Dose-Response最新文献

{"title":"Glass-Based Bone-Equivalent Retrospective Dosimeters: A Comprehensive Review of Thermoluminescence and Structural Evolution.","authors":"Amal Alqahtani","doi":"10.1177/15593258261441391","DOIUrl":"10.1177/15593258261441391","url":null,"abstract":"<p><p>This paper addresses recent studies on numerous glass materials for retrospective analysis to ascertain radiation dose after catastrophic, large-scale radioactive incidents. These glasses have shown to be versatile retrospective dosimeters in medical and industrial settings, providing great spatial resolution, sensitivity, and water resistance. A review analyzing the retrospective applications of the glass has been conducted, emphasizing the potential of these materials in measuring unintentional radiation exposures. The novelty of this work lies in providing a comparative framework linking thermoluminescence (TL) response, effective atomic number (Z_eff), dose-response behavior, and radiation-induced structural alterations across multiple glass materials. The relevant scientific research was rigorously assessed to compare thermoluminescence (TL) response, effective atomic number (Z_eff), dose response, and radiation-induced structural alterations in glass materials. From the review, effective atomic numbers ranged from 9.23 to 15.1, strongly aligning with the Z_eff of bone, indicating the potential of glass materials as bone-equivalent retrospective dosimeters. The dose-response relationship demonstrates that TL intensity exhibits the most significant correlation with the administered dose and glow curve occurring between 150 to 273 °C, indicating stable charge trapping and recombination processes. Morphological and structural analysis confirmed the dose dependent structural alteration of the glass samples. Despite certain constraints, such as long-term stability, optical bleaching, and dependable dose reconstruction, glasses exhibit potential efficacy as a retrospective dosimeter. This study incorporates thermoluminescence, effective atomic number, and dose-induced structural evolution in a cohesive framework, providing a comprehensive comparative analysis to improve the understanding of glass-based materials as bone-equivalent retrospective dosimeters for post-accidental radiation evaluation.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261441391"},"PeriodicalIF":2.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Throughput Automated Construction and Validation of Dicentric Chromosome and Micronucleus Biodosimetry Calibration Curves for Radiation Emergency Response.","authors":"Mengyun Wu, Haojun Li, Huadong Zhang, Wei Li, Yeqing Gu","doi":"10.1177/15593258261435382","DOIUrl":"10.1177/15593258261435382","url":null,"abstract":"<p><strong>Objectives: </strong>Develop a high-throughput, fully automated workflow for dicentric chromosome and micronucleus assays to enable rapid, accurate radiation dose estimation in radiological or nuclear emergencies.</p><p><strong>Methods: </strong>Blood from four healthy donors was irradiated (0-5.00 Gy, ¹³⁷Cs γ-rays), repaired for 2 h at 37°C, and processed via an integrated platform (Chromprep + Metafer 4 + LS-CAS). Dicentric chromosomes (per 100 cells) and micronucleus (per 1,000 cells) were automatically scored. Dose-response data fitted to a quadratic model and validated using blinded samples with 95% confidence intervals accounting for Poisson statistics and curve uncertainty.</p><p><strong>Results: </strong>The automated dose-response curves for chromosome aberrations and micronuclei are <i>y</i>=8.4642x²-3.7786x+1.5439 and <i>y</i>=23.348x²+60.469x-1.6856, respectively. Calibration curves showed excellent fit (<i>R</i> ²=0.997 fordicentric chromosome; <i>R</i> ²=0.996 formicronucleus). All validation doses fell within estimated confidence intervals. The system achieved end-to-end automation with minimal human intervention while maintaining high accuracy and reproducibility.</p><p><strong>Conclusion: </strong>This workflow provides a standardized, scalable, and reliable solution for rapid biodosimetry in mass-casualty radiological incidents, effectively bridging laboratory capacity and real-world emergency response needs.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261435382"},"PeriodicalIF":2.8,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Stemcell Treatment on Nephrotoxicity Developing After Cyclophosphamide Treatment.","authors":"Muzaffer Çaydere, Aytaj Jafarzade, Feyza Bayrakdar Çağlayan, Elvan Anadol, Durmuş Burgucu, Canan Yılmaz, Semih Ergişi, Tamer Mungan","doi":"10.1177/15593258261437450","DOIUrl":"10.1177/15593258261437450","url":null,"abstract":"<p><strong>Objectives: </strong>This study examines the effects of cyclophosphamide, a cancer treatment that also functions as a cytotoxic agent, on the nephrotic system. The extent to which stem cell applications can be effective in preventing nephrotoxicity caused by agents is also a subject of investigation. The extent to which the nephrotoxic effects detected in the animal model treated with cyclophosphamide can be prevented by stem cell application will be investigated.</p><p><strong>Material and methods: </strong>A total of 18 Sprague Dawley rats were included in the study, divided into 3 groups. Group 1 consisted of the control group, which received intraperitoneal (IP) saline injection. Group 2-cyclophosphamide and Group 3-cyclophosphamide + stem cell was administered IP cyclophosphamide (50 mg/kg cyclophosphamide on the first day and then 8 mg/kg intraperitoneally for 14 days) to create a nephrotoxicity model. Group 3-cyclophosphamide + stem cell also received weekly hUCMSC 10*6 IP for 2 weeks. 4 weeks after the treatment, the animals were euthanized, their kidney tissues were histopathologically and immunohistochemically evaluated, and their blood values were biochemically evaluated.</p><p><strong>Result: </strong>In histopathological examination, glomerulosclerosis and tubular damage were seen the most in Group 2, and this difference was found to be statistically significant (p<0.001 and p<0.01). However, no statistically significant difference was observed in terms of inflammation in the kidney tissues (p=0.068). No significant change was observed in the biochemically evaluated BUN, creatinine, or urea levels in all three groups (p<0.8; p<0.141; p<0.8).</p><p><strong>Conclusion: </strong>In light of the current information, human Umbilical Cord Mesenchymal Stem Cell (hUC-MCS) has been demonstrated to reduce the nephrotoxicity caused by cyclophosphamide given for cytotoxic purposes on the kidney and exhibit induced renal regeneration. Our findings create new hope for the use of stem cell therapies in the field of kidney diseases.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261437450"},"PeriodicalIF":2.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Gentiana lutea</i> Root Extract Attenuates Radiation-Induced Damage in Human PBMCs <i>in vitro</i>.","authors":"Mila Kostić, Jelena Filipović Tričković, Ksenija Radošević, Tamara Lazarević Pašti, Srboljub Stanković, Ivana Kolić, Aleksandra Stanković, Ana Valenta Šobot","doi":"10.1177/15593258261435484","DOIUrl":"10.1177/15593258261435484","url":null,"abstract":"<p><strong>Background: </strong>Ionizing radiation (IR) has the potential to harm cellular macromolecules, raising concerns across a range of exposure contexts. This study investigates the radioprotective potential of <i>Gentiana lutea</i> root extract (GRE), a natural product known for its antioxidant properties.</p><p><strong>Research design: </strong>The GRE composition was analysed using ultra-performance liquid chromatography (UPLC). Peripheral blood mononuclear cells were treated with 0.25-2 mg/mL GRE 24 hours prior to 0.5 and 2 Gy gamma radiation exposure (Co-60 source). Oxidative stress and antioxidant responses were evaluated via lipid peroxidation products, reduced glutathione, and pro-oxidant/antioxidant balance assays. Genomic damage was assessed using the micronuclei test, comet and colorimetric DNA fragmentation assay, and DNA repair was assessed through evaluation of gene expression levels that are involved in base excision repair.</p><p><strong>Results: </strong>The presence of gentiopicroside, loganic acid, sweroside, swertiamarin, and rosmarinic acid was confirmed by UPLC analysis. GRE pretreatment significantly improved cell viability, reduced oxidative and genomic damage, and enhanced antioxidative responses in irradiated cells.</p><p><strong>Conclusions: </strong>Natural compounds in GRE induce cellular responses that attenuate sublethal radiation damage in human PBMCs <i>in vitro</i>, supporting its further evaluation as a potential radioprotective strategy.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261435484"},"PeriodicalIF":2.8,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric Comparison of Intracavitary Versus Combined Intracavitary-Interstitial Image-Guided Brachytherapy in Locally Advanced Cervical Cancer.","authors":"Xi Yang, Bo Zhao, Guiyong Yu, Zhuokai He, Meilian Liu, Rensheng Wang, Kai Hu","doi":"10.1177/15593258261430575","DOIUrl":"10.1177/15593258261430575","url":null,"abstract":"<p><strong>Purpose: </strong>The present study aimed to compare the dose distributions between conventional three-catheter intracavitary (IC) brachytherapy and combined intracavitary-interstitial (IC/IS) brachytherapy in the management of locally advanced cervical cancer (LACC).</p><p><strong>Materials and methods: </strong>A retrospective dosimetric analysis was performed using data from 78 patients with cervical cancer who underwent high-dose-rate (HDR) brachytherapy. To evaluate the dosimetric advantages of IC/IS brachytherapy, patients were stratified into two groups: those treated with IC brachytherapy and those treated with IC/IS brachytherapy. Dosimetric parameters between the two groups were compared.</p><p><strong>Results: </strong>In the IC/IS brachytherapy group, V150 values for the high-risk clinical target volume (HR-CTV) were significantly higher than those in the IC group (<i>p</i> < 0.001). Subsequent comparison of organ-at-risk (OAR) dosimetric parameters revealed that D_0.1cc, D₁cc, D₂cc, D₅cc, and D₁₀cc values for the bladder and sigmoid colon were significantly lower in the IC/IS group than in the IC group (all <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Compared with conventional IC brachytherapy, combined IC/IS brachytherapy provides superior HR-CTV coverage with higher doses while simultaneously reducing radiation exposure to the bladder and sigmoid colon, provided that the D90 dose constraint for the HR-CTV is met.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261430575"},"PeriodicalIF":2.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Quercetin Paradox, Evaluation of its Therapeutic Efficacy as a Nutraceutical in Clinical Trials: Evidence and Speculation.","authors":"Raquel García Alvarez, Juan Luis Chávez-Pacheco, Nelly Francisca Altamirano-Bustamante, Edelmira Solorio-López, Josefina Gómez-Garduño, Liliana Rivera-Espinosa","doi":"10.1177/15593258261419728","DOIUrl":"10.1177/15593258261419728","url":null,"abstract":"<p><strong>Introduction: </strong>Quercetin, a dietary flavonoid typically consumed as a glycoside, is available in supplements in its aglycone form. This aglycone form is the most studied in preclinical and clinical research because of its antioxidant, anti-inflammatory, and metabolic properties. Several clinical trials have demonstrated the benefits of quercetin for enzymatic, metabolic and cardiovascular health, approximately 60% of these studies fail to verify the actual concentration administered, generating uncertainty on their findings.</p><p><strong>Objective: </strong>This study aimed to evaluate the concentration, stability, and cost-concentration of commercial quercetin nutraceutical formulations.</p><p><strong>Methodology: </strong>The concentrations of five commercial brands were quantified by high-performance liquid chromatography. Stability was assessed over 6 months at both room temperature and 40°C.</p><p><strong>Results: </strong>Only one brand contained the amount labeled; three contained approximately 80%, and one contained merely 14.8%. This study is the first to evaluate the long and thermal stability of quercetin in nutraceutical products, demonstrating that the active ingredient remains stable for at least 6 months. Brand C was identified as the most suitable option.</p><p><strong>Conclusion: </strong>There was significant variability in the quercetin concentration of commercial supplements. These findings underscore the need for stricter regulatory oversight to ensure the quality, therapeutic efficacy, and safety of nutraceutical products.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261419728"},"PeriodicalIF":2.8,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Transcriptomics Leads From Discovery to in Vivo Validation: COL4A3/COL4A6/ COL4A5 and ITGA8 as Novel Arthrofibrosis Biomarkers in Post-traumatic Joint Contracture.","authors":"Yijia Wang, Hong Zeng, Zilin Li, Li Cheng, Xintong Zhu, Mengting Liang, Zhongyi Fang, Shujing Lai, Bin Cai","doi":"10.1177/15593258261424570","DOIUrl":"10.1177/15593258261424570","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic joint contracture (PTJC), characterized by progressive fibrosis, is a frequent complication following joint injury. Nevertheless, the molecular mechanisms driving its progression remain elusive. To address this, our study aims to delineate the dynamic transcriptomic alterations during arthrofibrosis development and to identify potential biomarkers associated with PTJC.</p><p><strong>Methods: </strong>A rat model of PTJC was established, and RNA sequencing was performed on joint capsules at 0, 3, 7, 14, and 28 days post injury. We then applied Mfuzz time-series clustering, WGCNA, KEGG pathway enrichment analysis, and PPI networks to pinpoint key genes and pathways involved. Cross-species validation was conducted using human transcriptomic data from the GSE135854 dataset.</p><p><strong>Results: </strong>Progressive joint stiffness and fibrosis were observed, peaking at 28 days post-injury. Transcriptome analysis identified 1385 differentially expressed genes (DEGs). KEGG analysis revealed significant enrichment in processes such as \"extracellular matrix (ECM)-receptor interaction,\" \"focal adhesion,\" \"cyclic Guanosine Monophosphate - Protein Kinase G (cGMP-PKG) signaling,\" and \"vascular smooth muscle contraction\". By integrating rat and human data, we identified COL4A3, COL4A6, COL4A5, and ITGA8 as consistently upregulated hub genes. Their elevated expression in fibrotic joint tissues was further validated using RT-qPCR and immunohistochemistry (IHC).</p><p><strong>Conclusion: </strong>This study provides a comprehensive transcriptomic landscape of PTJC progression and highlights COL4A3/COL4A6/COL4A5 and ITGA8 as promising biomarkers and therapeutic targets for arthrofibrosis.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261424570"},"PeriodicalIF":2.8,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Radioprotective Effects of (-)-Epigallocatechin-3-gallate (EGCG): Restoring the Gut Microbiota-Immune Axis to Ameliorate Radiation-Induced Intestinal Injury.","authors":"Jia Gu, Qing Guo, Qian Hua, Zhibing Tang, Ying Yang, Chen Ji, Jia Yu, Dongqian Zhu, Qiong Feng, Jiaying Xu, Lin Zhao","doi":"10.1177/15593258261422635","DOIUrl":"10.1177/15593258261422635","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the protective effect and mechanism of (-)-epigallocatechin-3-gallate (EGCG) against radiation-induced intestinal injury (RIII).</p><p><strong>Methods: </strong>C57BL/6J mice were pretreated with 10 mg/kg EGCG for 10 weeks or 3 days before 10 Gy total body irradiation (TBI) or whole abdominal irradiation (WAI), focusing on survival, body weight, intestinal structure, inflammation, and gut microbiota. For mechanism exploration, peritoneal and RAW264.7 macrophages were pretreated with 0-50 μM EGCG before irradiation, followed by assessments of cell viability, inflammatory proteins, and related signaling.</p><p><strong>Results: </strong>EGCG protects mice from TBI-induced toxicity and weight loss, and alleviates WAI-induced intestinal injury, characterized by preserved villus architecture and reduced crypt cell apoptosis. Mechanistically, EGCG inhibits RIII by suppressing pro-inflammatory cytokine production (TNF-α, IL-6) and maintains the composition of gut microbiota disrupted by irradiation. In vitro studies confirm EGCG directly regulates the release of radiation-induced inflammatory factors in macrophages via inhibiting toll-like receptor (TLR) signaling, independent of microbial effects. The radioprotective effect of EGCG is attributed to its dual actions: preserving macrophage function to dampen inflammatory responses and maintaining gut microbiota homeostasis.</p><p><strong>Conclusion: </strong>These findings highlight EGCG as a potential therapeutic agent for RIII, offering a novel strategy to improve outcomes in irradiated patients.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261422635"},"PeriodicalIF":2.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12925019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Determination of Six Components in Zhuqi Piantan Granules and the Protective Effect of Combined Electroacupuncture on Cerebral Injury in Rats With Ischemic Stroke.","authors":"Ping Yang, Zi Wang, Lingyu Kong, Di Hao, Weiwei Liu, Na Gu, Nan Li, Ting Zhang, Xiaolin Wang, Ling Zhang, Yedong Bi","doi":"10.1177/15593258261418851","DOIUrl":"10.1177/15593258261418851","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to establish a high-performance liquid chromatography (HPLC) method for the simultaneous quantification of six components in Zhuqi Piantan Granules, and to investigate the protective effect and underlying mechanism of Zhuqi Piantan Granules alone or combined with electroacupuncture on cerebral ischemia-reperfusion injury in rats.</p><p><strong>Methods: </strong>Zhuqi Piantan Granules were extracted with 80% methanol. HPLC analysis employed a C18 column and gradient elution using acetonitrile and 0.3% phosphoric acid as the mobile phase. Modeled rats were randomly grouped, given corresponding interventions for 14 days, and evaluated for neurological function, cerebral infarct ratio, vascular density, brain histological changes (hematoxylin-eosin (HE) staining), and Angiopoietin-1/Tyrosine Kinase Receptor-2(Ang-1/Tie-2) protein expressions (Western Blotting).</p><p><strong>Results: </strong>All six target components exhibited excellent linear relationships (r ≥ 0.9994). The average recoveries ranged from 97.1% to 99.5%. Both Zhuqi Piantan Granules alone and their combination with electroacupuncture improved neurological function, reduced infarct ratio, increased vascular density, alleviated brain pathological damage, and upregulated Ang-1/Tie-2 expressions-with the combined treatment showing superior efficacy.</p><p><strong>Conclusion: </strong>The established HPLC method is reliable and suitable for Zhuqi Piantan Granules quality control. Zhuqi Piantan Granules alone or combined with electroacupuncture alleviates rat cerebral injury by activating the Ang-1/Tie-2 pathway to promote angiogenesis.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261418851"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"I-129 in Nuclear Waste: Much Ado About Nothing.","authors":"Hugh Henry, James S Welsh","doi":"10.1177/15593258261420242","DOIUrl":"10.1177/15593258261420242","url":null,"abstract":"<p><p>Recent articles and news blogs have been written about nuclear waste management, specifically focusing on the alleged hazards of iodine-129. Here, we objectively review the specific details of iodine-129 as a radiation hazard. In contrast with the alarmist tone of these recent papers and news items, we conclude that iodine-129 is not nearly as concerning as has been projected. Rather, it appears to be a classic case of \"much ado about nothing\".</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 1","pages":"15593258261420242"},"PeriodicalIF":2.4,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}