Editorial highlights

IF 2 3区 生物学 Q2 ANATOMY & MORPHOLOGY
Paul A. Trainor
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Cilia are required for reproduction and regulate multiple cellular processes, including cell motility, cell cycle, cell differentiation, autophagy, and cell–cell communication. Their evolutionary conservation from algae to mammals, has informed our understanding of the basic biology of mammalian primary cilia, organismal development, and the genetic etiology of ciliopathies. This review discusses studies that have revealed the importance of regulating the actin cytoskeleton in ciliary homeostasis, including centrosome migration and positioning, vesicle transport to the basal body, ectocytosis, and ciliary-mediated signaling. It also highlights both conserved and divergent mechanisms in algae and mammalian cells. Finally, the authors compare the phenotypic manifestations of patients with ciliopathies, to those with mutations in actin and actin-associated genes and propose that primary cilia defects caused by genetic alteration of the actin cytoskeleton may underlie specific birth defects.</p><p><b>Organogenesis, Teeth, and Retinoic Acid</b> “Differential retinoic acid sensitivity of oral and pharyngeal teeth in medaka (<i>Oryzias latipes</i>) supports the importance of pouch–cleft contacts in pharyngeal tooth initiation” by Daria Loarinova and Ann Huysseune; <i>Dev Dyn</i> 253:12, pp. 1094–1105. https://doi.org/10.1002/dvdy.723. In early actinopterygian evolution, the dentition was widespread throughout the oropharynx, encompassing teeth on each pharyngeal arch. This wide distribution was reduced over time, as teeth were retained only on the most anterior and most posterior parts of the visceral skeleton, establishing an oral and a pharyngeal dentition, respectively. However, advanced teleost such as medaka, have retained both oral dentition and pharyngeal dentition, whereas less advanced teleosts such as zebrafish have lost oral dentition, retaining teeth exclusively on the last pharyngeal arch. Learn how previous studies claiming that pharyngeal teeth in medaka (<i>Oryzias latipes</i>) were induced independent of retinoic acid signaling unlike in zebrafish (<i>Danio rerio</i>) prompted the authors to explore genetic or molecular mechanisms that could explain the distinct distribution patterns. The authors discovered that the requirement for retinoic acid during pharyngeal tooth formation is equivalent between zebrafish and medaka. However, the differential response of the oral versus pharyngeal teeth in medaka could be due to the distinct germ layer origin of the epithelia involved in tooth formation.</p><p><b>Regeneration in Zebrafish</b> “Disruption of the &lt;<i>fcreb3l1</i>&gt; gene causes defects in caudal fin regeneration and patterning in zebrafish ‘<i>Danio rerio</i>’” by Peyton VanWinkle, Eunjoo Lee, Bridge Wynn, Tomasz Nawara, Holly Thomas, John Parant, Cecilia Alvarez, Rosa Serra, Elizabeth Sztu; <i>Dev Dyn</i> 253:12, pp. 1106–1129. https://doi.org/10.1002/dvdy.726. Complex programs that regulate cell fate determination and tissue patterning are a central part of normal cell and tissue homeostasis and are often temporarily reactivated during tissue repair and regeneration. This is particularly true for bone, which may seem relatively static, but requires dynamic expression of many interacting proteins, together with rigid mineralized structures to support vertebrate animal bodies. Of note, <i>Creb3l1</i> is a member of the ATF/CREB family of transmembrane transcription factors, and variants with <i>CREB3L1</i> mutations have been linked to osteogenesis imperfecta. However, the mechanism through which Creb3l1 regulates bone development is not fully understood. Learn how the authors generated novel <i>creb3l1</i> mutant fish, which express Creb3l1 but lack most of its coding region and the essential DNA-binding bZIP domain. The authors then demonstrate that Creb3l1 plays an important role in the development and regeneration of the zebrafish caudal fin. More specifically, the authors show that Creb3l1 participates in re-establishing the proximo-distal axis during fin regeneration by impacting the shha signaling pathway. Finally, the authors suggest that shha-Creb3l1 signaling interactions have important implications for therapeutic approaches to fracture healing in mammals.</p>","PeriodicalId":11247,"journal":{"name":"Developmental Dynamics","volume":"253 12","pages":"1074-1075"},"PeriodicalIF":2.0000,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvdy.760","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Dynamics","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dvdy.760","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in Developmental Dynamics that illustrate the complex dynamics of developmental biology.

Ciliogenesis in Development and Disease “Actin cytoskeletal regulation of ciliogenesis in development and disease” by Brittany Hufft-Martinez, Henry Wang, Irfan Saadi, and Pamela Tran; Dev Dyn 253:12, pp. 1076–1093. https://doi.org/10.1002/dvdy.724. Primary cilia are antenna-like sensory organelles, comprised of microtubule-based cellular projections, which serve both motile and non-motile sensory functions. Cilia are required for reproduction and regulate multiple cellular processes, including cell motility, cell cycle, cell differentiation, autophagy, and cell–cell communication. Their evolutionary conservation from algae to mammals, has informed our understanding of the basic biology of mammalian primary cilia, organismal development, and the genetic etiology of ciliopathies. This review discusses studies that have revealed the importance of regulating the actin cytoskeleton in ciliary homeostasis, including centrosome migration and positioning, vesicle transport to the basal body, ectocytosis, and ciliary-mediated signaling. It also highlights both conserved and divergent mechanisms in algae and mammalian cells. Finally, the authors compare the phenotypic manifestations of patients with ciliopathies, to those with mutations in actin and actin-associated genes and propose that primary cilia defects caused by genetic alteration of the actin cytoskeleton may underlie specific birth defects.

Organogenesis, Teeth, and Retinoic Acid “Differential retinoic acid sensitivity of oral and pharyngeal teeth in medaka (Oryzias latipes) supports the importance of pouch–cleft contacts in pharyngeal tooth initiation” by Daria Loarinova and Ann Huysseune; Dev Dyn 253:12, pp. 1094–1105. https://doi.org/10.1002/dvdy.723. In early actinopterygian evolution, the dentition was widespread throughout the oropharynx, encompassing teeth on each pharyngeal arch. This wide distribution was reduced over time, as teeth were retained only on the most anterior and most posterior parts of the visceral skeleton, establishing an oral and a pharyngeal dentition, respectively. However, advanced teleost such as medaka, have retained both oral dentition and pharyngeal dentition, whereas less advanced teleosts such as zebrafish have lost oral dentition, retaining teeth exclusively on the last pharyngeal arch. Learn how previous studies claiming that pharyngeal teeth in medaka (Oryzias latipes) were induced independent of retinoic acid signaling unlike in zebrafish (Danio rerio) prompted the authors to explore genetic or molecular mechanisms that could explain the distinct distribution patterns. The authors discovered that the requirement for retinoic acid during pharyngeal tooth formation is equivalent between zebrafish and medaka. However, the differential response of the oral versus pharyngeal teeth in medaka could be due to the distinct germ layer origin of the epithelia involved in tooth formation.

Regeneration in Zebrafish “Disruption of the <fcreb3l1> gene causes defects in caudal fin regeneration and patterning in zebrafish ‘Danio rerio’” by Peyton VanWinkle, Eunjoo Lee, Bridge Wynn, Tomasz Nawara, Holly Thomas, John Parant, Cecilia Alvarez, Rosa Serra, Elizabeth Sztu; Dev Dyn 253:12, pp. 1106–1129. https://doi.org/10.1002/dvdy.726. Complex programs that regulate cell fate determination and tissue patterning are a central part of normal cell and tissue homeostasis and are often temporarily reactivated during tissue repair and regeneration. This is particularly true for bone, which may seem relatively static, but requires dynamic expression of many interacting proteins, together with rigid mineralized structures to support vertebrate animal bodies. Of note, Creb3l1 is a member of the ATF/CREB family of transmembrane transcription factors, and variants with CREB3L1 mutations have been linked to osteogenesis imperfecta. However, the mechanism through which Creb3l1 regulates bone development is not fully understood. Learn how the authors generated novel creb3l1 mutant fish, which express Creb3l1 but lack most of its coding region and the essential DNA-binding bZIP domain. The authors then demonstrate that Creb3l1 plays an important role in the development and regeneration of the zebrafish caudal fin. More specifically, the authors show that Creb3l1 participates in re-establishing the proximo-distal axis during fin regeneration by impacting the shha signaling pathway. Finally, the authors suggest that shha-Creb3l1 signaling interactions have important implications for therapeutic approaches to fracture healing in mammals.

社论强调
每一种生物都是理解发育、进化、疾病和再生的模式生物,而我们才刚刚开始触及调节这些生物过程的跨学科遗传、分子、细胞和发育机制的表面。这些“亮点”表示最近在《发育动力学》上报道的令人兴奋的进展,这些进展说明了发育生物学的复杂动力学。《纤毛发育与疾病中的肌动蛋白细胞骨架调控纤毛发育与疾病》,作者:Brittany Hufft-Martinez, Henry Wang, Irfan Saadi, and Pamela Tran;Dev Dyn 253:12, pp. 1076-1093。https://doi.org/10.1002/dvdy.724。初级纤毛是天线状的感觉细胞器,由基于微管的细胞突起组成,具有运动和非运动感觉功能。纤毛是生殖所必需的,并调节多种细胞过程,包括细胞运动、细胞周期、细胞分化、自噬和细胞间通讯。它们从藻类到哺乳动物的进化保护,使我们了解了哺乳动物初级纤毛的基本生物学,有机体发育和纤毛病的遗传病因。本文综述了在纤毛稳态中肌动蛋白细胞骨架调节的重要性,包括中心体迁移和定位、囊泡向基底体的运输、胞外增殖和纤毛介导的信号传导。它还强调了藻类和哺乳动物细胞中保守和不同的机制。最后,作者比较了纤毛病患者与肌动蛋白和肌动蛋白相关基因突变患者的表型表现,并提出由肌动蛋白细胞骨架的遗传改变引起的原发性纤毛缺陷可能是特定出生缺陷的基础。Daria Loarinova和Ann Huysseune发表的“米达卡人(Oryzias latipes)口腔和咽齿对视黄酸的不同敏感性支持了袋裂接触在咽齿形成中的重要性”;Dev Dyn 253:12, pp. 1094-1105。https://doi.org/10.1002/dvdy.723。在早期的放线翼龙进化中,齿列广泛分布于口咽部,包括每个咽弓上的牙齿。随着时间的推移,这种广泛的分布减少了,因为牙齿只保留在内脏骨骼的最前部和最后部,分别建立了口腔和咽齿列。然而,先进的硬骨鱼,如medaka,保留了口腔牙齿和咽牙齿,而较不先进的硬骨鱼,如斑马鱼,失去了口腔牙齿,只在最后的咽弓上保留牙齿。了解先前的研究是如何声称medaka (Oryzias latipes)的咽齿是独立于视黄酸信号诱导的,不像斑马鱼(Danio rerio),这促使作者探索可以解释不同分布模式的遗传或分子机制。作者发现斑马鱼和medaka在咽齿形成过程中对维甲酸的需求是相当的。然而,在medaka中,口腔和咽齿的不同反应可能是由于参与牙齿形成的上皮细胞的不同胚层起源。斑马鱼的再生&lt; fcreb31 &gt;Peyton VanWinkle, Eunjoo Lee, Bridge Wynn, Tomasz Nawara, Holly Thomas, John Parant, Cecilia Alvarez, Rosa Serra, Elizabeth Sztu的研究表明,基因导致斑马鱼“Danio rerio”尾鳍再生和图案缺陷;Dev Dyn 253:12, pp. 1106-1129。https://doi.org/10.1002/dvdy.726。调节细胞命运决定和组织模式的复杂程序是正常细胞和组织稳态的核心部分,在组织修复和再生过程中经常被暂时重新激活。对于骨骼来说尤其如此,它可能看起来相对静止,但需要许多相互作用的蛋白质的动态表达,以及刚性的矿化结构来支持脊椎动物的身体。值得注意的是,Creb3l1是跨膜转录因子ATF/CREB家族的成员,Creb3l1突变的变体与成骨不完全性有关。然而,Creb3l1调控骨发育的机制尚不完全清楚。了解作者如何生成新的creb3l1突变鱼,它们表达creb3l1,但缺乏其大部分编码区和基本的dna结合bZIP结构域。作者随后证明了Creb3l1在斑马鱼尾鳍的发育和再生中发挥重要作用,更具体地说,作者表明Creb3l1通过影响shha信号通路参与鳍再生过程中近端-远端轴的重建。 最后,作者认为sha - creb3l1信号相互作用对哺乳动物骨折愈合的治疗方法具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Developmental Dynamics
Developmental Dynamics 生物-发育生物学
CiteScore
5.10
自引率
8.00%
发文量
116
审稿时长
3-8 weeks
期刊介绍: Developmental Dynamics, is an official publication of the American Association for Anatomy. This peer reviewed journal provides an international forum for publishing novel discoveries, using any model system, that advances our understanding of development, morphology, form and function, evolution, disease, stem cells, repair and regeneration.
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