Developmental Dynamics最新文献_第7页

In silico analysis of putative interactions identifies fibroblasts as hubs for cell-cell communication during early regeneration of the zebrafish heart. 对推测的相互作用进行的计算机分析表明，在斑马鱼心脏早期再生过程中，成纤维细胞是细胞间通信的枢纽。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-06-09 DOI: 10.1002/dvdy.70158

João A S Carvalho, Prateek Arora, Ines J Marques, María Galardi-Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader

{"title":"In silico analysis of putative interactions identifies fibroblasts as hubs for cell-cell communication during early regeneration of the zebrafish heart.","authors":"João A S Carvalho, Prateek Arora, Ines J Marques, María Galardi-Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader","doi":"10.1002/dvdy.70158","DOIUrl":"https://doi.org/10.1002/dvdy.70158","url":null,"abstract":"Background: The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.Results: We present an in silico meta-analysis of ligand-receptor (LR) interactions among periostin b+ fibroblasts, kdlr+ endothelial cells, sox10-derived and rest of ventricular cardiomyocytes, at 7 days post-injury. Using bulk RNA-seq data sets from fluorophore-activated cell-sorted populations, we selected for differentially expressed genes encoding LR pairs. Human-centric interaction data from the OmniPath database were adapted to zebrafish data through ortholog mapping to reconstruct a comprehensive interactome. We observed that fibroblasts and, to a lesser extent, endothelial cells emerged as signaling hubs, while cardiomyocytes primarily acted as signal recipients. Network analysis, combining PageRank, expression change, and literature-based novelty, revealed both known and novel candidate genes in regeneration, and allowed pathway enrichment analysis. An interactive web tool enables exploration of the ranked interaction data set, providing a systematic resource to guide future functional studies.Conclusions: This study provides a systematic and unbiased map of regenerative signaling in the zebrafish heart, establishing a resource to guide functional investigations.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of centromeric fluorescence in situ hybridization probes for embryological and cell studies-A practical approach to validate chromosome stability in Bovinae. 着丝粒荧光原位杂交探针在胚胎学和细胞研究中的应用——一种验证牛染色体稳定性的实用方法。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-06-09 DOI: 10.1002/dvdy.70159

Zofia E Madeja, Izabela Szczerbal, Marcelina H Osyra, Marta M Ziętek, Agnieszka Bernat

{"title":"Application of centromeric fluorescence in situ hybridization probes for embryological and cell studies-A practical approach to validate chromosome stability in Bovinae.","authors":"Zofia E Madeja, Izabela Szczerbal, Marcelina H Osyra, Marta M Ziętek, Agnieszka Bernat","doi":"10.1002/dvdy.70159","DOIUrl":"https://doi.org/10.1002/dvdy.70159","url":null,"abstract":"Background: Advances in reproductive and cellular biotechnology have significantly enhanced the ability to study, conserve, and manipulate species within the Bovinae family, including domestic cattle and the endangered European bison (wisent). Central to the success of such technologies, including in vitro fertilization, somatic cell nuclear transfer, and the culture of pluripotent stem cells (PSCs), is the chromosome stability of cultured cells and embryos.Results: Here, we present the design and application of a specific centromere Cot-1 DNA probe for fluorescence in situ hybridization (FISH). We demonstrate its utility in assessing chromosomal stability of bovine and wisent somatic cells and in vitro-produced embryos. The probe shows high specificity for Bovinae cells and can be used on both metaphase plates and interphase nuclei, enabling rapid cytogenetic analysis even in slow-dividing or senescent cells.Conclusions: The newly generated Cot-1 DNA-based FISH probe provides a rapid and reliable method for species-specific cytogenetic monitoring in Bovinae. Furthermore, it allows accurate monitoring of chromosomal stability and quality control in PSC systems reliant on feeder layers and offers a streamlined approach for monitoring embryo chromosomal integrity in vitro. Broader application of this method may improve outcomes in reproductive technologies, conservation programs, and the generation of stable cell lines for biotechnological and agricultural use.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and temporal coordination of signaling pathways in tissue differentiation: Developmental atlas of protein expression during zebra finch beak maturation. 组织分化信号通路的时空协调：斑胸草雀喙成熟过程中蛋白质表达的发育图谱。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-05-31 DOI: 10.1002/dvdy.70156

Renée A Duckworth, Sarah E Britton, Cody A Lee, Kathryn C Chenard, Alexander V Badyaev

{"title":"Spatial and temporal coordination of signaling pathways in tissue differentiation: Developmental atlas of protein expression during zebra finch beak maturation.","authors":"Renée A Duckworth, Sarah E Britton, Cody A Lee, Kathryn C Chenard, Alexander V Badyaev","doi":"10.1002/dvdy.70156","DOIUrl":"https://doi.org/10.1002/dvdy.70156","url":null,"abstract":"Background: Morphogenesis depends on spatial and temporal coordination of signaling pathways, yet context-specificity in interactions among these pathways during cartilage and bone differentiation remains poorly understood. Here we map cellular and histological localization of regulatory proteins forming core craniofacial developmental pathways of the zebra finch (Taeniopygia guttata) to provide insight into their functional roles during beak morphogenesis.Results: We present an atlas of spatiotemporal coexpression of β-catenin, Bmp4, CaM, Dkk3, Fgf8, Ihh, Tgfβ2, and Wnt4 across embryonic stages HH29-42. Early stages (HH29-32), showed broad expression across epithelial and mesenchymal tissues, followed by progressive compartmentalization by HH36, with pronounced divergence among tissues. Notably, at later stages, proteins showed tissue-specific distributions in boundary versus core regions of chondrogenic and osteogenic domains, indicating coordinated cross-pathway patterning during cartilage and bone formation.Conclusions: We find that osteogenesis in the zebra finch beak is organized by coordinated signaling between boundary-associated cells and differentiating cores; cross-pathway feedback establishes bone and cartilage differentiation while maintaining boundaries. Our results corroborate core aspects of craniofacial signaling dynamics and yet reveal unexpected subcellular localization of some key proteins identifying regulatory complexity not captured by prior transcript-level maps. This atlas provides a protein-level baseline for comparative and mechanistic studies of avian beak morphogenesis.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interspecific patterns of variation in dental growth increments of crocodilians. 鳄鱼牙齿生长增量的种间变异模式。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-05-30 DOI: 10.1002/dvdy.70157

Russell Hogg

{"title":"Interspecific patterns of variation in dental growth increments of crocodilians.","authors":"Russell Hogg","doi":"10.1002/dvdy.70157","DOIUrl":"https://doi.org/10.1002/dvdy.70157","url":null,"abstract":"Background: Multiple studies have supported the hypothesis that incremental growth lines in crocodilian dentin are analogous with circadian von Ebner's lines in mammals; however, variation in these growth lines has been largely unstudied. It is also unknown whether accentuated dentin striations in crocodilians may represent a supradian periodicity analogous to Andresen lines in mammalian dentin. Therefore, the objective of this study is to histologically assess variation in von Ebner's lines and accentuated growth lines among crocodilians.Results: The data do not support the hypothesis that crocodilians express supradian periodicity in accentuated striations of dentin. DSR is significantly correlated with total length and body mass. DSR variance also shows a significant relationship with body size.Conclusions: Body size seems to be the major factor governing DSR in crocodilians; this relationship is expressed both intra- and interspecifically in this dataset, warranting further study of intraspecific variation to assess the impact of ontogeny on DSR within this group. Accentuated striations may not be useful as markers of periodicity in crocodilians, but may be useful indicators of stress or other physiological events in life history analyses.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hedgehog co-receptors cdon and boc function redundantly to regulate zebrafish craniofacial development. hedgehog共受体cdon和boc在斑马鱼颅面发育中起冗余调节作用。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-05-30 DOI: 10.1002/dvdy.70153

Ryan Nickens, Sophia Guitar, Bryan Zepeda, Julaine Roffers-Agarwal, Kristin B Artinger, Ezra Lencer

{"title":"The hedgehog co-receptors cdon and boc function redundantly to regulate zebrafish craniofacial development.","authors":"Ryan Nickens, Sophia Guitar, Bryan Zepeda, Julaine Roffers-Agarwal, Kristin B Artinger, Ezra Lencer","doi":"10.1002/dvdy.70153","DOIUrl":"https://doi.org/10.1002/dvdy.70153","url":null,"abstract":"Background: Craniofacial development is a complex developmental process that involves formation of the skeleton, muscle, and tendons. Defects in craniofacial development result in common hereditary disorders. Among genetic factors regulating craniofacial development, dysregulated hedgehog signaling is associated with craniofacial skeletal defects such as orofacial clefting and holoprosencephaly. Here, we characterize craniofacial phenotypes associated with two hedgehog signaling co-receptors, cdon and boc, in zebrafish. Genetic pedigree analyses have previously linked both cdon and boc to microform holoprosencephaly, and mutations of Cdon and Boc in mouse result in craniofacial phenotypes. However, a detailed analysis of craniofacial phenotypes associated with cdon and boc in zebrafish has not been completed.Results: Our studies show that cdon and boc act redundantly to promote craniofacial cartilage, tendon, and muscle development in zebrafish. Using RNA-seq and HCR in situ hybridization, we show that mutations of cdon and boc result in misregulation of chondrogenesis gene expression including Indian hedgehog ligand, tendon-associated thrombospondin genes, and FOX transcription factors.Conclusions: Our data are consistent with a model whereby cdon and boc together modify hedgehog activity in the head and establish a foundation for using zebrafish to further understand the role of cdon and boc in craniofacial hereditary disorders such as holoprosencephaly.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotrophin signaling is required for the correct formation of the precerebellar nuclei in mouse embryos. 神经营养因子信号是小鼠胚胎小脑前核正确形成所必需的。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-05-29 DOI: 10.1002/dvdy.70155

Takuya Okada, Kazuko Keino-Masu, Masayuki Masu

{"title":"Neurotrophin signaling is required for the correct formation of the precerebellar nuclei in mouse embryos.","authors":"Takuya Okada, Kazuko Keino-Masu, Masayuki Masu","doi":"10.1002/dvdy.70155","DOIUrl":"https://doi.org/10.1002/dvdy.70155","url":null,"abstract":"Background: In the developing brain, neuronal migration is one of the critical steps in the establishment of an accurate neural network. When neurons reach their final destination, they form layered structures or nuclei. Precerebellar neurons (PCNs) form several nuclei in the pons and medulla and project mossy and climbing fibers to the cerebellum. PCNs originate from the lower rhombic lip in the dorsal hindbrain and migrate tangentially toward their destinations. When PCNs reach their presumptive nucleus-forming region, they change their migration direction from tangential to radial to form the precerebellar nuclei. Although various molecules have been shown to control PCN migration and nucleogenesis, the mechanisms underlying the development of the precerebellar system remain largely unknown.Results: We investigated the possible roles of two members of the neurotrophin family, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), in PCN development in mouse embryos. We found that Bdnf and Ntf3, which encode BDNF and NT-3, respectively, are expressed in their nucleus-forming regions in the pons and medulla, whereas their receptor genes are expressed in migrating PCNs. Disrupting these genes singly or in combination led to abnormal nucleogenesis of PCNs.Conclusion: Our findings indicate that neurotrophin signaling is required for accurate formation of the precerebellar nuclei.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinction of dental mesenchymal cell populations during molar tooth germ development via analysis of the spatiotemporal expression patterns of mRNAs for Shh ligand receptors Ptch1 and Hip1 using in situ hybridization. 利用原位杂交技术分析Shh配体受体Ptch1和Hip1 mrna的时空表达模式，以区分磨牙胚发育过程中的牙间充质细胞群。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-05-27 DOI: 10.1002/dvdy.70154

Masataka Sunohara, Shigeru Morikawa, Miyoko Yokoyama, Yuuki Maeda, Dai Nakashima, Atsushi Kasamatsu, Katsuhiro Uzawa, Kingo Suzuki

{"title":"Distinction of dental mesenchymal cell populations during molar tooth germ development via analysis of the spatiotemporal expression patterns of mRNAs for Shh ligand receptors Ptch1 and Hip1 using in situ hybridization.","authors":"Masataka Sunohara, Shigeru Morikawa, Miyoko Yokoyama, Yuuki Maeda, Dai Nakashima, Atsushi Kasamatsu, Katsuhiro Uzawa, Kingo Suzuki","doi":"10.1002/dvdy.70154","DOIUrl":"https://doi.org/10.1002/dvdy.70154","url":null,"abstract":"Background: During early tooth development, cranial neural crest cells migrating to the oral region form dental mesenchyme. To date, the molecular mechanism by which dental mesenchymal cells further migrate and differentiate into odontoblasts remains largely unknown. We hypothesize that the dental epithelium, being the only source of Shh, a chemotactic peptide, attracts future odontoblasts expressing the Shh receptor Ptch1.Results: Changes in the spatiotemporal distribution of cells expressing Shh, Ptch1, and Hip1 and of nestin protein throughout early tooth development were evaluated via in situ hybridization and immunohistochemistry, respectively. Dental mesenchymal cells were found to be separated into three putative cell population types based on spatiotemporal gene expression patterns: presumptive Ptch1(-)/Hip1(-) non-odontoblastic cells forming the initial dental papilla cell cluster; presumptive Ptch1(+)/Hip1(-) odontoblast lineage cells; and presumptive Ptch1(+)/Hip1(+) cells possibly forming dental follicle and surrounding mesenchyme. Ptch1(+)/Hip1(-) cells seemed to invade the developing dental papilla actively at embryonic day 15.5 (E15.5), resulting in an abundant distribution of the cells by the early bell stage at E16.5. The distribution pattern of presumptive Ptch1(+)/Hip1(-) cells partially overlapped with that of nestin-expressing cells.Conclusion: Presumptive Ptch1(+)/Hip1(-) dental mesenchymal cells may migrate to the cusp region of the dental papilla, leading to odontoblast differentiation.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of midgut loop formation: Influence of midgut length, diameter, and location. 中肠袢形成的决定因素：中肠长度、直径和位置的影响。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-05-25 DOI: 10.1002/dvdy.70149

Nanase Ishida, Toru Kanahashi, Jun Matsubayashi, Sena Fujii, Hirohiko Imai, Hiroki Otani, Shigehito Yamada, Tetsuya Takakuwa

{"title":"Determinants of midgut loop formation: Influence of midgut length, diameter, and location.","authors":"Nanase Ishida, Toru Kanahashi, Jun Matsubayashi, Sena Fujii, Hirohiko Imai, Hiroki Otani, Shigehito Yamada, Tetsuya Takakuwa","doi":"10.1002/dvdy.70149","DOIUrl":"https://doi.org/10.1002/dvdy.70149","url":null,"abstract":"Background: The midgut forms tertiary loops in the extraembryonic coelom, where biomechanical factors are thought to influence this process. The number of loops may stabilize once the midgut returns to the abdominal cavity. We therefore examined how midgut length and diameter affect the number of tertiary loops before and after intestinal return.Results: Magnetic resonance images from 50 human embryo and fetus specimens and serial tissue sections from six fetuses were analyzed. The midgut was divided into four segments, and the length of each segment and the tube diameter at a representative central loop were measured and subjected to regression analysis. In the extraembryonic coelom, loop number increased linearly with midgut length, whereas diameter showed no independent association. In the abdominal cavity, greater length was associated with more loops, whereas greater diameter tended to be associated with fewer loops, particularly in Segment-2 and Segment-4. This pattern may be related to the apparent attenuation of further loop increase after return to the abdominal cavity during later fetal development.Conclusions: The effects of midgut length and diameter on tertiary loop formation differ between the extraembryonic coelom and the abdominal cavity, highlighting the importance of midgut position in loop formation.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal obesity and offspring neurodevelopment: Mechanisms, risks, and prevention opportunities. 母亲肥胖与后代神经发育：机制、风险和预防机会。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-05-25 DOI: 10.1002/dvdy.70146

Iroda Djamalutdinova, Khusan Turdibekov, Azam Kholikov, Diyorjon Abdullaev, Gulsara Ruziyeva

{"title":"Maternal obesity and offspring neurodevelopment: Mechanisms, risks, and prevention opportunities.","authors":"Iroda Djamalutdinova, Khusan Turdibekov, Azam Kholikov, Diyorjon Abdullaev, Gulsara Ruziyeva","doi":"10.1002/dvdy.70146","DOIUrl":"https://doi.org/10.1002/dvdy.70146","url":null,"abstract":"The prevalence of maternal obesity is continuously increasing worldwide, making maternal overweight and obesity one of the most important early life risk factors that can affect the neurodevelopment of offspring. Data from large epidemiological studies indicate that higher prepregnancy BMI, as well as excessive weight gain during pregnancy, are associated with an increased risk of autism spectrum disorder, attention deficit/hyperactivity disorder, internalizing symptoms, cognitive impairment, cerebral palsy, and other neurodevelopmental outcomes. Preclinical studies have also provided a clearer understanding of the biological mechanisms, suggesting that maternal obesity can induce oxidative stress, metabolic inflammation, and placental dysfunction, which impair nutrient and oxygen delivery during critical periods of brain development. Other proposed pathways include activation of microglia and astroglia, dysbiosis of the gut microbiota with alterations in microbial metabolites, epigenetic rearrangements of DNA and histones, and disruption of serotonergic and dopaminergic signaling. Collectively, these biological alterations affect processes such as synaptogenesis, neuroimmune maturation, and neuroplasticity, and sex-specific and even multigenerational effects have been reported in animal studies. Although the presence of familial factors and socioeconomic conditions makes it difficult to draw causal conclusions in human studies, the body of evidence supports the existence of a real biological vulnerability. Various interventions, including improved maternal nutrition, n-3 fatty acid intake, antioxidant strategies, and prenatal physical activity, have shown promising potential to improve metabolic and inflammatory status during pregnancy. Understanding these intertwined mechanisms highlights the importance of early prevention and implementation of targeted maternal health strategies to achieve the best neurodevelopmental outcomes in offspring.","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects. 斑马鱼逆转录突变体在没有侧侧缺陷的情况下发展为脊柱侧凸。

IF 1.5 3区生物学

Developmental Dynamics Pub Date : 2026-05-21 DOI: 10.1002/dvdy.70147

Christopher J Derrick, Lorraine Eley, Deborah J Henderson, Bill Chaudhry

引用次数: 0