Dental and Medical Problems最新文献

{"title":"Effect of non-surgical periodontal therapy on the salivary levels of IL-18 and IL-35 in patients with periodontitis.","authors":"Surabhi Durgapal, Mamatha Shetty","doi":"10.17219/dmp/169387","DOIUrl":"10.17219/dmp/169387","url":null,"abstract":"<p><strong>Background: </strong>Periodontal disease is the most prevalent chronic inflammatory condition that can cause the destruction of supporting periodontal tissues. It has been hypothesized that while the synthesis of proinflammatory cytokines causes tissue destruction and disease progression, anti-inflammatory cytokine production can result in protective immunity. The balance of inflammatory cytokines is central to the immunoregulation of the disease.</p><p><strong>Objectives: </strong>The aim of the study was to assess and compare the salivary levels of interleukin (IL)-18 and IL‑35 in subjects diagnosed with gingivitis, periodontitis, and healthy individuals. Additionally, the study sought to evaluate the difference in the concentration of IL‑18 and IL‑35 after non-surgical periodontal therapy (NSPT) in subjects diagnosed with periodontal disease.</p><p><strong>Material and methods: </strong>A total of 69 individuals were divided into 3 groups: healthy (group 1; n = 23); gingivitis (group 2; n = 23); and stage II periodontitis (group 3A; n = 23). Saliva samples were obtained from each participant at baseline and, in the periodontitis group, at baseline and 12 weeks after NSPT (group 3B; n = 23). Probing pocket depth (PD), bleeding on probing (BoP), gingival index (GI), and clinical attachment level (CAL) were recorded and IL‑18 and IL‑35 levels were analyzed using an enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>The mean salivary level of IL‑18 was significantly higher in the gingivitis group compared to the other groups (p < 0.05), whereas the mean IL‑35 level was significantly higher in the healthy group compared to the other groups (p < 0.05). Twelve weeks after NSPT, the periodontitis group demonstrated a statistically significant difference in cytokine levels, characterized by a decline in the IL‑18 concentration (229.63 ±49.35 pg/mL) and an increase in the concentration of IL‑35 (29.47 ±17.88 pg/mL).</p><p><strong>Conclusions: </strong>In the present study, a significant difference in the salivary levels of IL‑18 and IL‑35 before and after NSPT was observed. Therefore, these cytokines could serve as potential inflammatory biomarkers.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"41-48"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture resistance in severely damaged primary maxillary central incisors restored with glass fiber and composite posts: An in vitro study.","authors":"Fahimeh Kooshki, Helia Sadat Haeri Boroojeni, Fatemeh Shekarchi, Reyhaneh Rahimi","doi":"10.17219/dmp/158859","DOIUrl":"https://doi.org/10.17219/dmp/158859","url":null,"abstract":"<p><strong>Background: </strong>A variety of non-metal prefabricated posts, including fiber posts, can be used as an alternative to metal posts due to their numerous feasible characteristics. Further research is necessary to assess physical and mechanical properties of restorations supported by intracanal posts in primary teeth.</p><p><strong>Objectives: </strong>The aim of the study was to compare fracture resistance of maxillary central incisors that were extensively restored with glass fiber and composite posts.</p><p><strong>Material and methods: </strong>A total of 40 primary maxillary central incisors were randomly divided into 4 equal groups. Group 1 received conventional intracanal composite posts, group 2 was treated with prefabricated intracanal glass fiber posts, group 3 received precured intracanal composite posts, and group 4 was treated with intracanal lucent glass fiber posts. Crowns were restored using composite resin, and the specimens were subsequently exposed to 5,000 thermal cycles and progressive load at a crosshead speed of 0.5 mm/min until fracture. The fracture resistance values were compared via one-way analysis of variance (ANOVA) followed by Tukey's test for pairwise comparisons (α = 0.05).</p><p><strong>Results: </strong>The highest fracture resistance was observed in the lucent post group (343.2 N), followed by the prefabricated glass fiber post (284.8 N), conventional composite post (270.3 N) and precured composite post (261.1 N) groups, respectively. A statistically significant difference in the mean fracture resistance was observed among the 4 groups (p < 0.05). Pairwise comparisons revealed that the mean fracture resistance of the lucent post group was significantly higher than that of the other groups (p < 0.05).</p><p><strong>Conclusions: </strong>All of the intracanal posts provided apt fracture resistance and can be used to restore severely damaged primary maxillary central incisors. However, lucent posts demonstrated significantly higher levels of fracture resistance.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 1","pages":"107-113"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is prevalence of dental anomalies site-specific in cleft lip and palate patients? A systematic review and meta-analysis.","authors":"Jitesh Wadhwa, Simar Sethi, Alpa Gupta, Puneet Batra, Serena Lalfakawmi","doi":"10.17219/dmp/170879","DOIUrl":"https://doi.org/10.17219/dmp/170879","url":null,"abstract":"<p><p>The prevalence of cleft lip in conjunction with cleft palate is twice that of cleft lip or palate alone. Dental abnormalities are more frequent in patients with cleft lip and palate (CLP) than in non-cleft individuals. The present systematic review aimed to identify studies that examined the prevalence of dental anomalies in unilateral and bilateral clefts. Relevant articles that met the specified inclusion criteria were identified with the use of MEDLINE/PubMed®, Scopus and EBSCOhost databases. The systematic review protocol was formulated using the established PRISMA (Preferred Reporting Items for Systematic Reviews and MetaAnalyses) checklist. The results of the meta-analysis demonstrated a statistically significant difference in the prevalence of supernumerary teeth (ST) in patients with left unilateral CLP (p = 0.021). The difference was statistically insignificant for ST between unilateral and bilateral CLP (p = 0.542). The present analysis demonstrated that the difference between unilateral and bilateral CLP, as well as between right and left unilateral CLP regarding tooth agenesis/missing teeth (A/MT) was statistically insignificant (p = 0.301 and p = 0.130, respectively). However, the black diamond presented in the forest plot indicates that the unilateral CLP and left unilateral CLP groups are in favor, respectively. Consequently, patients with left unilateral CLP exhibited a higher frequency of ST. The analysis suggests a potential association between the type of unilateral CLP and bilateral CLP concerning A/MT and ST in particular.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 1","pages":"125-133"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism and clinical aspects of sodium hypochlorite accidents: A narrative review.","authors":"Annappa Raghavendra Vivekananda Pai","doi":"10.17219/dmp/171284","DOIUrl":"https://doi.org/10.17219/dmp/171284","url":null,"abstract":"<p><p>Sodium hypochlorite (NaOCl) solution is a widely used irrigant in endodontics. However, it is highly cytotoxic and can have destructive effects on surrounding tissues when it is not confined to the root canal during irrigation. The extrusion of NaOCl beyond the confines of the root canal into the surrounding tissues or anatomical spaces is known as a NaOCl accident. The NaOCl accident is a serious iatrogenic mishap that can lead to severe tissue damage and complications, which can be life-threatening and/or cause long-term or permanent consequences with medico-legal implications. Therefore, this narrative review was conducted to provide clinicians with a comprehensive understanding of the mechanism and clinical aspects of NaOCl accidents. A literature search was conducted in various online databases using specific Medical Subject Headings (MeSH) and key search terms. The review included all categories of articles dealing with the NaOCl accident and available as full text. Additionally, a manual method of search was conducted by screening references of the included articles. Duplicate articles and articles available only as abstracts were excluded from the review. The included articles were reviewed, analyzed and discussed according to the following sections: causative factors; mechanism; clinical categorization; clinical manifestations; diagnosis, including history, clinical assessment and examination, clinical investigation, and differential diagnoses; and treatment planning of NaOCl accidents. This would enable clinicians to recognize and manage NaOCl accidents in the best possible manner and minimize their serious consequences. Future research should prioritize the identification of solutions or measures to address the challenges associated with conducting clinical or in vivo studies on NaOCl irrigation and extrusion.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 1","pages":"173-185"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the voxel size on the accuracy of endodontic length measurements using cone-beam computed tomography: A systematic review conducted according to the PRISMA guidelines and Cochrane Handbook for Systematic Reviews of Interventions.","authors":"Shilpa Bhandi, Benjamin Ricks, Shankargouda Patil, Kamran Habib Awan, Frank Licari, Marco Cicciù, Giuseppe Minervini","doi":"10.17219/dmp/172845","DOIUrl":"10.17219/dmp/172845","url":null,"abstract":"<p><strong>Background: </strong>The accurate determination of the working length (WL) is imperative for endodontic success.</p><p><strong>Objectives: </strong>Our objective was to systematically analyze the available evidence on the impact of voxel size variation on the estimation of WL using cone-beam computed tomography (CBCT).</p><p><strong>Material and methods: </strong>An electronic search of the PubMed, Scopus, Embase, and Web of Science databases was conducted according to specific inclusion and exclusion criteria in March 2022. Studies published in English, comparing the influence of 2 or more voxel sizes on the CBCT assessments of WL in human teeth against physical or electronic methods qualified for inclusion. Multiple authors independently carried out study selection, data extraction and quality assessment.</p><p><strong>Results: </strong>We included 4 studies involving the assessment of 220 teeth. There were some concerns with regard to the risk of bias in all studies, owing to methodological insufficiencies. Voxel sizes can affect the accuracy of CBCT measurements. All 4 studies reported that the voxel size in CBCT measurements was closely correlated with the estimation of WL. The smallest voxel sizes showed a greater correlation with the actual length (AL). Larger voxel sizes can reduce accuracy by ±0.05 mm. The differences may be clinically irrelevant. Cone-beam computed tomography assessments correlate strongly with the endodontic WL as measured by electronic apex locators (EALs), but are associated with a larger radiation dose in comparison with periapical radiographs.</p><p><strong>Conclusions: </strong>Based on the limited evidence available, it can be stated with low certainty that voxel sizes may impact CBCT accuracy. However, the differences may be clinically irrelevant. The pre-existing CBCT scans may be useful in the estimation of WL, rather than additional periapical radiographs.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 1","pages":"135-144"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence versus semi-automatic segmentation of the inferior alveolar canal on cone-beam computed tomography scans: A pilot study.","authors":"Julien Issa, Tomasz Kulczyk, Michał Rychlik, Agata Czajka-Jakubowska, Raphael Olszewski, Marta Dyszkiewicz-Konwińska","doi":"10.17219/dmp/175968","DOIUrl":"https://doi.org/10.17219/dmp/175968","url":null,"abstract":"<p><strong>Background: </strong>The inferior alveolar canal (IAC) is a fundamental mandibular structure. It is important to conduct a precise pre-surgical evaluation of the IAC to prevent complications. Recently, the use of artificial intelligence (AI) has demonstrated potential as a valuable tool for dentists, particularly in the field of oral and maxillofacial radiology.</p><p><strong>Objectives: </strong>The aim of the study was to compare the segmentation time and accuracy of AI-based IAC segmentation with semi-automatic segmentation performed by a specialist.</p><p><strong>Material and methods: </strong>Thirty individual IACs from 15 anonymized cone-beam computed tomography (CBCT) scans of patients with at least 1 lower third molar were collected from the database of Poznan University of Medical Sciences, Poland. The IACs were segmented by a trainee in the field of oral and maxillofacial radiology using a semi-automatic method and automatically by an AI-based platform (Diagnocat). The resulting segmentations were overlapped with the use of Geomagic Studio, reverse engineering software, and then subjected to a statistical analysis.</p><p><strong>Results: </strong>The AI-based segmentation closely matched the semi-automatic method, with an average deviation of 0.275 ±0.475 mm between the overlapped segmentations. The mean segmentation time for the AI-based method (175.00 s) was similar to that of the semi-automatic method (175.67 s).</p><p><strong>Conclusions: </strong>The results of the study indicate that AI-based tools may offer a reliable approach for the segmentation of the IAC in the context of dental pre-surgical planning. However, further comprehensive studies are required to compare the methods and consider their limitations more comprehensively.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"61 6","pages":"893-899"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Dental and Medical Problems\": Where we are and where we are going.","authors":"Mieszko Więckiewicz, Helena Martynowicz","doi":"10.17219/dmp/194670","DOIUrl":"https://doi.org/10.17219/dmp/194670","url":null,"abstract":"<p><p>The important thing is not to stop questioning. Curiosity has its own reason for existence. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery each day.Albert Einstein.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"61 6","pages":"807-808"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the accuracy of one-piece and three-piece 3D-printed indirect bonding transfer trays: An in vitro study.","authors":"Michał Wajda, Joanna Lis, Beata Kawala","doi":"10.17219/dmp/184145","DOIUrl":"10.17219/dmp/184145","url":null,"abstract":"<p><strong>Background: </strong>Recent developments in computer-aided design/computer-aided manufacturing (CAD/CAM) and 3D printing have enabled the fabrication of digital indirect bonding (IDB) transfer trays. These modern products require thorough investigation.</p><p><strong>Objectives: </strong>The aim of the study was to determine the accuracy of one-piece and three-piece IDB transfer trays in vitro.</p><p><strong>Material and methods: </strong>An initial dental scan (IDS) of a randomly selected patient with digitally positioned brackets served as the master scan (MS) for designing 16 IDB transfer trays of each type. They were 3D printed and used for bonding 448 brackets to the models. Subsequently, the models were scanned with a TRIOS® 3 Intraoral Scanner (3Shape A/S, Copenhagen, Denmark), producing actual scans (ASs). The accuracy of bracket positioning was measured digitally on both MSs and ASs. The measurements were compared to the Objective Grading System for dental casts provided by the American Board of Orthodontics (ABO).</p><p><strong>Results: </strong>The 2 types of IDB transfer trays showed comparable accuracy. All linear errors were within the clinically acceptable range, whereas the angular measurements demonstrated significant variability, resulting in clinically unacceptable transfer errors that ranged from 3.3% to 90.3%.</p><p><strong>Conclusions: </strong>The study results cannot be unconditionally extrapolated to other types of IDB transfer trays due to the diversity of their properties and features. The study evaluated the in vitro accuracy of IDB transfer trays. The revealed number of errors may be even higher in vivo due to limitations in visibility, salivary flow, interference from the tongue, and difficulties in achieving a proper fit of the IDB transfer tray to the teeth.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"901-908"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Searching for a relationship between the elemental composition of archaeological bones and the occurrence of caries.","authors":"Paweł Dąbrowski, Wioletta Nowaczewska, Dominika Domagała, Marzena Styczyńska, Joanna Grzelak, Hubert Szyller, Cyprian Olchowy, Michał Kulus","doi":"10.17219/dmp/186623","DOIUrl":"10.17219/dmp/186623","url":null,"abstract":"<p><strong>Background: </strong>Although the macroscopic assessment of dental caries and the assessment of bone elemental composition are quite different, efforts can be made to identify commonalities in the assessment of health and nutritional quality. Both indicators are correlated with dietary habits and are dependent on taphonomic processes occurring in the postmortem substrate. However, teeth exhibit structural resilience of their hard tissues to adverse environmental factors.</p><p><strong>Objectives: </strong>The aim of the study was to establish a correlation between the elemental composition of bones and the presence of carious lesions.</p><p><strong>Material and methods: </strong>The study material consisted of the following skeletal parts: 161 permanent teeth from 36 individuals and bridge fragments of 36 ribs. The presence of caries was assessed visually using a modified International Caries Detection & Assessment System (ICDAS II) scale. The rib samples were subjected to elemental analysis (zinc (Zn), iron (Fe), magnesium (Mg), calcium (Ca), phosphorus (P), strontium (Sr), barium (Ba)) using spectroscopic methods.</p><p><strong>Results: </strong>The odontological and chemical analyses did not reveal any statistically significant relationships between the Ca/P diagenesis index and dental features. Postmortem tooth loss showed a weak correlation with the diagenesis index.</p><p><strong>Conclusions: </strong>Discoloration, cracks and flaking of the dental crown surfaces may be associated with the intensity of Ca/P diagenesis. However, no significant correlation was found between these phenomena. Among other elements, only Zn levels exhibited a correlation with the caries index.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"875-884"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stevia vs. triple antibiotic paste: An intracanal battle?","authors":"Raghavendra Havale, Shrutha Santhebachalli Prakasha, Sharon Elizebeth George, Namratha Tharay, Shiny Raj, Chandrabanda Bhavana, Afreen Anjum Syed, Anand Kumar, Venkatesh Naik","doi":"10.17219/dmp/161681","DOIUrl":"10.17219/dmp/161681","url":null,"abstract":"<p><strong>Background: </strong>Intracanal medicaments are vital in treating the infections of the deciduous dentition due to the large percentage of accessory canals that hasten the microbial spread to the periradicular region. Though countless medicaments have been produced to reduce the microbial load and aid symptomatic relief, they still do not fulfill every function of an ideal medicament.</p><p><strong>Objectives: </strong>The aim of the present study was to evaluate and compare the antimicrobial efficacy of Stevia rebaudiana (S. rebaudiana) and triple antibiotic paste (TAP) against Enterococcus faecalis (E. faecalis).</p><p><strong>Material and methods: </strong>The present in vitro, parallel, double-blinded study had an equal allocation ratio. The specimens were prepared, randomly divided into 4 groups and inoculated with E. faecalis (ATCC35550). Following incubation, the first 3 groups were treated with S. rebaudiana, triple antibiotic therapy or carbopol gel, respectively, with the 4th negative control group left untreated. The microbial samples were collected before and after treatment, and the counts of colony-forming units (CFUs) were compared. The results were analyzed using the Kruskal-Wallis, Dunn's post-hoc and Wilcoxon's signed rank tests.</p><p><strong>Results: </strong>The first 2 groups displayed a significant decrease in CFUs after drug application, while the carbopol and control groups showed an exponential increase. There was no statistically significant difference between the stevia and TAP groups (p = 0.630).</p><p><strong>Conclusions: </strong>Stevia gel was comparable to TAP in terms of antimicrobial efficacy, and can therefore be considered a new alternative in intracanal treatment.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"919-924"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9835195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}