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Drug Metabolism and Pharmacokinetics最新文献

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Automated workflow to study microsomal clearance and analysis of metabolites using collision-induced dissociation and electron-activated dissociation MS/MS data 利用碰撞诱导解离和电子激活解离 MS/MS 数据研究微粒体清除和代谢物分析的自动化工作流程
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100936
Eshani Nandita, Rahul Baghla
{"title":"Automated workflow to study microsomal clearance and analysis of metabolites using collision-induced dissociation and electron-activated dissociation MS/MS data","authors":"Eshani Nandita, Rahul Baghla","doi":"10.1016/j.dmpk.2023.100936","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100936","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of cyp and non-cyp hepatic abundance changes in PBPK modelling of renal impairment (RI) populations 在肾功能损伤（RI）人群的 PBPK 建模中整合细胞色素和非细胞色素肝丰度变化
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100971
Oliver Hatley, Trevor Johnson, Iain Gardner, Karen Rowland Yeo
{"title":"Integration of cyp and non-cyp hepatic abundance changes in PBPK modelling of renal impairment (RI) populations","authors":"Oliver Hatley, Trevor Johnson, Iain Gardner, Karen Rowland Yeo","doi":"10.1016/j.dmpk.2023.100971","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100971","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rifampin- and silymarin-mediated pharmcokinetic interactions of pitavastatin, pravastatin, coproporphyrin I, and coproporphyrin III in a transgenic OATP1B mouse model 利福平和水飞蓟素介导的匹伐他汀、普伐他汀、共卟啉 I 和共卟啉 III 在转基因 OATP1B 小鼠模型中的药物动力学相互作用
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100980
Baron Bechtold, Katherine Lynch, Victoria Oyanna, Michael Ridge Call, John Clarke
{"title":"Rifampin- and silymarin-mediated pharmcokinetic interactions of pitavastatin, pravastatin, coproporphyrin I, and coproporphyrin III in a transgenic OATP1B mouse model","authors":"Baron Bechtold, Katherine Lynch, Victoria Oyanna, Michael Ridge Call, John Clarke","doi":"10.1016/j.dmpk.2023.100980","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100980","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional characterization of ENT2/SLC29A2 as a uric acid transporter ENT2/SLC29A2作为尿酸转运体的功能特征
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100984
Isamu Matake, Takahiro Yamashiro, Tomoya Yasujima, Hiroaki Yuasa
{"title":"Functional characterization of ENT2/SLC29A2 as a uric acid transporter","authors":"Isamu Matake, Takahiro Yamashiro, Tomoya Yasujima, Hiroaki Yuasa","doi":"10.1016/j.dmpk.2023.100984","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100984","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the cell and zonal distribution of drug metabolizing enzymes and transporters in humans by single cell transcriptomics 通过单细胞转录组学破解药物代谢酶和转运体在人体内的细胞和区域分布
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100931
Joe Lim, Julia Cui, Curtis Klaassen
{"title":"Deciphering the cell and zonal distribution of drug metabolizing enzymes and transporters in humans by single cell transcriptomics","authors":"Joe Lim, Julia Cui, Curtis Klaassen","doi":"10.1016/j.dmpk.2023.100931","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100931","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141062585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
De-risking idiosyncratic adverse drug reactions and toxicities in drug discovery utilizing a qualitative in-vitro high-throughput reactive metabolite trapping method 利用定性体外高通量反应性代谢物捕获法降低药物发现过程中的特异性药物不良反应和毒性风险
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100940
Shantanu Roychowdhury, Kevin Thomas, Allison Liverar, Michell Martineau, Libby Bell, Lucus Albrecht
{"title":"De-risking idiosyncratic adverse drug reactions and toxicities in drug discovery utilizing a qualitative in-vitro high-throughput reactive metabolite trapping method","authors":"Shantanu Roychowdhury, Kevin Thomas, Allison Liverar, Michell Martineau, Libby Bell, Lucus Albrecht","doi":"10.1016/j.dmpk.2023.100940","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100940","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of substrate concentration on reactive metabolite assessment in drug discovery research 底物浓度对药物发现研究中活性代谢物评估的影响
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100937
Makoto Ozawa, Hideyuki Shiozawa, Masaya Shimada, Chie Makino, Hideo Takakusa, Kengo Watanabe, Kyosuke Suzuki
{"title":"Effect of substrate concentration on reactive metabolite assessment in drug discovery research","authors":"Makoto Ozawa, Hideyuki Shiozawa, Masaya Shimada, Chie Makino, Hideo Takakusa, Kengo Watanabe, Kyosuke Suzuki","doi":"10.1016/j.dmpk.2023.100937","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100937","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction and validation of human hepatobiliary clearances and hepatic concentrations of transported drugs using the relative expression factor (REF) and PET imaging approaches 利用相对表达因子 (REF) 和 PET 成像方法预测和验证人体肝胆清除率和运输药物的肝脏浓度
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100992
Mengyue (Melody) Yin, Ankit Balhara, Solène Marie, Nicolas Tournier, Jashvant Unadkat
{"title":"Prediction and validation of human hepatobiliary clearances and hepatic concentrations of transported drugs using the relative expression factor (REF) and PET imaging approaches","authors":"Mengyue (Melody) Yin, Ankit Balhara, Solène Marie, Nicolas Tournier, Jashvant Unadkat","doi":"10.1016/j.dmpk.2023.100992","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100992","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
For hepatically cleared drugs, liver to blood KPUU at steady-state is always equal to FH , which exposes the deficiency of the present extended clearance concept equation 对于肝脏清除的药物，稳态时肝脏到血液的 KPUU 始终等于 FH，这暴露了目前扩展清除概念方程的不足之处
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100919
Leslie Z. Benet, Jasleen K. Sodhi
{"title":"For hepatically cleared drugs, liver to blood KPUU at steady-state is always equal to FH , which exposes the deficiency of the present extended clearance concept equation","authors":"Leslie Z. Benet, Jasleen K. Sodhi","doi":"10.1016/j.dmpk.2023.100919","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100919","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of human liver microsomes to assess flavin-containing monooxygenase (FMO) metabolism in vitro 利用人体肝脏微粒体评估含黄素单氧化酶（FMO）的体外代谢情况
IF 2.1 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI: 10.1016/j.dmpk.2023.100951
Nathan Delvaux, Morgan Knapp, Michael Schicker, Tyler Wittkopp, Mitchell Lavarias
{"title":"Use of human liver microsomes to assess flavin-containing monooxygenase (FMO) metabolism in vitro","authors":"Nathan Delvaux, Morgan Knapp, Michael Schicker, Tyler Wittkopp, Mitchell Lavarias","doi":"10.1016/j.dmpk.2023.100951","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100951","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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