Dental and Medical Problems最新文献

{"title":"Global co-occurrence of bruxism and temporomandibular disorders: A meta-regression analysis.","authors":"Grzegorz Zieliński, Beata Pająk-Zielińska, Agnieszka Pająk, Marcin Wójcicki, Monika Litko-Rola, Michał Ginszt","doi":"10.17219/dmp/201376","DOIUrl":"https://doi.org/10.17219/dmp/201376","url":null,"abstract":"<p><strong>Background: </strong>Bruxism and temporomandibular disorders (TMD) are closely related, yet the relationship between bruxism and TMD remains one of the most debated topics in the literature.</p><p><strong>Objectives: </strong>The aim of the study was to estimate the overall proportions of the co-occurrence of bruxism and TMD, and the prevalence of TMD in individuals with bruxism by continent. Additionally, factors that have an influence on these proportions, including geographical region, sex and other demographic variables, were analyzed.</p><p><strong>Material and methods: </strong>A synthesis of data from 6 meta-analyses and systematic reviews published up to October 2024 was conducted. The data was extracted from 30 studies that analyzed 31 populations, with a total of 37,680 participants, of whom 5,117 were diagnosed with both bruxism and TMD. The analyses were conducted using the R statistical language.</p><p><strong>Results: </strong>The global co-occurrence of bruxism and TMD was 17%, with significant differences observed between continents. In North America, the co-occurrence of these 2 conditions was 70%, followed by 24% in South America, 14% in Europe and 9% in Asia. The analysis revealed that the sex of the participants was a significant factor, as higher proportions of female participants in a study sample increased the likelihood of the co-occurrence of TMD and bruxism. The mean prevalence of TMD among patients with bruxism was 63.5%, with the highest rate observed in North America (98.3%) and the lowest in Asia (53.9%).</p><p><strong>Conclusions: </strong>The meta-analysis underscores the high prevalence of TMD in individuals with bruxism, highlighting significant geographical variations in the co-occurrence of these conditions. A 1% increase in the proportion of female participants in a study group was associated with a 4.4% rise in the probability of the co-occurrence of TMD and bruxism. These findings suggest that temporal factors and the average age of participants did not significantly contribute to observed variability across studies. The results underscore the importance of geographical and demographic factors in understanding the interplay between bruxism and TMD.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of simple and combined oral rinses with chlorhexidine digluconate against selected bacterial and yeast species: An in vitro study.","authors":"Rafał Wiench, Anna Kuśka-Kiełbratowska, Małgorzata Kępa, Zuzanna Grzech-Leśniak, Maciej Jabłoński, Jan Kiryk, Kinga Grzech-Leśniak, Dariusz Skaba","doi":"10.17219/dmp/187834","DOIUrl":"https://doi.org/10.17219/dmp/187834","url":null,"abstract":"<p><strong>Background: </strong>Chlorhexidine digluconate (CHG) is considered the most effective and safe antimicrobial agent in dentistry. Recently, it has often been produced in the form of preparations with additional substances that may modify its effect.</p><p><strong>Objectives: </strong>The aim of the present study was to compare the efficacy of various simple and combined CHG rinses against selected bacterial and yeast strains.</p><p><strong>Material and methods: </strong>This research followed the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines, using the disk diffusion method. The study was carried out on the following reference strains: Staphylococcus aureus ATCC 43300; Streptococcus pyogenes ATCC 19615; Pseudomonas aeruginosa ATCC 27853; Enterococcus faecalis ATCC 29212; Candida albicans ATCC 10231; C. glabrata ATCC 15126; C. krusei ATCC 14243; and C. parapsilosis ATCC 22019. The disinfection efficacy of 9 commercial mouthwashes with CHG was assessed (4 simple preparations, with different concentrations (0.5%, 0.2%, 0.12%, and 0.05%), and 5 combined preparations (0.2% CHG with adjuvants)) by comparing the size of the growth inhibition zones (GIZs) of microorganisms after 24 h of incubation.</p><p><strong>Results: </strong>Growth inhibition zones were observed around all tested substances, for all assessed strains. In simple preparations, the greatest reduction in growth was observed for Gram-positive bacteria. Statistically significantly smaller GIZs were recorded for P. aeruginosa and all Candida strains. The size of GIZ also depended on the CHG concentration used. In combined preparations, the greatest reduction in growth was also observed for Gram-positive bacteria (especially large GIZs for S. aureus when using 0.2% CHG with colostrum). Statistically significantly smaller GIZs were observed for P. aeruginosa and all yeasts. None of the evaluated adjuvants impaired the disinfecting effect of CHG.</p><p><strong>Conclusions: </strong>The evaluated combined preparations of CHG showed disinfecting efficacy against selected bacterial and fungal strains comparable to that of simple formulations. The combination of 0.2% CHG with colostrum showed the additive synergism of antimicrobial activity against the S. aureus ATCC 43300 strain.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, perception and attitude of dentists regarding the role of artificial intelligence in the field of pediatric dentistry: An online questionnaire study.","authors":"Priyanka Razdan, Anirban Das, Syeda Habiba, Sulekha Doley, Durgesh Ashok Tiwari, Prachi Hazari","doi":"10.17219/dmp/183901","DOIUrl":"https://doi.org/10.17219/dmp/183901","url":null,"abstract":"<p><strong>Background: </strong>Knowledge on the potential applications of artificial intelligence (AI) as a diagnostic instrument in the domain of pediatric dentistry is imperative, as AI may significantly influence present and future dental practice.</p><p><strong>Objectives: </strong>The present study aimed to evaluate the knowledge, perception and attitude of pediatric dentists and postgraduate students in the pediatric specialty with regard to the employment of AI in pediatric dental practice.</p><p><strong>Material and methods: </strong>An online questionnaire survey was conducted among 375 participants (92 postgraduates, 203 faculty members and 80 private practitioners), who were provided with 19 closeended questions through the Google Forms link sent via email. The questions referred to the knowledge, perception and attitude of the participants, with 17 questions answered using a three-point Likert scale and 2 of them being multiple-choice questions. The responses were analyzed using the χ2, Kruskal-Wallis and Mann-Whitney U tests.</p><p><strong>Results: </strong>A total of 62% of the participants were familiar with the term 'artificial intelligence', and the majority confirmed that AI could be used for the identification of plaque (57%) and supernumerary teeth (52%), the detection of early childhood caries (ECC) (68%) and the ectopic eruption of first permanent molars (67%), the assessment of child psychology (82%), and the estimation of chronological age (67%). Most participants felt that AI training should be incorporated into the postgraduate curriculum (82%) and were willing to introduce AI to clinical practice (87%). The barriers related to the use of AI were high costs (83%), the lack of training after graduation (78%), the lack of technical knowledge (77%), the fear of misdiagnosis (73%), and the lack of awareness (71%).</p><p><strong>Conclusions: </strong>The present study concluded that although most pedodontists and postgraduate students had knowledge on AI, there were many obstacles connected with the use of AI in the field of pediatric dentistry. Therefore, the basic training of AI should be included in the curriculum of postgraduate studies.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of dental caries, the prevalence of hygiene and dietary habits, and the influence of the workout session on the selected parameters of saliva in youth swimmers.","authors":"Iwona Grzesiak-Gasek, Katarzyna Dębska-Łasut","doi":"10.17219/dmp/187213","DOIUrl":"https://doi.org/10.17219/dmp/187213","url":null,"abstract":"<p><strong>Background: </strong>Poor oral health can affect the overall health of the body, which may result in suboptimal performance in sports.</p><p><strong>Objectives: </strong>The aim of the present study was to evaluate the occurrence of tooth decay, the prevalence of hygiene and dietary habits, and the influence of the workout session on the selected salivary parameters in youth swimmers.</p><p><strong>Material and methods: </strong>The study involved 40 adolescents, aged 12-15 years (mean age: 13 ±0.5 years), including 30 competitive swimmers and 10 controls. The decayed, missing and filled teeth index (DMFT) was assessed. Data on oral hygiene and dietary habits was collected through a questionnaire created by the authors. Salivary samples were collected from all subjects in the morning and in the afternoon, and from swimmers before and after training. The salivary flow rate (V), pH, buffering capacity, and calcium (Ca) level were measured.</p><p><strong>Results: </strong>The DMFT in the group of swimmers was 4.5 ±3.54, which was significantly higher than in the control group (1.6 ±2.59) (p = 0.0007). There were no statistically significant differences in oral hygiene habits between the 2 groups. However, swimmers significantly more often consumed chocolate bars (p = 0.004), energy drinks (p = 0.017) and water (p = 0.002) as compared to the control group. Among the consumed beverages, significantly more sweet carbonated drinks were consumed by swimmers than controls (p = 0.026). After the workout session, both in the morning and in the afternoon, there was a significant decrease in V (p = 0.006 and p = 0.009, respectively) and a significant increase in the Ca level (p = 0.001 and p = 0.001, respectively) in swimmers. While comparing swimmers before training with the control group in the morning, significantly higher V (p = 0.012) and lower pH (p = 0.003) were observed in swimmers. In the afternoon, significantly lower pH was found in swimmers (p = 0.006).</p><p><strong>Conclusions: </strong>Oral health prevention and promotion should be an important aspect of sports participation, through greater awareness of the impact of oral hygiene and diet on overall health, which can influence sports performance.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating biomarkers of nitrosative stress, protein glycoxidation and inflammation in maxillofacial surgery patients treated with titanium implants.","authors":"Bożena Antonowicz, Jan Borys, Anna Zalewska, Małgorzata Żendzian-Piotrowska, Kamila Łukaszuk, Łukasz Woźniak, Mariusz Szuta, Mateusz Maciejczyk","doi":"10.17219/dmp/188863","DOIUrl":"https://doi.org/10.17219/dmp/188863","url":null,"abstract":"<p><strong>Background: </strong>Titanium (Ti) biomaterials are widely used in the surgical management of maxillofacial trauma, in oncology and orthognathic surgery. Although Ti is considered highly biocompatible, adverse reactions at the implant site have been reported in numerous clinical studies. However, the influence of Ti mandibular implants on glutathione metabolism, nitrosative stress and systemic inflammation has not been investigated to date.</p><p><strong>Objectives: </strong>The study aimed to evaluate the acute (short-term) effects of Ti mandibular implants on the circulating biomarkers of the antioxidant defense system, on oxidative and nitrosative stress, as well as the inflammatory response of the blood plasma/erythrocytes, in maxillofacial surgery patients compared to the control group.</p><p><strong>Material and methods: </strong>The experimental group consisted of 40 patients with bilateral mandibular fractures, who received osteosynthesis treatment with the use of Ti-6Al-4V alloy miniplates and screws. The control group comprised 40 ageand gender-matched patients who were qualified for the surgical treatment of craniofacial defects through bimaxillary osteotomy.</p><p><strong>Results: </strong>An increase in the activity of pro-oxidant enzymes (↑ nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX), ↑ xanthine oxidase (XO)), impaired glutathione metabolism (↓ total glutathione, ↑ oxidized glutathione (GSSG), ↓ reduced glutathione (GSH), ↓ redox status), higher levels of oxidative stress (↓ total thiols, ↑ malondialdehyde (MDA), ↑ lipid hydroperoxides (LOOHs)), ↓ total antioxidant status (TAS)), carbonyl stress (↑ dityrosine, ↑ N-formylkynurenine) and nitrosative stress (↑ nitric oxide (NO), ↑ S-nitrosothiols, ↑ peroxynitrite, ↑ nitrotyrosine), as well as an intensified systemic inflammatory response (↑ interleukin (IL)-1β, ↑ IL-6), were observed in maxillofacial surgery patients.</p><p><strong>Conclusions: </strong>Despite the fact that the study examined only the circulating biomarkers of redox balance and inflammation, the results suggest that a systemic inflammatory response can be triggered by local immune reactions. Systemic inflammation and oxidative stress may stem from an early adaptive immune response to foreign objects in the body. Although further research is required, the removal of the existing Ti mandibular implants should be considered.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle, daily habits, sleep hygiene, and diet: Proposal of a new approach for sleep bruxism management.","authors":"Mieszko Więckiewicz, Joanna Smardz, Helena Martynowicz","doi":"10.17219/dmp/191517","DOIUrl":"10.17219/dmp/191517","url":null,"abstract":"<p><p>This perspective presents a new comprehensive proposal for sleep bruxism management.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"5-7"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the opinions and attitudes of medical doctors, dentists and mothers toward teething symptoms.","authors":"Burcu Güçyetmez Topal, Tuğba Yiğit, Sıdıka Beril Falay","doi":"10.17219/dmp/143063","DOIUrl":"10.17219/dmp/143063","url":null,"abstract":"<p><strong>Background: </strong>The signs and symptoms associated with teething can be local or systemic. It remains unclear whether the disturbances are caused by the eruption of primary teeth or whether they simply coincide with tooth eruption. Parents and healthcare professionals can have different perceptions about teething symptoms, especially in different cultural or socio-economic contexts.</p><p><strong>Objectives: </strong>The study aimed to compare the opinions and attitudes of medical doctors, dentists and mothers toward the symptoms of teething.</p><p><strong>Material and methods: </strong>Data about the signs and symptoms was collected using a researcher-made questionnaire. The questionnaire was mailed in December 2019 to 800 randomly selected medical doctors and dentists working in the Central Aegean Region of Turkey. Mothers of children aged 0-3 years who were referred to the pediatric department were selected for the study. Data from 199 medical doctors (109 family physicians, 90 pediatricians), 293 dentists (169 general dentists, 124 pediatric dentists) and 352 mothers who completed the questionnaire was included in the study. The data was analyzed using the IBM SPSS Statistics for Windows program.</p><p><strong>Results: </strong>Each participant identified at least one symptom related to teething. Statistically significant differences were found between the 3 groups in terms of symptoms except for stomach ache (p < 0.05). Gingival irritation was the most common symptom among dentists (95.6%) and mothers (70.7%), while irritability was the most common symptom among medical doctors (90.5%). Mothers believed to a greater extent than the other groups that fever, vomiting and cough were associated with teething (p < 0.05), whereas medical doctors tended to point to drooling, irritability, biting/chewing, diarrhea, and ear rubbing more often than the other groups (p < 0.05). In addition, sleep disturbance and loss of appetite were associated with teething less frequently by mothers as compared to the other groups (p < 0.05).</p><p><strong>Conclusions: </strong>In the present study, medical doctors, dentists and mothers reported unproven and controversial associations between teething and certain local or systemic symptoms. Mothers especially were more likely to believe that systemic symptoms that can be confused with other serious diseases were associated with teething.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"73-78"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9154390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health behaviors and tooth decay at the age of 12 and 15-18 years in Poland.","authors":"Jacek Tomczyk, Dorota Olczak-Kowalczyk, Anna Turska-Szybka, Marcin Studnicki","doi":"10.17219/dmp/184054","DOIUrl":"10.17219/dmp/184054","url":null,"abstract":"<p><strong>Background: </strong>Oral health behaviors are the primary determinants of dental health. They undergo modification and stabilization during adolescence, and can persist into adulthood.</p><p><strong>Objectives: </strong>The aim of the study was to assess the oral health behaviors of individuals aged 12 and 15-18 years, and to examine the impact of these behaviors on the occurrence and severity of dental caries in different age groups.</p><p><strong>Material and methods: </strong>A cross-sectional oral health national survey was conducted between 2016 and 2020, encompassing a total of 5,099 participants, including 2,496 individuals aged 12 and 2,603 participants aged 15-18 years. The presence of non-cavitated decay (D1-2), cavitation (D≥3), and missing (M) or filled (F) status at the tooth (T) or surface (S) levels was evaluated. The prevalence of caries (D≥3MFT > 0), as well as the mean values of the D1-2, D≥3MFT and D≥3MFS indexes were assessed. The questionnaire contained information on sociodemographic factors, oral health behaviors and the participants' diet.</p><p><strong>Results: </strong>The prevalence of dental caries was 75% among 12-year-old and 90% among 15-18-year-old individuals. Indicators associated with a reduced likelihood and lower severity of dental caries in both groups included prophylactic dental visits (adjusted odds ratio (AOR) (12-year-olds): 0.83; AOR (15-18-yearolds): 0.64) and brushing teeth at least twice a day (AOR (12-year-olds): 0.72; AOR (15-18-year-olds): 0.59). Frequent consumption of sweet products and chips by 12-year-olds increased the likelihood of developing and exacerbating tooth decay. In the older group, the risk of developing caries was associated with the consumption of sweets and sugar-sweetened carbonated beverages.</p><p><strong>Conclusions: </strong>Poor oral hygiene and inadequate diet are conducive to the development of caries, with the condition being exacerbated by these factors regardless of age. However, the influence of diet appears to be more pronounced in less mature dentition. The benefits of dental visits, oral hygiene practices and a preference for mineral water in quenching thirst have also been demonstrated. The health behaviors exhibited by older and younger adolescents are comparable, suggesting that these habits may persist into adulthood.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":" ","pages":"13-22"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential protective role of parsley on induced tongue carcinogenesis in albino rats.","authors":"Hussein Salah Eldin Mohamed, Radwa Hamed Hegazy, Maha Hassan Bashir, Iman Mahmoud Aboushady, Meselhy Ragab Meselhy, Hesham Ibrahim El-Askary, Nermeen AbuBakr","doi":"10.17219/dmp/161507","DOIUrl":"https://doi.org/10.17219/dmp/161507","url":null,"abstract":"<p><strong>Background: </strong>Parsley has been traditionally used as a food additive and herbal medicament. The flavonoid apigenin and its glycosides constitute the most abundant phenolic compounds found in parsley. They exhibit numerous pharmacological effects, including antioxidant, anti-inflammatory, antitoxic, and anticancer properties.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the potential chemopreventive effect of orally administered parsley extract on tongue cancer induced by 7,12-dimethylbenz[a]anthracene (DMBA) and formaldehyde in rats.</p><p><strong>Material and methods: </strong>A total of 36 adult male albino rats were randomly allocated into 3 equal groups: the parsley group was administered 2 g/kg body weight parsley extract through oral gavage 3 times per week; the carcinogenesis group received a topical application of 0.5% DMBA in acetone and formaldehyde to the tongues; and the parsley-treated carcinogenesis group was administered parsley extract combined with a topical application of DMBA and formaldehyde. Additionally, a group of 5 rats served as a negative control group. After 8 weeks, the tongues of the rats were dissected and subjected to histopathological, immunohistochemical, histomorphometric, and quantitative real-time polymerase chain reaction (qRT-PCR) analyses.</p><p><strong>Results: </strong>Histopathologically, the tongues from the carcinogenesis group revealed several signs of hyperplasia, dysplasia and the invasion of dysplastic cells into the underlying connective tissue. The tongues of the parsley-treated carcinogenesis group exhibited a reduction in dysplastic changes and almost regained their normal architecture, as observed in both the control and parsley groups. The immunohistochemical analysis of the area percentage of caspase-3 immunoexpression revealed a significant increase in the parsley-treated carcinogenesis group compared to the carcinogenesis group, which approached the results observed in both the control and parsley groups. The qRT-PCR results of tumor necrosis factor-alpha (TNF-α) expression displayed a significantly decreased expression in the parsley-treated carcinogenesis group as compared to the carcinogenesis group. These findings were comparable to those observed in the control and parsley groups.</p><p><strong>Conclusions: </strong>In a rat model, oral administration of parsley extract has been shown to impede the initiation of several cellular carcinogenic changes in tongue tissues.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 1","pages":"79-87"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro-computed tomography evaluation of dentinal cracks after root canal preparation with different endodontic rotary files: An ex vivo study.","authors":"Mohammed Mana Alzamanan, Abdullah Abdulrahman Albassam, Emad Mahmoud Khattab, Faisal Turki Alghamdi","doi":"10.17219/dmp/149733","DOIUrl":"https://doi.org/10.17219/dmp/149733","url":null,"abstract":"<p><strong>Background: </strong>The occurrence of dentinal cracks is rather frequent during root canal preparation and increases with some endodontic file systems. There have been few ex vivo studies on the incidence of the formation of microcracks after root canal preparation, using the micro-computed tomography (micro-CT) analysis.</p><p><strong>Objectives: </strong>The aim of the present study was to compare the incidence of dentinal cracks after using the XP-endo® Shaper, TRUShape®, ProTaper Next™ (PTN), and ProTaper Universal™ (PTU) instruments in the preparation of mandibular premolar teeth with oval canals, using the micro-CT evaluation method.</p><p><strong>Material and methods: </strong>Thirty-six extracted human mandibular premolars with single oval root canals were distributed randomly to 4 experimental groups (n = 9) for root canal preparation: group 1 - XP-endo Shaper; group 2 - TRUShape; group 3 - PTN; and group 4 - PTU. The teeth were scanned using micro-CT with high resolution, before and after mechanical root preparation. Then, the cross-sectional images of preand post-scanning were visualized simultaneously to detect new dentinal cracks. The number of dentinal cracks was determined as percentage for each group, and the results were statistically analyzed using the Wilcoxon signed rank test and the Kruskal-Wallis test.</p><p><strong>Results: </strong>A total of 49,628 cross-sectional images were obtained from preand post-scanning with micro-CT. Dentinal cracks were observed in 11,223 (22.6%) of the images. No new dentinal cracks were formed after using XP-endo Shaper, TRUShape or PTN. New dentinal cracks were found in the PTU group, and the difference between the percentages of the preand post-preparation dentinal cracks was statistically significant (37.6% vs. 62.4%) (p = 0.008).</p><p><strong>Conclusions: </strong>The use of the heat-treated nickel-titanium (NiTi) files (XP-endo Shaper, TRUShape, PTN) did not lead to the formation of new dentinal cracks. New dentinal cracks were formed while using the traditional NiTi file (PTU) only. Future studies are required to investigate the association between the formation of dentinal cracks and new endodontic file systems.</p>","PeriodicalId":11191,"journal":{"name":"Dental and Medical Problems","volume":"62 1","pages":"89-98"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}