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Drug Metabolism and Pharmacokinetics最新文献

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Best practice of mitigating P-Glycoprotein liabilities in drug discovery - Assessment and prediction of P-GP mediated nonlinear PK, brain penetration, and interactions 减轻p糖蛋白在药物发现中的负作用的最佳实践——p糖蛋白介导的非线性PK、脑渗透和相互作用的评估和预测
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101109
Hideki Hirabayashi
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引用次数: 0
A seven cytochrome P450 index substrate cocktail for clinical trials – Profiling the effects of clopidogrel and gemfibrozil on CYP enzymes and OATP1B1 biomarkers 用于临床试验的7细胞色素P450指数底物鸡尾酒-分析氯吡格雷和吉非齐尔对CYP酶和OATP1B1生物标志物的影响
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101154
Laura Aurinsalo , Outi Lapatto-Reiniluoto , Mikko Neuvonen , Mika Kurkela , Johanna Kiiski , Mikko Niemi , Aleksi Tornio , Janne Backman
{"title":"A seven cytochrome P450 index substrate cocktail for clinical trials – Profiling the effects of clopidogrel and gemfibrozil on CYP enzymes and OATP1B1 biomarkers","authors":"Laura Aurinsalo , Outi Lapatto-Reiniluoto , Mikko Neuvonen , Mika Kurkela , Johanna Kiiski , Mikko Niemi , Aleksi Tornio , Janne Backman","doi":"10.1016/j.dmpk.2025.101154","DOIUrl":"10.1016/j.dmpk.2025.101154","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101154"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening towards a CYP3A7-specific marker reaction against CYP3A4 and CYP3A5 筛选针对CYP3A4和CYP3A5的cyp3a7特异性标记反应
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101155
Elias Carvalho Padilha
{"title":"Screening towards a CYP3A7-specific marker reaction against CYP3A4 and CYP3A5","authors":"Elias Carvalho Padilha","doi":"10.1016/j.dmpk.2025.101155","DOIUrl":"10.1016/j.dmpk.2025.101155","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101155"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food 食源性神经营养氨基酸麦角硫因及其转运体SLC22A4：从实验室到健康食品
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101094
Yukio Kato
{"title":"Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food","authors":"Yukio Kato","doi":"10.1016/j.dmpk.2025.101094","DOIUrl":"10.1016/j.dmpk.2025.101094","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101094"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update from the IQ TALG quantitative fraction metabolized working group 来自IQ TALG定量组分代谢工作组的更新
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101101
Angela Doran
{"title":"Update from the IQ TALG quantitative fraction metabolized working group","authors":"Angela Doran","doi":"10.1016/j.dmpk.2025.101101","DOIUrl":"10.1016/j.dmpk.2025.101101","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101101"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical DDI risk assessment in drug discovery and development 药物发现和开发中的临床前DDI风险评估
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101080
Niresh Hariparsad
{"title":"Preclinical DDI risk assessment in drug discovery and development","authors":"Niresh Hariparsad","doi":"10.1016/j.dmpk.2025.101080","DOIUrl":"10.1016/j.dmpk.2025.101080","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101080"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-induced gastrointestinal toxicity due to disruption of the interinfluence between serotonin and gut microbiota 5 -羟色胺与肠道微生物群之间相互影响的破坏引起的药物诱导胃肠道毒性
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101121
Suguru Asaji , Yuta Funai , Yuta Seki , Kotone Banba , Jun Hida , Ikumi Tamai , Yoshiyuki Shirasaka
{"title":"Drug-induced gastrointestinal toxicity due to disruption of the interinfluence between serotonin and gut microbiota","authors":"Suguru Asaji , Yuta Funai , Yuta Seki , Kotone Banba , Jun Hida , Ikumi Tamai , Yoshiyuki Shirasaka","doi":"10.1016/j.dmpk.2025.101121","DOIUrl":"10.1016/j.dmpk.2025.101121","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101121"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex drug-drug interactions: Study design and clinical interpretation 复杂的药物-药物相互作用：研究设计和临床解释
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101081
Manoli Vourvahis
{"title":"Complex drug-drug interactions: Study design and clinical interpretation","authors":"Manoli Vourvahis","doi":"10.1016/j.dmpk.2025.101081","DOIUrl":"10.1016/j.dmpk.2025.101081","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101081"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range 蛋白表达作为评估CYP2B6诱导的终点：应用免疫亲和捕获方法可以提高动态反应范围
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101156
Julius Enoru, Anand Joshi, Paramasivam Natarajan, Mira Jones, Hetal Sarvaiya, Steve Keller
{"title":"Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range","authors":"Julius Enoru, Anand Joshi, Paramasivam Natarajan, Mira Jones, Hetal Sarvaiya, Steve Keller","doi":"10.1016/j.dmpk.2025.101156","DOIUrl":"10.1016/j.dmpk.2025.101156","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101156"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of QPCR method to detect human cells in mouse and rat tissues 小鼠和大鼠组织中检测人细胞的QPCR方法的验证
IF 2.7 4区 医学
Drug Metabolism and Pharmacokinetics Pub Date : 2025-06-01 DOI: 10.1016/j.dmpk.2025.101143
Kuniyoshi Abe, Haruka Inoue, Yuka Torikai, Naoki Kaname, Seulgi Lee, Akiko Suzuki, Yukiko Arimura, Yurie Okawa, Tetsuya Yoshikawa
{"title":"Validation of QPCR method to detect human cells in mouse and rat tissues","authors":"Kuniyoshi Abe, Haruka Inoue, Yuka Torikai, Naoki Kaname, Seulgi Lee, Akiko Suzuki, Yukiko Arimura, Yurie Okawa, Tetsuya Yoshikawa","doi":"10.1016/j.dmpk.2025.101143","DOIUrl":"10.1016/j.dmpk.2025.101143","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101143"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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