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Drug Metabolism and Pharmacokinetics最新文献

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Enhanced effect of ionic liquid on intestinal absorption of macromolecules (< 10 kDa) 离子液体对肠道大分子（< 10 kDa）吸收的促进作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101137
Shoichiro Fukuda , Haruka Takata , Takashi Nakae , Noboru Tatsumi , Hidetoshi Hamamoto , Hidenori Ando , Tatsuhiro Ishida
{"title":"Enhanced effect of ionic liquid on intestinal absorption of macromolecules (< 10 kDa)","authors":"Shoichiro Fukuda ,&nbsp;Haruka Takata ,&nbsp;Takashi Nakae ,&nbsp;Noboru Tatsumi ,&nbsp;Hidetoshi Hamamoto ,&nbsp;Hidenori Ando ,&nbsp;Tatsuhiro Ishida","doi":"10.1016/j.dmpk.2025.101137","DOIUrl":"10.1016/j.dmpk.2025.101137","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101137"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the mechanism of metronidazole-induced encephalopathy focusing on the possible effect on thiamine transport 甲硝唑致脑病机制的研究重点是对硫胺素运输的可能影响
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101130
Yoshiaki Yamagishi, Mitsuhiro Hashimoto, Miyuki Sugita, Satomi Watanabe, Nana Sekine, Yuki Takahashi, Yasuko Ogawa, Toshiyuki Kudo, Kiyomi Ito
{"title":"Investigation of the mechanism of metronidazole-induced encephalopathy focusing on the possible effect on thiamine transport","authors":"Yoshiaki Yamagishi,&nbsp;Mitsuhiro Hashimoto,&nbsp;Miyuki Sugita,&nbsp;Satomi Watanabe,&nbsp;Nana Sekine,&nbsp;Yuki Takahashi,&nbsp;Yasuko Ogawa,&nbsp;Toshiyuki Kudo,&nbsp;Kiyomi Ito","doi":"10.1016/j.dmpk.2025.101130","DOIUrl":"10.1016/j.dmpk.2025.101130","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101130"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing PBPK modeling and in vitro data for predicting complex DDIS of OATP1B and CYP substrates caused by various perpetrators 利用PBPK模型和体外数据预测多种作案者引起的OATP1B和CYP底物的复杂DDIS
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101082
Yuichi Sugiyama
{"title":"Utilizing PBPK modeling and in vitro data for predicting complex DDIS of OATP1B and CYP substrates caused by various perpetrators","authors":"Yuichi Sugiyama","doi":"10.1016/j.dmpk.2025.101082","DOIUrl":"10.1016/j.dmpk.2025.101082","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101082"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of ADME and DDI for LNP-MRNA therapeutics 评估ADME和DDI对LNP-MRNA治疗的影响
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101084
Lei Ci
{"title":"Assessment of ADME and DDI for LNP-MRNA therapeutics","authors":"Lei Ci","doi":"10.1016/j.dmpk.2025.101084","DOIUrl":"10.1016/j.dmpk.2025.101084","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101084"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering Target-Mediated Drug Disposition (TMDD) of small molecule brain penetrant EBP inhibitors 揭示小分子脑渗透EBP抑制剂的靶介导药物处置（TMDD）
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101107
Laurent Salphati
{"title":"Uncovering Target-Mediated Drug Disposition (TMDD) of small molecule brain penetrant EBP inhibitors","authors":"Laurent Salphati","doi":"10.1016/j.dmpk.2025.101107","DOIUrl":"10.1016/j.dmpk.2025.101107","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101107"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Model-based meta-analysis of ethnic differences - General changes in clearance by pathways and aging 基于模型的种族差异荟萃分析-清除途径和衰老的一般变化
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101111
Akihiro Hisaka
{"title":"Model-based meta-analysis of ethnic differences - General changes in clearance by pathways and aging","authors":"Akihiro Hisaka","doi":"10.1016/j.dmpk.2025.101111","DOIUrl":"10.1016/j.dmpk.2025.101111","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101111"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling 通过PBPK模型整合肠道生理学和药物代谢、处置和相互作用
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101072
Bhagwat Prasad
{"title":"Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling","authors":"Bhagwat Prasad","doi":"10.1016/j.dmpk.2025.101072","DOIUrl":"10.1016/j.dmpk.2025.101072","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101072"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro study of payload release of an anti-TNF glucocorticoid receptor modulator immunology antibody-drug conjugate (ADC-T) and payload metabolism 抗肿瘤坏死因子糖皮质激素受体调节剂免疫抗体-药物偶联物（ADC-T）和有效载荷代谢的体外研究
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101132
Mingshe Zhu , Zhiqiang Li , Chongzhuang Tang , Yang Gao , Lijuan Chen , Xingxing Diao
{"title":"In vitro study of payload release of an anti-TNF glucocorticoid receptor modulator immunology antibody-drug conjugate (ADC-T) and payload metabolism","authors":"Mingshe Zhu ,&nbsp;Zhiqiang Li ,&nbsp;Chongzhuang Tang ,&nbsp;Yang Gao ,&nbsp;Lijuan Chen ,&nbsp;Xingxing Diao","doi":"10.1016/j.dmpk.2025.101132","DOIUrl":"10.1016/j.dmpk.2025.101132","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101132"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms underlying altered drug clearance in pregnancy 妊娠期药物清除改变的机制
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101112
Muluneh Fashe
{"title":"Mechanisms underlying altered drug clearance in pregnancy","authors":"Muluneh Fashe","doi":"10.1016/j.dmpk.2025.101112","DOIUrl":"10.1016/j.dmpk.2025.101112","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101112"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do i use PBPK modeling to discern complex drug-drug interactions? 如何使用PBPK模型来识别复杂的药物-药物相互作用？
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dmpk.2025.101062
Jayaprakasam Bolleddula
{"title":"How do i use PBPK modeling to discern complex drug-drug interactions?","authors":"Jayaprakasam Bolleddula","doi":"10.1016/j.dmpk.2025.101062","DOIUrl":"10.1016/j.dmpk.2025.101062","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101062"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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