The Impact of APOE ε4 on Neuropsychological Test Performance in Hispanics: The Panama Aging Research Initiative - Health Disparities Study.

IF 2.2 4区医学 Q3 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Pub Date : 2025-06-20 DOI:10.1159/000546741

Alcibiades E Villarreal, Giselle A Rangel, Adam E Tratner, Diana C Oviedo, Maria B Carreira F, Sid E O'Bryant, Estefani C Sanchez Castillo, Carolina E Rodríguez, Gabrielle B Britton

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引用次数: 0

Abstract

Introduction: The apolipoprotein E (APOE) gene is a well-established risk factor for Alzheimer's disease, with the APOEε4 allele being the most strongly associated genetic variant. Research has suggested that the influence of APOEε4 on cognitive decline may vary across different populations. This study aims to investigate the relationship between APOE genotype and cognitive aging in Hispanics.

Methods: A diverse sample of Hispanic adults was recruited for a study on cognitive aging. Data were analyzed for n = 725 participants from the Panama Aging Research Initiative - Health Disparities (PARI-HD) study. Participants were divided into 2 groups, an outpatient cohort (n = 269) and a community cohort (n = 456) and underwent comprehensive neuropsychological assessments.

Results: A greater number of participants in the outpatient cohort were cognitively impaired than the community cohort, and the outpatient cohort had a significantly higher frequency of ε4 (33.8% vs. 25.7%). Results showed that carrying at least one copy of the APOEε4 allele was a significant predictor of cognitive impairment in the community cohort (OR = 2.06, 95% CI = 1.14-3.72, p = 0.017), but was not significantly associated with performance on cognitive tests for either cohort.

Conclusion: These findings suggest that APOEε4 confers risk for cognitive deterioration in the Panamanian population, highlighting the importance of considering genetic and demographic factors in understanding the heterogeneity of cognitive impairment.

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载脂蛋白E （APOE）基因是阿尔茨海默病的一个公认的危险因素，APOEε4等位基因是与阿尔茨海默病相关性最强的遗传变异。研究表明，APOEε4对认知能力下降的影响可能在不同的人群中有所不同。本研究旨在探讨APOE基因型与西班牙裔认知衰老的关系。方法：一个不同的西班牙裔成年人的样本被招募为研究认知老化。数据分析来自巴拿马老龄化研究倡议-健康差距（PARI-HD）研究的n = 725名参与者。参与者被分为两组，门诊队列（n = 269）和社区队列（n = 456），并进行了全面的神经心理学评估。结果：门诊队列的认知障碍发生率高于社区队列，且ε4发生率显著高于社区队列（33.8% vs. 25.7%）。结果显示，携带至少一个APOEε4等位基因拷贝是社区队列中认知障碍的重要预测因子（OR = 2.06, 95% CI = 1.14-3.72, p = 0.017），但与两个队列的认知测试成绩无显著相关性。结论：这些研究结果表明，APOEε4在巴拿马人群中具有认知功能退化的风险，强调了在理解认知功能障碍异质性时考虑遗传和人口统计学因素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders 医学-精神病学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.