The relationship between age and cognitive subtypes of Alzheimer's disease and related dementias.

IF 2.2 4区医学 Q3 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Pub Date : 2025-06-30 DOI:10.1159/000547124

Bruna Seixas-Lima, Malcolm Binns, Sandra E Black, Morris Freedman, Sanjeev Kumar, Durjoy Lahiri, Carlos Tyler Roncero, Stephen Strother, David F Tang-Wai, Maria Carmela Tartaglia, Howard Chertkow

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引用次数: 0

Abstract

Introduction: We aimed to identify cognitive subgroups of clinically diagnosed Alzheimer's disease (Alzheimer syndrome) and related dementias and test if age of presentation influences patterns of cognitive impairment.

Methods: Participants were individuals with mild cognitive impairment (n=360), vascular mild cognitive impairment (n=73), Alzheimer syndrome (n=127), vascular dementia (n=32), mixed dementia (n=23), and healthy controls (n=305). Principal Component analysis was run on 25 cognitive variables measured by the Toronto Cognitive Assessment (TorCA). We used hierarchical clustering to identify cognitive subgroups.

Results: We identified seven subgroups. The youngest group was characterized by the lowest scores on the overall TorCA mean, and also on Executive Function, Visuospatial function and Attention, while showing the highest scores on Memory, Orientation, and Language. The oldest clusters had low scores on Memory and Orientation, but higher scores on Attention. The intermediary clusters had similar age and severity distributions.

Conclusion: The results demonstrate that patterns of cognitive impairment are different in different age groups.

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年龄与阿尔茨海默病及相关痴呆认知亚型的关系

我们的目的是确定临床诊断的阿尔茨海默病（阿尔茨海默综合征）和相关痴呆的认知亚组，并测试出现的年龄是否影响认知障碍的模式。方法：参与者为轻度认知障碍患者（360例）、血管性轻度认知障碍患者（73例）、阿尔茨海默综合征患者（127例）、血管性痴呆患者（32例）、混合性痴呆患者（23例）和健康对照（305例）。主成分分析对多伦多认知评估（TorCA）测量的25个认知变量进行了分析。我们使用层次聚类来识别认知子组。结果：我们确定了7个亚组。最年轻的一组在总体TorCA平均值、执行功能、视觉空间功能和注意力方面得分最低，而在记忆、定向和语言方面得分最高。年龄最大的群体在记忆和定向方面得分较低，但在注意力方面得分较高。中间集群具有相似的年龄和严重程度分布。结论：不同年龄组的儿童认知功能障碍模式存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders 医学-精神病学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.