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Drug Metabolism and Pharmacokinetics最新文献

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Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems 巴马猪皮肤不同组织处理方法作为局部给药系统动物模型的评价
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101144
Chao Zhang, Huan He, Shoutao Liu, Lijuan Hou, Jacob Zhi Chen, Yi Tao, Liang Shen
{"title":"Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems","authors":"Chao Zhang, Huan He, Shoutao Liu, Lijuan Hou, Jacob Zhi Chen, Yi Tao, Liang Shen","doi":"10.1016/j.dmpk.2025.101144","DOIUrl":"10.1016/j.dmpk.2025.101144","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101144"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions 内源性生物标志物信息评估转运体介导的药物-药物和药物-疾病相互作用的方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101078
Aleksandra Galetin
{"title":"Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions","authors":"Aleksandra Galetin","doi":"10.1016/j.dmpk.2025.101078","DOIUrl":"10.1016/j.dmpk.2025.101078","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101078"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of mechanistic static models for predicting CYP- and transporter-mediated DDI 机械性静态模型预测CYP和转运体介导的DDI的效用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101083
Sheila Peters
{"title":"Utility of mechanistic static models for predicting CYP- and transporter-mediated DDI","authors":"Sheila Peters","doi":"10.1016/j.dmpk.2025.101083","DOIUrl":"10.1016/j.dmpk.2025.101083","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101083"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture 无免疫捕获的LC - MS/MS定量分析抗体偶联物
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101131
Suhong Zhang, Samuel Koppara
{"title":"Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture","authors":"Suhong Zhang, Samuel Koppara","doi":"10.1016/j.dmpk.2025.101131","DOIUrl":"10.1016/j.dmpk.2025.101131","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101131"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a PAC-LC-MS/MS method for simultaneous quantification of mipomersen, its metabolites, and analogues in tissue samples 建立PAC-LC-MS/MS同时定量组织样品中米波莫森及其代谢物和类似物的方法
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101136
Yuchen Sun , Shin-ichiro Nitta , Hiroaki Aikawa , Tomoko Saito , Yonemasu Tsutomu , Ryoya Goda , Masaaki Kakehi , Yoshiharu Hayashi , Satoshi Ito , Tsuyoshi Kawahara , Naoto Masui , Kazuko Inoue , Kazutaka Shimbo , Takeru Yamaguchi , Fumihiro Jinno , Kaori Murakoshi , Kentaro Takahara , Chie Murata , Hitoshi Uchiyama , Mitsuhiko Kawabata , Yoshiro Saito
{"title":"Development of a PAC-LC-MS/MS method for simultaneous quantification of mipomersen, its metabolites, and analogues in tissue samples","authors":"Yuchen Sun , Shin-ichiro Nitta , Hiroaki Aikawa , Tomoko Saito , Yonemasu Tsutomu , Ryoya Goda , Masaaki Kakehi , Yoshiharu Hayashi , Satoshi Ito , Tsuyoshi Kawahara , Naoto Masui , Kazuko Inoue , Kazutaka Shimbo , Takeru Yamaguchi , Fumihiro Jinno , Kaori Murakoshi , Kentaro Takahara , Chie Murata , Hitoshi Uchiyama , Mitsuhiko Kawabata , Yoshiro Saito","doi":"10.1016/j.dmpk.2025.101136","DOIUrl":"10.1016/j.dmpk.2025.101136","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101136"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Best practice of mitigating P-Glycoprotein liabilities in drug discovery - Assessment and prediction of P-GP mediated nonlinear PK, brain penetration, and interactions 减轻p糖蛋白在药物发现中的负作用的最佳实践——p糖蛋白介导的非线性PK、脑渗透和相互作用的评估和预测
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101109
Hideki Hirabayashi
{"title":"Best practice of mitigating P-Glycoprotein liabilities in drug discovery - Assessment and prediction of P-GP mediated nonlinear PK, brain penetration, and interactions","authors":"Hideki Hirabayashi","doi":"10.1016/j.dmpk.2025.101109","DOIUrl":"10.1016/j.dmpk.2025.101109","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101109"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A seven cytochrome P450 index substrate cocktail for clinical trials – Profiling the effects of clopidogrel and gemfibrozil on CYP enzymes and OATP1B1 biomarkers 用于临床试验的7细胞色素P450指数底物鸡尾酒-分析氯吡格雷和吉非齐尔对CYP酶和OATP1B1生物标志物的影响
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101154
Laura Aurinsalo , Outi Lapatto-Reiniluoto , Mikko Neuvonen , Mika Kurkela , Johanna Kiiski , Mikko Niemi , Aleksi Tornio , Janne Backman
{"title":"A seven cytochrome P450 index substrate cocktail for clinical trials – Profiling the effects of clopidogrel and gemfibrozil on CYP enzymes and OATP1B1 biomarkers","authors":"Laura Aurinsalo , Outi Lapatto-Reiniluoto , Mikko Neuvonen , Mika Kurkela , Johanna Kiiski , Mikko Niemi , Aleksi Tornio , Janne Backman","doi":"10.1016/j.dmpk.2025.101154","DOIUrl":"10.1016/j.dmpk.2025.101154","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101154"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening towards a CYP3A7-specific marker reaction against CYP3A4 and CYP3A5 筛选针对CYP3A4和CYP3A5的cyp3a7特异性标记反应
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101155
Elias Carvalho Padilha
{"title":"Screening towards a CYP3A7-specific marker reaction against CYP3A4 and CYP3A5","authors":"Elias Carvalho Padilha","doi":"10.1016/j.dmpk.2025.101155","DOIUrl":"10.1016/j.dmpk.2025.101155","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101155"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food 食源性神经营养氨基酸麦角硫因及其转运体SLC22A4：从实验室到健康食品
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101094
Yukio Kato
{"title":"Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food","authors":"Yukio Kato","doi":"10.1016/j.dmpk.2025.101094","DOIUrl":"10.1016/j.dmpk.2025.101094","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101094"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update from the IQ TALG quantitative fraction metabolized working group 来自IQ TALG定量组分代谢工作组的更新
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101101
Angela Doran
{"title":"Update from the IQ TALG quantitative fraction metabolized working group","authors":"Angela Doran","doi":"10.1016/j.dmpk.2025.101101","DOIUrl":"10.1016/j.dmpk.2025.101101","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101101"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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