Dental and Medical Problems最新文献

{"title":"Romanian version of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis I: Cross-cultural adaptation, criterion validity, and reliability.","authors":"Alexandru Măzăreanu, Mieszko Więckiewicz, Dragos George Balaiasa, Maria Iacob, Alin Pandea, Tibor Szatmari, Petre Razvan Liviu, Tzvika Greenbaum","doi":"10.17219/dmp/213202","DOIUrl":"10.17219/dmp/213202","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular disorders (TMD) are the most common cause of non-dental orofacial pain, affecting about 1/3 of the population worldwide. The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis I is recognized as the international gold standard for the clinical and research diagnosis of TMD; however, no validated Romanian version has been available to date.</p><p><strong>Objectives: </strong>The aim of the present study was to translate and culturally adapt the DC/TMD Axis I into Romanian, and to evaluate its criterion validity and interand intra-examiner reliability.</p><p><strong>Material and methods: </strong>This cross-sectional methodological study followed the Beaton et al. and DC/TMD translation guidelines. The process included forward-backward translation, an expert panel review, and pre-testing on 20 patients to ensure semantic and conceptual equivalence. A total of 140 Romanian-speaking adults (mean age: 34.7 ±12.1 years; 70.7% women) were examined by 2 calibrated clinicians. Criterion validity was assessed against an expert-consensus reference diagnosis. Interand intra-examiner reliability for categorical variables was analyzed using Cohen's κ, and for continuous measurements using intraclass correlation coefficients (ICCs). The Bland-Altman plots and demographic analyses further evaluated measurement consistency.</p><p><strong>Results: </strong>The Romanian DC/TMD Axis I showed excellent diagnostic performance, with sensitivity ranging from 85.7% (for disc displacement without reduction) to 91.2% (for myalgia), specificity of 93.5-98.2%, and AUC (the area under the receiver operating characteristic (ROC) curve) ≥ 0.91 for all diagnostic categories. Inter-examiner agreement was substantial to almost perfect (κ = 0.78-0.94), and intra-examiner agreement similarly high (κ = 0.80-0.95). Continuous mandibular measurements demonstrated excellent reproducibility (ICC = 0.89-0.96). Slightly lower sensitivity for disc displacement without reduction indicates an area for further refinement of diagnostic criteria.</p><p><strong>Conclusions: </strong>The Romanian version of the DC/TMD Axis I is a valid, reliable and culturally equivalent tool for diagnosing TMD. Its adoption will standardize clinical assessment, enhance interdisciplinary communication, and enable Romanian participation in multicenter and educational initiatives across Central and Eastern Europe.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"525-531"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dynamic fatigue loading on the adaptation and retention of maxillary single dentures reinforced with digitally constructed zirconia and cobalt-chromium frameworks.","authors":"Ghada Mahmoud Elgindy, Hebatallah Mohamed Tarek, Fardos Nabil Rizk, Marwa Ezzat Sabet","doi":"10.17219/dmp/177931","DOIUrl":"10.17219/dmp/177931","url":null,"abstract":"<p><strong>Background: </strong>The impact of dynamic fatigue loading on denture adaptation and retention is clinically important. Zirconia and cobalt-chromium (Co-Cr) frameworks enhance denture strength, but their performance under cyclic loading remains unclear.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the adaptation and retention of maxillary single dentures reinforced with digitally constructed Co-Cr or zirconia frameworks after a simulated 1 year of function.</p><p><strong>Material and methods: </strong>Three types of maxillary single dentures were constructed on maxillary master casts. Group A included maxillary dentures without reinforcement (control group), whereas groups B and C encompassed maxillary dentures reinforced with digitally designed and milled Co-Cr and zirconia frameworks, respectively (n = 13/group). Acrylic resin was conventionally processed on stone casts. Initial adaptation was evaluated for each denture using Geomagic software, which allowed for accurate matching and superimposition of the scanned master cast with the standard tessellation language (STL) file of the scanned fitting denture surface obtained with the use of a desktop scanner. Initial retention was evaluated using a universal testing machine. Dynamic fatigue loading of 50 N at a speed of 60 mm/s was applied in the chewing simulator, after which final adaptation and retention values were recorded. Paired t-tests were conducted to compare results within each group, and one-way analysis of variance (ANOVA) was performed to compare the 3 groups. When ANOVA revealed significant differences, Tukey's honestly significant difference (HSD) test was used for post hoc pairwise comparisons. The significance level was set at p ≤ 0.05.</p><p><strong>Results: </strong>Group C showed the most favorable adaptation after dynamic fatigue loading (0.31 ±0.04 mm), while group B exhibited the least favorable adaptation (0.61 ±0.08 mm). Regarding retention, group C demonstrated the highest values (20.04 ±0.96 N), while group B exhibited the lowest values (9.32 ±0.78 N). Significant differences were observed among the 3 groups for both adaptation and retention.</p><p><strong>Conclusions: </strong>Maxillary single dentures reinforced with zirconia frameworks may represent a successful alternative to Co-Cr frameworks for prosthetic rehabilitation using digital technology.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"455-463"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of discoloration and surface alteration in self-adhesive resin cements using CIELAB and 3D profilometry.","authors":"Christoph Matthias Schoppmeier, Anja Liebermann, Malin Janson","doi":"10.17219/dmp/205161","DOIUrl":"10.17219/dmp/205161","url":null,"abstract":"<p><strong>Background: </strong>Self-adhesive resin cements (SARCs) are widely used in the field of restorative dentistry due to their simplified application and adequate bonding properties. However, their long-term color and surface stability, particularly under the influence of pigment-rich dietary substances, remain a critical concern in aesthetic restorations.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the color stability and surface roughness of 4 contemporary SARCs after immersion in various staining media using digital photography.</p><p><strong>Material and methods: </strong>A total of 160 disc-shaped specimens (n = 40 per group) were fabricated from 4 SARCs: Maxcem Elite™ (MXC); G-CEM ONE™ (GCO); SpeedCEM® Plus (SPC); and RelyX™ Universal (RLX). The specimens were immersed in artificial saliva, coffee, red wine, or matcha tea at 37°C for 0 (T0), 7 (T1), 14 (T2), 21 (T3), and 28 (T4) days. Color changes (ΔE₀₀) were measured, and surface roughness parameters were evaluated using 3D laser scanning microscopy. The statistical analysis was performed using linear mixed models (LMMs) and Tukey's honestly significant difference (HSD) post hoc test (α = 0.05).</p><p><strong>Results: </strong>All materials showed visually perceptible color changes (ΔE₀₀ > 1.1). The highest discoloration and roughness values were observed in MXC, especially after exposure to red wine. RelyX™ Universal exhibited the greatest resistance to staining and surface degradation. 2-Hydroxyethyl methacrylate (HEMA)-based SARCs (MXC, GCO) were more susceptible to pigment infiltration and roughness increase than urethane dimethacrylate (UDMA)-based cements (RLX, SPC).</p><p><strong>Conclusions: </strong>The aesthetic stability of SARCs is influenced by both material composition and exposure to staining agents. Red wine caused the most severe discoloration and surface changes, followed by coffee, matcha tea and artificial saliva. Higher water sorption and surface roughness were associated with increased staining. Preserving surface integrity is essential for maintaining the long-term aesthetic performance of SARCs.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"385-396"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the cytokine profile in platelet-rich fibrin and hyperacute serum from periodontitis patients with or without type 2 diabetes mellitus: An ex vivo cross-sectional study.","authors":"Vivek Kumar Bains, Jaideep Mahendra, Madhukar Mittal, Gunam Valli, Pankhi Vatsa, Sana Sarkar, Little Mahendra, Prakhar Pant","doi":"10.17219/dmp/191408","DOIUrl":"10.17219/dmp/191408","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is regarded as the 6th microvascular complication of type 2 diabetes mellitus (T2DM). In individuals with both periodontitis and T2DM, the condition may adversely influence the regenerative potential of the platelet-rich fibrin (PRF) and hyperacute serum (HAS) derived from these patients.</p><p><strong>Objectives: </strong>The present cross-sectional study was conducted to evaluate the weight and cytokine levels of the PRF and HAS obtained from periodontitis patients with or without T2DM in a laboratory setting.</p><p><strong>Material and methods: </strong>Platelet-rich fibrin and HAS were obtained from 17 periodontitis patients with T2DM (group 1: T2DM+/P+), 17 periodontitis patients without T2DM (group 2: T2DM-/P+), and 16 periodontally healthy participants (group 3: T2DM-/P-). Demographic, periodontal and hematological parameters were recorded for all participants. Serum, PRF and HAS samples were quantified and analyzed for inflammatory markers - interleukin-6 (IL-6), resistin (RETN), tumor necrosis factor-alpha (TNF-α), IL-1β, and interleukin-1 receptor antagonist (IL-1ra) - as well as growth factors, including insulin-like growth factor-1 (IGF-1), transforming growth factor-beta 1 (TGF-β1), platelet-derived growth factor-BB (PDGF-BB), and fibroblast growth factor-21 (FGF-21).</p><p><strong>Results: </strong>The quantities of PRF and HAS obtained were significantly higher in healthy individuals as compared to diabetic patients. The concentrations of inflammatory markers and growth factors in serum, PRF and HAS from periodontitis patients were not significantly different between those with and without T2DM.</p><p><strong>Conclusions: </strong>Periodontitis in conjunction with T2DM may influence the weight of PRF and HAS; however, no significant association was observed with respect to the levels of inflammatory markers and growth factors.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 2","pages":"323-334"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoplasmic reticulum stress in women with polycystic ovary syndrome and gingivitis: A case-control study of metabolic-periodontal interplay.","authors":"María Pelechá-Salvador, Sandra López-Domènech, Cecilia Fabiana Márquez-Arrico, Meylin Fernández-Reyes, Laura Perea-Galera, Jonathan Hermenejildo, Carlos Morillas, Pablo Fernández-Collazo, Javier Silvestre-Rangil, Víctor Manuel Víctor, Francisco Javier Silvestre, Milagros Rocha","doi":"10.17219/dmp/211428","DOIUrl":"https://doi.org/10.17219/dmp/211428","url":null,"abstract":"<p><strong>Background: </strong>Gingival inflammation has been increasingly linked to metabolic and endocrine disorders, such as polycystic ovary syndrome (PCOS). This connection may involve immune system activation and cellular stress mechanisms, particularly the unfolded protein response (UPR), which regulates endoplasmic reticulum (ER) stress.</p><p><strong>Objectives: </strong>The aim of the study was to investigate whether gingivitis modulates UPR activation in peripheral blood mononuclear cells (PBMCs) of women with PCOS.</p><p><strong>Material and methods: </strong>In this case-control study, female subjects were divided into 2 groups: a control group (n = 48); and a PCOS group (n = 68), which included 24 individuals with gingivitis (PCOS+). Anthropometric, biochemical and periodontal parameters were determined, namely probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index. Markers of oxidative stress, including total superoxide and glutathione peroxidase 1 (GPx1), and UPR mediators, such as glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), phosphorylated eukaryotic initiation factor 2 alpha subunit (p-eIF2α), and C/EBP homologous protein (CHOP), were evaluated in PBMCs.</p><p><strong>Results: </strong>Polycystic ovary syndrome was associated with an increased plaque index and significantly higher BOP in PCOS+. Increased superoxide and reduced GPx1 levels were observed in women with PCOS, with no significant differences between subgroups. Gingivitis in PCOS was correlated with the activation of specific UPR pathways; higher levels of p-eIF2α and CHOP and lower GRP78 levels were detected in PCOS+, while ATF6 was increased in the overall PCOS group. Moreover, BOP demonstrated a direct correlation with p-eIF2α and the plaque index.</p><p><strong>Conclusions: </strong>The association of leukocyte ER stress responses in PCOS with gingival inflammation underscores the impact of periodontal disease on modulating systemic cellular stress in the context of multifactorial metabolic disorders.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of the effect of Er:YAG laser with a fractional PS04 handpiece on microbial biofilm survival.","authors":"Zuzanna Grzech-Leśniak, Jakub Pyrkosz, Jagoda Szwach, Martyna Lelonkiewicz, Magdalena Pajączkowska, Joanna Nowicka, Jacek Matys, Kinga Grzech-Leśniak","doi":"10.17219/dmp/201941","DOIUrl":"10.17219/dmp/201941","url":null,"abstract":"<p><strong>Background: </strong>The oral microbiota consists of a diverse range of microorganisms, with Streptococcus spp. and Candida spp. frequently coexisting in oral infections.</p><p><strong>Objectives: </strong>The aim of the study was to investigate the impact of Er:YAG (erbium-doped yttrium aluminum garnet) laser therapy, utilizing the PS04 fractional beam, on the in vitro growth and biofilm formation of clinical strains of Candida albicans, Candida glabrata and Streptococcus mutans.</p><p><strong>Material and methods: </strong>Singleand dual-species planktonic cultures and biofilms were exposed to an Er:YAG laser using a fractional PS04 handpiece. The effects of the laser were evaluated immediately after irradiation and 24 h post-irradiation by measuring colony-forming units per milliliter (CFU/mL). Biofilm biomass (singleand dual-species) was quantified using the crystal violet staining method. The study tested 2 sets of laser parameters: group 1 (T1): 1.5 W, 10 Hz, 30 s, 0.4 J/cm2, irradiance: 3.9 W/cm2; and group 2 (T2): 6.15 W, 10 Hz, 30 s, 1.6 J/cm2, irradiance: 16 W/cm2. Non-irradiated samples served as controls. The parameters were selected based on their frequent clinical use for snoring treatment and facial rejuvenation.</p><p><strong>Results: </strong>Candida albicans exhibited a significantly greater reduction under T2 settings in comparison to T1 (85.3 ±1.2% vs. 43.9 ±4.5%, respectively; p = 0.006) within single-species biofilms. For C. glabrata, a significant reduction was observed under T1 parameters (69.8 ±14.9%). Furthermore, S. mutans demonstrated a significantly higher reduction at T2 settings (97.1 ±0.6%) compared to T1 settings (81.1 ±19.6%), with statistically significant differences noted between S. mutans and both C. albicans and C. glabrata under T1, as well as between S. mutans and C. glabrata under T2. In dual-species biofilms, T2 fluence led to greater reductions in C. glabrata, S. mutans and C. albicans in mixed cultures (p < 0.05).</p><p><strong>Conclusions: </strong>The Er:YAG laser, when used in conjunction with the PS04 handpiece, demonstrated a substantial reduction in the biofilms of C. albicans and C. glabrata. Higher fluence maintained reductions over a 24-h period, particularly in the case of C. glabrata and S. mutans. This study highlights the antifungal potential of low-fluence laser settings that are commonly used in facial aesthetic procedures and snoring treatment.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"169-178"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of maxillary edentulism with weldable wing spindles and allogenic bone for sinus lift: A retrospective study.","authors":"Sergio Dovigo, Filippo Michelon, Nicolò Zuffellato, Giulia Montagner, Diletta Trojan","doi":"10.17219/dmp/191059","DOIUrl":"10.17219/dmp/191059","url":null,"abstract":"<p><strong>Background: </strong>The technique described in this study has been used by our group for approx. 20 years. It involves fabricating a provisional or definitive prosthesis over a metal structure made of several wing abutments that can be intraorally welded to connect the adjacent implants.</p><p><strong>Objectives: </strong>The aim of this retrospective observational study was to evaluate the effectiveness of and the complications associated with the use of intraorally welded wing abutments in patients with edentulous maxilla undergoing sinus floor augmentation with frozen homologous bone.</p><p><strong>Material and methods: </strong>Data from adult patients diagnosed with edentulism in the posterior maxilla were retrospectively analyzed. All patients underwent sinus augmentation with homologous bone and were rehabilitated for 5-6 months after surgery, using wing spindles. The primary outcome of the study was to evaluate the prosthetic success, while the secondary outcomes included the assessment of the implant success and the incidence of complications.</p><p><strong>Results: </strong>Data analysis included 35 patients, corresponding to 220 implants. At the last follow-up, a 100% prosthetic success and a 96.36% implant survival rate were obtained. A total of 8 patients (22.86%, corresponding to 8.64% of total implants) experienced complications, such as radiographic radiolucency, peri-implantitis and implant mobility.</p><p><strong>Conclusions: </strong>The results of this retrospective study suggest that patients with edentulous maxilla undergoing sinus floor augmentation with frozen homologous bone might benefit from the use of intraorally welded wing abutments.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"65-71"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of a local drug delivery system using Blue®M gel and Gengigel® as an adjunct to scaling and root planing in chronic periodontitis patients.","authors":"Aiysha Nudrath, Rupa Rani Bodduru, Ramanarayana Boyapati, Shahbaz Hassan, Sushmita Hari, Archita Vadla","doi":"10.17219/dmp/187885","DOIUrl":"10.17219/dmp/187885","url":null,"abstract":"<p><strong>Background: </strong>Periodontal disease is a condition that impacts the tissues surrounding the teeth, sparked by the build-up of bacteria leading to inflammation. These bacteria form biofilms, shielding themselves from antimicrobial treatment. Typically, mechanical cleaning disrupts these biofilms and lowers bacterial levels. However, in some cases, it might not fully address the disease due to intricate root structures and irregular lesion shapes. Local drug delivery directly to the affected area serves as a reservoir for drugs, potentially altering harmful bacteria and aiding in the healing process.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate and compare the effectiveness of various local drug delivery systems, specifically Blue®M gel along with scaling and root planing (SRP), Gengigel® with SRP, and SRP alone, in managing patients with chronic periodontitis.</p><p><strong>Material and methods: </strong>The study population comprised 36 patients of both sexes in the age group of 35-60 years, with supra-bony pockets of 4-6 mm in any quadrant. The participants were randomly divided into 3 groups according to the treatment provided: group A - SRP alone; group B - SRP with BlueM gel; and group C - SRP with Gengigel. The gels were applied into the pockets. The follow-up period was 6 months.</p><p><strong>Results: </strong>In a study involving 36 patients, predominantly males, with an average age of 42.03 years, Gengigel demonstrated a slightly greater reduction in the probing pocket depth (PPD) (-0.16 ±0.04 mm), the oral hygiene index (OHI) (-0.45 ±0.81) and the plaque index (PI) (-0.51 ±0.33) as compared to the other 2 groups. BlueM gel exhibited a superior reduction in the clinical attachment level (CAL) when compared to the control and Gengigel groups (-0.35 ±0.31 mm).</p><p><strong>Conclusions: </strong>Both BlueM Gel and Gengigel have proven to be dependable choices or adjuncts to SRP. However, additional studies are needed to further explore their effectiveness.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"43-49"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatibility of NeoPUTTY™ versus TheraCal PT® and TheraCal LC® pulp-capping materials, and tissue reaction following subcutaneous implantation in rats: Histological and molecular investigation.","authors":"Dina Rady, Sara El Moshy, Yasmin Mohamed Yousry, Mohamed Ramadan, Israa Ahmed Radwan","doi":"10.17219/dmp/168627","DOIUrl":"10.17219/dmp/168627","url":null,"abstract":"<p><strong>Background: </strong>Materials used for vital pulp therapy should support the natural healing and regeneration of the dental pulp. Ideally, these materials should be biocompatible, bioactive, non-toxic, and noncarcinogenic. Although numerous medicaments are currently available on the market, none fully meet all the criteria required for an ideal material. In recent years, calcium silicate-based materials, known for their bioactivity and biocompatibility, have gained widespread use in dental practice.</p><p><strong>Objectives: </strong>This in vivo study investigated the tissue response and biological characteristics of mineral trioxide aggregate (MTA) - NeoPUTTY™, as well as TheraCal PT® and TheraCal LC®, following subcutaneous implantation in rats.</p><p><strong>Material and methods: </strong>Twenty adult male albino rats were randomly assigned according to the sacrifice time (2 or 4 weeks) into 2 equal groups, which were further subdivided into 4 subgroups based on the material used. Four incisions were made on the back of each rat to create 4 pockets, into which polyethylene tubes were implanted. Three tubes were filled with biomaterials, while the 4th was left empty as a control. After sacrifice, the samples were analyzed histopathologically, histomorphometrically, and for gene expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6).</p><p><strong>Results: </strong>Moderate inflammation was the predominant tissue response to NeoPUTTY. TheraCal LC demonstrated the formation of a thick connective tissue capsule with moderate chronic inflammatory cell infiltration. In contrast, TheraCal PT showed a mild inflammatory response and a lower area percentage of collagen fibers in the capsule as compared to NeoPUTTY and TheraCal LC. NeoPUTTY and TheraCal LC were associated with higher VEGF and IL-6 expression levels than those observed in the TheraCal PT and control groups.</p><p><strong>Conclusions: </strong>TheraCal PT appears to be a promising material for direct pulp capping, owing to its favorable biocompatibility when tested in vivo in comparison with NeoPUTTY and TheraCal LC. These findings may assist clinicians in selecting appropriate materials for direct pulp capping, as TheraCal PT demonstrated greater biocompatibility with respect to its effects on the surrounding tissues.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"131-143"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yawning as a clinical clue? Revisiting COMISA phenotypes in sleep-disordered breathing.","authors":"Miguel Meira E Cruz","doi":"10.17219/dmp/209575","DOIUrl":"10.17219/dmp/209575","url":null,"abstract":"<p><p>Nocturnal yawning may represent a subtle clinical marker of arousal instability in patients with sleep-disordered breathing (SDB), potentially unveiling latent comorbid insomnia and sleep apnea (COMISA) phenotypes, and expanding the interpretative scope of sleep-related behaviors.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"63 1","pages":"5-7"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}