发布求助
文献互助 智能选刊 最新文献

Drug Metabolism and Pharmacokinetics最新文献

筛选
英文 中文
Screening towards a CYP3A7-specific marker reaction against CYP3A4 and CYP3A5 筛选针对CYP3A4和CYP3A5的cyp3a7特异性标记反应
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101155
Elias Carvalho Padilha
{"title":"Screening towards a CYP3A7-specific marker reaction against CYP3A4 and CYP3A5","authors":"Elias Carvalho Padilha","doi":"10.1016/j.dmpk.2025.101155","DOIUrl":"10.1016/j.dmpk.2025.101155","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101155"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a PAC-LC-MS/MS method for simultaneous quantification of mipomersen, its metabolites, and analogues in tissue samples 建立PAC-LC-MS/MS同时定量组织样品中米波莫森及其代谢物和类似物的方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101136
Yuchen Sun , Shin-ichiro Nitta , Hiroaki Aikawa , Tomoko Saito , Yonemasu Tsutomu , Ryoya Goda , Masaaki Kakehi , Yoshiharu Hayashi , Satoshi Ito , Tsuyoshi Kawahara , Naoto Masui , Kazuko Inoue , Kazutaka Shimbo , Takeru Yamaguchi , Fumihiro Jinno , Kaori Murakoshi , Kentaro Takahara , Chie Murata , Hitoshi Uchiyama , Mitsuhiko Kawabata , Yoshiro Saito
{"title":"Development of a PAC-LC-MS/MS method for simultaneous quantification of mipomersen, its metabolites, and analogues in tissue samples","authors":"Yuchen Sun , Shin-ichiro Nitta , Hiroaki Aikawa , Tomoko Saito , Yonemasu Tsutomu , Ryoya Goda , Masaaki Kakehi , Yoshiharu Hayashi , Satoshi Ito , Tsuyoshi Kawahara , Naoto Masui , Kazuko Inoue , Kazutaka Shimbo , Takeru Yamaguchi , Fumihiro Jinno , Kaori Murakoshi , Kentaro Takahara , Chie Murata , Hitoshi Uchiyama , Mitsuhiko Kawabata , Yoshiro Saito","doi":"10.1016/j.dmpk.2025.101136","DOIUrl":"10.1016/j.dmpk.2025.101136","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101136"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food 食源性神经营养氨基酸麦角硫因及其转运体SLC22A4：从实验室到健康食品
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101094
Yukio Kato
{"title":"Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food","authors":"Yukio Kato","doi":"10.1016/j.dmpk.2025.101094","DOIUrl":"10.1016/j.dmpk.2025.101094","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101094"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update from the IQ TALG quantitative fraction metabolized working group 来自IQ TALG定量组分代谢工作组的更新
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101101
Angela Doran
{"title":"Update from the IQ TALG quantitative fraction metabolized working group","authors":"Angela Doran","doi":"10.1016/j.dmpk.2025.101101","DOIUrl":"10.1016/j.dmpk.2025.101101","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101101"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-drug interaction between trastuzumab emtansine (T-DM1) and orally administered tacrolimus in a patient and in rats 曲妥珠单抗emtansine （T-DM1）和口服他克莫司在患者和大鼠中的药物相互作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-05-03 DOI: 10.1016/j.dmpk.2025.101486
Tomohiro Nakamura , Moeko Shimada , Makiko Takabayashi , Arimi Fujita , Takahiro Kawakami , Hiroyuki Maruyama , Hirofumi Terakawa , Takahiro Ishimoto , Tsutomu Shimada , Toshihiro Miyamoto , Yoshimichi Sai
{"title":"Drug-drug interaction between trastuzumab emtansine (T-DM1) and orally administered tacrolimus in a patient and in rats","authors":"Tomohiro Nakamura ,&nbsp;Moeko Shimada ,&nbsp;Makiko Takabayashi ,&nbsp;Arimi Fujita ,&nbsp;Takahiro Kawakami ,&nbsp;Hiroyuki Maruyama ,&nbsp;Hirofumi Terakawa ,&nbsp;Takahiro Ishimoto ,&nbsp;Tsutomu Shimada ,&nbsp;Toshihiro Miyamoto ,&nbsp;Yoshimichi Sai","doi":"10.1016/j.dmpk.2025.101486","DOIUrl":"10.1016/j.dmpk.2025.101486","url":null,"abstract":"<div><div>We have experienced a 2.3-fold increase in the trough concentration of orally administered tacrolimus in a patient for 7 days after intravenous administration of trastuzumab emtansine (T-DM1), an antibody-drug conjugate. Retrospective clinical study revealed no change in factors known to alter the pharmacokinetics of tacrolimus, and the change in the trough concentration of tacrolimus was reversed after switching T-DM1 to trastuzumab (Tmab). Thus, interaction with T-DM1 was suspected as the cause of the increased trough concentration of tacrolimus. An animal study in rats showed that T-DM1 significantly increased the <em>AUC</em><sub>0-∞</sub> of orally administered tacrolimus by more than 2-fold on day 0, day 3, and day 7, whereas no change was observed in the case of intravenous administration of tacrolimus. T-DM1 also significantly increased <em>F</em><sub>a</sub>・<em>F</em><sub>g</sub> of tacrolimus by more than 2-fold on day 7. In contrast, Tmab itself had no effect on the blood concentration of tacrolimus. These results suggest that T-DM1 increased the blood concentration of orally administered tacrolimus, and the effect persisted for 1 week after T-DM1 administration. Metabolites of T-DM1 excreted via the biliary route may contribute to the increase in the gastrointestinal absorption of tacrolimus.</div></div>","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"62 ","pages":"Article 101486"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range 蛋白表达作为评估CYP2B6诱导的终点：应用免疫亲和捕获方法可以提高动态反应范围
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101156
Julius Enoru, Anand Joshi, Paramasivam Natarajan, Mira Jones, Hetal Sarvaiya, Steve Keller
{"title":"Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range","authors":"Julius Enoru,&nbsp;Anand Joshi,&nbsp;Paramasivam Natarajan,&nbsp;Mira Jones,&nbsp;Hetal Sarvaiya,&nbsp;Steve Keller","doi":"10.1016/j.dmpk.2025.101156","DOIUrl":"10.1016/j.dmpk.2025.101156","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101156"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex drug-drug interactions: Study design and clinical interpretation 复杂的药物-药物相互作用：研究设计和临床解释
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101081
Manoli Vourvahis
{"title":"Complex drug-drug interactions: Study design and clinical interpretation","authors":"Manoli Vourvahis","doi":"10.1016/j.dmpk.2025.101081","DOIUrl":"10.1016/j.dmpk.2025.101081","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101081"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oligonucleotide target engagement 寡核苷酸目标交战
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101076
Michael McCoy
{"title":"Oligonucleotide target engagement","authors":"Michael McCoy","doi":"10.1016/j.dmpk.2025.101076","DOIUrl":"10.1016/j.dmpk.2025.101076","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101076"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alteration of blood brain-barrier proteome in various conditions 不同条件下血脑屏障蛋白质组的改变
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101113
Sumio Ohtsuki
{"title":"Alteration of blood brain-barrier proteome in various conditions","authors":"Sumio Ohtsuki","doi":"10.1016/j.dmpk.2025.101113","DOIUrl":"10.1016/j.dmpk.2025.101113","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101113"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The blood brain barrier demonstrates capability to influence heterogenous tenofovir and emtricitabine metabolism and transport in the brain 血脑屏障显示有能力影响异质替诺福韦和恩曲他滨在大脑中的代谢和运输
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101119
Hannah Wilkins , Ben Orsburn , Dionna Williams
{"title":"The blood brain barrier demonstrates capability to influence heterogenous tenofovir and emtricitabine metabolism and transport in the brain","authors":"Hannah Wilkins ,&nbsp;Ben Orsburn ,&nbsp;Dionna Williams","doi":"10.1016/j.dmpk.2025.101119","DOIUrl":"10.1016/j.dmpk.2025.101119","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101119"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书