{"title":"Pathogen Detection and Diagnostic Scenarios in Chronic Prostatitis.","authors":"Vittorio Magri, Gianpaolo Perletti, Konstantinos Stamatiou","doi":"10.3390/diagnostics15060762","DOIUrl":"10.3390/diagnostics15060762","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Chronic prostatitis (CP) is characterized by a variety of symptoms, including pelvic pain, urinary disturbances, and sexual dysfunction, often without clear signs of infection, which complicates its diagnosis. For decades, the NIH consensus definitions and the Meares-Stamey 4-glass test have been the cornerstone of diagnosing and classifying CP. However, emerging research suggests that some cases with negative microbiological findings may still respond to antibacterial therapy, potentially due to undiagnosed infections. This study aimed to compare four lower genito-urinary tract diagnostic methods to identify which is most effective at detecting causative pathogens in CP patients. Two simplified tests, each involving only two specimens, were also simulated. <b>Methods:</b> This retrospective study examined a database of patients diagnosed with chronic prostatitis according to NIH criteria. Patients aged 18-59 underwent clinical and microbiological diagnostic assessments using four testing modalities: the Meares-Stamey 4-glass \"gold standard\" test, the two-glass pre-post-massage test, and two tests incorporating post-massage semen samples, namely the five-glass test and the VB2-semen test. The diagnostic outcomes and pathogen detection rates for each test were compared using the ANOVA and the Pearson's chi-squared tests. <b>Results:</b> Compared to the four-glass and two-glass tests, the five-glass and VB2-semen tests detected similar proportions of <i>E. coli</i> and other Gram-negative traditional prostatic pathogens. However, they were more effective in detecting significantly higher percentages of Enterococci. Moreover, the five-glass and VB2-semen tests, which included semen samples, identified a broader spectrum of pathogens and significantly higher proportions of sexually transmitted pathogens. <b>Conclusions:</b> Tests that included semen samples were more effective at detecting Gram-positive pathogens such as Enterococci and sexually transmitted pathogens. We advocate for incorporating semen samples into the standard four-glass test to enhance diagnostic accuracy and improve the targeted antibacterial treatment of chronic prostatitis.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship Between Aortic Stenosis and the Possibility of Subsequent Macular Diseases: A Nationwide Database Study.","authors":"Chia-Yi Lee, Shun-Fa Yang, Elsa Lin-Chin Mai, Jing-Yang Huang, Chao-Bin Yeh, Chao-Kai Chang","doi":"10.3390/diagnostics15060760","DOIUrl":"10.3390/diagnostics15060760","url":null,"abstract":"<p><p><b>Objectives</b>: This study aimed to investigate the possible relationship between aortic stenosis (AS) occupancy and the incidence of subsequent macular diseases. <b>Methods</b>: A retrospective cohort study was conducted using the TriNetX database, and participants with AS were enrolled and matched to non-AS participants. A total of 421,860 and 421,860 participants were evenly divided into the AS and non-AS groups, respectively. The major outcomes of the present study include the development of age-related macular degeneration (AMD), retinal vascular occlusion (RVO), epiretinal membrane (ERM), and central serous chorioretinopathy (CSC). Cox proportional hazard regression was utilized for statistical analysis. <b>Results</b>: There were 4426 and 3013 AMD events; 7315 and 4753 RVO events; 2780 and 1910 ERM events; and 113 and 64 CSC events in the AS and non-AS groups, respectively. According to the results of Cox proportional hazard regression analysis, the AS group demonstrated significantly higher incidences of all macular diseases, including AMD, RVO, ERM, and CSC, compared to the non-AS group (all <i>p</i> < 0.05). The cumulative probabilities of all macular diseases were significantly higher in the AS group than in the non-AS group (all <i>p</i> < 0.05). In the sensitivity analysis, the developmental risks of AMD were significantly higher in the AS group than in the non-AS group with all traits. <b>Conclusions</b>: This study determined that AS occupancy is related to a higher risk of developing macular diseases, which positively correlated to the disease time of AS.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DiagnosticsPub Date : 2025-03-18DOI: 10.3390/diagnostics15060763
Riddhi Shenoy, Gail D E Maconachie, Swati Parida, Zhanhan Tu, Abdullah Aamir, Chung S Chean, Ayesha Roked, Michael Taylor, George Garratt, Sohaib Rufai, Basu Dawar, Steven Isherwood, Ryan Ramoutar, Alex Stubbing-Moore, Esha Prakash, Kishan Lakhani, Ethan Maltyn, Jennifer Kwan, Ian DeSilva, Helen J Kuht, Irene Gottlob, Mervyn G Thomas
{"title":"Foveal Hypoplasia Grading with Optical Coherence Tomography: Agreement and Challenges Across Experience Levels.","authors":"Riddhi Shenoy, Gail D E Maconachie, Swati Parida, Zhanhan Tu, Abdullah Aamir, Chung S Chean, Ayesha Roked, Michael Taylor, George Garratt, Sohaib Rufai, Basu Dawar, Steven Isherwood, Ryan Ramoutar, Alex Stubbing-Moore, Esha Prakash, Kishan Lakhani, Ethan Maltyn, Jennifer Kwan, Ian DeSilva, Helen J Kuht, Irene Gottlob, Mervyn G Thomas","doi":"10.3390/diagnostics15060763","DOIUrl":"10.3390/diagnostics15060763","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The diagnosis and prognosis of arrested foveal development or foveal hypoplasia (FH) can be made using the Leicester grading system for FH and optical coherence tomography (OCT). In clinical practice, ophthalmologists and ophthalmic health professionals with varying experience consult patients with FH; however, to date, the FH grading system has only been validated amongst experts. We compare the inter-grader and intra-grade agreement of healthcare professionals against expert consensus across all grades of FH. <b>Methods</b>: Handheld and table-mounted OCT images (<i>n</i> = 341) were graded independently at a single centre by experts (<i>n</i> = 3) with over six years of experience and \"novice\" medical and allied health professionals (<i>n</i> = 5) with less than three years of experience. Sensitivity, specificity, and Cohen's kappa scores were calculated for each grader, and expert vs. novice performance was compared. <b>Results</b>: All graders showed high sensitivity (median 97% (IQR: 94-99)) and specificity (median 94% (IQR: 90-95)) in identifying the presence or absence of FH. No significant difference was seen in specificity between expert and novice graders, but experts had significantly greater diagnostic sensitivity (median difference = 5.3%, H = 5.00, <i>p</i> = 0.025). Expert graders had the highest agreement with the ground truth and novice graders showed great variability in grading uncommon grades, such as atypical FH. The proposed causes of misclassification included macular decentring in handheld OCT scans in children. <b>Conclusions</b>: Ophthalmologists of varying experience and allied health professionals can accurately identify FH using handheld and table-mounted OCT images. FH identification and paediatric OCT interpretation can be improved in wider ophthalmic clinical settings through the education of ophthalmic staff.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients.","authors":"Mei-Yun Wu, Yu-Hung Lin, Wei-Juo Tzeng, Shih-Feng Weng, Wan-Ching Chang, Chich-Hsiu Hung","doi":"10.3390/diagnostics15060757","DOIUrl":"10.3390/diagnostics15060757","url":null,"abstract":"<p><p><b>Purpose</b>: Living-donor liver transplantation (LDLT) serves as a solution for patients facing end-stage liver disease. The existing literature indicates that sex differences between transplant donors and recipients might influence survival rates. <b>Methods</b>: We used a retrospective study design to investigate the impact of different sex pairings on the survival rates of adult LDLT recipients. This study involved the long-term tracking of recipients who underwent LDLT between 7 June 2000 and 31 December 2021. <b>Results</b>: In total, 169 pairs (37.1%) of male recipients with male donors, 145 pairs (31.8%) of male recipients with female donors, 77 pairs (16.9%) of female recipients with female donors, and 65 pairs (14.3%) of female recipients with male donors were submitted for analysis. With independent <i>t</i>-tests or chi-squared tests demonstrating that liver weight and graft-to-recipient weight ratio (GRWR) for same-sex LDLT recipients were significantly higher than opposite-sex recipients; significant differences in disease diagnoses between same-sex and opposite-sex LDLT recipients were found. The Kaplan-Meier survival curve indicates that while same-sex pair survival rates were higher than opposite-sex pairs, the difference was not statistically significant. <b>Conclusions</b>: While sex matching might have some impact on survival rates, it is influenced by a variety of factors, so the effects of donor and recipient sex matching on liver transplantation remains controversial. The findings of this study can serve as a reference for living-donor liver transplant teams when making donor selection decisions.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Melanoma Skin Cancer Recognition with a Convolutional Neural Network and Feature Dimensions Reduction with Aquila Optimizer.","authors":"Jalaleddin Mohamed, Necmi Serkan Tezel, Javad Rahebi, Raheleh Ghadami","doi":"10.3390/diagnostics15060761","DOIUrl":"10.3390/diagnostics15060761","url":null,"abstract":"<p><p><b>Background:</b> Melanoma is a highly aggressive form of skin cancer, necessitating early and accurate detection for effective treatment. This study aims to develop a novel classification system for melanoma detection that integrates Convolutional Neural Networks (CNNs) for feature extraction and the Aquila Optimizer (AO) for feature dimension reduction, improving both computational efficiency and classification accuracy. <b>Methods:</b> The proposed method utilized CNNs to extract features from melanoma images, while the AO was employed to reduce feature dimensionality, enhancing the performance of the model. The effectiveness of this hybrid approach was evaluated on three publicly available datasets: ISIC 2019, ISBI 2016, and ISBI 2017. <b>Results:</b> For the ISIC 2019 dataset, the model achieved 97.46% sensitivity, 98.89% specificity, 98.42% accuracy, 97.91% precision, 97.68% F1-score, and 99.12% AUC-ROC. On the ISBI 2016 dataset, it reached 98.45% sensitivity, 98.24% specificity, 97.22% accuracy, 97.84% precision, 97.62% F1-score, and 98.97% AUC-ROC. For ISBI 2017, the results were 98.44% sensitivity, 98.86% specificity, 97.96% accuracy, 98.12% precision, 97.88% F1-score, and 99.03% AUC-ROC. The proposed method outperforms existing advanced techniques, with a 4.2% higher accuracy, a 6.2% improvement in sensitivity, and a 5.8% increase in specificity. Additionally, the AO reduced computational complexity by up to 37.5%. <b>Conclusions:</b> The deep learning-Aquila Optimizer (DL-AO) framework offers a highly efficient and accurate approach for melanoma detection, making it suitable for deployment in resource-constrained environments such as mobile and edge computing platforms. The integration of DL with metaheuristic optimization significantly enhances accuracy, robustness, and computational efficiency in melanoma detection.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DiagnosticsPub Date : 2025-03-18DOI: 10.3390/diagnostics15060765
Shogo Ando, Atsutoshi Yoshimura
{"title":"Implant-Natural Teeth Connection for a Patient with Periodontitis and Malocclusion: A Case Report.","authors":"Shogo Ando, Atsutoshi Yoshimura","doi":"10.3390/diagnostics15060765","DOIUrl":"10.3390/diagnostics15060765","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Dental implants are widely used; however, tooth extraction often results in alveolar bone loss and gingival recession, necessitating bone and connective tissue reconstruction, especially in the esthetic anterior regions. To address these issues, implants are occasionally connected to adjacent teeth, but this remains controversial, as complications (e.g., intrusion of natural teeth) have been observed. This report demonstrates the long-term success of implants replaced after removing maxillary bilateral central incisors and connecting them to lateral incisors with reduced supportive bone due to periodontitis. <b>Case Presentation</b>: A 57-year-old woman with root fractures in maxillary bilateral central incisors, periodontitis, and malocclusion was treated with connecting implants and natural teeth. Bone levels surrounding maxillary bilateral lateral incisors were diminished due to root fractures in adjacent central incisors and periodontitis. After initial periodontal therapy, hopeless maxillary central incisors were extracted, replaced with implants using a digitally simulated surgical guide, and guided bone regeneration and connective tissue grafting were performed. Implants were connected to lateral incisors with provisional restorations, and orthodontic treatment was initiated following digital set-ups incorporating implants into the overall strategy. Final porcelain-fused-to-zirconia restorations were placed after orthodontic treatment. At the 5-year follow-up, gingival morphology, coloration, and position of lateral incisors remained stable. <b>Conclusions</b>: This case demonstrates that connecting implants to natural teeth in the anterior region can effectively maintain periodontal tissues around natural teeth and allow for minimally invasive, short-term, and esthetic treatment. However, careful long-term observation through maintenance is necessary due to limited evidence for this approach in the anterior region.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unilateral Reverse Pupillary Block Associated with Multiple Ciliary Body Cysts and Pseudoexfoliative Syndrome.","authors":"Idoia Goñi Guarro, Mia Zorić Geber, Rašeljka Tadić, Renata Iveković, Zoran Vatavuk","doi":"10.3390/diagnostics15060758","DOIUrl":"10.3390/diagnostics15060758","url":null,"abstract":"<p><p>The aim of this study is to present interesting images of a clinical case of asymmetrical bilateral ciliary body cysts associated with pseudoexfoliative syndrome (PEX), leading to unilateral reverse pupillary block and subsequent secondary angle-closure glaucoma in a 64-year-old patient who presented with vision loss and redness, revealing angle-closure glaucoma in the left eye. Slit lamp examination showed an asymmetrical iris configuration between the eyes, with a normal appearance in the right eye and an inverted \"volcano-shape\" iris appearance, corresponding to reverse pupillary block, with pseudoexfoliation in the left eye. Multimodal imaging confirmed the presence of bilateral ciliary body cysts, which were unexpectedly identified in the right eye. The patient's secondary angle-closure glaucoma in the left eye was likely due to anterior displacement of the iris from these cysts. Following an inadequate response to topical and systemic treatments, the patient underwent trabeculectomy in the left eye, successfully stabilizing the intraocular pressure (IOP) and leading to the resolution of the reverse pupillary block. This case underscores the importance of thorough ocular examination and multimodal imaging in diagnosing complex clinical presentations like secondary angle-closure glaucoma stemming from the combination of ciliary body cysts' pressure towards the angle, the pseudoexfoliative material component, and the reverse pupillary block configuration. All of the findings provided critical diagnostic clues leading to the identification of the underlying pathology.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Hologic LOCalizer™ RFID Tags for Preoperative Localization of Breast Lesions: A Single-Center Experience.","authors":"Charlotte Munday, Anmol Malhotra, Sawsan Taif, Adeola Omotade, Arathi Menon, Kefah Mokbel","doi":"10.3390/diagnostics15060746","DOIUrl":"10.3390/diagnostics15060746","url":null,"abstract":"<p><p><b>Background</b>: The increasing detection of non-palpable breast lesions necessitates accurate preoperative localization to ensure complete excision while preserving healthy tissue and optimizing cosmetic outcomes. Traditional wire-guided localization (WL) has been the gold standard; however, it has several drawbacks, including patient discomfort and scheduling challenges. This study evaluates the accuracy and feasibility of radiofrequency identification (RFID) tag localization using the Hologic LOCalizer™ system as an alternative technique. <b>Methods</b>: This retrospective study included 258 consecutive patients who underwent image-guided RFID tag localization from March 2021 to February 2023 from a single-center London breast unit. The primary outcome measured was the accuracy of RFID tag placement, defined as within 10 mm of the target lesion on post-clip mammograms. Secondary outcomes included type and size of lesions, re-excision rates, review of post-operative specimen radiographs, and patient demographics. <b>Results</b>: A total of 297 RFID tags were placed, with 95.6% accurately positioned within the target range. The median target size was 29 mm, with the most common abnormalities being mass lesions (64%). Among the 13 inaccurately placed RFID tags (4.4%), all were identified preoperatively, with two requiring additional wire placements. RFID tags were successfully identified in 92% of specimen radiographs, and 8% of patients required re-excision due to positive or close margins. Notably, patients with multiple RFID tags showed a higher incidence of re-excision. <b>Conclusions</b>: The LOCalizer™ RFID system demonstrated a high accuracy rate for preoperative localization of breast lesions, presenting a viable alternative to WL. This technique improves surgical scheduling flexibility and enhances patient comfort. Comparative studies with other wire-free localization technologies, such as magnetic seeds and radar reflectors, are needed to determine the optimal approach for clinical practice.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DiagnosticsPub Date : 2025-03-17DOI: 10.3390/diagnostics15060748
Mehmet Altay Sevimay, Müjde Gürsu, Muhammed Abdullah Çege, Dilek Aynur Çankal, Zühre Akarslan, Sedat Çetiner
{"title":"Fractal Dimension Analysis of Mandibular Trabecular Bone in Patients Receiving Antiresorptive Therapy for Osteoporosis and Oncologic Conditions.","authors":"Mehmet Altay Sevimay, Müjde Gürsu, Muhammed Abdullah Çege, Dilek Aynur Çankal, Zühre Akarslan, Sedat Çetiner","doi":"10.3390/diagnostics15060748","DOIUrl":"10.3390/diagnostics15060748","url":null,"abstract":"<p><p><b>Objectives</b>: This study aimed to assess the effects of antiresorptive drugs on mandibular trabecular bone structure in patients with osteoporosis and those receiving antiresorptive therapy for oncologic conditions using fractal dimension (FD) analysis of panoramic radiographs. Additionally, it investigated the influences of age, gender, drug type, administration route, and treatment duration on mandibular trabecular bone structure. <b>Methods:</b> This retrospective cross-sectional study included 73 patients categorized into the following three groups: 23 osteoporosis patients, 25 oncologic patients, and 25 systemically healthy controls. FD analysis was conducted on panoramic radiographs to assess trabecular bone complexity in the following three standardized regions of interest: the mandibular condyle, angle, and molar region. Statistical analyses compared the groups and evaluated the associations between FD values and demographic and clinical parameters. <b>Results</b>: Osteoporosis patients exhibited significantly lower FD values in the molar region than controls (<i>p</i> < 0.05). In oncologic patients, the FD values in the condyle region were significantly higher in those receiving denosumab than in those treated with intravenous zoledronic acid (<i>p</i> < 0.05), and in those who had undergone antiresorptive therapy for ≥6 years than in those treated for 1-5 years (<i>p</i> < 0.05). A significant negative correlation was found between age and the FD values of the mandibular angle in osteoporosis patients (<i>p</i> < 0.05); no such association was observed in oncologic patients or controls. <b>Conclusions</b>: Long-term antiresorptive therapy may induce structural alterations in mandibular trabecular bone structure in patients with osteoporosis and oncologic diseases. FD analysis is a non-invasive and objective tool for clinically assessing such drug-induced skeletal changes. However, further large-scale, prospective studies are necessary to confirm these findings and shed light on their clinical significance.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DiagnosticsPub Date : 2025-03-17DOI: 10.3390/diagnostics15060745
Daniele Del Re, Luigi Palla, Paolo Meridiani, Livia Soffi, Michele Tancredi Loiudice, Martina Antinozzi, Maria Sofia Cattaruzza
{"title":"Correction: del Re et al. Data from Emergency Medical Service Activities: A Novel Approach to Monitoring COVID-19 and Other Infectious Diseases. <i>Diagnostics</i> 2025, <i>15</i>, 181.","authors":"Daniele Del Re, Luigi Palla, Paolo Meridiani, Livia Soffi, Michele Tancredi Loiudice, Martina Antinozzi, Maria Sofia Cattaruzza","doi":"10.3390/diagnostics15060745","DOIUrl":"10.3390/diagnostics15060745","url":null,"abstract":"<p><p>In the original publication [...].</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}