Disease and Diagnosis最新文献_第7页

Prevention and Control Measures in Coronavirus Disease-19 Pandemic 第 19 次冠状病毒病大流行的防控措施

Disease and Diagnosis Pub Date : 2022-01-01 DOI: 10.34172/ddj.2022.01

V. Ranaei, Z. Pilevar, Sakineh Dadipoor, A. Madani

引用次数: 1

The Prevalence of Metabolic and Endocrine Disorders Among HIV-infected Patients in a Population From the South of Iran 伊朗南部人群中hiv感染患者的代谢和内分泌紊乱患病率

Disease and Diagnosis Pub Date : 2022-01-01 DOI: 10.34172/ddj.2022.02

P. Davoodian, Marzie Nourozian, A. Atashabparvar, Ghazal Zoghi, Mahsa Ghasemi, Masoumeh Kheirandish

{"title":"The Prevalence of Metabolic and Endocrine Disorders Among HIV-infected Patients in a Population From the South of Iran","authors":"P. Davoodian, Marzie Nourozian, A. Atashabparvar, Ghazal Zoghi, Mahsa Ghasemi, Masoumeh Kheirandish","doi":"10.34172/ddj.2022.02","DOIUrl":"https://doi.org/10.34172/ddj.2022.02","url":null,"abstract":"Background: Since the beginning of the acquired immunodeficiency syndrome (AIDS) pandemic, the number of people infected with human immunodeficiency virus (HIV) has shown a steady increase. Previous evidence exists regarding the evaluation of endocrine dysfunction in HIV-infected individuals. The present study sought to investigate the prevalence of metabolic and endocrine disorders in HIV-positive patients. Materials and Methods: In this cross-sectional study, 72 HIV-positive patients supported by the Behavioral Diseases Center of Bandar Abbas, Iran were recruited from April, 2016 to September, 2017. Patients who did not consent to participate were excluded from the study. Several parameters were measured, including serum free T3, free T4, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), free testosterone, cortisol, fasting plasma glucose (FPG), 2-hour plasma glucose, cholesterol, triglyceride, and low- and high-density lipoprotein levels. Finally, data were analyzed using chi-square and Mann-Whitney tests. Results: High serum lipoprotein levels, diabetes, and prediabetes were observed in 28/72 (38.9%), 13/72 (18.1%), and 17/72 (23.6%) patients, respectively. The prevalence of overt hypothyroidism and subclinical hypothyroidism, as well as overt hyperthyroidism and subclinical hyperthyroidism was 32.8% (22/67), 9% (6/67), 1.5% (1/67), and 7.5% (5/67), respectively. Primary and secondary gonadal dysfunction were found in 1/47 (2.1%) and 9/47 (19.1%) patients, respectively. Primary and secondary adrenal insufficiency were detected in 8/53 (15.1%) and 1/53 (1.9%) patients, respectively. Diabetes was significantly more frequent among older patients and those with a history of addiction. Conclusions: The results of this study indicated a relatively high frequency of metabolic and endocrine disorders, especially dyslipidemia and hypothyroidism in HIV-positive patients.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86384137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallstone Frequency in Adults With Celiac Disease: Results of a Population-Based Celiac Disease Registry From West Azerbaijan, IRAN 成年乳糜泻患者胆结石频率:来自伊朗西阿塞拜疆以人群为基础的乳糜泻登记结果

Disease and Diagnosis Pub Date : 2022-01-01 DOI: 10.34172/ddj.2022.04

K. Shateri, Fatemeh Halimi shabestari, M. Pashaei

{"title":"Gallstone Frequency in Adults With Celiac Disease: Results of a Population-Based Celiac Disease Registry From West Azerbaijan, IRAN","authors":"K. Shateri, Fatemeh Halimi shabestari, M. Pashaei","doi":"10.34172/ddj.2022.04","DOIUrl":"https://doi.org/10.34172/ddj.2022.04","url":null,"abstract":"Background: Among people who are genetically predisposed to celiac disease (CD), eating gluten, which is part of the structure of many grains, can lead to intestinal tract damage with an inadequate immune response. The purpose of the present study was to investigate the frequency of gallstones in CD. Materials and Methods: In this analytical cross-sectional study, all CD data were analyzed using the West Azerbaijan Population-Based Celiac Registry (WA-PBCR) database. The mainly evaluated criterion in this study was the frequency of gallstone in samples with CD. For evaluating the results, information related to gender, age, body mass index (BMI), bilirubin, and cholesterol level, anti-transglutaminase antibody level, and the frequency of gallstones were extracted from CD files. Results: Overall, 260 patients with CD were included in the study. The median age of the patients with CD was 33 years, and 66.5% and 33.5% of the patients were females and males, respectively. Gallstones were detected in 11 CD-diagnosed cases (4.23%). There was no significant relationship between the frequency of gallstones and age (P=0.193), gender (1.00), and obesity based on the BMI (P= 0.684) in patients with CD. Finally, 3 (1.15%) of the referred patients with the recognition of gallstones were diagnosed with CD. Conclusion: The prevalence of biliary stones in celiac patients may be higher compared to the normal population. Hypocholesteremia is the predisposing factor for gallstones. In general, a significant relationship was found between the frequency of gallstones and bilirubin levels in patients with CD.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79895297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokines in Schizophrenia: Predisposing Factors and Inflammatory Responses 精神分裂症中的细胞因子:诱发因素和炎症反应

Disease and Diagnosis Pub Date : 2022-01-01 DOI: 10.34172/ddj.2022.05

Mohammad Javad Azmand, Reza Divanbeigi, Marziyeh Hajati Pirabas

{"title":"Cytokines in Schizophrenia: Predisposing Factors and Inflammatory Responses","authors":"Mohammad Javad Azmand, Reza Divanbeigi, Marziyeh Hajati Pirabas","doi":"10.34172/ddj.2022.05","DOIUrl":"https://doi.org/10.34172/ddj.2022.05","url":null,"abstract":"Schizophrenia is a multifactorial disease that may be triggered by environmental disorders, mental stress, or physical illness in a person who is genetically predisposed to it. Recent research has extremely evaluated the role of inflammatory cytokines in schizophrenia. The current study attempted to find any association between cytokines and schizophrenia. This narrative study was conducted through a literature review in Scopus, PubMed, and Web of Science databases using keywords related to schizophrenia and cytokines without any time limitation. This review focused on discussing the relationship between various symptoms of disease and cytokine levels. Environmental factors such as embryonical infections were found to be associated with alternations in mothers’ blood cytokines and further effects on schizophrenia probability in children. Heritable factors including disrupted-in-schizophrenia 1 (DISC1) and neuregulin 1 (NRG1) genes were shown to be linked with immunological responses, as well as Toll-like receptors or AKT1/p13k activation and following alternations in the cytokine profile. Based on the findings, the cytokines and inflammatory responses of the body were reported to be involved in many psychological disorders and schizophrenia. Various interleukins (ILs), as well as IL-6, IL-8, and IL-2R are known to be associated with the severity of schizophrenia symptoms. Although various data exist regarding different cytokines and their association with schizophrenia, no study has so far formulated research fields on specific types of cytokines that have the potential to be further studied for therapeutic hope.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87580728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possibility of Vertical Transmission of COVID-19 During Pregnancy, Labor and After Delivery: A Systematic Review Study COVID-19在妊娠、分娩和分娩后垂直传播的可能性:一项系统综述研究

Disease and Diagnosis Pub Date : 2022-01-01 DOI: 10.34172/ddj.2022.06

Ameneh Rahnama, Ali Salimi Asl, Z. Kazemi, M. Nobakht, Mahshid Abbaszadeh, F. Dabiri, N. Roozbeh

{"title":"Possibility of Vertical Transmission of COVID-19 During Pregnancy, Labor and After Delivery: A Systematic Review Study","authors":"Ameneh Rahnama, Ali Salimi Asl, Z. Kazemi, M. Nobakht, Mahshid Abbaszadeh, F. Dabiri, N. Roozbeh","doi":"10.34172/ddj.2022.06","DOIUrl":"https://doi.org/10.34172/ddj.2022.06","url":null,"abstract":"Background: In general, although the placenta is a good barrier to prevent infections, several cases of coronavirus disease 19 (COVID-19) transmission have been reported during pregnancy. Moreover, considering the potential for vertical maternal-fetal transmission, there is a concern that the fetus is at risk for congenital COVID-19. The aim of the present review and systematic study was to investigate the possibility of the vertical transmission of COVID-19 during pregnancy, labor, and postpartum using available data. Methods: Studies conducted by February 12, 2021 were included in this systematic review study. Articles were searched in Medline, Magiran, SID, Civilica, Irandoc, ScienceDirect, PubMed, EMBASE, Web of Science, Scopus, and Google Scholar using English keywords such as \"Coronavirus\", \"COVID-19, \"SARS-CoV-2\", \"Vertical intrauterine transmission\", \"Vertical transmission\", \"Vertical fetal infection\", \"Maternal infection\", and \"Fetal infection\". The inclusion criterion included all observational studies related to vertical maternal-fetal transmission. Overall, 31 articles were completely analyzed after reviewing and deleting non-eligible and duplicate articles. Results: The results of reviewing 24 studies showed that collected samples were all negative but positive blood samples, immunoglobulin M (IgM) and IgG antibodies, and expression of placental factors were reported in seven studies. Conclusion: Although contradictory results were found in this study, the results of the samples revealed the lowest probability of vertical transmission. There was also no evidence confirming the effectiveness of cesarean section in reducing the rate of transmission. In general, adherence to hygienic protocols can have a significant impact on reducing neonatal incidence.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73994957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Ultrasound Results Performed by Emergency Medicine and Radiology Assistants in the Diagnosis of Testicular Diseases for Visitors in Emergency Departments in Kermanshah 克尔曼沙赫市急诊科急诊医学助理与放射学助理诊断睾丸疾病的超声结果比较

Disease and Diagnosis Pub Date : 2022-01-01 DOI: 10.34172/ddj.2022.03

M. Horriat, Amirhosein Meisami

{"title":"Comparison of Ultrasound Results Performed by Emergency Medicine and Radiology Assistants in the Diagnosis of Testicular Diseases for Visitors in Emergency Departments in Kermanshah","authors":"M. Horriat, Amirhosein Meisami","doi":"10.34172/ddj.2022.03","DOIUrl":"https://doi.org/10.34172/ddj.2022.03","url":null,"abstract":"Background: Scrotum pain is a common complaint in urology patients. Its diagnosis can be challenging, and a complete history and physical examination of the patient will be required for all acute and chronic scrotum pain. The present study was designed to compare the results of the performed ultrasound by emergency medicine and radiology assistants in the diagnosis of testicular disease for visitors who have been referred to the emergency department of Imam Reza hospital in Kermanshah. Materials and Methods: In general, 100 patients with testicle injuries and acute scrotum pain who were referred to the emergency department of the hospital from September 2017 to September 2019 were evaluated in this analytical cross-sectional study. The kappa coefficient was used to assess the contingency between the diagnosis of performed ultrasound by the emergency medicine assistants and radiology assistants. Results: The obtained value (82.5%) of this coefficient showed a high contingency between the diagnosis of testicle disease by radiology assistants and emergency medicine assistants, and this contingence was statistically significant (P<0.001). Conclusion: Based on the kappa coefficient (82.5%) for evaluating the contingency diagnosis of performed ultrasound, a high level of contingency was found between the diagnosis of testicle disease by radiology assistants and emergency medicine assistants. A value higher than 75% of the kappa coefficient indicates that the desired contingency performing an ultrasound with an emergency medicine specialist causes a reduction in time wastage and costs for patients and provides quicker access to treatment and a chance of less complications for the patients.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85707420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Variant of Turner Syndrome (the X Isochromosome-X Syndrome): A Case Report 特纳综合征(X同染色体-X综合征)的一种罕见变异:一例报告

Disease and Diagnosis Pub Date : 2021-12-30 DOI: 10.34172/ddj.2021.31

H. Samimagham, Mitra Kazemi Jahromi

引用次数: 0

Serum and Salivary Levels of Glucose and Urea in Pregnant and Non-pregnant Women: A Comparative Study 妊娠和非妊娠妇女血清和唾液中葡萄糖和尿素水平的比较研究

Disease and Diagnosis Pub Date : 2021-12-30 DOI: 10.34172/ddj.2021.29

M. Alemrajabi, Azam Dadkhah, Seyed-Ali Kasayizadegan-Mahabadi, Maryam-Sadat Sadrzadeh-Afshar

{"title":"Serum and Salivary Levels of Glucose and Urea in Pregnant and Non-pregnant Women: A Comparative Study","authors":"M. Alemrajabi, Azam Dadkhah, Seyed-Ali Kasayizadegan-Mahabadi, Maryam-Sadat Sadrzadeh-Afshar","doi":"10.34172/ddj.2021.29","DOIUrl":"https://doi.org/10.34172/ddj.2021.29","url":null,"abstract":"Background: Pregnancy is one of the most critical periods in the life of most women. Since it is necessary to be aware of the health of the mother and fetus, serum markers (i.e., glucose and urea) need to be monitored during pregnancy. A routine strategy in this area is venipuncture which is applied to measure the level of these markers. It is also a stressful procedure for pregnant women. The purpose of this study was to determine the salivary level of these markers as a stress-free method in pregnant women. Materials and Methods: The samples were collected from 30 pregnant and 30 non-pregnant fasting women. Then, the serum and salivary levels of glucose and urea were measured, analyzed, and compared by photometry. Results: Results indicated that the mean salivary glucose level was 10.2±1.4 mg/dL and 6.4±0.9 mg/ dL in non-pregnant and pregnant women, respectively. In addition, the mean serum glucose level was 106.5±5.3 mg/dL and 82.9±4.5 mg/dL in non-pregnant and pregnant women, respectively. Further, the mean salivary urea level was 37.1±3.3 mg/dL in non-pregnant women and 27.1±1.9 mg/dL in pregnant women. Moreover, the mean serum urea level was 26.9±1.9 mg/dL and 19.5±2.3 mg/dL in non-pregnant and pregnant women, respectively. Conclusion: Serum and salivary levels of glucose and urea in pregnant women were lower than those in non-pregnant women, and there was a positive correlation between serum and salivary levels. Therefore, it seems that saliva can be a substitute for serum regarding the measurement of glucose and urea levels.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86787023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinformatic Evaluation of the miRNAs Targeting ACE2 Gene in COVID-19 靶向ACE2基因的mirna在COVID-19中的生物信息学评价

Disease and Diagnosis Pub Date : 2021-12-30 DOI: 10.34172/ddj.2021.26

M. Rafat, Aida Roshan, Mahya Abyar, Saba Keramati, A. Nikpoor

{"title":"Bioinformatic Evaluation of the miRNAs Targeting ACE2 Gene in COVID-19","authors":"M. Rafat, Aida Roshan, Mahya Abyar, Saba Keramati, A. Nikpoor","doi":"10.34172/ddj.2021.26","DOIUrl":"https://doi.org/10.34172/ddj.2021.26","url":null,"abstract":"Introduction: Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which began in late 2019 in Wuhan, China, has become a global epidemic. Angiotensin 2 converting enzyme (ACE2) acts as a receptor for host function to cause acute coronavirus 2 acute respiratory syndrome (SARS-CoV-2). ACE2 is abundantly expressed in different cells of different human organs. In human physiology, ACE2 is a major player in the renin-angiotensin-aldosterone (RAAS) system by degrading angiotensin II. Many factors have been associated with altered ACE2 expression and the severity and progression of COVID-19, including microRNAs that may be effective in it. Identifying pathological changes due to SARS-CoV-2 infection is important because it has major implications for understanding the pathophysiology of COVID-19 and developing evidence-based treatment strategies. Currently, many intervention strategies are being explored in ongoing clinical trials. Objective: The aim of this study is to use bioinformatics databases to find potential antiviral therapies against SARS-CoV-2 through host microRNAs (miRNAs) that can reduce viral gene expression to inhibit virus entry and replication. Methods: Using different algorithms in TargetScan, DIANA, ENCORI and miRWalk databases, the potential microRNAs were identified that target ACE2. Then, a score table was prepared from the candidate microRNAs, based on the affinity of the seed region of microRNAs and the 3`-UTR region of the ACE2 gene. Finally, microRNAs with higher scores were chosen as candidates for practical analysis. Results: The results of Bioinformatical analysis showed that Has-miR-200c-3p, Has-miR-29a, Has-miR-29c, and Has-miR-942 are most likely to inhibit ACE2. These microRNAs are the most potent factors that might be affected on ACE2 during virulence. Conclusion: It seems that ACE2 is under the control of the miR-200c-3p and plays a crucial role in the pathophysiology process. Therefore, this microRNA can be considered as a suitable new candidate for experimental evaluation.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85393400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Potential of Machine Learning Algorithms in Discriminating Chronic Obstructive Pulmonary Disease and Healthy Saliva Samples 机器学习算法在区分慢性阻塞性肺疾病和健康唾液样本中的潜力

Disease and Diagnosis Pub Date : 2021-12-30 DOI: 10.34172/ddj.2021.28

Atefeh Goshvarpour, A. Goshvarpour

{"title":"The Potential of Machine Learning Algorithms in Discriminating Chronic Obstructive Pulmonary Disease and Healthy Saliva Samples","authors":"Atefeh Goshvarpour, A. Goshvarpour","doi":"10.34172/ddj.2021.28","DOIUrl":"https://doi.org/10.34172/ddj.2021.28","url":null,"abstract":"Background: Today, with the spread of tobacco use and increased environmental pollutions, respiratory diseases are considered important factors threatening human life. Chronic obstructive pulmonary disease (COPD) is a kind of inflammatory lung disease. Clinically, COPD is currently diagnosed and monitored by spirometry as the gold-standard technique although spirometry systems encounter some limitations. Thanks to the economical handling and sampling, practicality, and non-invasiveness of saliva biomarkers, it is promising for the testing environment. Accordingly, the current analytic observational study aimed to propose an intelligent system for COPD detection. Materials and Methods: To this end, 40 COPD (8 females and 32 males in the age range of 71.67±8.27 years) and 40 controls (17 females and 23 males within the age range of 38.23±14.05 years) were considered in this study. The samples were characterized by absolute minimum value and the average value of the real and imaginary parts of saliva permittivity. Additionally, the age, gender, and smoking status of the participants were determined, and then the performance of various classifiers was evaluated by adjusting k in k-fold cross-validation (CV) and classifier parameterization. Results: The results showed that the k-nearest neighbor outperformed other classifiers. Using both 8- and 10-fold CV, the maximum classification rates of 100% were achieved for all k values. On the other hand, increasing the k in k-fold CV improved classification performances. The positive role of parameterization was revealed as well. Conclusions: Overall, these findings authenticated the potential of machine learning (ML) algorithms in the diagnosis of COPD using subjects’ saliva features and demographic information.","PeriodicalId":11143,"journal":{"name":"Disease and Diagnosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89805513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0