Drug Metabolism and Pharmacokinetics最新文献_第4页

Improving ADME properties of therapeutic antibodies by novel engineering technologies 利用新的工程技术改善治疗性抗体的ADME特性

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101086

Kenta Haraya

引用次数: 0

Investigation of the mechanism of metronidazole-induced encephalopathy focusing on the possible effect on thiamine transport 甲硝唑致脑病机制的研究重点是对硫胺素运输的可能影响

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101130

Yoshiaki Yamagishi, Mitsuhiro Hashimoto, Miyuki Sugita, Satomi Watanabe, Nana Sekine, Yuki Takahashi, Yasuko Ogawa, Toshiyuki Kudo, Kiyomi Ito

引用次数: 0

Investigation of pilocarpine oxidative and hydrolytic metabolism in chimeric mice with humanized liver 人肝嵌合小鼠匹罗卡品氧化和水解代谢的研究

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101484

Shotaro Uehara , Yuichiro Higuchi , Nao Yoneda , Hiroshi Yamazaki , Hiroshi Suemizu

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引用次数: 0

Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling 通过PBPK模型整合肠道生理学和药物代谢、处置和相互作用

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101072

Bhagwat Prasad

引用次数: 0

In vitro study of payload release of an anti-TNF glucocorticoid receptor modulator immunology antibody-drug conjugate (ADC-T) and payload metabolism 抗肿瘤坏死因子糖皮质激素受体调节剂免疫抗体-药物偶联物（ADC-T）和有效载荷代谢的体外研究

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101132

Mingshe Zhu , Zhiqiang Li , Chongzhuang Tang , Yang Gao , Lijuan Chen , Xingxing Diao

引用次数: 0

Discovery of PF-07817883, a second-generation oral SARS-CoV2 main protease inhibitor 第二代口服SARS-CoV2主要蛋白酶抑制剂PF-07817883的发现

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101106

Amit Kalgutkar

引用次数: 0

How do i use PBPK modeling to discern complex drug-drug interactions? 如何使用PBPK模型来识别复杂的药物-药物相互作用？

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101062

Jayaprakasam Bolleddula

引用次数: 0

How will CYP induction related PBPK applications be evaluated during the NDA reviews? 在NDA审查期间，如何评估CYP诱导相关的PBPK申请？

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101063

Ying-Hong Wang

引用次数: 0

Quantitative analysis of gastrointestinal drug absorption and disposition using state-of-the-art technology 利用最新技术对胃肠道药物吸收和处置进行定量分析

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101068

Yoshiyuki Shirasaka

引用次数: 0

Mechanisms underlying altered drug clearance in pregnancy 妊娠期药物清除改变的机制

IF 2.7 4区医学

Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101112

Muluneh Fashe

引用次数: 0