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Drug Metabolism and Pharmacokinetics最新文献

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In vivo models for assessing the toxicity of reactive metabolites 用于评估活性代谢物毒性的体内模型
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101067
Xinxin Ding
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引用次数: 0
Rapid production of rabbit monoclonal anti-idiotype antibody for antibody drugs by ecobody technology 利用生态体技术快速生产兔单克隆抗独特型抗体用于抗体药物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101133
Shin Kawano, Tomoe Yamauchi, Tomiko Yamada, Risumi Isogai, Satoko Yamamoto, Shoji Ohuchi
{"title":"Rapid production of rabbit monoclonal anti-idiotype antibody for antibody drugs by ecobody technology","authors":"Shin Kawano, Tomoe Yamauchi, Tomiko Yamada, Risumi Isogai, Satoko Yamamoto, Shoji Ohuchi","doi":"10.1016/j.dmpk.2025.101133","DOIUrl":"10.1016/j.dmpk.2025.101133","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101133"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rat and dog quad-culture liver chip models: Characterization and use to interrogate a potential flavin-containing monooxygenase-mediated, species-specific toxicity of a histamine receptor antagonist 大鼠和狗的四培养肝脏芯片模型：表征和用于询问潜在的含黄素单氧化酶介导的组胺受体拮抗剂的物种特异性毒性
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101099
David Stresser
{"title":"Rat and dog quad-culture liver chip models: Characterization and use to interrogate a potential flavin-containing monooxygenase-mediated, species-specific toxicity of a histamine receptor antagonist","authors":"David Stresser","doi":"10.1016/j.dmpk.2025.101099","DOIUrl":"10.1016/j.dmpk.2025.101099","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101099"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-Based feature generation for molecular design 基于人工智能的分子设计特征生成
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101088
Tadahaya Mizuno
{"title":"AI-Based feature generation for molecular design","authors":"Tadahaya Mizuno","doi":"10.1016/j.dmpk.2025.101088","DOIUrl":"10.1016/j.dmpk.2025.101088","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101088"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tips for bioanalytical method development of peptides, and their DDI risk evaluation 多肽生物分析方法发展提示及其DDI风险评估
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101075
Kosuke Saito
{"title":"Tips for bioanalytical method development of peptides, and their DDI risk evaluation","authors":"Kosuke Saito","doi":"10.1016/j.dmpk.2025.101075","DOIUrl":"10.1016/j.dmpk.2025.101075","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101075"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hybrid trial approach by combining 13C8-lableded and radiolabeled brilaroxazine to assess absolute bioavailability and hame in a single clinical trial 结合13c8标记和放射性标记布拉恶嗪的混合试验方法，在单一临床试验中评估绝对生物利用度和甲胺
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101139
Li Shen , Laxminarayan Bhat , Seema Bhat , Palaniappan Kulanthaivel , Yanfeng Fan , Ganesh Moorthy , Lisa Diamond , Christine Brzostowski , Abdul Mutlib
{"title":"A hybrid trial approach by combining 13C8-lableded and radiolabeled brilaroxazine to assess absolute bioavailability and hame in a single clinical trial","authors":"Li Shen , Laxminarayan Bhat , Seema Bhat , Palaniappan Kulanthaivel , Yanfeng Fan , Ganesh Moorthy , Lisa Diamond , Christine Brzostowski , Abdul Mutlib","doi":"10.1016/j.dmpk.2025.101139","DOIUrl":"10.1016/j.dmpk.2025.101139","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101139"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ontogeny and inter-individual variability of hydrolytic drug-metabolizing enzymes in human liver 人肝脏中水解药物代谢酶的个体发生和个体间变异
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101127
Dilip Singh , Deepak Ahire , Robert Jones , Bin Ma , Tian Yu , Bernard Murray , Bill Smith , Michael Zientek , Scott Heyward , Bhagwat Prasad
{"title":"The ontogeny and inter-individual variability of hydrolytic drug-metabolizing enzymes in human liver","authors":"Dilip Singh , Deepak Ahire , Robert Jones , Bin Ma , Tian Yu , Bernard Murray , Bill Smith , Michael Zientek , Scott Heyward , Bhagwat Prasad","doi":"10.1016/j.dmpk.2025.101127","DOIUrl":"10.1016/j.dmpk.2025.101127","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101127"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of pazopanib as an OATP1B1 substrate by competitive counterflow screeen 竞争性逆流筛选法鉴定帕唑帕尼为OATP1B1底物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101128
Kevin Huang, Thomas Drabison, Mike Boeckman, Alex Sparreboom, Shuiying Hu
{"title":"Identification of pazopanib as an OATP1B1 substrate by competitive counterflow screeen","authors":"Kevin Huang, Thomas Drabison, Mike Boeckman, Alex Sparreboom, Shuiying Hu","doi":"10.1016/j.dmpk.2025.101128","DOIUrl":"10.1016/j.dmpk.2025.101128","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101128"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The regulatory roles of the lncRNA HNF1AOS1 in hepatic drug metabolism in mice lncRNA HNF1AOS1在小鼠肝脏药物代谢中的调控作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101153
Beshoy Armanios
{"title":"The regulatory roles of the lncRNA HNF1AOS1 in hepatic drug metabolism in mice","authors":"Beshoy Armanios","doi":"10.1016/j.dmpk.2025.101153","DOIUrl":"10.1016/j.dmpk.2025.101153","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101153"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a pharma[e]cological view of precision medicine 从制药生态学的角度看精准医疗
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101071
Peter Turnbaugh
{"title":"Towards a pharma[e]cological view of precision medicine","authors":"Peter Turnbaugh","doi":"10.1016/j.dmpk.2025.101071","DOIUrl":"10.1016/j.dmpk.2025.101071","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101071"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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