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Drug Metabolism and Pharmacokinetics最新文献

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Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase 厄洛替尼作为基于机制的人类醛氧化酶强效失活剂的鉴定和表征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100952
Ryan A. Dick, Xiaomin Liang, Hailing Sun, Bernard P. Murray, Bill J. Smith
{"title":"Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase","authors":"Ryan A. Dick, Xiaomin Liang, Hailing Sun, Bernard P. Murray, Bill J. Smith","doi":"10.1016/j.dmpk.2023.100952","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100952","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"66 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice 暴露于混合微塑料颗粒会改变小鼠的粪便微生物群及其相关的预测功能途径
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100928
Kyle Kim, Julia Cui, Haiwei Gu, Marcus Garcia, Matthew Campen, Eliseo Castillo, Aaron Romero
{"title":"Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice","authors":"Kyle Kim, Julia Cui, Haiwei Gu, Marcus Garcia, Matthew Campen, Eliseo Castillo, Aaron Romero","doi":"10.1016/j.dmpk.2023.100928","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100928","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"27 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis 局部生物活性草药成分通过维持肠道氧化应激平衡预防伊立替康诱导的肠道毒性
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100892
Vesna Tumbas Saponjac, Rongjin Sun, Zicong Zheng, Jie Chen, Songpol Srinual, Ming Hu, Rashim Singh
{"title":"Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis","authors":"Vesna Tumbas Saponjac, Rongjin Sun, Zicong Zheng, Jie Chen, Songpol Srinual, Ming Hu, Rashim Singh","doi":"10.1016/j.dmpk.2023.100892","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100892","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"82 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From quantum mechanics to metabolism pathways 从量子力学到新陈代谢途径
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100935
Mario Oeren, Peter Walton, Sylvia Kaempf, James Suri, David Ponting, Peter Hunt, Tamsin Mansley, Matthew Segall
{"title":"From quantum mechanics to metabolism pathways","authors":"Mario Oeren, Peter Walton, Sylvia Kaempf, James Suri, David Ponting, Peter Hunt, Tamsin Mansley, Matthew Segall","doi":"10.1016/j.dmpk.2023.100935","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100935","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"164 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiologically based pharmacokinetic model for miltefosine in mice 基于生理学的小鼠米替福新药代动力学模型
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100975
Bhargavi Srija Ramisetty, Sihyung Yang, Michael Zhuo Wang
{"title":"Physiologically based pharmacokinetic model for miltefosine in mice","authors":"Bhargavi Srija Ramisetty, Sihyung Yang, Michael Zhuo Wang","doi":"10.1016/j.dmpk.2023.100975","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100975","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transporter activity characterization in a novel human hepatic cell-based tri-culture system 新型人肝细胞三层培养系统中转运体活性的表征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100986
Pallabi Mitra, Rumanah Kasliwala, Laeticia Iboki, Mitchell Taub
{"title":"Transporter activity characterization in a novel human hepatic cell-based tri-culture system","authors":"Pallabi Mitra, Rumanah Kasliwala, Laeticia Iboki, Mitchell Taub","doi":"10.1016/j.dmpk.2023.100986","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100986","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"35 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An approach using a gamma-distributed delay model to evaluate the anticancer effect of doxorubicin-encapsulated polymeric micelles by predictive pharmacokinetic-pharmacodynamic modeling 利用伽马分布延迟模型，通过预测药代动力学-药效学模型评估多柔比星包封聚合物胶束的抗癌效果
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100961
Shugo Yamashita, Shunsuke Kimura, Akiko Kiriyama
{"title":"An approach using a gamma-distributed delay model to evaluate the anticancer effect of doxorubicin-encapsulated polymeric micelles by predictive pharmacokinetic-pharmacodynamic modeling","authors":"Shugo Yamashita, Shunsuke Kimura, Akiko Kiriyama","doi":"10.1016/j.dmpk.2023.100961","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100961","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"50 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs 评估糖萼对基本药物分配和分布的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100964
Yifan Gong, Ken Korzekwa, Swati Nagar
{"title":"Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs","authors":"Yifan Gong, Ken Korzekwa, Swati Nagar","doi":"10.1016/j.dmpk.2023.100964","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100964","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"6 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Verification of a physiologically based pharmacokinetic model of caffeine that incorporates mechanistic descriptors of absorption 验证基于生理学的咖啡因药代动力学模型，该模型纳入了吸收机理描述指标
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100963
Jessica Rehmel, Maria Posada
{"title":"Verification of a physiologically based pharmacokinetic model of caffeine that incorporates mechanistic descriptors of absorption","authors":"Jessica Rehmel, Maria Posada","doi":"10.1016/j.dmpk.2023.100963","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100963","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"22 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of plasma stability assay for oligonucleotides 开发寡核苷酸血浆稳定性检测方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100948
Xiangling Wang, Haijuan Liu, Yilin Wei, Jie Wang, Nan Zhao, Yi Tao, Liang Shen, Genfu Chen
{"title":"Development of plasma stability assay for oligonucleotides","authors":"Xiangling Wang, Haijuan Liu, Yilin Wei, Jie Wang, Nan Zhao, Yi Tao, Liang Shen, Genfu Chen","doi":"10.1016/j.dmpk.2023.100948","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100948","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"40 1 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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