haijuan Liu, Zhengu Xu, Yi Tao, Liang Shen, Genfu Chen","doi":"10.1016/j.dmpk.2023.100947","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100947","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"69 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elacridar leads to a much more pronounced boost in dog absorption than expected based on available non-clinical and clinical observations 根据现有的非临床和临床观察结果，Elacridar 对狗吸收的促进作用比预期的要明显得多
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100987
Diane Ramsden, Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad
{"title":"Elacridar leads to a much more pronounced boost in dog absorption than expected based on available non-clinical and clinical observations","authors":"Diane Ramsden, Paresh Chothe, Andrea Whitcher-Johnstone, Niresh Hariparsad","doi":"10.1016/j.dmpk.2023.100987","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100987","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"11 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a renal OCT2/Mate biomarker (N1-methylnicotinamide) to enable the early clinical assessment of metformin drug interaction potential 利用肾脏 OCT2/Mate 生物标记物（N1-甲基烟酰胺）对二甲双胍药物相互作用潜力进行早期临床评估
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100985
Sumathy Mathialagan, A. David Rodrigues
{"title":"Use of a renal OCT2/Mate biomarker (N1-methylnicotinamide) to enable the early clinical assessment of metformin drug interaction potential","authors":"Sumathy Mathialagan, A. David Rodrigues","doi":"10.1016/j.dmpk.2023.100985","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100985","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"3 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers 评估 CACO-2 细胞单层基底膜上 OSTΑ/Β 转运体的活性
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100991
Emi Yamaguchi, A. David Rodrigues, Emi Kimoto
{"title":"Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers","authors":"Emi Yamaguchi, A. David Rodrigues, Emi Kimoto","doi":"10.1016/j.dmpk.2023.100991","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100991","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"20 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catabolites identification and quantification of antisense oligonucleotides by liquid chromatography - high resolution mass spectrometry (LC-HRMS) 利用液相色谱-高分辨质谱法（LC-HRMS）鉴定和定量反义寡核苷酸的代谢物
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100949
Xin Zhang, Khishig Tsogtbaatar, Mai Thayer, Ryan Takahashi
{"title":"Catabolites identification and quantification of antisense oligonucleotides by liquid chromatography - high resolution mass spectrometry (LC-HRMS)","authors":"Xin Zhang, Khishig Tsogtbaatar, Mai Thayer, Ryan Takahashi","doi":"10.1016/j.dmpk.2023.100949","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100949","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"46 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous metabolites change associated with pioglitazone administration in healthy male subjects 健康男性服用吡格列酮后的内源性代谢物变化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100968
Jihyun Kang, SeungHwan Lee, Kyung-Sang Yu, Joo-Youn Cho
{"title":"Endogenous metabolites change associated with pioglitazone administration in healthy male subjects","authors":"Jihyun Kang, SeungHwan Lee, Kyung-Sang Yu, Joo-Youn Cho","doi":"10.1016/j.dmpk.2023.100968","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100968","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"29 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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