减轻p糖蛋白在药物发现中的负作用的最佳实践——p糖蛋白介导的非线性PK、脑渗透和相互作用的评估和预测

IF 2.2 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Hideki Hirabayashi
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Best practice of mitigating P-Glycoprotein liabilities in drug discovery - Assessment and prediction of P-GP mediated nonlinear PK, brain penetration, and interactions
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来源期刊
CiteScore
4.80
自引率
9.50%
发文量
50
审稿时长
69 days
期刊介绍: DMPK publishes original and innovative scientific papers that address topics broadly related to xenobiotics. The term xenobiotic includes medicinal as well as environmental and agricultural chemicals and macromolecules. The journal is organized into sections as follows: - Drug metabolism / Biotransformation - Pharmacokinetics and pharmacodynamics - Toxicokinetics and toxicodynamics - Drug-drug interaction / Drug-food interaction - Mechanism of drug absorption and disposition (including transporter) - Drug delivery system - Clinical pharmacy and pharmacology - Analytical method - Factors affecting drug metabolism and transport - Expression of genes for drug-metabolizing enzymes and transporters - Pharmacogenetics and pharmacogenomics - Pharmacoepidemiology.
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