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Botanical-drug interactions: Blazing the trail using translational tools 植物-药物相互作用：利用翻译工具开辟道路
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101116
Mary Paine
{"title":"Botanical-drug interactions: Blazing the trail using translational tools","authors":"Mary Paine","doi":"10.1016/j.dmpk.2025.101116","DOIUrl":"10.1016/j.dmpk.2025.101116","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101116"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotyping assay using genetically manipulated human IPS cell-derived hepatocyte- like cells 利用基因操纵的人IPS细胞衍生的肝细胞样细胞进行表型分析
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101102
Hiroyuki Mizuguchi
{"title":"Phenotyping assay using genetically manipulated human IPS cell-derived hepatocyte- like cells","authors":"Hiroyuki Mizuguchi","doi":"10.1016/j.dmpk.2025.101102","DOIUrl":"10.1016/j.dmpk.2025.101102","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101102"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do i build an ‘Ideal’ PBPK model if my drug is either a substrate or inducer 如果我的药物是底物或诱导剂，我如何建立一个“理想的”PBPK模型
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101061
Ryuta Asaumi
{"title":"How do i build an ‘Ideal’ PBPK model if my drug is either a substrate or inducer","authors":"Ryuta Asaumi","doi":"10.1016/j.dmpk.2025.101061","DOIUrl":"10.1016/j.dmpk.2025.101061","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101061"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery, validation, and application of transporter endogenous biomarkers: A work of translation 转运体内源性生物标志物的发现、验证和应用：翻译工作
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101093
Hong Shen
{"title":"Discovery, validation, and application of transporter endogenous biomarkers: A work of translation","authors":"Hong Shen","doi":"10.1016/j.dmpk.2025.101093","DOIUrl":"10.1016/j.dmpk.2025.101093","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101093"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human aldo-keto reductase (AKR) 1C1 and 1C2 act as coactivators of pregnane X receptor, a master regulator of drug-metabolizing and gluconeogenesis enzymes 人醛酮还原酶（AKR） 1C1和1C2是孕激素X受体的共激活因子，是药物代谢和糖异生酶的主要调节因子
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.dmpk.2025.101481
Rei Mitamura , Seiya Takemoto , Yuka Aoyama , Koki Morita , Yuichiro Higuchi , Shotaro Uehara , Nao Yoneda , Hiroshi Suemizu , Tatsuki Fukami , Masataka Nakano , Miki Nakajima
{"title":"Human aldo-keto reductase (AKR) 1C1 and 1C2 act as coactivators of pregnane X receptor, a master regulator of drug-metabolizing and gluconeogenesis enzymes","authors":"Rei Mitamura ,&nbsp;Seiya Takemoto ,&nbsp;Yuka Aoyama ,&nbsp;Koki Morita ,&nbsp;Yuichiro Higuchi ,&nbsp;Shotaro Uehara ,&nbsp;Nao Yoneda ,&nbsp;Hiroshi Suemizu ,&nbsp;Tatsuki Fukami ,&nbsp;Masataka Nakano ,&nbsp;Miki Nakajima","doi":"10.1016/j.dmpk.2025.101481","DOIUrl":"10.1016/j.dmpk.2025.101481","url":null,"abstract":"<div><div>The aldo-keto reductase (AKR) 1C subfamily, comprising AKR1C1-1C4, plays a crucial role in drug metabolism and hormone biosynthesis. Recent studies have identified AKR1C3 as a co-activator of the androgen receptor. This study aimed to investigate whether AKR1Cs function as regulators of the pregnane X receptor (PXR), a member of the nuclear receptor superfamily, which upregulates drug-metabolizing enzymes such as cytochrome P450 (CYP) 3A4. Rifampicin-activated CYP3A4 induction was attenuated by AKR1C1/1C2 knockdown in ShP51 cells (PXR-overexpressing HepG2 cells), HepaRG cells, and HepaSH cells (hepatocytes from humanized liver mice). Co-immunoprecipitation analysis revealed that AKR1Cs interact with PXR. Immunofluorescent staining revealed that AKR1Cs are translocated into the nucleus with PXR by rifampicin in HepaRG cells. These results suggested that AKR1C1/1C2 has an ability to enhance transactivity of PXR. Consistent with the results of knockdown experiments, PXR-mediated CYP3A4 induction was significantly attenuated by treatment with AKR1C1/1C2 inhibitors, diazepam or flunitrazepam, in ShP51, HepaRG, and HepaSH cells. Furthermore, the induction of CYP2B6, CYP2C9, glucose 6-phosphatase, and phosphoenolpyruvate carboxykinase 1, all regulated by PXR, was attenuated by AKR1C1/1C2 inhibitors. Collectively, we demonstrated that AKR1C1/1C2 upregulates PXR transactivation. Clinically used drugs that inhibit AKR1C1/1C2 may suppress PXR-mediated transactivation of genes encoding drug-metabolizing and gluconeogenesis enzymes.</div></div>","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"62 ","pages":"Article 101481"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal secretion is potentially an important clearance mechanism for highly plasma-bound and low metabolic clearance efflux substrates 肠道分泌可能是高血浆结合和低代谢清除外排底物的重要清除机制
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101149
Murali Subramanian, Deepak Ahire, Rakshit Tanna, Josh Yu, Kelly Wang, Wei Wang, Gillian Smith, Xingrong Liu
{"title":"Intestinal secretion is potentially an important clearance mechanism for highly plasma-bound and low metabolic clearance efflux substrates","authors":"Murali Subramanian,&nbsp;Deepak Ahire,&nbsp;Rakshit Tanna,&nbsp;Josh Yu,&nbsp;Kelly Wang,&nbsp;Wei Wang,&nbsp;Gillian Smith,&nbsp;Xingrong Liu","doi":"10.1016/j.dmpk.2025.101149","DOIUrl":"10.1016/j.dmpk.2025.101149","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101149"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selection of liver models of hepatic drug clearance: Improvements and implications for ivive and PBPK modeling 肝脏药物清除模型的选择：活体和PBPK模型的改进和意义
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101148
K. Sandy Pang, Weijia Ivy Lu, Gerard Mulder
{"title":"Selection of liver models of hepatic drug clearance: Improvements and implications for ivive and PBPK modeling","authors":"K. Sandy Pang,&nbsp;Weijia Ivy Lu,&nbsp;Gerard Mulder","doi":"10.1016/j.dmpk.2025.101148","DOIUrl":"10.1016/j.dmpk.2025.101148","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101148"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of physiological factors suppressing colonic drug absorption using quantum imaging technology 利用量子成像技术鉴定抑制结肠药物吸收的生理因素
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101141
Yugo Yasugi , Maho Hirosaki , Kazuki Hotta , Yumi Kato , Yasuyuki Ueda , Mayumi Iwatake , Hiroshi Yukawa , Ikumi Tamai , Yoshiyuki Shirasaka
{"title":"Identification of physiological factors suppressing colonic drug absorption using quantum imaging technology","authors":"Yugo Yasugi ,&nbsp;Maho Hirosaki ,&nbsp;Kazuki Hotta ,&nbsp;Yumi Kato ,&nbsp;Yasuyuki Ueda ,&nbsp;Mayumi Iwatake ,&nbsp;Hiroshi Yukawa ,&nbsp;Ikumi Tamai ,&nbsp;Yoshiyuki Shirasaka","doi":"10.1016/j.dmpk.2025.101141","DOIUrl":"10.1016/j.dmpk.2025.101141","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101141"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling cannabinoids-drug interactions in aging: Insights from PBPK modeling 揭示大麻素-药物在衰老中的相互作用：来自PBPK模型的见解
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101110
Zhu Zhou
{"title":"Unraveling cannabinoids-drug interactions in aging: Insights from PBPK modeling","authors":"Zhu Zhou","doi":"10.1016/j.dmpk.2025.101110","DOIUrl":"10.1016/j.dmpk.2025.101110","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101110"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitigating strategy for drug induced liver injury LED by reactive metabolites 反应性代谢物对药物性肝损伤的缓解策略
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101065
Sean Zhu
{"title":"Mitigating strategy for drug induced liver injury LED by reactive metabolites","authors":"Sean Zhu","doi":"10.1016/j.dmpk.2025.101065","DOIUrl":"10.1016/j.dmpk.2025.101065","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101065"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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