Developmental Dynamics最新文献

{"title":"Endocytosis mediated by megalin and cubilin is involved in enamel development.","authors":"Aijia Wang, Yangxi Chen, Xinye Zhang, Ming Liu, Shumin Liu, Renata Kozyraki, Zhi Chen","doi":"10.1002/dvdy.771","DOIUrl":"https://doi.org/10.1002/dvdy.771","url":null,"abstract":"<p><strong>Background: </strong>Endocytosis of enamel matrix proteins (EMPs) by ameloblasts is a key process in the mineralization of enamel during the maturation stage of amelogenesis. However, the relevant receptor mediating endocytosis of EMPs is still unclear. The aim of this study was to explore potential endocytic receptors involved in this process.</p><p><strong>Results: </strong>Two endocytic receptors, megalin, and cubilin, were found to be distributed in ameloblasts of mouse incisors and molars during the secretory and maturation stages. Megalin was located at the distal end of ameloblasts during the maturation stage when proteolysis and recycling were the most active. Megalin and cubilin were also expressed in an ameloblast-lineage cell (ALC) line. The immunoelectron microscopy results showed that megalin was positively labeled on the vesicle structures of ALC, where endocytosis happened. Immunofluorescence showed that megalin and cubilin were colocalized with amelogenin, and the absorption of amelogenin was significantly reduced when megalin and cubilin were inhibited by their inhibitor, receptor-associated protein (RAP). Knockdown of megalin and cubilin with siRNA also reduced the ability of ALC to absorb amelogenin.</p><p><strong>Conclusions: </strong>The results of this study suggest that megalin and cubilin are involved in the absorption process of ameloblasts during amelogenesis.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T-tubule pH regulation.","authors":"Leif R Neitzel, Maya Silver, Aaron H Wasserman, Samantha Rea, Charles C Hong, Charles H Williams","doi":"10.1002/dvdy.770","DOIUrl":"https://doi.org/10.1002/dvdy.770","url":null,"abstract":"<p><p>Disruption of extracellular pH and proton-sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH-sensitive fluorescent protein pHluorin2, tethered to the extracellular face of the plasma membrane using a glycosylphosphatidylinositol (GPI) anchor. Monitoring of pHluorin2 with ratiometric fluorescence revealed dynamic and discrete domains of extracellular acidification over the first 72 h of embryonic development. These included acidification of the notochord intercalations, transient acidification of the otic placode, and persistent acidification of the extracellular space of the myotome at distinctly different pH from that within the T-tubules. Knockdown of centronuclear myopathy genes Bin1b (OMIM: 255200) and MTM1 (OMIM: 310400), which disrupt T-tubule formation, also disrupted myotome acidification. In this study we visualize extracellular acidic microdomains in the tissues of whole live animals. This real-time reporter line for directly measuring changes in extracellular pH can be used to illuminate the role of extracellular pH in normal physiological development and disease states.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cochlea phenotypically differs from the vestibule in the Gfi1^GFP/GFP mouse.","authors":"Zhuo Li, Hongzhi Chen, Hao Feng","doi":"10.1002/dvdy.772","DOIUrl":"https://doi.org/10.1002/dvdy.772","url":null,"abstract":"<p><strong>Background: </strong>Previous studies with Gfi1-mutated lines have shown that Gfi1 is essential for hair cell maturation and survival.</p><p><strong>Results: </strong>We analyzed the phenotype of another Gfi1-mutated line Gfi1^GFP/GFP in the inner ears of neonates at P5-7 and found that the cochlea phenotypically differed from the vestibule in the Gfi1^GFP/GFP mouse. Specifically, there was a marked reduction in hair cells in the cochlea, which was characterized by greater reductions in the outer hair cells but far less reductions (mainly in the basal turn) in the inner hair cells, whereas the vestibular hair cells remained unaffected. These results were consistent with findings from previous studies. Unexpectedly, the number of cochlear non-sensory supporting cells significantly decreased. However, the vestibular supporting cells did not demonstrate any abnormalities in number.</p><p><strong>Conclusion: </strong>Gfi1 exhibits different functions in the cochlea and vestibule during inner ear development.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial highlights","authors":"Paul A. Trainor","doi":"10.1002/dvdy.767","DOIUrl":"10.1002/dvdy.767","url":null,"abstract":"&lt;p&gt;Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in &lt;i&gt;Developmental Dynamics&lt;/i&gt; that illustrate the complex dynamics of developmental biology.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Cell Differentiation&lt;/b&gt; “Emerging biological functions of Twist1 in cell differentiation” by Mengjie Tu, Bingqian Ge, Jiali Li, Yanbing Pan, Binbin Zhao, Jiayang Han, Jialin Wu, Kaifeng Zhang, Guangchao Liu, Mengwen Hou, Man Yue, Xu Han, Tiantian Sun and Yang An &lt;i&gt;DevDyn&lt;/i&gt; 254.1, pp. 8–25. https://doi.org/10.1002/dvdy.736. Twist1 is a basic helix–loop–helix (bHLH) transcription factor, first identified in Drosophila as a crucial regulator of mesoderm development. Twist1 is evolutionarily highly conserved and can induce epithelial–mesenchymal transition (EMT) during development and in the pathogenesis of cancer metastasis. Twist1, therefore, plays a key role in a variety of developmental processes, including mesoderm formation, neurulation, neural crest cell formation, neurogenesis, and organogenesis. This review article discusses the physiological roles of Twist1 in osteogenic, chondrogenic, and myogenic differentiation and the molecular mechanisms and signaling pathways mediated by Twist1. In addition, it summarizes the structure of Twist1, its post-translational regulation, and roles in developmental disorders and diseases, with a focus on cellular differentiation. Finally, the authors consider Twist1 as a biomarker for mesenchymal stem cells and speculate that stem cell fate can be regulated through metabolic reprogramming as part of a discussion of new strategies for clinical research involving Twist1 as a regulator of EMT and in organogenesis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Craniofacial Biology&lt;/b&gt; “Transcription factor Meis1b regulates craniofacial morphogenesis in zebrafish” by Viktorie Psutkova, Petr Nickl, Veronika Brezinova, Olga Machonova and Ondrej Machon &lt;i&gt;DevDyn&lt;/i&gt; 254.1, pp. 40–60. https://doi.org/10.1002/dvdy.731. The vertebrate skull is composed of the viscerocranium (splanchnocranium), chondrocranium (neurocranium), and dermatocranium, and the co-ordinated development of tendons, muscles, nerves, cartilage, and bone are necessary for proper jaw formation and functional integration with the skull. MEIS transcription factors (MEIS1, MEIS2, MEIS3) regulate cartilage and bone development during development in mammals such as mice. This study focuses on the key roles of Meis transcription factors in zebrafish craniofacial. Zebrafish have six &lt;i&gt;meis&lt;/i&gt; genes as the zebrafish genome contains two paralogs of each &lt;i&gt;meis&lt;/i&gt; gene due to whole genome duplication in teleosts. The authors generated &lt;i&gt;meis1a&lt;/i&gt;, &lt;i&gt;meis1b&lt;/i&gt;, &lt;i&gt;meis2a&lt;/i&gt;, and &lt;i&gt;meis2b&lt;/i&gt; mutant zebrafish and analyzed their craniofacial skeleto","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":"254 1","pages":"6-7"},"PeriodicalIF":2.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvdy.767","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing candidate DLX-regulated genes in the first pharyngeal arch of chick embryos.","authors":"Afshan Sohail, Olivia Nicoll, Andrew J Bendall","doi":"10.1002/dvdy.765","DOIUrl":"https://doi.org/10.1002/dvdy.765","url":null,"abstract":"<p><strong>Background: </strong>Insights into the development and evolution of asymmetrical jaws will require an understanding of the gene regulatory networks that underpin the differential morphogenesis of the maxillary and mandibular domains of the first pharyngeal arch in a variety of gnathostomes. While a robust relationship has been demonstrated between jaw patterning and the Endothelin-Dlx gene axis, much less is known of the next level of genes in the jaw patterning hierarchy.</p><p><strong>Results: </strong>Several genes, whose expression depends on Dlx5 and/or Dlx6, have been identified in mice. Here, we examined the expression patterns of the chick orthologues of some of those genes, namely GSC, PITX1, HAND2, and GBX2, and tested their dependence on endothelin signaling to assess whether there is a conserved regulatory relationship between those genes in the chick embryo. To further validate these genes as direct DLX targets, we identified conserved non-coding sequences containing candidate DLX binding motifs and demonstrated DLX-responsiveness in vitro.</p><p><strong>Conclusions: </strong>The evidence presented in this study combines to support the hypothesis that these four genes are direct targets of DLX transcription factors in the lower jaw-forming tissue.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link of FOXO1 and FOXO4 transcription factors to development of the lens.","authors":"Rifah N Gheyas, Ruby C Williams, Kelly A Ryan, A Sue Menko","doi":"10.1002/dvdy.766","DOIUrl":"https://doi.org/10.1002/dvdy.766","url":null,"abstract":"<p><strong>Background: </strong>The FOXOs regulate the transcription of many genes, including ones directly linked to pathways required for lens development. However, this transcription factor family has rarely been studied in the context of development, including the development of the lens. FOXO expression, regulation, and function during lens development remained unexplored.</p><p><strong>Results: </strong>In studies of the embryonic lens, we showed that both FOXO1 and FOXO4, which share many downstream targets, are expressed in a differentiation-state-specific manner, most highly in lens epithelial and differentiating cortical fiber cells. Their expression patterns and subcellular distributions suggest both shared and distinct functions. Stabilization of FOXO cytoplasmic pools involved their binding to the chaperone protein 14-3-3. FOXO association with β-catenin linked this transcription complex to fiber cell-specific gene activation. Inhibition of PI3K/Akt signaling promoted FOXO1/FOXO4 nuclear localization in lens epithelial and fiber cells and expression of the CDKi p27 in the lens epithelium where it has been linked to lens cell withdrawal from the cell cycle and initiation of the lens differentiation program. We showed that FOXO1 transcriptional activation is required for the induction of p27 when Akt signaling is blocked, demonstrating the linearity of the PI3K/Akt/FOXO1/p27 pathway.</p><p><strong>Conclusions: </strong>PI3K/Akt signaling regulates FOXO-dependent lens cell differentiation.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between perfluoro-octanoic sulfonate and common antibiotics induces developmental anomalies and lethality in Xenopus laevis.","authors":"Emma Harrison, Shreya Chattapadhyay, Ganad Neka, Maya Baskin, Nora Richmond, Quynh Nguyen, Isabel Wade, Arya Anekal, Olive Lucanish, John J Young","doi":"10.1002/dvdy.764","DOIUrl":"https://doi.org/10.1002/dvdy.764","url":null,"abstract":"<p><strong>Background: </strong>Perfluoroalkyl substances (PFAS) are persistent environmental contaminants previously used for industrial purposes as a non-stick coating and flame retardant. The stability of these molecules prevents their breakdown, which results in ground water contamination across the globe. Perfluoroalkyl substances molecules are known to bioaccumulate in various organisms. However, the health consequences remain unclear due to the large number of molecules in the PFAS family and different effects on various tissues. Here, we use the frog Xenopus laevis to investigate the developmental consequences of exposure to the PFAS molecule perfluoro-octanoic sulfonate (PFOS).</p><p><strong>Results: </strong>We find that exposure to high levels of PFOS results in significant axial shortening of developing tadpoles. Further, we find that PFOS exposure results in a dose-dependent formation of a cellular mass in the dorsal fin. Unexpectedly, we found that these developmental phenotypes are exacerbated upon co-exposure with commonly used antibiotics. Specifically, PFOS and gentamicin co-treatment results in increased apoptosis, loss of cellular integrity, and increased overall lethality.</p><p><strong>Conclusions: </strong>Our results suggest a mechanism whereby gentamicin reaches levels that are toxic to mitochondria only in the presence of PFOS. These findings add to our understanding of PFOS exposure to vertebrate development and present an added concern with potential interactions with antibiotics.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urodele amphibian newt bridges the missing link in evo-devo of the pancreas.","authors":"Ryosuke Morozumi, Kazuko Okamoto, Eriko Enomoto, Yuta Tsukamoto, Mitsuki Kyakuno, Nanoka Suzuki, Ichiro Tazawa, Nobuaki Furuno, Hajime Ogino, Yasuhiro Kamei, Masatoshi Matsunami, Shuji Shigenobu, Kenichi Suzuki, Hitoshi Uemasu, Noriyuki Namba, Toshinori Hayashi","doi":"10.1002/dvdy.763","DOIUrl":"https://doi.org/10.1002/dvdy.763","url":null,"abstract":"<p><strong>Background: </strong>The pancreas exhibits diverse structures and roles across vertebrates. The pancreas has evolved to include both endocrine and exocrine cells, a change that occurred during the transition from fish to amphibian. This event emphasizes the evolutionary significance of amphibians. However, research has focused predominantly on anuran amphibians, with urodeles, such as newts, remaining underexplored. In this study, we investigated the development of the pancreas using Pleurodeles waltl as a model species of urodele.</p><p><strong>Results: </strong>The newt pancreas consists of a single organ with exocrine tissue characterized by acinar structures and endocrine tissue forming islets. Notably, the newt possesses unique pancreas-like tissues on their intestines. We found that disruption of the newt Pancreatic and Duodenal Homeobox (Pdx) 1 gene resulted in an underdeveloped pancreas. Conversely, disruption of the Pdx2 paralog in newt had no significant impact on pancreatic development.</p><p><strong>Conclusion: </strong>The newt pancreas shows a morphology similar to that of the mammalian pancreas, which includes both exocrine and endocrine tissues. These results highlight the intermediate evolutionary position of the newt in the context of the evolution of pancreatic development. Our findings indicate that characterization of the newt pancreas will be crucial for understanding the evolutionary progression of pancreatic function in vertebrates.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on pathogenesis and treatment of Alzheimer's disease","authors":"Jinxia Cai,&nbsp;Yanqing Liu,&nbsp;Haojun Fan","doi":"10.1002/dvdy.762","DOIUrl":"10.1002/dvdy.762","url":null,"abstract":"<p>The rising incidence of Alzheimer's disease (AD) and the associated economic impacts has prompted a global focus in the field. In recent years, there has been a growing understanding of the pathogenic mechanisms of AD, including the aggregation of β-amyloid, hyperphosphorylated tau, and neuroinflammation. These processes collectively lead to neurodegeneration and cognitive decline, which ultimately results in the loss of autonomy in patients. Currently, there are three main types of AD treatments: clinical tools, pharmacological treatment, and material interventions. This review provides a comprehensive analysis of the underlying etiology and pathogenesis of AD, as well as an overview of the current prevalence of AD treatments. We believe this article can help deepen our understanding of the AD mechanism, and facilitate the clinical translation of scientific research or therapies, to address this global problem of AD.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":"254 4","pages":"296-309"},"PeriodicalIF":2.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvdy.762","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial highlights","authors":"Paul A. Trainor","doi":"10.1002/dvdy.760","DOIUrl":"https://doi.org/10.1002/dvdy.760","url":null,"abstract":"&lt;p&gt;Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in &lt;i&gt;Developmental Dynamics&lt;/i&gt; that illustrate the complex dynamics of developmental biology.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Ciliogenesis in Development and Disease&lt;/b&gt; “Actin cytoskeletal regulation of ciliogenesis in development and disease” by Brittany Hufft-Martinez, Henry Wang, Irfan Saadi, and Pamela Tran; &lt;i&gt;Dev Dyn&lt;/i&gt; 253:12, pp. 1076–1093. https://doi.org/10.1002/dvdy.724. Primary cilia are antenna-like sensory organelles, comprised of microtubule-based cellular projections, which serve both motile and non-motile sensory functions. Cilia are required for reproduction and regulate multiple cellular processes, including cell motility, cell cycle, cell differentiation, autophagy, and cell–cell communication. Their evolutionary conservation from algae to mammals, has informed our understanding of the basic biology of mammalian primary cilia, organismal development, and the genetic etiology of ciliopathies. This review discusses studies that have revealed the importance of regulating the actin cytoskeleton in ciliary homeostasis, including centrosome migration and positioning, vesicle transport to the basal body, ectocytosis, and ciliary-mediated signaling. It also highlights both conserved and divergent mechanisms in algae and mammalian cells. Finally, the authors compare the phenotypic manifestations of patients with ciliopathies, to those with mutations in actin and actin-associated genes and propose that primary cilia defects caused by genetic alteration of the actin cytoskeleton may underlie specific birth defects.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Organogenesis, Teeth, and Retinoic Acid&lt;/b&gt; “Differential retinoic acid sensitivity of oral and pharyngeal teeth in medaka (&lt;i&gt;Oryzias latipes&lt;/i&gt;) supports the importance of pouch–cleft contacts in pharyngeal tooth initiation” by Daria Loarinova and Ann Huysseune; &lt;i&gt;Dev Dyn&lt;/i&gt; 253:12, pp. 1094–1105. https://doi.org/10.1002/dvdy.723. In early actinopterygian evolution, the dentition was widespread throughout the oropharynx, encompassing teeth on each pharyngeal arch. This wide distribution was reduced over time, as teeth were retained only on the most anterior and most posterior parts of the visceral skeleton, establishing an oral and a pharyngeal dentition, respectively. However, advanced teleost such as medaka, have retained both oral dentition and pharyngeal dentition, whereas less advanced teleosts such as zebrafish have lost oral dentition, retaining teeth exclusively on the last pharyngeal arch. Learn how previous studies claiming that pharyngeal teeth in medaka (&lt;i&gt;Oryzias latipes&lt;/i&gt;) were induced independent of retinoic acid signaling unlike in zebrafish (&lt;i&gt;Danio rerio&lt;/i&gt;) prompted the aut","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":"253 12","pages":"1074-1075"},"PeriodicalIF":2.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvdy.760","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}