Dementia and Geriatric Cognitive Disorders最新文献

{"title":"Trends in the Incidence of Early- and Late-Onset Dementia in 2011-2019: A Nationwide Population-Based Study.","authors":"Miri Lutski, Inbar Zucker, Mikhail Rozenshmidt, Eshed Lin, Revital Gross-Nevo, Irit Laxer, Lital Keinan-Boker, Michal Bromberg","doi":"10.1159/000552194","DOIUrl":"https://doi.org/10.1159/000552194","url":null,"abstract":"<p><strong>Purpose: </strong>To examine secular trends in the incidence of early- (ages 45-64) and late-onset (ages 65+) dementia in Israel from 2011 to 2019 and to assess sex-specific patterns.</p><p><strong>Methods: </strong>A nationwide, population-based study using electronic health records from all four Israeli health maintenance organizations, which provide universal healthcare coverage. Incident cases were identified by International Classification of Diseases (ICD-9/10) codes and/or purchases of anti-dementia medications. Age- and sex-specific incidence rates were calculated, and joinpoint regression models were used to assess trends over time.</p><p><strong>Results: </strong>Over the 9-year period, dementia incidence declined significantly in both early- and late-onset groups. Mean annual incidence per 100 individuals was 0.04 for early-onset dementia overall (0.05 in men, 0.04 in women), and 1.55 for late-onset dementia (1.35 in men, 1.72 in women). Statistically significant annual percentage changes (APCs) were observed across most age groups, with the sharpest declines in those aged 65-74 (-4.0% per year) and 75-84 (-4.1% per year). Among adults aged 85+, incidence was stable from 2011-2015, followed by a significant decline from 2015-2019 (-6.6% per year). These trends were consistent across sexes.</p><p><strong>Conclusions: </strong>These findings highlight important public health and community health implications, underscoring the need for continued dementia surveillance, early detection, and evidence-based policy to support healthy aging.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-14"},"PeriodicalIF":1.9,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth Loss as A Modifiable Risk Factor for Mild Cognitive Impairment: A Systematic Review of Mechanisms and Evidence.","authors":"Dandan Sun, Janak L Pathak, Yanling Liang, Jieling Lin, Zirui Li, Jianwei Chen, Qiuhui Jiang, Yuqin Shen, Kongbin Yang, Yangbin Zeng","doi":"10.1159/000551780","DOIUrl":"https://doi.org/10.1159/000551780","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between cognitive defects and missing teeth has drawn increasing research attention in recent years. However, little research has specifically demonstrated the correlation between mild cognitive impairment (MCI) and missing teeth, and existing findings remain inconsistent. Thus, we conducted a systematic review synthesizing current evidence on tooth loss and MCI, aiming to address this gap.</p><p><strong>Methods: </strong>The reviewers searched Embase, Scopus, and PubMed for relevant studies published up to May 2025. An updated search was conducted in December 2025. Dual-independent literature reviewing was performed at all stages, with conflicts resolved by consensus.</p><p><strong>Results: </strong>From an initial pool of 2,709 articles, 113 underwent full-text reading, and 10 met the inclusion criteria. Our findings suggest that missing teeth, including the number of teeth lost, the number of functional teeth remaining, categorized tooth loss, and the rate of tooth loss, are significantly associated with MCI. Potential mechanisms may involve periodontal inflammation triggering neuroinflammation, reduced chewing-related neural stimulation, impaired nutrient intake and social isolation.</p><p><strong>Conclusions: </strong>Although limited evidence suggests an association between tooth loss and MCI, offering potential avenues for MCI prevention through oral health interventions, the overall quality of the research remains low. Further high-quality studies will be needed to validate these findings.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-19"},"PeriodicalIF":1.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of adverse childhood experiences with later-life motoric cognitive risk syndrome among older adults in China: mediating role of depression and chronic pain.","authors":"Hongtao Cheng, Hexiao Ding, Jie Jiang, Qian Yu, Yangyang Wu, Zhengyang Hui, June Zhang","doi":"10.1159/000551688","DOIUrl":"https://doi.org/10.1159/000551688","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the association between adverse childhood experiences (ACEs) and motoric cognitive risk syndrome (MCR) among older adults in China, and to investigate whether depression and chronic pain mediate this relationship.</p><p><strong>Method: </strong>This cross-sectional study analyzed 3,983 adults aged ≥60 years from the China Health and Retirement Longitudinal Study (CHARLS). Twelve ACE indicators were assessed across conventional, extended, and new categories. MCR was diagnosed based on cognitive complaints and slow gait speed. Depression was evaluated using the 10-item Center for Epidemiologic Studies Depression Scale, and chronic pain through standardized questionnaires. Multiple regression models and parallel mediation analyses examined associations between ACEs and MCR.</p><p><strong>Results: </strong>The study included 3,983 older adults with a median age of 66 years (interquartile range: 63-71), of whom 59.3% were male. MCR was identified in 12.9% (n=512) of participants, with emotional neglect (40.1%) and physical abuse (30.7%) being the most common ACEs. Participants with 1-3 ACEs (adjusted odds ratio [OR]=1.42, 95% confidence interval [CI]: 1.07-1.94) and ≥4 ACEs (adjusted OR=1.74, 95% CI: 1.24-2.46) showed significantly higher odds of MCR compared to those without ACEs. Depression and chronic pain mediated 14.3% and 21.4% of the total effect, respectively.</p><p><strong>Conclusion: </strong>ACEs demonstrated dose-dependent associations with MCR in Chinese older adults, partially mediated through depression and chronic pain. These findings suggest early-life screening for ACEs and addressing mental and physical health may be critical for preventing cognitive-motor decline in later life.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-21"},"PeriodicalIF":1.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlational Validity and Biomarker Associations of the Korean Computerized Cognitive Function Test (CFT-S) Relative to the Seoul Neuropsychological Screening Battery in MCI and Alzheimer's Disease.","authors":"Donghyun Kim, Woong Jin Lee, Daniel Hyojae Jeon, Hyungyu Lee, Minkyu Kang, Minsung Park, Min Kim, Seungho Ha, Kyoungjoo Cho","doi":"10.1159/000551744","DOIUrl":"https://doi.org/10.1159/000551744","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluates the clinical validity of the Korean Computerized Cognitive Function Test (CFT-S) by comparing its domain-specific scores with those of the Seoul Neuropsychological Screening Battery-II (SNSB-II) in patients with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD).</p><p><strong>Methods: </strong>A total of 300 participants (MCI: n = 163; AD: n = 137) from Severance Hospital completed both CFT-S and SNSB-II assessments within a two-week interval, along with brain MRI and APOE genotyping. Pearson correlations and multiple regression analyses examined relationships between cognitive scores and biomarker variables. Receiver operating characteristic curves assessed diagnostic accuracy. Bland-Altman plots evaluated agreement across five shared cognitive domains.</p><p><strong>Results: </strong>CFT-S index scores showed significant positive correlations with SNSB-II in attention, language, visuospatial, and executive domains (r = 0.59-0.71, p < 0.001). The memory domain showed a lower correlation in AD patients (r = 0.28), reflecting limitations under severe impairment. Hippocampal volume was positively associated with MMSE (r = 0.54), CFT-S memory (r = 0.50), and SNSB memory scores (r = 0.52). Education correlated with MMSE (r = 0.32) but not with CFT-S or SNSB, suggesting minimal education bias. APOE-ε4 carriers had smaller hippocampal volumes, higher FBB-PET BAPL scores, and poorer cognitive outcomes. The Bland-Altman plots demonstrated acceptable agreement at the group level between CFT-S and SNSB-II across all cognitive domains, with small mean biases and symmetric distributions despite relatively wide limits of agreement.</p><p><strong>Conclusion: </strong>CFT-S index scores and Bland-Altman plot analysis demonstrated validity relative to SNSB-II, with significant associations to hippocampal atrophy and genetic risk factors. The findings support CFT-S as a viable and efficient cognitive assessment tool for diagnosing MCI and AD.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-21"},"PeriodicalIF":1.9,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Cognitive Assessment for Older Adults: Validation of an Automated Three-Module Tool for Mild Cognitive Impairment and Dementia Screening.","authors":"Dong-Ni Pan, Hailun Xie, Juejing Ren, Ji Shen, Jing Li, Yanjia Zeng, Wen Wang, Dingyao Fan, Gui Xue","doi":"10.1159/000549530","DOIUrl":"10.1159/000549530","url":null,"abstract":"<p><strong>Introduction: </strong>With the aging global population, effective screening tools for age-related cognitive disorders are urgently needed. Mild cognitive impairment (MCI), a transitional stage between normal aging and dementia, requires early detection for timely intervention.</p><p><strong>Methods: </strong>The current research developed an innovative electronic assessment tool designed with three task modules targeting executive function, memory binding, and spatial navigation to quickly screen for MCI in older adults. A validation study was conducted with 271 older participants, aged 56 to 89, comprising 138 individuals with MCI and 133 cognitively normal controls. An independent dataset from a community hospital was used for further confirmation.</p><p><strong>Results: </strong>The validation study indicated excellent reliability and validity, achieving 72% accuracy in distinguishing MCI from cognitively normal individuals, with excellent screening power (AUC = 0.807; 95% CI: 0.756-0.858). This performance surpasses that of the paper-and-pencil Mini-Mental State Examination (MMSE). The independent dataset from a community hospital further confirmed that the tool achieved a good accuracy rate of 93% (26/28) in predicting MCI.</p><p><strong>Conclusion: </strong>These results provide strong tool support for the early identification of MCI, enhancing the effective management of cognitive decline in at-risk elderly individuals.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VALIDATION AND PSYCHOMETRIC PROPERTIES OF THE VIETNAMESE VERSION OF THE NEUROPSYCHIATRIC INVENTORY (V-NPI) IN COMMUNITY-DWELLING OLDER ADULTS WITH DEMENTIA.","authors":"Huong Thu Vu, Hung Trong Nguyen, Anh Trung Nguyen","doi":"10.1159/000551358","DOIUrl":"https://doi.org/10.1159/000551358","url":null,"abstract":"<p><strong>Background: </strong>Behavioral and psychological symptoms of dementia (BPSD) substantially contribute to functional decline and caregiver burden, yet culturally validated assessment tools remain limited in Vietnam.</p><p><strong>Objective: </strong>To translate, culturally adapt, and assess the reliability and selected aspects of construct validity of the Vietnamese version of the Neuropsychiatric Inventory (V-NPI).</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 399 individuals with dementia and their caregivers in Hai Duong province. The V-NPI was administered alongside the Clinical Dementia Rating (CDR), Geriatric Depression Scale-15 (GDS-15), and Pittsburgh Sleep Quality Index (PSQI). Internal consistency, domain-level associations, and convergent and discriminant validity were assessed.</p><p><strong>Results: </strong>The V-NPI demonstrated excellent internal consistency for both the severity (Cronbach's α = 0.91) and caregiver distress (Cronbach's α = 0.93) subscales. Domain-total correlations ranged from 0.44 to 0.64, indicating moderate internal convergence alongside meaningful heterogeneity across symptom domains. The depression domain showed a modest correlation with the GDS-15, and the night-time disturbances domain showed a weak but statistically significant correlation with the PSQI, supporting domain-level construct validity. Neuropsychiatric symptoms were highly prevalent, with night-time disturbances (71.2%), apathy/indifference (60.2%), and depression/dysphoria (59.6%) being the most frequently reported domains.</p><p><strong>Conclusion: </strong>The V-NPI appears to be a reliable and culturally appropriate instrument for assessing BPSD and caregiver distress among older adults with dementia in Vietnam, supporting its use in both clinical practice and research.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of CSF Total Tau Protein in Patients with Familial and Sporadic Creutzfeldt-Jakob Disease.","authors":"Yacov Balash, Esther Kahana, Hanna Rosenmann, Nurit Omer, Ronit Gilad, Anda Eilam, Shmuel Appel, Amos D Korczyn","doi":"10.1159/000551359","DOIUrl":"10.1159/000551359","url":null,"abstract":"<p><strong>Introduction: </strong>Elevated total tau protein (t-τ) in the cerebrospinal fluid (CSF) is routinely used as a marker of Creutzfeldt-Jakob disease (CJD). We hypothesized that CSF t-τ and patients' age may anticipate survival time (ST) also in subjects with familial CJD (f-CJD) as has been shown previously in sporadic CJD (s-CJD).</p><p><strong>Methods: </strong>We analyzed data from the Israeli National CJD Registry from 1991 to 2022. The data included cases of both f-CJD and s-CJD in whom demographic data and CSF t-τ levels were measured, and the date of death was available. Using X-tile software, we determined the optimal cut-off points for continuous variables in survival analysis and found the cut-points for t-τ level and patients' age.</p><p><strong>Results: </strong>We analyzed data on 183 sequential CJD patients. The data included definite (n = 9), probable (n = 165), and possible (n = 9) CJD cases of whom 120 (61 males) were f-CJD (65.6%) and 63 (35 males) patients were s-CJD (34.4%). The cut-off value of CSF t-τ level was found to be 1,226 pg/mL. It separated ST into two groups, 105 days (interquartile ranges [IQR]: 59-305) in the lower group vs. 59 days (IQR: 29.5-147.5) in the higher, p = 0.0005. Cox analyses showed that for every 100 pg/mL increase in CSF t-τ, ST shortened by 3% in days (Exp β = 1.0003; 95% confidence interval: 1.0001-1.0005). Age had no direct prognostic value but correlated with CSF t-τ levels (rho = 0.243, p < 0.001).</p><p><strong>Conclusions: </strong>Age and CSF t-τ levels above the cut-off value predict ST shortening in patients with both f-CJD and s-CJD.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter: \"Dementia Should Not Be Interpreted as a Cause of Ischemic Stroke\".","authors":"Chaeyoon Kang, Seung Won Lee, Hohyun Jung, Youngoh Bae","doi":"10.1159/000551285","DOIUrl":"10.1159/000551285","url":null,"abstract":"","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-2"},"PeriodicalIF":1.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ageing, Wealth, and Diet: A Global Cross-National Analysis of Cereal Consumption and Dementia Risk.","authors":"Wenpeng You, Luisa Garcia, Shyama G K Ratnayake, Bashir Sumar, Maciej Henneberg, Shuhuan Feng, Hui-Chen Chang","doi":"10.1159/000551241","DOIUrl":"10.1159/000551241","url":null,"abstract":"<p><strong>Introduction: </strong>Global variation in dementia incidence reflects demographic and socioeconomic forces, yet the role of staple dietary patterns remains less defined. While population ageing is a key determinant of dementia burden, differences in cereal consumption, particularly rice, wheat, and maize, have received limited attention. This ecological study examined whether national cereal consumption patterns are associated with dementia incidence across countries independent of confounding factors.</p><p><strong>Methods: </strong>Country-level data from 204 nations were compiled, with complete case analyses conducted in 184 countries. Alzheimer's disease and other dementias incidence in 2021 served as the outcome variable. Predictors included per capita consumptions of total cereals, rice, wheat, and maize, alongside genetic predisposition, economic affluence, urban living, ageing indexed by life expectancy at age sixty, and meat consumption. Pearson and partial correlations, principal component analysis, and stepwise multiple regression were applied.</p><p><strong>Results: </strong>Wheat consumption was positively associated with dementia incidence, affluence, and longevity, whereas rice and maize consumption showed inverse associations. Partial correlations confirmed a persistent inverse association for rice consumption and a weaker inverse association for total cereal consumption after adjustment. Principal component analysis identified a socioeconomic component aligned with wheat consumption and ageing, while rice and maize loaded inversely. Stepwise regression demonstrated that ageing was the strongest predictor of dementia incidence, while rice and total cereal consumption retained small independent inverse associations.</p><p><strong>Conclusions: </strong>Global dementia incidence is driven primarily by population ageing and socioeconomic development. Cereal type reflects distinct developmental contexts, with rice-based patterns associated with a modestly lower dementia burden.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-18"},"PeriodicalIF":1.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiating Behavioural Presentations of Biomarker-Confirmed Alzheimer's Disease from Frontotemporal Lobar Degeneration Using the Addenbrooke's Cognitive Examination-III.","authors":"Joshua Flavell, Emily G M Ahern, Benignus Logan, Thomas B Shaw, Robert J Adam, Caitlin A T McElligott, Peter J Nestor","doi":"10.1159/000551258","DOIUrl":"10.1159/000551258","url":null,"abstract":"<p><strong>Introduction: </strong>Differentiating frontotemporal lobar degeneration (FTLD) from Alzheimer's disease (AD), particularly when presenting with overlapping behavioural symptoms, remains clinically challenging. This study assessed the utility of Addenbrooke's Cognitive Examination-III (ACE-III)-derived ratios in distinguishing these conditions.</p><p><strong>Methods: </strong>A retrospective cohort of 115 patients (n = 52 biomarker-confirmed AD, n = 63 FTLD) with overlapping behavioural symptoms was analysed. ACE-III scores and behavioural profiles were examined, and novel ratios were tested.</p><p><strong>Results: </strong>The novel Phonemic Fluency/Orientation-Memory (PFOM) ratio outperformed existing ACE-III metrics, achieving an area under the curve of 0.85 (sensitivity 84.1%, specificity 73.1%) for differentiating FTLD from AD. Notably, longer symptom duration in AD, but not in FTLD, was associated with worsening frontal and cognitive symptoms. Patients with AD were significantly older than those with FTLD.</p><p><strong>Conclusion: </strong>These novel ratios showed robust diagnostic performance, regardless of disease duration, and better reflect FTLDs cognitive profile. They may offer improved clinical utility over traditional ACE-III measures.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}