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Human enteroid monolayers – A fit-for purpose model to elucidate intestinal natural product-drug interactions 人肠道单分子层-一个适合目的的模型来阐明肠道天然产物-药物相互作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101070
Kenneth E. Thummel, Eimear O’Mahony, Christopher Arian, Edward J. Kelly
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引用次数: 0
Computer aided metid for small molecules and peptide drugs 小分子和多肽药物的计算机辅助方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101091
Ismael Zamora
{"title":"Computer aided metid for small molecules and peptide drugs","authors":"Ismael Zamora","doi":"10.1016/j.dmpk.2025.101091","DOIUrl":"10.1016/j.dmpk.2025.101091","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101091"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Membrane transporters in drug development and as determinants of precision medicine; an update from the international transporter consortium 膜转运蛋白在药物开发和精准医疗的决定因素来自国际运输联盟的最新消息
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101092
Kim Brouwer
{"title":"Membrane transporters in drug development and as determinants of precision medicine; an update from the international transporter consortium","authors":"Kim Brouwer","doi":"10.1016/j.dmpk.2025.101092","DOIUrl":"10.1016/j.dmpk.2025.101092","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101092"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incorporation of well-stirred, dispersion and parallel tube liver models into simple and permeability limited PBPK frameworks for clearance prediction 将充分搅拌、分散和平行管肝模型纳入简单和渗透率有限的PBPK框架，用于预测清除
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101147
Swati Nagar, Rachel Parise, Ken Korzekwa
{"title":"Incorporation of well-stirred, dispersion and parallel tube liver models into simple and permeability limited PBPK frameworks for clearance prediction","authors":"Swati Nagar, Rachel Parise, Ken Korzekwa","doi":"10.1016/j.dmpk.2025.101147","DOIUrl":"10.1016/j.dmpk.2025.101147","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101147"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetic modeling leveraging in vitro to in vivo extrapolation of the gut microbiome’s role in sulfasalazine metabolism into sulfapyridine and mesalamine 利用体外到体内的药代动力学模型，推断肠道微生物组在磺胺吡啶和美沙拉胺代谢中的作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101120
Lisa Cheng , Jingwei Cai , Alexis Auster , Sungjoon Cho , Miaoran Ning
{"title":"Pharmacokinetic modeling leveraging in vitro to in vivo extrapolation of the gut microbiome’s role in sulfasalazine metabolism into sulfapyridine and mesalamine","authors":"Lisa Cheng , Jingwei Cai , Alexis Auster , Sungjoon Cho , Miaoran Ning","doi":"10.1016/j.dmpk.2025.101120","DOIUrl":"10.1016/j.dmpk.2025.101120","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101120"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industrial perspective of reactive metabolites: When to be afraid and when to be very afraid 反应性代谢物的工业观点：什么时候害怕，什么时候非常害怕
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101064
Jonathan Bauman
{"title":"Industrial perspective of reactive metabolites: When to be afraid and when to be very afraid","authors":"Jonathan Bauman","doi":"10.1016/j.dmpk.2025.101064","DOIUrl":"10.1016/j.dmpk.2025.101064","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101064"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing the challenges of determining fraction metabolized for low turnover drugs – An update from the quantitative fraction metabolized working group of the IQ consortium 解决确定低周转率药物代谢分数的挑战-来自IQ联盟定量代谢分数工作组的更新
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101146
Lawrence Cohen , Priscilla Brun , Upendra Dahal , Angela Doran , Sarah Glass , Niresh Hariparsad , Felix Huth , Gary Jenkins , Charles Locuson , Birk Poller , Lilian Richter , Dustin Smith
{"title":"Addressing the challenges of determining fraction metabolized for low turnover drugs – An update from the quantitative fraction metabolized working group of the IQ consortium","authors":"Lawrence Cohen , Priscilla Brun , Upendra Dahal , Angela Doran , Sarah Glass , Niresh Hariparsad , Felix Huth , Gary Jenkins , Charles Locuson , Birk Poller , Lilian Richter , Dustin Smith","doi":"10.1016/j.dmpk.2025.101146","DOIUrl":"10.1016/j.dmpk.2025.101146","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101146"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Confounding effects of B-glucuronidase on UDP-Glucuronosyltransferase stability: Development of a modified metabolic stability assay to enable SAR for a discovery program b -葡糖醛酸酶对udp -葡糖醛酸基转移酶稳定性的混淆影响：开发一种改进的代谢稳定性测定方法，使SAR能够用于发现计划
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101150
Sarah Glass, Isaiah Swauncy, Annie Caudle, Kevin Coe
{"title":"Confounding effects of B-glucuronidase on UDP-Glucuronosyltransferase stability: Development of a modified metabolic stability assay to enable SAR for a discovery program","authors":"Sarah Glass, Isaiah Swauncy, Annie Caudle, Kevin Coe","doi":"10.1016/j.dmpk.2025.101150","DOIUrl":"10.1016/j.dmpk.2025.101150","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101150"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SDS-stable homo-oligomers of UDP-Glucuronosyltransferase 2B7: Involvement of disulfide bond formation via a specific cystein residue sds稳定的udp -葡萄糖醛基转移酶2B7的同型低聚物：通过特定的半胱氨酸残基参与二硫键的形成
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101152
Yuu Miyauchi , Madoka Sawai , Hisao Kansui , Shinji Takechi , Peter I. Mackenzie , Yuji Ishii
{"title":"SDS-stable homo-oligomers of UDP-Glucuronosyltransferase 2B7: Involvement of disulfide bond formation via a specific cystein residue","authors":"Yuu Miyauchi , Madoka Sawai , Hisao Kansui , Shinji Takechi , Peter I. Mackenzie , Yuji Ishii","doi":"10.1016/j.dmpk.2025.101152","DOIUrl":"10.1016/j.dmpk.2025.101152","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101152"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI platform to accelerate drug discovery 人工智能平台加速药物发现
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101077
Yasushi Okuno
{"title":"AI platform to accelerate drug discovery","authors":"Yasushi Okuno","doi":"10.1016/j.dmpk.2025.101077","DOIUrl":"10.1016/j.dmpk.2025.101077","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101077"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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