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Drug Metabolism and Pharmacokinetics最新文献

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Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes 蛋白质降解剂巴夫地加鲁胺和 XL01126 在透化低温保存的人肝细胞中的生物转化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100934
Bin Ma, Susan Wong, Joyce Liu, Jingwei Cai, Cyrus Khojasteh, Donglu Zhang
{"title":"Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes","authors":"Bin Ma, Susan Wong, Joyce Liu, Jingwei Cai, Cyrus Khojasteh, Donglu Zhang","doi":"10.1016/j.dmpk.2023.100934","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100934","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"25 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for DDI risk assessment between novel oncology agents and combination generic standard of care (SOC) agents 新型肿瘤药物与普通标准疗法 (SOC) 联合用药之间的 DDI 风险评估策略
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100945
Ravi Visswanathan, Elaine Tseng, Loretta Cox, Julie Cianfrogna, R. Scott Obach, Rhys Jones
{"title":"Strategies for DDI risk assessment between novel oncology agents and combination generic standard of care (SOC) agents","authors":"Ravi Visswanathan, Elaine Tseng, Loretta Cox, Julie Cianfrogna, R. Scott Obach, Rhys Jones","doi":"10.1016/j.dmpk.2023.100945","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100945","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"45 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment and characterization of an in vitro model for NTCP substrate and inhibition assessment 建立并鉴定用于评估 NTCP 底物和抑制作用的体外模型
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100982
Tao Xiong, Yuxi Wang, Xuan Zhang, Xiangling Wang, Hong Zhang, Weiqun Cao, Yi Tao, Liang Shen, Genfu Chen
{"title":"Establishment and characterization of an in vitro model for NTCP substrate and inhibition assessment","authors":"Tao Xiong, Yuxi Wang, Xuan Zhang, Xiangling Wang, Hong Zhang, Weiqun Cao, Yi Tao, Liang Shen, Genfu Chen","doi":"10.1016/j.dmpk.2023.100982","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100982","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"6 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying accurate metabolism sites of vepdegestrant using novel electron-activated dissociation high-resolution mass spectrometry 利用新型电子激活解离高分辨质谱法确定维替孕甾的准确代谢位点
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100950
Yifei He, Pengyi Hou, Zhimin Long, Yuadong Zheng, Chongzhuang Tang, Elliott Jones, Xingxing Diao, Mingshe Zhu
{"title":"Identifying accurate metabolism sites of vepdegestrant using novel electron-activated dissociation high-resolution mass spectrometry","authors":"Yifei He, Pengyi Hou, Zhimin Long, Yuadong Zheng, Chongzhuang Tang, Elliott Jones, Xingxing Diao, Mingshe Zhu","doi":"10.1016/j.dmpk.2023.100950","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100950","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"128 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tenofovir activation is diminished in the brain and liver of creatine kinase brain-type knockout mice 脑型肌酸激酶基因敲除小鼠的大脑和肝脏中替诺福韦的激活作用减弱
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100956
Colten Eberhard, Benjamin Orsburn, Namandjé Bumpus
{"title":"Tenofovir activation is diminished in the brain and liver of creatine kinase brain-type knockout mice","authors":"Colten Eberhard, Benjamin Orsburn, Namandjé Bumpus","doi":"10.1016/j.dmpk.2023.100956","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100956","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"64 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase 厄洛替尼作为基于机制的人类醛氧化酶强效失活剂的鉴定和表征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100952
Ryan A. Dick, Xiaomin Liang, Hailing Sun, Bernard P. Murray, Bill J. Smith
{"title":"Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase","authors":"Ryan A. Dick, Xiaomin Liang, Hailing Sun, Bernard P. Murray, Bill J. Smith","doi":"10.1016/j.dmpk.2023.100952","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100952","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"66 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice 暴露于混合微塑料颗粒会改变小鼠的粪便微生物群及其相关的预测功能途径
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100928
Kyle Kim, Julia Cui, Haiwei Gu, Marcus Garcia, Matthew Campen, Eliseo Castillo, Aaron Romero
{"title":"Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice","authors":"Kyle Kim, Julia Cui, Haiwei Gu, Marcus Garcia, Matthew Campen, Eliseo Castillo, Aaron Romero","doi":"10.1016/j.dmpk.2023.100928","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100928","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"27 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis 局部生物活性草药成分通过维持肠道氧化应激平衡预防伊立替康诱导的肠道毒性
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100892
Vesna Tumbas Saponjac, Rongjin Sun, Zicong Zheng, Jie Chen, Songpol Srinual, Ming Hu, Rashim Singh
{"title":"Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis","authors":"Vesna Tumbas Saponjac, Rongjin Sun, Zicong Zheng, Jie Chen, Songpol Srinual, Ming Hu, Rashim Singh","doi":"10.1016/j.dmpk.2023.100892","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100892","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"82 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From quantum mechanics to metabolism pathways 从量子力学到新陈代谢途径
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100935
Mario Oeren, Peter Walton, Sylvia Kaempf, James Suri, David Ponting, Peter Hunt, Tamsin Mansley, Matthew Segall
{"title":"From quantum mechanics to metabolism pathways","authors":"Mario Oeren, Peter Walton, Sylvia Kaempf, James Suri, David Ponting, Peter Hunt, Tamsin Mansley, Matthew Segall","doi":"10.1016/j.dmpk.2023.100935","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100935","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"164 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiologically based pharmacokinetic model for miltefosine in mice 基于生理学的小鼠米替福新药代动力学模型
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100975
Bhargavi Srija Ramisetty, Sihyung Yang, Michael Zhuo Wang
{"title":"Physiologically based pharmacokinetic model for miltefosine in mice","authors":"Bhargavi Srija Ramisetty, Sihyung Yang, Michael Zhuo Wang","doi":"10.1016/j.dmpk.2023.100975","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100975","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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