Dental and Medical Problems最新文献

{"title":"Short-term follow-up complications associated with inferior alveolar nerve block using different anesthetics: A systematic review.","authors":"Maral Berenova, Ifrah Sarfaraz, Selma Pascoal, João Gião Carvalho, José Paulo Macedo, Jorge Pereira","doi":"10.17219/dmp/171269","DOIUrl":"https://doi.org/10.17219/dmp/171269","url":null,"abstract":"<p><p>Inferior alveolar nerve block (IANB) is considered the most widely used anesthetic technique and the gold standard for blocking the hemimandible. This method is used in routine dental and oral surgical practice. The aim of this systematic review was to analyze reports related to the IANB technique combined with different local anesthetics. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were adopted to identify relevant studies, and the PICO (Patient/Population, Intervention, Comparison, and Outcomes) criteria were used to structure the research question. The literature search was conducted using PubMed/MEDLINE, Cochrane Library and Embase databases. The search was undertaken without temporal constraints. Prospective randomized clinical trials and randomized controlled trials were used as filters. Inclusion and exclusion criteria were chosen to initially select the appropriate articles from the published titles, followed by abstract reading. After evaluating the selected articles, the results of the research indicated that no relevant side effects were noted in any of the groups, irrespective of the anesthetic solution utilized. However, it is important to acknowledge that a follow-up period of 1 day may be too short to observe subsequent complications, evolution, or spontaneous remission of its eventual sequelae. Therefore, future randomized controlled clinical trials with large samples and longer follow-up periods are required to confirm these findings.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronological age estimation by measuring pulp chamber volume in teeth with open apices: A CBCT analysis.","authors":"Kevser Kolcakoglu, Mehmet Amuk, Esra Kizilci, Gamze Sirin Sarıbal, Özlem Askaroglu, Damla İzel Korkut","doi":"10.17219/dmp/153419","DOIUrl":"https://doi.org/10.17219/dmp/153419","url":null,"abstract":"<p><strong>Background: </strong>In the domain of forensic medicine, the estimation of age is a critical aspect of human identification, including that of adolescents.</p><p><strong>Objectives: </strong>The study aimed to examine the relationship between the pulp chamber volume of teeth with open apices and the chronological age of adolescents from the Turkish population.</p><p><strong>Material and methods: </strong>The study was conducted by examining cone beam computed tomography (CBCT) images of 51 pediatric patients who visited the Department of Pedodontics for routine dental examinations. All CBCT images were captured using a NewTom 5G unit (QR, Verona, Italy). The measurements were recorded in DICOM format using the SimPlant Pro 16 software (Materialise NV, Leuven, Belgium).</p><p><strong>Results: </strong>A moderate and positive significant correlation was observed between the age of the premolar group patients and impacted pulp volume (IMPV). The increase in volume measurements of the patients in the premolar group indicates that their age is significantly higher (r = 0.561, p = 0.030). A moderate and negative significant relationship was identified between the age of the premolar group patients and erupted pulp volume (EPV). The increase in the EPV measurements of the patients in the premolar group indicates that their age is significantly lower (r = -0.491, p = 0.041).</p><p><strong>Conclusions: </strong>The pulp chamber volume of premolars, which narrows due to secondary dentin deposition, served as the physical marker for chronological age estimation of adolescents in the Turkish population. The measurement of the mature and immature premolar pulp volume could be used for age estimation, particularly in the context of CBCT analysis.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bond strength of resin composite to caries-affected dentin after remineralization by different remineralizing agents: An in vitro study.","authors":"Sara Ibrahim Mohamed Fahmy, Ola Mohamed Ibrahim Fahmy, Sabry El Korashy, Mohamed Essam Mohamed Labib","doi":"10.17219/dmp/183841","DOIUrl":"https://doi.org/10.17219/dmp/183841","url":null,"abstract":"<p><strong>Background: </strong>Following selective caries removal, the efficacy of bonding to the dentin substrate is questionable due to alterations in mineral content and the quality of remaining dentin, especially in deep proximal cavities.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the microtensile bond strength of resin composite to artificially demineralized dentin and sound dentin compared to demineralized dentin that underwent different remineralization protocols. Additionally, the study sought to evaluate the effect of the 2 bonding modes (total-etch/self-etch) on the applied remineralizing agent, and to analyze the failure mode.</p><p><strong>Material and methods: </strong>The study utilized 30 sound proximal molar surfaces. They were randomly divided into 5 groups based on the remineralization protocols, as follows: sound dentin as positive control (G1); artificially demineralized dentin but without surface treatment as negative control (G2); and artificially demineralized dentin surface groups with surface treatments (sodium fluoride (NaF) solution (G3), nano-hydroxyapatite (nHAp) (G4), and a combination of remineralizing agents (G5)). Different modes of application of the bonding agent (total-etch (B1) and self-etch (B2)) were implemented. Then, a nanohybrid composite was applied and light cured. The microtensile bond strength test was performed, and the failure mode was evaluated.</p><p><strong>Results: </strong>The application of the total-etch mode resulted in a statistically significant difference between microtensile bond strength values of remineralization protocols. The NaF and nHAp groups (G3 and G4) exhibited the highest values. A statistically significant difference was observed between the microtensile bond strength values of remineralization protocols in the self-etch mode. The positive control, NaF, nHAp, and combined groups (G1, G3, G4, and G5) showed the highest values. The negative control group (G2) in both bonding modes demonstrated the lowest microtensile bond strength.</p><p><strong>Conclusions: </strong>All remineralization protocols applied to demineralized dentin demonstrated an improvement in bond strength that was equivalent to sound dentin. All remineralized dentin surfaces exhibited a favorable failure mode in comparison to the negative control group.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status, dental caries and parental attitude to junior oral hygiene among children and adolescents with Down syndrome.","authors":"Ramah Eimad Makieh, Chaza Nader Kouchaji","doi":"10.17219/dmp/174161","DOIUrl":"10.17219/dmp/174161","url":null,"abstract":"<p><strong>Background: </strong>Children with Down syndrome (DS) frequently experience nutritional issues. Some of them are attributed to gastrointestinal tract abnormalities, while others are due to feeding behaviors. Previous studies have reported inconclusive results regarding the prevalence of dental caries among individuals with DS.</p><p><strong>Objectives: </strong>The study aimed to assess the nutritional status, prevalence of dental caries and oral hygiene level among children and adolescents with DS aged 8-15 years in comparison to healthy peers.</p><p><strong>Material and methods: </strong>A case-control observational study was carried out in Damascus, Syria, and its surrounding countryside. The study included 135 participants between the ages of 8 and 15 years who were divided into 2 groups based on the presence of DS. The data was processed using the IBM SPSS Statistics for Windows software, v. 26. The Kruskal-Wallis H test, Mann-Whitney U test and χ2 test, as well as Spearman's correlation were implemented.</p><p><strong>Results: </strong>Almost half of the participants in the DS group were classified as overweight or obese (33.9% and 19.1%, respectively), while the percentages of overweight and obese children in the control group were 14.9% and 10.4%, respectively. No statistically significant results were noted between oral hygiene levels and the prevalence of dental caries among the study groups (p > 0.05). Only 50% of parents thought that their children needed help during daily oral hygiene practices; however, only 39.4% of parents actually provided such assistance.</p><p><strong>Conclusions: </strong>Children and adolescents with DS exhibited a tendency toward shorter stature in comparison to their peers. In the DS group, the economic status and paternal education level exhibited an inverse correlation with body mass index (BMI)-for-age. Oral hygiene practices and dietary habits are the most influential factors in the development of dental caries. The DS group followed an unhealthy dietary pattern, characterized by elevated levels of sugar consumption. There is an urgent need for effective promotion programs within the educational plans of schools and centers of special needs. These programs must educate parents and caregivers about effective oral hygiene practices and make them aware of their children's need for help during the oral hygiene process.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"409-418"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of oral health and the impact of regular physical activity on selected salivary parameters in young athletes in relation to the sport-specific environment.","authors":"Iwona Grzesiak-Gasek, Katarzyna Dębska-Łasut, Kamil Michalik, Marek Popowczak, Jarosław Domaradzki","doi":"10.17219/dmp/187969","DOIUrl":"https://doi.org/10.17219/dmp/187969","url":null,"abstract":"<p><strong>Background: </strong>Poor oral health is correlated with participation in various sports and has a significant impact on athletes' quality of life (QoL).</p><p><strong>Objectives: </strong>The aim of the present study was to evaluate oral health and selected salivary parameters in young athletes in relation to the environment of the performed sport.</p><p><strong>Material and methods: </strong>Sixty adolescents aged 12-15 years (mean age: 13.0 ±0.5 years), including 30 competitive swimmers and 30 competitive basketball players, participated in the study. The following indices were calculated: the number of teeth affected by caries - decayed, missing and filled teeth (DMFT); and the simplified oral hygiene index (OHI-S). Saliva samples were collected from all subjects before and after the training. The saliva flow rate (V), pH, buffer capacity, and calcium (Ca) level, as well as salivary alpha-amylase (sAA) and salivary peroxidase (sPO) concentrations, were measured. In addition, the athletes rated the intensity of the training session using Foster's rating of perceived exertion (RPE) 0-10 scale.</p><p><strong>Results: </strong>The mean DMFT score was 4.53 ±3.54 in the swimmers and 3.43 ±2.45 in the basketball players. The mean OHI-S score in the swimmers was 0.73 ±0.58, which was significantly higher than in the case of the basketball players (0.34 ±0.37). Some fluctuations in the salivary parameters were noticed in the swimmers vs. the basketball players, which was related to the type of training. When comparing the swimmers with the basketball players after the training, a significantly lower Ca level was observed in the latter group. However, when comparing post-training changes in the salivary parameters with regard to the pre-training values, significant decreases in V and increases in pH were observed in both groups. After the training, significant increases in the Ca level and the sAA concentration were found in the swimmers. The average RPE score was 4.96 ±2.16 in the swimmers vs. 5.13 ±2.02 in the basketball players. Most swimmers perceived the training as 'somewhat hard' or 'hard', and so did the basketball players.</p><p><strong>Conclusions: </strong>While the data showed no significant differences in DMFT between the groups, the basketball players presented significantly better oral hygiene in comparison with the swimmers. The data suggests that the salivary V and pH, and the levels of Ca and sAA are associated with the swimming training session, whereas V and pH are also associated with the basketball training session. The regression model showed that the sAA concentration could be a predictor of OHl-S, and that the salivary V, pH, buffer capacity, and Ca level could be predictors of the effort rating among swimmers. Also, pH could be a predictor of DMFT in basketball players.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of oral hygiene knowledge and health-promoting behaviors among adults in the Masovian Voivodeship, Poland: A cross-sectional survey study.","authors":"Ewa Rusyan, Mariusz Panczyk, Zuzanna Jończyk, Filip Budnik, Karolina Zalisz, Agnieszka Mielczarek","doi":"10.17219/dmp/194167","DOIUrl":"https://doi.org/10.17219/dmp/194167","url":null,"abstract":"<p><strong>Background: </strong>The examination of pro-health behaviors is important in the assessment of factors that influence the health of the population. Despite a constant increase in pro-health awareness observed within Polish society, the epidemiological picture of adult oral health remains unsatisfactory.</p><p><strong>Objectives: </strong>The aim of the study was to assess the level of knowledge of the study population regarding the prevention of caries, the role of fluoride compounds, and hygiene habits.</p><p><strong>Material and methods: </strong>A quantitative cross-sectional methodology was employed in the study. A specially designed anonymous survey was used to ensure the confidentiality of participants and to encourage truthful responses. The data was collected over a 5-month period using computer-assisted web interviewing (CAWI) with a Google Forms survey. The link to the survey was shared in public groups and on social media platforms, ensuring the collection of a diverse sample. Submitted surveys were cataloged and de-identified prior to analysis.</p><p><strong>Results: </strong>The final sample size of the study was 643 participants. In the present study, only 95 respondents (14.77%) demonstrated sufficient knowledge about oral hygiene and declared behaviors that align with recommended practices. Factors such as place of residence, education and income did not have a statistically significant effect on the level of health awareness in relation to the preferred health attitude of the \"ideal patient\". The study revealed a lack of knowledge regarding the role of fluoride in caries prevention, with some individuals considering it harmful and refraining from using fluoride toothpaste. Approximately 20% of the surveyed population lacked awareness of the presence of fluoride in their toothpaste. These observations were comparable across both rural and urban areas.</p><p><strong>Conclusions: </strong>The present study indicates insufficient knowledge regarding oral health among the study population. It is necessary to introduce more comprehensive oral health education programs targeted at the adult population of Poland.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the contamination and cleaning methods on the tensile bond strength of the polyetheretherketone restorative material cemented with dual-cure resin cement.","authors":"Iman Moheb Ibrahim, Ahmed Ezzat Sabet, Marwa Wahsh, Fatma Adel Mohamed Ahmed","doi":"10.17219/dmp/163128","DOIUrl":"https://doi.org/10.17219/dmp/163128","url":null,"abstract":"<p><strong>Background: </strong>These days, computer-aided design/computer-aided manufacturing (CAD/CAM) resinbased materials are being used daily in clinical practice for restorations in prosthetic dentistry. In comparison with ceramic materials, they are characterized by better stress distribution and decreased abrasion of the enamel of the opposing teeth. Consequently, they have been applied as alternative materials to ceramics in various dental restorations.</p><p><strong>Objectives: </strong>The contamination of the indirect restorative material, which occurs at the clinical and dental laboratory stages, might deteriorate the bonding strength. The ideal surface treatment of the novel polyetheretherketone (PEEK) material for decontamination is yet unknown. The present study was conducted to evaluate the tensile bond strength (TBS) between PEEK and dual-cure self-adhesive resin cement, and determine the effect of contaminants, like temporary cement, artificial saliva and a fit checker, as well as the cleaning methods, like ultrasonic cleaning, phosphoric acid etching and universal cleaning paste (Ivoclean), on the bond.</p><p><strong>Material and methods: </strong>Eighty PEEK disks were milled, having the final dimensions of 12 mm × 4 mm. The specimens were air-abraded with 50-micrometer aluminum oxide particles at a pressure of 2.8 bar for 15 s at a fixed distance of 10 mm, and then divided into 4 groups according to the contaminant used: temporary cement; artificial saliva; a fit checker; and a control group with no contamination. Furthermore, the first 3 groups were subsequently subdivided into 3 subgroups each according to the cleaning method applied: ultrasonic cleaning; phosphoric acid etching; and universal cleaning paste Ivoclean. The bonding of the specimens was done using dual-cure self-adhesive resin cement. The TBS of the different groups and subgroups was then measured at a crosshead speed of 2 mm/min in a universal testing machine (UTM), using a special test configuration.</p><p><strong>Results: </strong>There was a significant interaction between both tested variables (the contamination and cleaning methods) (p < 0.001). The samples contaminated with artificial saliva showed a significantly higher TBS value than the samples subjected to other contaminants (p = 0.005). For the samples contaminated with temporary cement and a fit checker, there were significant differences between the different cleaning methods, with ultrasonic cleaning providing the highest TBS values, followed by phosphoric acid etching, and finally Ivoclean (p < 0.001).</p><p><strong>Conclusions: </strong>Under the conditions of the present study, temporary cement and a fit checker adversely affected the TBS of PEEK, and ultrasonic cleaning was most effective for decontamination.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex difference in the hyoid bone position in adults with obstructive sleep apnea: Systematic review and meta-analysis.","authors":"Diana Graizel-Armoni, Tzvika Greenbaum, Tamar Brosh, Ron Kedem, Alona Emodi-Perlman","doi":"10.17219/dmp/192096","DOIUrl":"https://doi.org/10.17219/dmp/192096","url":null,"abstract":"<p><p>The hyoid bone exhibits potential sex-based variations and is implicated in the severity of obstructive sleep apnea (OSA). Sex-specific comparisons are lacking. The present meta-analysis aimed to address this gap.The Embase, MEDLINE and Web of Science databases were searched. The inclusion criteria were as follows: studies that reported the measurements of the hyoid bone-mandibular plane distance (HMP), demonstrated in cephalometric imaging (CEPH) in patients with OSA of both sexes, involving a polysomnography (PSG) examination with the apnea-hypopnea index (AHI), as well as information on the body mass index (BMI) and age. The exclusion criteria comprised reviews, meta-analyses and case reports. The risk of bias was assessed with the use of the Scottish Intercollegiate Guidelines Network (SIGN) checklist. Statistical analysis was conducted using Comprehensive Meta-Analysis software (CMA) and IBM SPSS Statistics for Windows.Seven observational studies with 718 adult patients (515 males and 203 females) met the inclusion criteria. The mean HMP value was 20.5 ±3.8 mm, with a significant difference observed between males (21.6 ±3.3 mm) and females (17.8 ±3.7 mm) (p < 0.00001). The correlation between HMP and AHI was significantly stronger in females - 2.5 times higher than in males (r = 0.423 vs. r = 0.167, respectively).Although a standard range of the hyoid bone position for healthy adults and elderly individuals is currently lacking, sex significantly affects the anatomical variation of the hyoid mandibular position in patients with OSA. It is crucial to identify distinct OSA endotypes by sex to ensure accurate diagnosis and treatment planning, which could lead to sex-specific therapeutic strategies.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Stafne bone defect: Literature review and a case series.","authors":"Dominika Kopciuch, Marzena Dominiak, Ingrid Różyło-Kalinowska, Paweł Kubasiewicz-Ross","doi":"10.17219/dmp/188781","DOIUrl":"https://doi.org/10.17219/dmp/188781","url":null,"abstract":"<p><p>The study objective was to review the literature and to present 3 cases of the anterior Stafne bone defect (SBD). The electronic databases - MEDLINE via PubMed and Google Scholar - were searched by 2 independent authors, who retrieved 20 articles concerning this pathology. The Stafne bone defect is an asymptomatic bone lesion, diagnosed mostly incidentally through radiological imaging, typically located in the lateral section of the mandible. The anterior SBD is exceedingly rarely observed. So far, less than 40 cases have been described. The hypothesis of the formation of a bone cavity in connection with the sublingual salivary gland has not been confirmed in the literature, considering other tissue structures present within the lesion, including lymphoid or adipose tissues. The anterior variant of SBD can be mistaken for other lesions, considering its atypical location and lower incidence rate. In most cases, it does not require any treatment and the 'wait-and-see' strategy is adopted. In the present study, 2 cases of twochamber and 1 case of single-chamber anterior SBDs were presented. Their course was asymptomatic; however, in 2 cases, increased tension of the suprahyoid muscles on physical examination was reported. The cone-beam computed tomography (CBCT) imaging was employed in each case. There was no need for biopsy, and the monitoring of the lesion was established in each reported case.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of potential risk factors for the development of medication-related osteonecrosis of the jaw.","authors":"Monika Bełch, Grażyna Wyszyńska-Pawelec, Mariusz Szuta, Justyna Hajto-Bryk, Piotr Michalak, Jan Zapała, Joanna Zarzecka","doi":"10.17219/dmp/195758","DOIUrl":"https://doi.org/10.17219/dmp/195758","url":null,"abstract":"<p><strong>Background: </strong>Medication-related osteonecrosis of the jaw (MRONJ) is an undesirable consequence of the action of drugs, involving the exposure of bones in a patient not exposed to ionizing radiation in the head and neck area. The occurrence of MRONJ is associated with therapy with anti-resorptive drugs (bisphosphonates), receptor activator of nuclear factor-kappa B ligand (RANKL) drugs, e.g., denosumab, and anti-angiogenic drugs that are vascular endothelial growth factor (VEGF) inhibitors.</p><p><strong>Objectives: </strong>The aim of the present study was to identify risk factors for the development of MRONJ.</p><p><strong>Material and methods: </strong>The medical records of patients hospitalized in the years 2015-2022 in the Department of Maxillofacial Surgery of the Ludwik Rydygier Specialist Hospital in Krakow and the Clinical Department of Maxillofacial Surgery of University Hospital in Krakow, Poland, were retrospectively analyzed. The study included patients treated for MRONJ in the maxilla and/or the mandible with a history of past bisphosphonate therapy. Patients with symptoms of osteonecrosis after radiotherapy of the head and neck region were excluded from the study. The patients' demographic data, comorbidities, the initial disease treated with bisphosphonates, the route of drug administration, the type of causative dental surgery, the area of necrosis, and the MRONJ class according to the American Association of Oral and Maxillofacial Surgeons (AAOMS) criteria were analyzed.</p><p><strong>Results: </strong>The investigated group consisted of 29 females and 14 males. Common comorbidities were anemia, diabetes mellitus (DM) and hypertension. Bisphosphonates were used in 30 patients (69.8%) treated for cancer, in 10 patients (23.3%) treated for osteoporosis and in 2 patients (4.7%) treated for osteopenia. In the majority of cases (n = 19; 44.2%), bisphosphonates were administrated intravenously. Medication-related osteonecrosis of the jaw was diagnosed in the mandible in 25 cases (58.1%) and in 18 (41.9%) - in the maxilla. In 14 patients (32.6%), necrosis was initiated by a dental procedure, most often tooth extraction.</p><p><strong>Conclusions: </strong>Risk factors for the development of MRONJ in patients treated with bisphosphonates include the intravenous route of drug administration, past intraoral surgery, female gender, and senior age.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}