Dental and Medical Problems最新文献

{"title":"Increased inflammation, disturbed extracellular matrix remodeling and reduced parotid and submandibular salivary gland function in male Wistar rats with type 2 diabetes.","authors":"Anna Kotowska-Rodziewicz, Anna Zalewska, Małgorzata Żendzian-Piotrowska, Piotr Zukowski, Roberto Lo Giudice, Giuseppe Lo Giudice, Mateusz Maciejczyk","doi":"10.17219/dmp/188207","DOIUrl":"10.17219/dmp/188207","url":null,"abstract":"<p><strong>Background: </strong>Insulin-independent type 2 diabetes mellitus (DM2) causes numerous organ complications, some of which involve the oral cavity. However, to date, the causes of reduced salivary secretion in patients with DM2 remain unclear.</p><p><strong>Objectives: </strong>The present study is the first to evaluate the salivary inflammatory and anti-inflammatory profiles in the salivary glands of rats with DM2.</p><p><strong>Material and methods: </strong>Twenty male Wistar Cmdb:WI rats were randomly divided into 2 groups: a control group and a DM2 group. Type 2 diabetes mellitus was induced by feeding the rats a high-fat diet and administering a single intraperitoneal injection of low-dose streptozotocin (35 mg/kg bw). Salivary gland function was evaluated using pilocarpine-stimulated salivary flow rate and α-amylase activity. The salivary inflammatory profile was assessed using a multiplex enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Type 2 diabetes mellitus caused dysfunction of the parotid glands (PGs) and submandibular glands (SMGs), manifested by a reduction in the salivary flow rate and a decrease in salivary α-amylase activity. In DM2 rats, significantly higher levels of pro-inflammatory cytokines (interleukin (IL)-1α, tumor necrosis factor alpha (TNF-α), IL-6, IL-7, IL18), anti-inflammatory cytokines (IL-10), Th1 (IL-12) and Th17 (IL-17) cytokines, chemokines (monocyte chemoattractant protein (MCP)-1α/chemokine ligand 3 (CCL3), macrophage inflammatory protein (MIP)-1α/CCL3, regulated on activation, normal T-cell expressed and secreted chemokine (RANTES)/CCL5, MIP-3α/CCL20, growth-regulated oncogene (GRO)-1α/CCL1), and growth factors (macrophage colony-stimulating factor (M-CSF), granulocyte macrophage colony stimulating factor (GM-CSF) and vascular endothelial growth factor (VEGF)) were observed, as well as increased activity of salivary pro-inflammatory enzymes (myeloperoxidase (MPO), β-D-glucuronidase (GLU)). Evaluation of the inflammatory profile did not indicate the dominance of any branch of the immune system, with the PG being the main source of salivary cytokines, chemokines and growth factors. The activity of lysosomal exoglycosidases and extracellular matrix metalloproteinases (MMPs) involved in salivary gland remodeling was significantly higher in the PGs and SBGs of DM2 rats compared with controls.</p><p><strong>Conclusions: </strong>Increased levels of salivary inflammatory biomarkers accompanied by decreased salivary secretory function may indicate the contribution of inflammation to salivary gland dysfunction. During the course of DM2, impairment predominantly affects PGs.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"145-158"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment methods for deep carious lesions in permanent teeth: A literature review.","authors":"Klaudia Gałan, Sebastian Bobryk, Radosław Łojko, Ewa Rodakowska, Joanna Bagińska","doi":"10.17219/dmp/188208","DOIUrl":"10.17219/dmp/188208","url":null,"abstract":"<p><p>Complete removal of carious dentin is currently regarded as overtreatment, and the stepwise (twostep) or selective (one-step) caries removal procedures are recommended. This literature review was aimed to summarize research findings on deep caries lesion management approaches in permanent teeth, to determine which method provides better outcomes and to identify possible research gaps. Only intervention studies published between 2000 and 2023 in the English language were considered. The PubMed, Web of Science and Scopus databases were searched in September 2023, and 7 relevant records were considered for assessment. This literature review has shown that the number of studies comparing the methods of deep caries lesion management is limited, and the significant differences in protocols regarding the cavity depth, the endpoint of tissue excavation and the material used for cavity restoration indicate the need for the standardization of treatment. Both oneand two-stage caries removal significantly reduce the risk of pulp exposure in comparison with complete excavation; however, further clinical trials with long follow-up periods are necessary to determine which caries removal approach, stepwise or selective, provides better outcomes.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"249-256"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of curcumin and its nanoformulations in the management of oral squamous cell carcinoma: A systematic review.","authors":"Giuseppe Minervini, Chandini Rajkumar, Vishnu Priya Veeraraghavan, Saranya Ramsridhar, Arul Prakash Francis, Saranya Varadarajan, Salvatore Crimi, Marco Cicciù","doi":"10.17219/dmp/187214","DOIUrl":"10.17219/dmp/187214","url":null,"abstract":"<p><p>Indian spice curcumin, which has anti-tumor, anti-inflammatory and antioxidant effects, has showed its potential as an innovative adjunct for the treatment of oral squamous cell cancer (OSCC), as well as an intriguing chemopreventive drug. The goal of this review was to consolidate the salient characteristics of curcumin and its cutting-edge nanoformulations, and to further outline the role of curcumin in the management of OSCC.The PubMed, Scopus and Cochrane databases were used to search for evidence-based research papers on curcumin.The current systematic review included 35 publications. There were 5 clinical studies and 30 cell line studies. The included studies employed a wide range of OSCC cell lines, with CAL-27 in 6 studies, KB in 4 studies, FaDu in 3 studies, and SCC-9 in 3 studies, being the most common. Each of the entailed study found that when cell lines were treated with curcumin, there was an overall decrease in the proliferation of cells and cell growth when measured by the MTT assay, the luciferase assay and immunofluorescence. In clinical studies, APG-157 could inhibit tumor cell death by lowering the concentrations of NF-κB-driven cytokines that induce inflammation. The WCRF International/UoB framework-recommended quality assessment of cell line studies regarded 6 studies as high-quality and 3 studies were deemed of moderate quality.The novel formulations of curcumin have been explored for its usefulness in the management of oral cancer, with promising results.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"233-248"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of mandibular canal proximity to molar root apices in a Turkish subpopulation: A cone-beam computed tomography study.","authors":"Tuna Kaplan, Güzide Pelin Sezgin, Sema Sönmez Kaplan, Zeynep Öztürkmen","doi":"10.17219/dmp/163216","DOIUrl":"10.17219/dmp/163216","url":null,"abstract":"<p><strong>Background: </strong>The close anatomical relationship between root apices and the mandibular canal (MC) may be of clinical importance in preventing inferior alveolar nerve (IAN) injury during the root canal treatment (RCT) of mandibular molars.</p><p><strong>Objectives: </strong>The aim of the present study was to evaluate the impact of the mean distance between MC and the root apices of mandibular first and second molars on the risk of IAN injury during RCT in a Turkish subpopulation.</p><p><strong>Material and methods: </strong>Cone-beam computed tomography (CBCT) images of 934 patients were evaluated. Mandibular molars were examined, and parasagittal sections were used to measure the shortest linear distance between the root apex and the superior cortical border of MC.</p><p><strong>Results: </strong>The mesial and distal roots were closer to MC in the 18-25-year age group and in females (p < 0.05). Overall, 284 (10.5%) mesial roots were in intimate contact with or invading MC, and 80 (3.0%) were located very close to MC (<1.00 mm). Among distal roots, 328 (12.2%) were in intimate contact with or invading MC, 76 (2.8%) were very close to MC, and 2,288 (85.0%) were distant from MC.</p><p><strong>Conclusions: </strong>The risk of IAN injury during RCT was higher for the distal roots of second molar teeth, especially in the age group of 18-25 years and in female patients.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"111-118"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the global prevalence of oral and facial pain.","authors":"Grzegorz Zieliński, Michał Ginszt, Agata Ginszt, Marcin Wójcicki, Monika Litko-Rola, Mieszko Wieckiewicz","doi":"10.17219/dmp/214956","DOIUrl":"10.17219/dmp/214956","url":null,"abstract":"<p><strong>Background: </strong>Pain is one of the most fundamental yet complex human biological experiences. A distinct category within this domain is orofacial pain. The orofacial region is anatomically complex, comprising a dense network of muscles, nerves and blood vessels. This complexity often makes the diagnosis and management of conditions affecting this area particularly challenging for clinicians.</p><p><strong>Objectives: </strong>The primary aim of this study was to determine the global prevalence of oral and facial pain in the general population and to assess its distribution across different continents.</p><p><strong>Material and methods: </strong>Literature searches were conducted in the MEDLINE and Scopus databases. This analysis synthesized data from 155 observational studies published between 2004 and 2024, encompassing 1,712,161 participants and 163,154 reported cases. Statistical analyses were performed using the R statistical language.</p><p><strong>Results: </strong>The pooled global prevalence of concurrent oral and facial pain was 19.19%. By continent, the prevalence rates were as follows: Africa - 27.44%; Asia - 30.78%; Australia - 15.58%; Europe - 12.27%; North America - 14.53%; and South America - 25.61%.</p><p><strong>Conclusions: </strong>Globally, the prevalence of concurrent oral and facial pain is 19%, compared with 12% for facial pain alone, and 21% for oral pain. Concurrent oral and facial pain was most common among individuals under 18 years of age (24%), decreasing to 16% among those aged 18-60 years and 10% in those aged >60 years. Females reported a higher prevalence (21%) of oral and facial pain than males (15%). Overall, the burden of concurrent oral and facial pain is greatest in Asia and South America, particularly among females, where prevalence exceeds 28%, while the lowest rates are found in Europe, especially among males (8%). The results of the present study should be interpreted with caution due to the high heterogeneity of the included studies. Further epidemiological research is recommended, employing rigorous methodology and adhering to current pain classification systems.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"219-231"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel demineralized freeze-dried bovine bone xenograft nanoparticles (DFDBBX-NPs) for enhanced bone repair.","authors":"Ariyati Retno Pratiwi, Mohd Zobir Hussein, Che Azurahanim Che Abdullah, Feni Istikharoh, Sinta Candra Wardani, Sharida Fakurazi, Mohamed Abdelmonem","doi":"10.17219/dmp/184180","DOIUrl":"10.17219/dmp/184180","url":null,"abstract":"<p><strong>Background: </strong>The number of patients with bone defects is increasing. The treatment of damaged bones or bone defects is essential. Bone graft materials are frequently used in bone repair procedures. Researchers are attempting to replace damaged or defective bones with artificial ones, while also striving to improve the mechanical and biological compatibility of the scaffolds.</p><p><strong>Objectives: </strong>The study aimed to establish and validate novel demineralized freeze-dried bovine bone xenograft nanoparticles (DFDBBX-NPs) for enhancing bone repair.</p><p><strong>Material and methods: </strong>Demineralized freeze-dried bovine bone xenograft nanoparticles were extracted from bovine femoral bone. The physicochemical and biochemical properties of both native and demineralized freeze-dried materials were evaluated using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), and the BrunauerEmmett-Teller (BET) analysis. Enzyme-linked immunosorbent assay (ELISA) kits were utilized to determine the content of type 1 collagen (Col-1) and bone morphogenetic protein-2 (BMP-2), water content percentage (WCP), and enzymatic degradation.</p><p><strong>Results: </strong>The physicochemical analysis revealed non-porous DFDBBX-NPs with near spherical shapes of various sizes. The dried sample presented the nanoparticles agglomerated together, with an average size of 10-50 nm. The nanoparticles exhibit a type IV isotherm with an H3 hysteresis loop. They have a BET-specific surface area of 3 m2/g and a pore diameter of approx. 5.9 nm. The bioactive content of BMP-2 was higher than that of Col-1 in the DFDBBX-NPs. The DFDBBX-NP scaffold exhibited a slow rate of enzymatic degradation (0.098-0.240% over 14 days) and high water absorption (WCP ~202-215%).</p><p><strong>Conclusions: </strong>Demineralized freeze-dried bovine bone xenograft nanoparticles demonstrated remarkable potential for the development of new bone grafts.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"209-217"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of non-coding RNAs in Fusobacterium nucleatum-infected mice using machine learning.","authors":"Pradeep Kumar Yadalam, Thilagar Sivasankari, Muthupandian Saravanan, Kumar Chandan Srivastava, Deepti Shrivastava, Maria Maddalena Marrapodi, Marco Cicciù, Giuseppe Minervini","doi":"10.17219/dmp/189304","DOIUrl":"https://doi.org/10.17219/dmp/189304","url":null,"abstract":"<p><strong>Background: </strong>The anaerobic commensal Fusobacterium nucleatum is scarce in healthy subgingival dental biofilms but is highly prevalent in periodontal pockets. Numerous genome-wide association studies and gene expression studies using microarrays or RNA sequencing (RNA-Seq) have been performed to better understand the genetic architecture of periodontal disease. However, these investigations have limited predictive capacity for identifying RNAs, particularly non-coding RNAs (ncRNAs). The mechanism of regulation of ncRNAs by F. nucleatum to alter disease progression in mice has not been thoroughly investigated.</p><p><strong>Objectives: </strong>The aim of the study was to predict previously uncharacterized ncRNAs in F. nucleatum-infected mice using machine learning (ML).</p><p><strong>Material and methods: </strong>Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) were identified from the periodontitis gene expression dataset (GSE225589) obtained from the Gene Expression Omnibus (GEO) database and subsequently preprocessed. Long non-coding RNAs and circRNAs were labeled based on the gene expression. Transcriptomic features were analyzed using 3 ML algorithms: random forest (RF); adaptive boosting (AdaBoost); and naïve Bayes (NB). The dataset was labeled and divided into training (80%) and testing (20%) subsets with cross-validation. Additionally, receiver operating characteristic (ROC) curves, confusion matrices and area under the ROC curve (AUC) values were determined.</p><p><strong>Results: </strong>The RF and AdaBoost models outperformed the NB model in classifying lncRNAs and circRNAs. Both RF and AdaBoost achieved an AUC of 100%, whereas the NB model achieved a slightly lower AUC of 92%.</p><p><strong>Conclusions: </strong>This study is the first to apply ML to predict ncRNAs in F. nucleatum-infected mice using transcriptomic data. Random forest and AdaBoost showed superior classification performance in identifying lncRNAs and circRNAs associated with the infection. Further studies with larger cohorts and external validation are needed to confirm these findings.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"159-168"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-related respiratory impairment and psychosocial stress in patients with persistent orofacial pain: A cross-sectional exploratory study.","authors":"Miguel Meira E Cruz, Inês Santos, Cristina Salles, Isabel Rocha, David Gozal, Dominik Alois Ettlin","doi":"10.17219/dmp/195283","DOIUrl":"https://doi.org/10.17219/dmp/195283","url":null,"abstract":"<p><strong>Background: </strong>Sleep-related breathing disorders (SRBD), including obstructive sleep apnea (OSA) and habitual snoring, can substantially impair quality of life (QoL). However, evidence regarding their impact in patients with orofacial pain (OFP) remains limited. Although disentangling the specific consequences of SRBD from the overlapping conditions is challenging, validated psychometric instruments provide a valuable means of screening for associated biopsychosocial burdens, such as depression and anxiety.</p><p><strong>Objectives: </strong>The aim of the present study was to investigate potential associations between respiratory distress caused by SRBD, using self-report data and psychometric variables as indicators of psychosocial stress, and the overall well-being in individuals with OFP.</p><p><strong>Material and methods: </strong>Anonymized data from 415 patients was analyzed. The participants were screened and categorized according to the presence or absence of respiratory distress. Psychometric measures were examined descriptively. Based on the responses (positive or negative) to the screening question, group differences were evaluated within subgroups matched for sex, age decade, employment status, body mass index (BMI), and typical pain intensity. Associations between the variables were subsequently analyzed using multiple regression models.</p><p><strong>Results: </strong>Most patients were female (n = 290; 69.9%), aged 20-59 years (n = 296; 71.3%), workers (n = 246; 59.3%), with a normal weight (n = 255; 61.4%) and without any respiratory distress (n = 324; 78.1%). Most patients who reported respiratory distress were female (n = 57; 62.6%), and more than a half were 40-59 years old (n = 49; 53.8%). For all domains of psychosocial stress, the percentage of patients reaching a clinically relevant score was higher for the group with respiratory distress, except for the Dysmorphic Concern Questionnaire (DCQ). Significant effects of typical pain intensity were observed across all questionnaires except DCQ, the Injustice Experience Questionnaire (IEQ), the Patient Health Questionnaire9 (PHQ-9), and the Patient Health Questionnaire for Stress (PHQ-Stress).</p><p><strong>Conclusions: </strong>In this cross-sectional study, about 22% of the evaluated patients reported some form of SRBD. Moreover, SRBD were associated with higher psychometric scores, suggesting a close relationship between sleep-related respiratory difficulties and psychosocial impairment.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"73-86"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of thermal aging on surface roughness of conventional and 3D-printed materials used in intraoral appliance manufacturing.","authors":"Joanna Smardz, Katarzyna Kresse-Walczak, Heike Meissner, Klaus Boening, Joanna Weżgowiec, Andrzej Małysa, Mieszko Więckiewicz","doi":"10.17219/dmp/213624","DOIUrl":"10.17219/dmp/213624","url":null,"abstract":"<p><strong>Background: </strong>Intraoral appliances are widely used in dentistry. Their surface roughness may influence patient comfort, biofilm formation and durability.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate and compare the effect of thermocycling on the surface roughness (Ra) of different materials used for the fabrication of intraoral appliances.</p><p><strong>Material and methods: </strong>Seventy-two standardized specimens (40 mm × 10 mm × 2 mm) were fabricated from 3 materials: a self-curing poly(methyl methacrylate) (PMMA) resin (PMMA group); a light-cured urethane dimethacrylate (UDMA)-based resin (UDMA group); and a stereolithography (SLA) 3D-printed resin (SLA group). Surface roughness was measured before and after thermocycling (5,000 and 10,000 cycles between 5°C and 55°C) using a contact profilometer. Values were reported as mean (M) ±standard deviation (SD). The data was analyzed using repeated-measures or ordinary one-way analysis of variance (ANOVA), followed by Bonferroni-corrected post hoc tests (α = 0.0167).</p><p><strong>Results: </strong>The UDMA group exhibited the lowest mean initial Ra values (0.078 ±0.020 μm). Thermocycling induced changes in surface roughness. In the PMMA group, a significant increase in mean Ra was observed after 5,000 cycles (0.103 ±0.028 μm before vs. 0.167 ±0.059 μm after; p = 0.0001) and after 10,000 cycles (0.107 ±0.024 μm before vs. 0.205 ±0.060 μm after; p < 0.0001). The increase in mean Ra following thermocycling was significantly greater in the PMMA group compared to the other groups (mean ΔRa after 5,000 cycles: 0.064 ±0.035 μm; after 10,000 cycles: 0.098 ±0.046 μm; all p < 0.0001).</p><p><strong>Conclusions: </strong>Materials used for the fabrication of intraoral appliances exhibit material-specific responses to thermal aging. The light-cured UDMA-based resin demonstrated superior surface integrity after aging, whereas conventional PMMA and the 3D-printed resin were more susceptible to surface alterations.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"179-187"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between cervico-cranio-mandibular musculoskeletal function and obstructive sleep apnea: A preliminary study.","authors":"Tzvika Greenbaum, Alona Emodi-Perlman, Adi Weinstein, Youval Slovik, Avi Barash, Michal Linkovski Nir, Leonid Kalichman","doi":"10.17219/dmp/207170","DOIUrl":"10.17219/dmp/207170","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is a prevalent chronic condition characterized by recurrent episodes of upper airway narrowing or collapse during sleep. Obstructive sleep apnea is associated with various health issues, including cardiovascular disease and metabolic disorders. The cervico-craniomandibular complex (CCMC) plays a critical role in musculoskeletal functions such as mouth opening and head stabilization; however, its relationship with OSA remains insufficiently explored.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the association between cervico-cranio-mandibular musculoskeletal function and OSA severity, based on the hypothesis that dysfunctions within the CCMC are associated with greater OSA severity.</p><p><strong>Material and methods: </strong>A pilot cross-sectional study was conducted involving 32 patients with symptoms of OSA. The participants underwent assessment of cervico-cranio-mandibular musculoskeletal function and an ambulatory sleep study to determine OSA severity. Spearman's tests were used to analyze the relationships between cervico-cranio-mandibular musculoskeletal parameters and OSA severity.</p><p><strong>Results: </strong>Significant negative correlations were observed between cervical range of motion (ROM) (flexion, left rotation, right/left lateral flexion) and OSA severity. The strongest correlation was identified for cervical movement in the frontal plane (r = -0.607, p < 0.001), especially among females (r = -0.772, p < 0.01). A positive relationship was found between mouth-opening muscle endurance and OSA severity in male participants (r = 0.445, p < 0.05).</p><p><strong>Conclusions: </strong>This preliminary study highlights potential associations between specific musculoskeletal characteristics of the CCMC and OSA severity, with notable sex-specific patterns. These findings may contribute to the development of targeted screening approaches and support individualized physiotherapeutic interventions.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"257-262"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}