Dental and Medical Problems最新文献

{"title":"Assessment of the antibacterial activity of glass ionomer cements modified by polyamidoamine and bioactive glass: An in vitro study.","authors":"Dalia Mohamed Elbahi, Rania El-Saady Badawy, Saber Ahmed Mohamed Ibrahim, Mariam Hassan, Nour Ahmed Habib","doi":"10.17219/dmp/166140","DOIUrl":"https://doi.org/10.17219/dmp/166140","url":null,"abstract":"<p><strong>Background: </strong>Secondary caries is one of the main reasons for the clinical failure in dental restorations. Therefore, it is preferable for restorative materials to possess antibacterial properties, which support a longlasting restoration.</p><p><strong>Objectives: </strong>The present in vitro study aimed to evaluate the effect of both the polyamidoamine (PAMAM) liquid and bioactive glass (BAG) powder added to glass ionomer cements (GICs) on their antibacterial properties.</p><p><strong>Material and methods: </strong>Polyamidoamine was prepared and characterized. Four groups were distinguished, as follows: GI - samples of commercially available GIC (control); GII - samples of GIC mixed with PAMAM; GIII - samples of GIC mixed with BAG; and GIV - samples of GIC mixed with PAMAM and BAG.The biofilm assessment test was conducted using a colony forming unit (CFU) count, and the ion release test was used to quantify the amount of released silica (Si), calcium (Ca), phosphorus (Ph), and sodium (Na) ions in mg/L. Thirty-six samples were prepared for each test. Furthermore, the pH of the soaking solution was measured for each sample in the ion release test. The parametric data was examined using one-way analysis of variance (ANOVA) followed by Tukey's post-hoc test.</p><p><strong>Results: </strong>The biofilm assessment test revealed a significant reduction in the recovered Streptococcus mutans counts in all modified groups compared to the control group (p < 0.05). Also, the ion release test demonstrated a significant increase in the release of Si and Na ions for all modified groups compared to the control group (p < 0.05).</p><p><strong>Conclusions: </strong>The modification of GICs with PAMAM and BAG enhances their antibacterial properties.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of deciduous teeth in children using the Er:YAG laser compared to the traditional method: A randomized clinical trial.","authors":"Agnieszka Milc, Jacek Kotuła, Jan Kiryk, Paweł Popecki, Zuzanna Grzech-Leśniak, Krzysztof Kotuła, Marzena Dominiak, Jacek Matys, Kinga Grzech-Leśniak","doi":"10.17219/dmp/194009","DOIUrl":"https://doi.org/10.17219/dmp/194009","url":null,"abstract":"<p><strong>Background: </strong>Erbium family lasers have been used as an alternative method for the treatment of dental caries in deciduous teeth, in comparison to traditional methods.</p><p><strong>Objectives: </strong>The study aimed to determine the most optimal erbium-doped yttrium-aluminum-garnet (Er:YAG) laser settings for carious lesions in deciduous teeth on different surfaces with the evaluation of treatment time and pain level on a visual analog scale (VAS).</p><p><strong>Material and methods: </strong>The randomized clinical trial involved 66 teeth with deep caries in 33 children aged 3-8 years, divided into 2 study groups: Er:YAG laser (test group); and conventional treatment with a dental turbine (control group). The time required for caries removal and cavity preparation using both methods was recorded. The inclusion criteria encompassed generally healthy pediatric patients, pain-free subjects, first-time dental appointment, and unicuspid primary teeth with caries. Dental caries treatment was performed without the administration of local anesthesia.</p><p><strong>Results: </strong>The cavity preparation time was on average 2.5 times longer when the Er:YAG laser was used compared to the conventional method. The study demonstrated the effectiveness of the Er:YAG laser in hard tissue preparation of deciduous teeth with a pulse energy of 230 mJ for enamel preparation, mainly on occlusal and proximal surfaces, and with a pulse energy of 120 mJ and 150 mJ for dentin preparation. Optimum operating frequencies were 10 Hz and 20 Hz with corresponding water consumption. The level of discomfort among the laser-treated patients indicated 0 based on VAS, meaning no pain. Among patients treated with the traditional method, the pain level averaged 5.27.</p><p><strong>Conclusions: </strong>The use of the Er:YAG laser offers substantial advancements in comparison to traditional treatment with dental turbines by enhancing the overall comfort during caries therapy in children. It fosters better patient cooperation and reduces the need for intraoperative anesthetics due to its minimally invasive nature and the fact that it is a relatively quiet operation. This approach minimizes anxiety and discomfort often associated with dental procedures, making them more amenable to children.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term follow-up complications associated with inferior alveolar nerve block using different anesthetics: A systematic review.","authors":"Maral Berenova, Ifrah Sarfaraz, Selma Pascoal, João Gião Carvalho, José Paulo Macedo, Jorge Pereira","doi":"10.17219/dmp/171269","DOIUrl":"https://doi.org/10.17219/dmp/171269","url":null,"abstract":"<p><p>Inferior alveolar nerve block (IANB) is considered the most widely used anesthetic technique and the gold standard for blocking the hemimandible. This method is used in routine dental and oral surgical practice. The aim of this systematic review was to analyze reports related to the IANB technique combined with different local anesthetics. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were adopted to identify relevant studies, and the PICO (Patient/Population, Intervention, Comparison, and Outcomes) criteria were used to structure the research question. The literature search was conducted using PubMed/MEDLINE, Cochrane Library and Embase databases. The search was undertaken without temporal constraints. Prospective randomized clinical trials and randomized controlled trials were used as filters. Inclusion and exclusion criteria were chosen to initially select the appropriate articles from the published titles, followed by abstract reading. After evaluating the selected articles, the results of the research indicated that no relevant side effects were noted in any of the groups, irrespective of the anesthetic solution utilized. However, it is important to acknowledge that a follow-up period of 1 day may be too short to observe subsequent complications, evolution, or spontaneous remission of its eventual sequelae. Therefore, future randomized controlled clinical trials with large samples and longer follow-up periods are required to confirm these findings.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronological age estimation by measuring pulp chamber volume in teeth with open apices: A CBCT analysis.","authors":"Kevser Kolcakoglu, Mehmet Amuk, Esra Kizilci, Gamze Sirin Sarıbal, Özlem Askaroglu, Damla İzel Korkut","doi":"10.17219/dmp/153419","DOIUrl":"https://doi.org/10.17219/dmp/153419","url":null,"abstract":"<p><strong>Background: </strong>In the domain of forensic medicine, the estimation of age is a critical aspect of human identification, including that of adolescents.</p><p><strong>Objectives: </strong>The study aimed to examine the relationship between the pulp chamber volume of teeth with open apices and the chronological age of adolescents from the Turkish population.</p><p><strong>Material and methods: </strong>The study was conducted by examining cone beam computed tomography (CBCT) images of 51 pediatric patients who visited the Department of Pedodontics for routine dental examinations. All CBCT images were captured using a NewTom 5G unit (QR, Verona, Italy). The measurements were recorded in DICOM format using the SimPlant Pro 16 software (Materialise NV, Leuven, Belgium).</p><p><strong>Results: </strong>A moderate and positive significant correlation was observed between the age of the premolar group patients and impacted pulp volume (IMPV). The increase in volume measurements of the patients in the premolar group indicates that their age is significantly higher (r = 0.561, p = 0.030). A moderate and negative significant relationship was identified between the age of the premolar group patients and erupted pulp volume (EPV). The increase in the EPV measurements of the patients in the premolar group indicates that their age is significantly lower (r = -0.491, p = 0.041).</p><p><strong>Conclusions: </strong>The pulp chamber volume of premolars, which narrows due to secondary dentin deposition, served as the physical marker for chronological age estimation of adolescents in the Turkish population. The measurement of the mature and immature premolar pulp volume could be used for age estimation, particularly in the context of CBCT analysis.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bond strength of resin composite to caries-affected dentin after remineralization by different remineralizing agents: An in vitro study.","authors":"Sara Ibrahim Mohamed Fahmy, Ola Mohamed Ibrahim Fahmy, Sabry El Korashy, Mohamed Essam Mohamed Labib","doi":"10.17219/dmp/183841","DOIUrl":"https://doi.org/10.17219/dmp/183841","url":null,"abstract":"<p><strong>Background: </strong>Following selective caries removal, the efficacy of bonding to the dentin substrate is questionable due to alterations in mineral content and the quality of remaining dentin, especially in deep proximal cavities.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the microtensile bond strength of resin composite to artificially demineralized dentin and sound dentin compared to demineralized dentin that underwent different remineralization protocols. Additionally, the study sought to evaluate the effect of the 2 bonding modes (total-etch/self-etch) on the applied remineralizing agent, and to analyze the failure mode.</p><p><strong>Material and methods: </strong>The study utilized 30 sound proximal molar surfaces. They were randomly divided into 5 groups based on the remineralization protocols, as follows: sound dentin as positive control (G1); artificially demineralized dentin but without surface treatment as negative control (G2); and artificially demineralized dentin surface groups with surface treatments (sodium fluoride (NaF) solution (G3), nano-hydroxyapatite (nHAp) (G4), and a combination of remineralizing agents (G5)). Different modes of application of the bonding agent (total-etch (B1) and self-etch (B2)) were implemented. Then, a nanohybrid composite was applied and light cured. The microtensile bond strength test was performed, and the failure mode was evaluated.</p><p><strong>Results: </strong>The application of the total-etch mode resulted in a statistically significant difference between microtensile bond strength values of remineralization protocols. The NaF and nHAp groups (G3 and G4) exhibited the highest values. A statistically significant difference was observed between the microtensile bond strength values of remineralization protocols in the self-etch mode. The positive control, NaF, nHAp, and combined groups (G1, G3, G4, and G5) showed the highest values. The negative control group (G2) in both bonding modes demonstrated the lowest microtensile bond strength.</p><p><strong>Conclusions: </strong>All remineralization protocols applied to demineralized dentin demonstrated an improvement in bond strength that was equivalent to sound dentin. All remineralized dentin surfaces exhibited a favorable failure mode in comparison to the negative control group.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of immediate implant placement and provisionalization (IIPP) with and without a concentrated growth factor-enriched bone graft: A randomized controlled trial.","authors":"Vinisha Bajaj, Abhay Pandurang Kolte, Rajashri Kolte, Pranjali Vijaykumar Bawankar","doi":"10.17219/dmp/170045","DOIUrl":"10.17219/dmp/170045","url":null,"abstract":"<p><strong>Background: </strong>The immediate placement of the implant into a fresh extraction socket site with immediate provisionalisation is considered to be a predictable and acceptable procedure. However, there are mixed results regarding the advantages of the immediate provisionalization of dental implants, using a biomaterial in the jump space (JS).</p><p><strong>Objectives: </strong>This randomized controlled trial (RCT) aimed to evaluate the use of a concentrated growth factor (CGF)-enriched bone graft in the JS of immediate implant placement with provisionalization (IIPP) in the maxillary esthetic zone.</p><p><strong>Material and methods: </strong>Forty immediate dental implants were placed with and without a CGF-enriched bone graft in the test and control groups, respectively, along with provisional restorations. The clinical evaluation of the modified plaque index (mPI), the modified sulcular bleeding index (mSBI), the probing depth (PD), the gingival thickness (GT), and the Testori implant esthetic score (TS) was done at baseline, and at 6 and 12 months postoperatively. The assessment of the crestal bone height (CBH), the buccal bone thickness (BBT), the ridge width (RW), the vertical distance (VD), JS, and the radiolucent area (RA) was carried out using cone-beam computed tomography (CBCT) at baseline and 12 months postoperatively. The visual analog scale (VAS) was used to assess pain and patient satisfaction.</p><p><strong>Results: </strong>Highly significant differences were observed with regard to the change in RW at 4 mm from the crest (9.80 ±0.89 mm), VD-distal (1.35 ±0.43 mm), JS-mesial (0.38 ±0.34 mm), JS-distal (0.25 ±0.34 mm), JS-buccal (0.42 ±0.39 mm), RA-mesial (0.63 ±0.48 mm2), and RA-buccal (0.19 ±0.47 mm2) in the test group as compared to the control group at 12 months. The intergroup comparison for TS showed a statistically significant difference (p < 0.05).</p><p><strong>Conclusions: </strong>It is recommended to use CGF-enriched bone grafting in JS, along with provisionalization, in the anterior esthetic zone.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 3","pages":"449-459"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral care associated with a stay in an intensive care unit (ICU): A systematic review of clinical practice guidelines and scientific statements.","authors":"Mayerly Espitia Espinosa, Rubiel Antonio Marin Jaramillo, Diego Fernando Rojas Gualdrón","doi":"10.17219/dmp/171992","DOIUrl":"10.17219/dmp/171992","url":null,"abstract":"<p><p>The aim of the present systematic review was to critically evaluate the recommendations from evidencebased clinical practice guidelines (CPG) and scientific statements (SS), as well as expert consensus, related to the management of oral complications in intensive care unit (ICU) patients.A search was made in the PubMed, Scopus, Ovid/Cochrane, and LILACS databases, following the CPG identification filters from the Canadian Agency for Drugs and Technologies in Health (CADTH). Both scientific repositories and document references were incorporated as well. The critical assessment was performed by means of the AGREE-II instrument (an ideal scenario) for CPG and SS, and using the AGREEREX instrument for recommendations (ideal and local scenarios).A total of 13 related recommendations from 4 SS were included. The mean score in AGREE-II was 58.25. The mean AGREE-REX scores were 45.82 and 39.07 for the ideal and local scenarios, respectively. The included recommendations focused on the oral care assessment, and the development of prevention and execution tools with regard to respiratory infections.There is a lack of CPG following a rigorous methodology that would incorporate recommendations for oral care in ICU. Dentists are responsible for the development and improvement of recommendations from CPG and/or SS to mitigate oral complications in ICU patients.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 3","pages":"547-555"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between periodontitis and cerebral atrophy: A cross-sectional study.","authors":"Alejandro Fernández-Cabrera, Jesús García-De Soto, Robustiano Pego-Reigosa, Juan Suárez-Quintanilla","doi":"10.17219/dmp/191093","DOIUrl":"https://doi.org/10.17219/dmp/191093","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is a chronic inflammatory condition caused by the bacterial infection of the gums that leads to tissue destruction, bone loss and tooth loss. Various risk factors, including smoking, age, diabetes, and obesity, contribute to its development and progression. Recent studies have revealed systemic effects of periodontitis, linking it to diabetes, atherosclerosis, stroke, and dementia.</p><p><strong>Objectives: </strong>The study aimed to assess the relationship between periodontitis and cerebral atrophy, an indirect marker of brain health.</p><p><strong>Material and methods: </strong>A cross-sectional study was conducted to examine the association between cerebral atrophy and periodontitis. A total of 166 participants were included in the study. All individuals underwent computed tomography (CT) of the head and a full-mouth periodontal assessment to verify if they met the diagnostic criteria for periodontitis. They also underwent a complete neurological examination to rule out dementia.</p><p><strong>Results: </strong>Sixty-four patients (38.6%) had periodontitis, 85 individuals (51.2%) had cerebral atrophy, and 43 patients presented with both conditions. The study sample included 89 females (53.6%), and the median age of the participants was 67 ±10 years. Patients diagnosed with periodontitis showed a higher grade of cerebral atrophy, as measured using the global cortical atrophy (GCA) scale. An independent association was identified between periodontitis and cerebral atrophy (odds ratio (OR): 2.56; 95% confidence interval (CI): 1.29-5.07).</p><p><strong>Conclusions: </strong>Cerebral atrophy, even in the absence of cognitive decline, is significantly associated with periodontitis.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 3","pages":"493-498"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dental implant macrogeometry on the probability of survival and strain distribution of an implant-abutment set.","authors":"Monalisa Barbosa Pereira, Lívia Fiorin, Adriana Cláudia Lapria Faria, Estevam Augusto Bonfante, Ricardo Faria Ribeiro, Renata Cristina Silveira Rodrigues","doi":"10.17219/dmp/174298","DOIUrl":"https://doi.org/10.17219/dmp/174298","url":null,"abstract":"<p><strong>Background: </strong>The effect of the macrogeometry of dental implants with double trapezoidal threads on the probability of survival and the long-term success of oral rehabilitation is unclear.</p><p><strong>Objectives: </strong>The purpose of this in vitro study was to evaluate the effect of dental implant macrogeometry on the probability of survival, failure mode and strain distribution of an implant-abutment set.</p><p><strong>Material and methods: </strong>Dental implants were divided into 2 groups according to their macrogeometry (n = 21 per group): trapezoidal thread (control group); and double trapezoidal thread (test group). The macrogeometry analysis was performed with the use of computed microtomography (n = 1). The specimens were subjected to single load to failure (SLF) (n = 3), which permitted the step-stress profiles for design-based step-stress accelerated life testing (SSALT) (n = 18). The probability of survival and reliability for a mission of 50,000 cycles were calculated at 100 N and 150 N. The scanning electron microscope (SEM) was used to analyze the failure mode of the implant-abutment set. The digital image correlation (DIC) (n = 3) was performed using the implant-abutment set embedded in a polyurethane resin subjected to a static load of 250 N in axial and non-axial positions.</p><p><strong>Results: </strong>No statistically significant differences were observed between the groups with respect to the probability of survival. All groups showed a reliability level higher than 95% at 100 N, while a decrease in reliability was observed at 150 N. The Weibull modulus and characteristic resistance exhibited no significant differences between the groups. The β mean values (control = 0.66, test = 0.33) indicated that failures were dictated by material strength. The SEM revealed an abutment and implant body fracture, characterized by fracture initiation on the lingual surface that subsequently propagated to the opposing buccal side. In the context of non-axial loading, the test group exhibited a higher concentration of tensile strain in the cervical region (152.05 μs), while the control group exhibited a predominance of compression strain (-800.00 μs).</p><p><strong>Conclusions: </strong>The macrogeometry of dental implants did not influence the failure mode and probability of survival, but modified the strain distribution of the implant-abutment set.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 3","pages":"537-545"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the effect of non-surgical periodontal therapy on serum levels of mannose-binding lectin, SIRT-1 and C-reactive protein in non-smokers and smokers with stage III periodontitis: A case-control study.","authors":"Aishwarya Purohit, Rajashri Kolte, Abhay Kolte, Prachi Rathi, Madhur Gupta","doi":"10.17219/dmp/174299","DOIUrl":"https://doi.org/10.17219/dmp/174299","url":null,"abstract":"<p><strong>Background: </strong>Host response to periodontal pathogens present in microbial plaque is characterized by the expression of various inflammatory and immune mediators known as biomarkers. There is a paucity of literature addressing the impact of non-surgical periodontal therapy (NSPT) on serum biomarkers, such as mannose-binding lectin (MBL), sirtuin 1 (SIRT-1) and C-reactive protein (CRP), in non-smokers and smokers with stage III periodontitis.</p><p><strong>Objectives: </strong>The study aimed to evaluate and compare the effect of NSPT on serum levels of MBL, SIRT-1 and CRP in non-smokers and smokers with stage III periodontitis.</p><p><strong>Material and methods: </strong>A total of 105 patients were equally divided into 3 groups, as follows: group I - periodontally healthy individuals; group II - non-smokers with stage III periodontitis; group III - smokers with stage III periodontitis. Probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), and papillary bleeding index (PBI) were recorded, and serum MBL, SIRT-1 and CRP levels were analyzed using enzyme-linked immunosorbent assay (ELISA). The patients underwent NSPT, and all parameters were re-evaluated 6 weeks after the procedure.</p><p><strong>Results: </strong>The mean change in MBL levels across the 3 groups from baseline to recall was significant. Conversely, SIRT-1 and CRP levels exhibited non-significant differences from baseline to recall, with p-values of 0.172 and 0.548, respectively. The mean differences in MBL and SIRT-1 levels between groups I and III at baseline (p < 0.0001 and p = 0.041 for MBL and SIRT-1, respectively) as well as in MBL between groups II and III at recall (p < 0.0001) were statistically significant.</p><p><strong>Conclusions: </strong>A positive association of serum MBL levels and CRP levels as well as a negative association of SIRT-1 with the severity of periodontal disease may serve as a valuable, precise and feasible method of identifying individuals at risk of developing periodontal disease.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 3","pages":"461-468"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}