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Drug Metabolism and Pharmacokinetics最新文献

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Transporter activity characterization in a novel human hepatic cell-based tri-culture system 新型人肝细胞三层培养系统中转运体活性的表征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100986
Pallabi Mitra, Rumanah Kasliwala, Laeticia Iboki, Mitchell Taub
{"title":"Transporter activity characterization in a novel human hepatic cell-based tri-culture system","authors":"Pallabi Mitra, Rumanah Kasliwala, Laeticia Iboki, Mitchell Taub","doi":"10.1016/j.dmpk.2023.100986","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100986","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"35 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An approach using a gamma-distributed delay model to evaluate the anticancer effect of doxorubicin-encapsulated polymeric micelles by predictive pharmacokinetic-pharmacodynamic modeling 利用伽马分布延迟模型，通过预测药代动力学-药效学模型评估多柔比星包封聚合物胶束的抗癌效果
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100961
Shugo Yamashita, Shunsuke Kimura, Akiko Kiriyama
{"title":"An approach using a gamma-distributed delay model to evaluate the anticancer effect of doxorubicin-encapsulated polymeric micelles by predictive pharmacokinetic-pharmacodynamic modeling","authors":"Shugo Yamashita, Shunsuke Kimura, Akiko Kiriyama","doi":"10.1016/j.dmpk.2023.100961","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100961","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"50 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs 评估糖萼对基本药物分配和分布的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100964
Yifan Gong, Ken Korzekwa, Swati Nagar
{"title":"Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs","authors":"Yifan Gong, Ken Korzekwa, Swati Nagar","doi":"10.1016/j.dmpk.2023.100964","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100964","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"6 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Verification of a physiologically based pharmacokinetic model of caffeine that incorporates mechanistic descriptors of absorption 验证基于生理学的咖啡因药代动力学模型，该模型纳入了吸收机理描述指标
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100963
Jessica Rehmel, Maria Posada
{"title":"Verification of a physiologically based pharmacokinetic model of caffeine that incorporates mechanistic descriptors of absorption","authors":"Jessica Rehmel, Maria Posada","doi":"10.1016/j.dmpk.2023.100963","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100963","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"22 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of plasma stability assay for oligonucleotides 开发寡核苷酸血浆稳定性检测方法
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100948
Xiangling Wang, Haijuan Liu, Yilin Wei, Jie Wang, Nan Zhao, Yi Tao, Liang Shen, Genfu Chen
{"title":"Development of plasma stability assay for oligonucleotides","authors":"Xiangling Wang, Haijuan Liu, Yilin Wei, Jie Wang, Nan Zhao, Yi Tao, Liang Shen, Genfu Chen","doi":"10.1016/j.dmpk.2023.100948","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100948","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"40 1 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel 3D imaging pipeline for analyzing efficacy of compounds on amyloid-beta plaque dynamics in preclinical alzheimer’s disease animal models 用于分析临床前阿尔茨海默病动物模型中化合物对淀粉样蛋白-β斑块动力学疗效的新型三维成像管道
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100958
Gianna Ferron, Stefan Linehan, Tim Ragan, Dylan Garceau, Kevin Elk, Mike Sasner
{"title":"A novel 3D imaging pipeline for analyzing efficacy of compounds on amyloid-beta plaque dynamics in preclinical alzheimer’s disease animal models","authors":"Gianna Ferron, Stefan Linehan, Tim Ragan, Dylan Garceau, Kevin Elk, Mike Sasner","doi":"10.1016/j.dmpk.2023.100958","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100958","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"21 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes 三维培养的原代人类肝细胞中的 OCT1 转运体动力学和长期调节研究
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100894
Maria Karlgren
{"title":"OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes","authors":"Maria Karlgren","doi":"10.1016/j.dmpk.2023.100894","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100894","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"19 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges associated with the biomarker-informed PBPK modeling of renal transporter-mediated drug interactions 与肾脏转运体介导的药物相互作用的生物标志物 PBPK 模型相关的挑战
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100973
Emi Kimoto, David Tess, Matthew Cerny, Sumathy Mathialagan, Sangwoo Ryu, Manoli Vourvahis, A. David Rodrigues, Manthena V. Varma
{"title":"Challenges associated with the biomarker-informed PBPK modeling of renal transporter-mediated drug interactions","authors":"Emi Kimoto, David Tess, Matthew Cerny, Sumathy Mathialagan, Sangwoo Ryu, Manoli Vourvahis, A. David Rodrigues, Manthena V. Varma","doi":"10.1016/j.dmpk.2023.100973","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100973","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"65 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the power of IVIVE-PBPK to explore potential discordance between local gut vs systemic bioequivalence in health and disease: the case of budesonide in crohn’s disease 利用 IVIVE-PBPK 的强大功能探索健康和疾病中肠道局部生物等效性与全身生物等效性之间可能存在的不一致：布地奈德治疗羊角风病的案例
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100970
Chunyan Han, Siri Kalyan Chirumamilla, Tiancheng Sun, Mandy Xu, Frederic Bois, Amin Rostami-Hodjegan
{"title":"Harnessing the power of IVIVE-PBPK to explore potential discordance between local gut vs systemic bioequivalence in health and disease: the case of budesonide in crohn’s disease","authors":"Chunyan Han, Siri Kalyan Chirumamilla, Tiancheng Sun, Mandy Xu, Frederic Bois, Amin Rostami-Hodjegan","doi":"10.1016/j.dmpk.2023.100970","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100970","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"163 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of traditional herbal medicine on the permeability of clarithromycin and loxoprofen in CACO-2 cell model 传统中药对克拉霉素和洛索洛芬在 CACO-2 细胞模型中渗透性的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100988
Sabin Shin, Sangyoung Lee, Chae Bin Lee, Seong Jun Jo, Soon Uk Chae, Da Hyun Kim, Duk Yeon Kim, Ui Min Jerng, Soo Kyung Bae
{"title":"The effect of traditional herbal medicine on the permeability of clarithromycin and loxoprofen in CACO-2 cell model","authors":"Sabin Shin, Sangyoung Lee, Chae Bin Lee, Seong Jun Jo, Soon Uk Chae, Da Hyun Kim, Duk Yeon Kim, Ui Min Jerng, Soo Kyung Bae","doi":"10.1016/j.dmpk.2023.100988","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100988","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"2 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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