精神分裂症中的细胞因子:诱发因素和炎症反应

Mohammad Javad Azmand, Reza Divanbeigi, Marziyeh Hajati Pirabas
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引用次数: 0

摘要

精神分裂症是一种多因素疾病,可能由环境障碍、精神压力或在遗传上易患精神分裂症的人身上的身体疾病引发。最近的研究高度评价了炎症细胞因子在精神分裂症中的作用。目前的研究试图找到细胞因子和精神分裂症之间的联系。本叙述性研究通过查阅Scopus、PubMed和Web of Science数据库的文献进行,使用与精神分裂症和细胞因子相关的关键词,不受时间限制。本文就各种疾病症状与细胞因子水平的关系作一综述。环境因素,如胚胎感染,被发现与母亲血液细胞因子的改变有关,并进一步影响儿童患精神分裂症的可能性。包括精神分裂症1 (DISC1)和神经调节蛋白1 (NRG1)基因在内的遗传因素被证明与免疫反应、toll样受体或AKT1/p13k激活以及随后的细胞因子谱变化有关。基于这些发现,身体的细胞因子和炎症反应被报道参与了许多心理障碍和精神分裂症。各种白细胞介素(il),以及IL-6、IL-8和IL-2R已知与精神分裂症症状的严重程度有关。尽管存在各种关于不同细胞因子及其与精神分裂症的关联的数据,但迄今为止还没有研究明确了特定类型的细胞因子的研究领域,这些细胞因子具有进一步研究治疗希望的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cytokines in Schizophrenia: Predisposing Factors and Inflammatory Responses
Schizophrenia is a multifactorial disease that may be triggered by environmental disorders, mental stress, or physical illness in a person who is genetically predisposed to it. Recent research has extremely evaluated the role of inflammatory cytokines in schizophrenia. The current study attempted to find any association between cytokines and schizophrenia. This narrative study was conducted through a literature review in Scopus, PubMed, and Web of Science databases using keywords related to schizophrenia and cytokines without any time limitation. This review focused on discussing the relationship between various symptoms of disease and cytokine levels. Environmental factors such as embryonical infections were found to be associated with alternations in mothers’ blood cytokines and further effects on schizophrenia probability in children. Heritable factors including disrupted-in-schizophrenia 1 (DISC1) and neuregulin 1 (NRG1) genes were shown to be linked with immunological responses, as well as Toll-like receptors or AKT1/p13k activation and following alternations in the cytokine profile. Based on the findings, the cytokines and inflammatory responses of the body were reported to be involved in many psychological disorders and schizophrenia. Various interleukins (ILs), as well as IL-6, IL-8, and IL-2R are known to be associated with the severity of schizophrenia symptoms. Although various data exist regarding different cytokines and their association with schizophrenia, no study has so far formulated research fields on specific types of cytokines that have the potential to be further studied for therapeutic hope.
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