Drug Metabolism and Pharmacokinetics最新文献_第4页

How do i use PBPK modeling to discern complex drug-drug interactions? 如何使用PBPK模型来识别复杂的药物-药物相互作用？

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101062

Jayaprakasam Bolleddula

引用次数: 0

How will CYP induction related PBPK applications be evaluated during the NDA reviews? 在NDA审查期间，如何评估CYP诱导相关的PBPK申请？

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101063

Ying-Hong Wang

引用次数: 0

Quantitative analysis of gastrointestinal drug absorption and disposition using state-of-the-art technology 利用最新技术对胃肠道药物吸收和处置进行定量分析

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101068

Yoshiyuki Shirasaka

引用次数: 0

Mechanisms underlying altered drug clearance in pregnancy 妊娠期药物清除改变的机制

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101112

Muluneh Fashe

引用次数: 0

Human enteroid monolayers – A fit-for purpose model to elucidate intestinal natural product-drug interactions 人肠道单分子层-一个适合目的的模型来阐明肠道天然产物-药物相互作用

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101070

Kenneth E. Thummel, Eimear O’Mahony, Christopher Arian, Edward J. Kelly

引用次数: 0

Computer aided metid for small molecules and peptide drugs 小分子和多肽药物的计算机辅助方法

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101091

Ismael Zamora

引用次数: 0

Membrane transporters in drug development and as determinants of precision medicine; an update from the international transporter consortium 膜转运蛋白在药物开发和精准医疗的决定因素来自国际运输联盟的最新消息

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101092

Kim Brouwer

引用次数: 0

Incorporation of well-stirred, dispersion and parallel tube liver models into simple and permeability limited PBPK frameworks for clearance prediction 将充分搅拌、分散和平行管肝模型纳入简单和渗透率有限的PBPK框架，用于预测清除

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101147

Swati Nagar, Rachel Parise, Ken Korzekwa

引用次数: 0

Investigation of pilocarpine oxidative and hydrolytic metabolism in chimeric mice with humanized liver 人肝嵌合小鼠匹罗卡品氧化和水解代谢的研究

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101484

Shotaro Uehara , Yuichiro Higuchi , Nao Yoneda , Hiroshi Yamazaki , Hiroshi Suemizu

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引用次数: 0

Pharmacokinetic modeling leveraging in vitro to in vivo extrapolation of the gut microbiome’s role in sulfasalazine metabolism into sulfapyridine and mesalamine 利用体外到体内的药代动力学模型，推断肠道微生物组在磺胺吡啶和美沙拉胺代谢中的作用

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101120

Lisa Cheng , Jingwei Cai , Alexis Auster , Sungjoon Cho , Miaoran Ning

引用次数: 0