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Drug Metabolism and Pharmacokinetics最新文献

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Industrial perspective of reactive metabolites: When to be afraid and when to be very afraid 反应性代谢物的工业观点：什么时候害怕，什么时候非常害怕
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101064
Jonathan Bauman
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引用次数: 0
Addressing the challenges of determining fraction metabolized for low turnover drugs – An update from the quantitative fraction metabolized working group of the IQ consortium 解决确定低周转率药物代谢分数的挑战-来自IQ联盟定量代谢分数工作组的更新
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101146
Lawrence Cohen , Priscilla Brun , Upendra Dahal , Angela Doran , Sarah Glass , Niresh Hariparsad , Felix Huth , Gary Jenkins , Charles Locuson , Birk Poller , Lilian Richter , Dustin Smith
{"title":"Addressing the challenges of determining fraction metabolized for low turnover drugs – An update from the quantitative fraction metabolized working group of the IQ consortium","authors":"Lawrence Cohen , Priscilla Brun , Upendra Dahal , Angela Doran , Sarah Glass , Niresh Hariparsad , Felix Huth , Gary Jenkins , Charles Locuson , Birk Poller , Lilian Richter , Dustin Smith","doi":"10.1016/j.dmpk.2025.101146","DOIUrl":"10.1016/j.dmpk.2025.101146","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101146"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Confounding effects of B-glucuronidase on UDP-Glucuronosyltransferase stability: Development of a modified metabolic stability assay to enable SAR for a discovery program b -葡糖醛酸酶对udp -葡糖醛酸基转移酶稳定性的混淆影响：开发一种改进的代谢稳定性测定方法，使SAR能够用于发现计划
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101150
Sarah Glass, Isaiah Swauncy, Annie Caudle, Kevin Coe
{"title":"Confounding effects of B-glucuronidase on UDP-Glucuronosyltransferase stability: Development of a modified metabolic stability assay to enable SAR for a discovery program","authors":"Sarah Glass, Isaiah Swauncy, Annie Caudle, Kevin Coe","doi":"10.1016/j.dmpk.2025.101150","DOIUrl":"10.1016/j.dmpk.2025.101150","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101150"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SDS-stable homo-oligomers of UDP-Glucuronosyltransferase 2B7: Involvement of disulfide bond formation via a specific cystein residue sds稳定的udp -葡萄糖醛基转移酶2B7的同型低聚物：通过特定的半胱氨酸残基参与二硫键的形成
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101152
Yuu Miyauchi , Madoka Sawai , Hisao Kansui , Shinji Takechi , Peter I. Mackenzie , Yuji Ishii
{"title":"SDS-stable homo-oligomers of UDP-Glucuronosyltransferase 2B7: Involvement of disulfide bond formation via a specific cystein residue","authors":"Yuu Miyauchi , Madoka Sawai , Hisao Kansui , Shinji Takechi , Peter I. Mackenzie , Yuji Ishii","doi":"10.1016/j.dmpk.2025.101152","DOIUrl":"10.1016/j.dmpk.2025.101152","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101152"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI platform to accelerate drug discovery 人工智能平台加速药物发现
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101077
Yasushi Okuno
{"title":"AI platform to accelerate drug discovery","authors":"Yasushi Okuno","doi":"10.1016/j.dmpk.2025.101077","DOIUrl":"10.1016/j.dmpk.2025.101077","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101077"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems 巴马猪皮肤不同组织处理方法作为局部给药系统动物模型的评价
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101144
Chao Zhang, Huan He, Shoutao Liu, Lijuan Hou, Jacob Zhi Chen, Yi Tao, Liang Shen
{"title":"Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems","authors":"Chao Zhang, Huan He, Shoutao Liu, Lijuan Hou, Jacob Zhi Chen, Yi Tao, Liang Shen","doi":"10.1016/j.dmpk.2025.101144","DOIUrl":"10.1016/j.dmpk.2025.101144","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101144"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions 内源性生物标志物信息评估转运体介导的药物-药物和药物-疾病相互作用的方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101078
Aleksandra Galetin
{"title":"Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions","authors":"Aleksandra Galetin","doi":"10.1016/j.dmpk.2025.101078","DOIUrl":"10.1016/j.dmpk.2025.101078","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101078"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of mechanistic static models for predicting CYP- and transporter-mediated DDI 机械性静态模型预测CYP和转运体介导的DDI的效用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101083
Sheila Peters
{"title":"Utility of mechanistic static models for predicting CYP- and transporter-mediated DDI","authors":"Sheila Peters","doi":"10.1016/j.dmpk.2025.101083","DOIUrl":"10.1016/j.dmpk.2025.101083","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101083"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture 无免疫捕获的LC - MS/MS定量分析抗体偶联物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101131
Suhong Zhang, Samuel Koppara
{"title":"Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture","authors":"Suhong Zhang, Samuel Koppara","doi":"10.1016/j.dmpk.2025.101131","DOIUrl":"10.1016/j.dmpk.2025.101131","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101131"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a PAC-LC-MS/MS method for simultaneous quantification of mipomersen, its metabolites, and analogues in tissue samples 建立PAC-LC-MS/MS同时定量组织样品中米波莫森及其代谢物和类似物的方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101136
Yuchen Sun , Shin-ichiro Nitta , Hiroaki Aikawa , Tomoko Saito , Yonemasu Tsutomu , Ryoya Goda , Masaaki Kakehi , Yoshiharu Hayashi , Satoshi Ito , Tsuyoshi Kawahara , Naoto Masui , Kazuko Inoue , Kazutaka Shimbo , Takeru Yamaguchi , Fumihiro Jinno , Kaori Murakoshi , Kentaro Takahara , Chie Murata , Hitoshi Uchiyama , Mitsuhiko Kawabata , Yoshiro Saito
{"title":"Development of a PAC-LC-MS/MS method for simultaneous quantification of mipomersen, its metabolites, and analogues in tissue samples","authors":"Yuchen Sun , Shin-ichiro Nitta , Hiroaki Aikawa , Tomoko Saito , Yonemasu Tsutomu , Ryoya Goda , Masaaki Kakehi , Yoshiharu Hayashi , Satoshi Ito , Tsuyoshi Kawahara , Naoto Masui , Kazuko Inoue , Kazutaka Shimbo , Takeru Yamaguchi , Fumihiro Jinno , Kaori Murakoshi , Kentaro Takahara , Chie Murata , Hitoshi Uchiyama , Mitsuhiko Kawabata , Yoshiro Saito","doi":"10.1016/j.dmpk.2025.101136","DOIUrl":"10.1016/j.dmpk.2025.101136","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101136"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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