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Drug Metabolism and Pharmacokinetics最新文献

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Hepatocyte CEBPA restricts the progression of liver fibrosis 肝细胞 CEBPA 限制肝纤维化的进展
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100898
Tingting Yan, Nana Yan, Yangliu Xia, Haiping Hao, Frank J. Gonzalez
{"title":"Hepatocyte CEBPA restricts the progression of liver fibrosis","authors":"Tingting Yan, Nana Yan, Yangliu Xia, Haiping Hao, Frank J. Gonzalez","doi":"10.1016/j.dmpk.2023.100898","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100898","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monocarboxylate transporter 10: substrate-dependent mode of transport 单羧酸盐转运体 10：依赖底物的转运模式
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100990
Acilegna Rodriguez, Megan Graves, Yewei Du, Roberta Kaufman, Jian-Lu Chen, Makenzie Sacca, Mark Warren
{"title":"Monocarboxylate transporter 10: substrate-dependent mode of transport","authors":"Acilegna Rodriguez, Megan Graves, Yewei Du, Roberta Kaufman, Jian-Lu Chen, Makenzie Sacca, Mark Warren","doi":"10.1016/j.dmpk.2023.100990","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100990","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OATP1B-mediated hepatic uptake of low-molecular weight acid compounds: assessment of HIF prolyl-hydroxylase inhibitors (DUSTATS) OATP1B 介导的肝脏对低分子量酸化合物的吸收：对 HIF 丙酰羟化酶抑制剂的评估 (DUSTATS)
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100981
Yi-An Bi, Samantha Jordan, Manthena V. Varma
{"title":"OATP1B-mediated hepatic uptake of low-molecular weight acid compounds: assessment of HIF prolyl-hydroxylase inhibitors (DUSTATS)","authors":"Yi-An Bi, Samantha Jordan, Manthena V. Varma","doi":"10.1016/j.dmpk.2023.100981","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100981","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel multi-tissue chips for predictive pharmacokinetic studies 用于预测药代动力学研究的新型多组织芯片
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100966
Jason Sherfey, Shiny Rajan, Shivam Ohri, Joseph Smith, Lauren Nichols, Paarth Parekh, Kevin O’Handley, Emily Geishecker, Murat Cirit
{"title":"Novel multi-tissue chips for predictive pharmacokinetic studies","authors":"Jason Sherfey, Shiny Rajan, Shivam Ohri, Joseph Smith, Lauren Nichols, Paarth Parekh, Kevin O’Handley, Emily Geishecker, Murat Cirit","doi":"10.1016/j.dmpk.2023.100966","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100966","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substrate-dependent characteristics in the transport function of SLC19A3: examination of the aspect of its sensitivity to flavonoids SLC19A3 转运功能的底物依赖性特征：研究其对黄酮类化合物的敏感性
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100993
Hiroaki Yuasa, Saena Yamashita, Takahiro Yamashiro, Tomoya Yasujima
{"title":"Substrate-dependent characteristics in the transport function of SLC19A3: examination of the aspect of its sensitivity to flavonoids","authors":"Hiroaki Yuasa, Saena Yamashita, Takahiro Yamashiro, Tomoya Yasujima","doi":"10.1016/j.dmpk.2023.100993","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100993","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of perfluoroocanoic acid and perfluorohexane sulfonic acid in various rat models 全氟辛酸和全氟己烷磺酸在各种大鼠模型中的药代动力学
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100959
Kyungsun Moon, Sung-Hoon Ahn
{"title":"Pharmacokinetics of perfluoroocanoic acid and perfluorohexane sulfonic acid in various rat models","authors":"Kyungsun Moon, Sung-Hoon Ahn","doi":"10.1016/j.dmpk.2023.100959","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100959","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A practical approach for measuring acyl glucuronide migration half life 测量酰基葡萄糖醛酸迁移半衰期的实用方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100944
Ying Tan, Zhoupeng Zhang, Niresh Hariparsad
{"title":"A practical approach for measuring acyl glucuronide migration half life","authors":"Ying Tan, Zhoupeng Zhang, Niresh Hariparsad","doi":"10.1016/j.dmpk.2023.100944","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100944","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The practical impact of the FDA draft guidance on human mass balance studies – a year of client discussions 美国食品药物管理局人体质量平衡研究指南草案的实际影响--一年来客户的讨论情况
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100943
Iain Shaw, Adam Robinson-Miller, Phil Evans, Stuart Mair
{"title":"The practical impact of the FDA draft guidance on human mass balance studies – a year of client discussions","authors":"Iain Shaw, Adam Robinson-Miller, Phil Evans, Stuart Mair","doi":"10.1016/j.dmpk.2023.100943","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100943","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Encequidar is a gut-restricted P-GP specific inhibitor that boosts oral bioavailability and inhibits intestinal secretion in rats and dogs. Encequidar 是一种肠道限制 P-GP 特异性抑制剂，可提高口服生物利用度，抑制大鼠和狗的肠道分泌。
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100989
Murali Subramanian, Aaliyah Shodeinde, Gregg Schwarzwalder, Ana Gonzalez, Josh Yu, Guangyu Zhao, Jia Hao, Xiaomin Liang, Yurong Lai, Raju Subramanian
{"title":"Encequidar is a gut-restricted P-GP specific inhibitor that boosts oral bioavailability and inhibits intestinal secretion in rats and dogs.","authors":"Murali Subramanian, Aaliyah Shodeinde, Gregg Schwarzwalder, Ana Gonzalez, Josh Yu, Guangyu Zhao, Jia Hao, Xiaomin Liang, Yurong Lai, Raju Subramanian","doi":"10.1016/j.dmpk.2023.100989","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100989","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo and in vitro biotransformation of molnupiravir (MOV), An oral prodrug of the antiviral ribonucleoside analog Β-D-N4-hydroxycytidine (NHC) 抗病毒核糖核苷类似物Β-D-N4-羟基胞苷（NHC）口服原药莫仑吡韦（MOV）的体内和体外生物转化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100933
Ping Lu, Randy Miller, Jianmei Pang, Sheri Smith, Jason Hoar, Mark Concilla
{"title":"In vivo and in vitro biotransformation of molnupiravir (MOV), An oral prodrug of the antiviral ribonucleoside analog Β-D-N4-hydroxycytidine (NHC)","authors":"Ping Lu, Randy Miller, Jianmei Pang, Sheri Smith, Jason Hoar, Mark Concilla","doi":"10.1016/j.dmpk.2023.100933","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100933","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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