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OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes 三维培养的原代人类肝细胞中的 OCT1 转运体动力学和长期调节研究
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100894
Maria Karlgren
{"title":"OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes","authors":"Maria Karlgren","doi":"10.1016/j.dmpk.2023.100894","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100894","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redox metabolism in intestine and liver aggravates retronecine-type pyrrolizidine alkaloids-induced liver injury 肠道和肝脏中的氧化还原代谢加剧了雷公藤碱类吡咯烷生物碱引起的肝损伤
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100932
Ge Lin, Yueyang Pan, Yuen Ching To, Zijing Song
{"title":"Redox metabolism in intestine and liver aggravates retronecine-type pyrrolizidine alkaloids-induced liver injury","authors":"Ge Lin, Yueyang Pan, Yuen Ching To, Zijing Song","doi":"10.1016/j.dmpk.2023.100932","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100932","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the power of IVIVE-PBPK to explore potential discordance between local gut vs systemic bioequivalence in health and disease: the case of budesonide in crohn’s disease 利用 IVIVE-PBPK 的强大功能探索健康和疾病中肠道局部生物等效性与全身生物等效性之间可能存在的不一致：布地奈德治疗羊角风病的案例
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100970
Chunyan Han, Siri Kalyan Chirumamilla, Tiancheng Sun, Mandy Xu, Frederic Bois, Amin Rostami-Hodjegan
{"title":"Harnessing the power of IVIVE-PBPK to explore potential discordance between local gut vs systemic bioequivalence in health and disease: the case of budesonide in crohn’s disease","authors":"Chunyan Han, Siri Kalyan Chirumamilla, Tiancheng Sun, Mandy Xu, Frederic Bois, Amin Rostami-Hodjegan","doi":"10.1016/j.dmpk.2023.100970","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100970","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges associated with the biomarker-informed PBPK modeling of renal transporter-mediated drug interactions 与肾脏转运体介导的药物相互作用的生物标志物 PBPK 模型相关的挑战
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100973
Emi Kimoto, David Tess, Matthew Cerny, Sumathy Mathialagan, Sangwoo Ryu, Manoli Vourvahis, A. David Rodrigues, Manthena V. Varma
{"title":"Challenges associated with the biomarker-informed PBPK modeling of renal transporter-mediated drug interactions","authors":"Emi Kimoto, David Tess, Matthew Cerny, Sumathy Mathialagan, Sangwoo Ryu, Manoli Vourvahis, A. David Rodrigues, Manthena V. Varma","doi":"10.1016/j.dmpk.2023.100973","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100973","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of pharmacokinetics and pharmacodynamics in human for IRAK4 targeted protein degrader IRAK4 靶向蛋白降解剂的人体药代动力学和药效学预测
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100957
Dapeng Chen, Haojing Rong, Michele Mayo, Alice McDonald, Veronica Campbell, Xiaozhang Zheng, Sagar Agarwal, Matt Weiss, Anthony Slavin
{"title":"Prediction of pharmacokinetics and pharmacodynamics in human for IRAK4 targeted protein degrader","authors":"Dapeng Chen, Haojing Rong, Michele Mayo, Alice McDonald, Veronica Campbell, Xiaozhang Zheng, Sagar Agarwal, Matt Weiss, Anthony Slavin","doi":"10.1016/j.dmpk.2023.100957","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100957","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of traditional herbal medicine on the permeability of clarithromycin and loxoprofen in CACO-2 cell model 传统中药对克拉霉素和洛索洛芬在 CACO-2 细胞模型中渗透性的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100988
Sabin Shin, Sangyoung Lee, Chae Bin Lee, Seong Jun Jo, Soon Uk Chae, Da Hyun Kim, Duk Yeon Kim, Ui Min Jerng, Soo Kyung Bae
{"title":"The effect of traditional herbal medicine on the permeability of clarithromycin and loxoprofen in CACO-2 cell model","authors":"Sabin Shin, Sangyoung Lee, Chae Bin Lee, Seong Jun Jo, Soon Uk Chae, Da Hyun Kim, Duk Yeon Kim, Ui Min Jerng, Soo Kyung Bae","doi":"10.1016/j.dmpk.2023.100988","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100988","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of quantitative translational model of neutropenia using nonclinical animal data and physiological parameters 利用非临床动物数据和生理参数建立中性粒细胞减少症定量转化模型
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100960
Naomi Wakayama, Yosuke Nakatani, Yukiko Miyajima, Yuko Nagayama, Yoko Nishino, Etsuko Ohta
{"title":"Development of quantitative translational model of neutropenia using nonclinical animal data and physiological parameters","authors":"Naomi Wakayama, Yosuke Nakatani, Yukiko Miyajima, Yuko Nagayama, Yoko Nishino, Etsuko Ohta","doi":"10.1016/j.dmpk.2023.100960","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100960","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of physiologically-based pharmacokinetic models to predict food effects and co-administration of proton pump inhibitors on the pharmacokinetics of sonidegib and vismodegib 开发基于生理学的药代动力学模型，以预测食物和联合使用质子泵抑制剂对 sonidegib 和 vismodegib 药代动力学的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100962
Duk Yeon Kim, Soo Kyung Bae, Seong Jun Jo, Chae Bin Lee, Soon Uk Chae, Sabin Shin, Da Hyun Kim
{"title":"Development of physiologically-based pharmacokinetic models to predict food effects and co-administration of proton pump inhibitors on the pharmacokinetics of sonidegib and vismodegib","authors":"Duk Yeon Kim, Soo Kyung Bae, Seong Jun Jo, Chae Bin Lee, Soon Uk Chae, Sabin Shin, Da Hyun Kim","doi":"10.1016/j.dmpk.2023.100962","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100962","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bringing totality-of-evidence into PBPK predictions: fraction metabolised by aldehyde oxidase 将证据整体性引入 PBPK 预测：通过醛氧化酶代谢的部分
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100953
Nihan Izat, J. Brian Houston, Jill Barber, Aleksandra Galetin, Daniel Scotcher
{"title":"Bringing totality-of-evidence into PBPK predictions: fraction metabolised by aldehyde oxidase","authors":"Nihan Izat, J. Brian Houston, Jill Barber, Aleksandra Galetin, Daniel Scotcher","doi":"10.1016/j.dmpk.2023.100953","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100953","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A workflow for oligonucleotide metabolite identification studies 寡核苷酸代谢物鉴定研究工作流程
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100938
Ruisong Pei, Bridget Becker, Rebecca Hansen, Robert Greene, Joe Marini, Dan Albaugh
{"title":"A workflow for oligonucleotide metabolite identification studies","authors":"Ruisong Pei, Bridget Becker, Rebecca Hansen, Robert Greene, Joe Marini, Dan Albaugh","doi":"10.1016/j.dmpk.2023.100938","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100938","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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