Danish medical journal最新文献_第7页

Challenges and solutions across sectors in multi-dose drug dispensing. 多剂量药物调剂中跨部门的挑战和解决方案。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-03-19 DOI: 10.61409/A03250182

Maja Schlünsen, Joo Hanne Poulsen Revell, Eva Holtved, Jens Søndergaard, Frans Brandt, Lene Juel Kjeldsen

{"title":"Challenges and solutions across sectors in multi-dose drug dispensing.","authors":"Maja Schlünsen, Joo Hanne Poulsen Revell, Eva Holtved, Jens Søndergaard, Frans Brandt, Lene Juel Kjeldsen","doi":"10.61409/A03250182","DOIUrl":"10.61409/A03250182","url":null,"abstract":"Introduction: Automated multi-dose drug dispensing (MDD) enhances patient safety and adherence and releases staff resources, but it also causes frustration among healthcare professionals during transitions between general practice and hospital admission. This study explored healthcare professionals' perspectives on the use of MDD during the transition from hospital to general practice.Methods: In April 2024, a focus group interview was conducted with four hospital-based physicians (HBPs), three general practitioners (GPs) and two clinical pharmacists at the University Hospital of Southern Denmark in Aabenraa, Denmark.Results: The GPs' attitudes towards MDD were generally more positive than those of HBPs, who found management of medication changes to MDD complex due to insufficient knowledge and lack of support for MDD in evenings and during weekends. Consequently, MDD was discontinued, which increased the workload of GPs after discharge. Proposed solutions included increased involvement of hospital pharmacy staff, the establishment of collaboration with community pharmacies, and regulatory amendments to transfer responsibility for MDD to community pharmacies.Conclusions: The proposed initiatives to optimise the management of MDDs in hospitals involved pharmacy personnel. Enhanced collaboration and coordination among pharmacies and healthcare providers concerning MDD were essential to strengthening the primary healthcare sector.Funding: None.Trial registration: NCT06451692.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative imaging lowers the negative appendectomy rate in acute appendicitis. 术前影像学检查可降低急性阑尾炎患者阑尾切除术阴性率。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-03-06 DOI: 10.61409/A11250958

Theresa Brem Sørensen, Lucas Kahl Angaard, David Reiss Axelsen, Mette Cathrine Lauridsen

{"title":"Preoperative imaging lowers the negative appendectomy rate in acute appendicitis.","authors":"Theresa Brem Sørensen, Lucas Kahl Angaard, David Reiss Axelsen, Mette Cathrine Lauridsen","doi":"10.61409/A11250958","DOIUrl":"10.61409/A11250958","url":null,"abstract":"Introduction: Acute appendicitis is a common surgical emergency, but accurate diagnosis remains challenging. Despite the 2020 World Society of Emergency Surgery Jerusalem guidelines recommending structured imaging pathways, including ultrasound and selective computed tomography, clinical assessment remains the primary diagnostic tool in Denmark. Contemporary practice emphasises rapid assessment, with imaging reserved for older or borderline cases. We hypothesised that reliance on clinical assessment alone contributes to a high number of negative appendectomies, particularly in young adults.Methods: We conducted a single-centre retrospective cohort study of adults (> 18 years) undergoing surgery for suspected appendicitis at a tertiary university hospital in Denmark between January 2021 and December 2023. Data were extracted from electronic medical records and analysed in Stata 19.5.Results: Among 613 patients, 522 had histologically confirmed appendicitis, yielding an overall negative appendectomy rate (NAR) of 14.9%. Patients without preoperative imaging (n = 279) had a NAR of 24.4%, compared with 6.9% among those who underwent preoperative imaging (n = 334).Conclusions: Reliance on clinical assessment alone results in a substantial number of unnecessary operations. Preoperative imaging significantly reduces NAR (p less-than 0.001), supporting broader adoption of guideline-based diagnostic strategies to improve diagnostic accuracy and optimise resource utilisation.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risks of automation in medicine - a review article for the obstetrics case. 医学自动化的风险——一篇关于产科案例的综述文章。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-02-26 DOI: 10.61409/A10250852

Joris Fournel, Aasa Feragen, Martin Tolsgaard

引用次数: 0

Clinical work perception and mental health in Danish resident doctors. 丹麦住院医师的临床工作感知与心理健康

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-02-19 DOI: 10.61409/A05250361

Emil Lønstrup Øhrstrøm, Henrik Bøggild, Nicolaj Johansson, Tine Lass Klitgaard, Peter Derek Hristian Leutscher, Louise Thomsen Schmidt Arenholt

{"title":"Clinical work perception and mental health in Danish resident doctors.","authors":"Emil Lønstrup Øhrstrøm, Henrik Bøggild, Nicolaj Johansson, Tine Lass Klitgaard, Peter Derek Hristian Leutscher, Louise Thomsen Schmidt Arenholt","doi":"10.61409/A05250361","DOIUrl":"10.61409/A05250361","url":null,"abstract":"Introduction: The transition from medical school to clinical practice is a demanding phase for junior doctors. This study examined associations between clinical work perceptions, mental health and pre-graduate clinical experience among Danish junior doctors, focusing on early training experiences and well-being.Methods: A cross-sectional survey was sent to junior doctors in the North Denmark Region. The questionnaire was developed with input from junior doctor focus groups and included validated items from the Copenhagen Psychosocial Questionnaire, the WHO-5 Well-Being Index and the Major Depression Inventory.Results: Overall, 297 junior doctors (38% response rate) completed the survey. Whereas the majority (66-79%) reported positive perceptions of the introduction, supervision and preparedness, 25% doubted their ability to remain in the profession. Approximately one-third reported exhaustion or stress more than half the time. Moreover, 13% scored below 35 on the WHO-5 Well-Being Index, indicating a high risk of stress-related disorders. Overall, 18% had a Major Depression Inventory score ≥ 20, consistent with depression. Pre-graduate locum experience was significantly associated with greater perceived preparedness and confidence, but not reduced stress or depressive symptoms.Conclusions: Substantial mental health concerns exist among Danish junior doctors. Pre-graduate experience enhances confidence but not emotional resilience. Institutional measures, such as structured supervision, mentorship and targeted well-being support, are needed in early medical careers.Funding: None.Trial registration: Registration F2025-058.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 3","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorectal cancer in Greenland. 格陵兰岛的结直肠癌。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-02-19 DOI: 10.61409/A07250563

Astrid Kerstine Buch, Ann-Mari Lawaetz, Simon Olav Bernth-Andersen, Tommie Mynster

{"title":"Colorectal cancer in Greenland.","authors":"Astrid Kerstine Buch, Ann-Mari Lawaetz, Simon Olav Bernth-Andersen, Tommie Mynster","doi":"10.61409/A07250563","DOIUrl":"10.61409/A07250563","url":null,"abstract":"Introduction: Distal radius fractures (DRFs) are common, with over 14,000 annual cases in Denmark. Most cases are treated non-surgically and may require closed reduction prior to casting. National guidelines for anaesthesia and reduction technique for closed reduction of DRFs are lacking, impacting clinical practices and potentially optimal care. This survey aimed to describe Danish clinical practice for initial treatment and closed reduction of DRFs.Methods: Between January and April 2025, the survey was distributed online to the 23 physicians responsible for all 44 emergency departments and minor injury units treating DRFs in Denmark. The survey examined the clinical practices used for anaesthesia, reduction technique and post-reduction follow-up for patients with DRFs.Results: The response rate was 100% (23/23). All departments used haematoma block as anaesthetic method. Manual reduction followed by induced muscle fatigue was reported as the preferred reduction technique (87%, 20/23). Among these, 80% (16/20) mentioned that finger-trap-traction was used as a muscle-fatiguing method. All sites used X-ray imaging to assess the reduction result. Surgery was offered when reduction was unsatisfactory, depending on various criteria, e.g. Clinical Frailty Scale, age or clinical assessment.Conclusions: In Denmark, haematoma block is the standard anaesthetic method for the closed reduction procedure of DRFs. Mostly finger-trap traction is used to induce muscle relaxation before manual reduction. Clinical practice is generally well-aligned with minor variation in surgical intervention criteria.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 3","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Danish cross-cultural adaptation of the Theoretical Framework of Acceptability questionnaire. 丹麦跨文化适应的可接受性问卷理论框架。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-02-19 DOI: 10.61409/A07250547

Ditte Bekker-Jensen, Jesper Kjaergaard, Søren T Skou, Anders Wieghorst, Caroline Matilde Elnegaard, Sofie Moesgaard Bergholdt, Henrik Schmidt, Nicola Straiton, Britt Borregaard

{"title":"Danish cross-cultural adaptation of the Theoretical Framework of Acceptability questionnaire.","authors":"Ditte Bekker-Jensen, Jesper Kjaergaard, Søren T Skou, Anders Wieghorst, Caroline Matilde Elnegaard, Sofie Moesgaard Bergholdt, Henrik Schmidt, Nicola Straiton, Britt Borregaard","doi":"10.61409/A07250547","DOIUrl":"10.61409/A07250547","url":null,"abstract":"Introduction: Acceptability of healthcare interventions among patients and healthcare professionals is important for effective and efficient implementation in clinical settings. To standardise the assessment of acceptability of healthcare interventions, the Theoretical Framework of Acceptability (TFA) questionnaire was developed. In this study, we aimed to translate and cross-culturally adapt the TFA questionnaire into Danish.Methods: The TFA was forward- and back-translated and pre-tested in accordance with Beaton's guidelines. Following an iterative process, the pre-final questionnaire was field-tested through cognitive interviews using verbal probing and think-aloud techniques to assess relevance, comprehensiveness and comprehensibility.Results: Following translation, 30 participants (37% female, mean age 61 years) completed cognitive interviews. The population included cardiac arrest survivors and their relatives, patients with hypercholesterolaemia, knee/hip osteoarthritis and patients at risk of heart failure. Five iterative rounds informed adaptations of the Danish version, resolving misinterpretations and improving clarity. Four main issues were identified: 1) structure of the questionnaire, 2) translation of the terms \"acceptability\" and \"intervention\", 3) wording of the Likert scale and 4) item-specific interpretation problems.Conclusions: Following international guidelines, the TFA questionnaire was successfully translated and cross-culturally adapted into Danish, addressing key linguistic and conceptual challenges.Funding: We acknowledge the University of Southern Denmark and the BOX-trial for supporting this project.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 3","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute haemodynamic and diuretic effects of intravenous furosemide in acute heart failure. 静脉滴注速尿对急性心力衰竭的急性血流动力学和利尿作用。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-02-19 DOI: 10.61409/A07250556

Nora Olsen El Caidi, Jasmin Dam Lukoschewitz, Ida Arentz Taraldsen, Jens Hove, Ekim Seven, Ulrik Dixen, Frederik Grund, Morten Petersen, Nicolai Bang Foss, Johannes Grand

{"title":"Acute haemodynamic and diuretic effects of intravenous furosemide in acute heart failure.","authors":"Nora Olsen El Caidi, Jasmin Dam Lukoschewitz, Ida Arentz Taraldsen, Jens Hove, Ekim Seven, Ulrik Dixen, Frederik Grund, Morten Petersen, Nicolai Bang Foss, Johannes Grand","doi":"10.61409/A07250556","DOIUrl":"10.61409/A07250556","url":null,"abstract":"Introduction: While the diuretic effect of loop diuretics in acute heart failure (AHF) is well established, it remains debated whether furosemide exerts any extrarenal decongestive effects. This study aimed to examine the acute effects of furosemide on pulmonary congestion, diuresis and haemodynamics in patients hospitalised with AHF.Methods: We conducted a prospective interventional study including 20 AHF patients, each receiving 80 mg of intravenous furosemide at baseline. Diuresis, perfusion index, echocardiography and pulmonary fluid via remote dielectric sensing (ReDS) were assessed at predefined time points until 360 minutes. The primary endpoint was a change in ReDS within 30 minutes.Results: The cohort had a mean age of 78 ± 9 years, with 65% diagnosed with heart failure with reduced ejection fraction. Baseline ReDS was 35.3 ± 1.8%. No significant reduction in ReDS was observed at any time point; a non-significant decrease of 1.7% was observed at 20 minutes (p = 0.32). Diuresis reached 134 ± 56 ml by 20 minutes (p = 0.02). Perfusion index declined significantly by 25 minutes (p = 0.03) and remained stable until 120 minutes. No other haemodynamic parameters changed significantly.Conclusions: Intravenous furosemide did not acutely reduce pulmonary fluid before diuresis, suggesting no immediate extrarenal effect. Haemodynamic changes occurred only after diuresis, indicating its primary acute action is diuretic, with later responses likely being secondary to volume loss.Funding: None.Trial registration: The protocol was registered with clinicaltrials.gov on 29 August 2023 (Identifier: NCT06024889).","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 3","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Frailty Scale scores of older patients admitted to an emergency department. 急诊科收治的老年患者的临床虚弱量表评分。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-02-19 DOI: 10.61409/A03250170

Lisa Kvist Antonsen, Charlotte Abrahamsen, Mette Rahbek Kristensen, Annmarie Touborg Lassen, Mikkel Brabrand, Line Emilie Laugesen, Frederik Pors Klinting, Ditte Kjær Orbesen, Christina Østervang

{"title":"Clinical Frailty Scale scores of older patients admitted to an emergency department.","authors":"Lisa Kvist Antonsen, Charlotte Abrahamsen, Mette Rahbek Kristensen, Annmarie Touborg Lassen, Mikkel Brabrand, Line Emilie Laugesen, Frederik Pors Klinting, Ditte Kjær Orbesen, Christina Østervang","doi":"10.61409/A03250170","DOIUrl":"10.61409/A03250170","url":null,"abstract":"Introduction: Frailty is prevalent in older adults attending emergency departments and is associated with adverse health outcomes. Early identification of frailty is important to develop appropriate care plans and targeted interventions that address specific healthcare needs. The Clinical Frailty Scale is a validated tool used to assess an individual's baseline health status and predict the risk of adverse outcomes in adults aged 65 years or older. This study aimed to delineate the demographic characteristics and baseline Clinical Frailty Scale scores of patients aged 65 years and older in three Danish emergency department populations.Methods: A flash mob study was conducted over two days to collect observational data from 6 AM to midnight at three emergency departments in Southern Denmark. Collected variables included demographics, the reasons for the emergency department presentation and Clinical Frailty Scale scores. The prevalence of frailty was determined using frequency and proportion analyses.Results: A total of 225 patients aged 65 years and older were recruited across three emergency departments. More than 58% exhibited mild or more severe frailty, defined by a Clinical Frailty Score of 4 or higher. Findings show that frailty was more common among the oldest patients. Participants had a median age of 78 years (IQR: 72-83 years), and 46.2% were female.Conclusions: This study shows that frailty was prevalent among people aged 65 years and older attending the emergency departments. Terminally ill patients were underrepresented in this study, probably because patients who could not give informed consent due to cognitive impairments were excluded.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 3","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical practice for closed reduction of distal radius fractures in Denmark. 丹麦桡骨远端骨折闭式复位术的临床实践。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-02-19 DOI: 10.61409/A08250653

Anne-Sofie Linde Jellestad, Rasmus Linnebjerg Knudsen, Cecilie Dupont Harwood, Mathias Therkel Stensbæk, Sanja Pisljagic, Bjarke Viberg, Jonas Askø Andersen, Claus Varnum, Per Hviid Gundtoft, Kai Henrik Wiborg Lange, Lars Hyldborg Lundstrøm, Anders Kehlet Nørskov

{"title":"Clinical practice for closed reduction of distal radius fractures in Denmark.","authors":"Anne-Sofie Linde Jellestad, Rasmus Linnebjerg Knudsen, Cecilie Dupont Harwood, Mathias Therkel Stensbæk, Sanja Pisljagic, Bjarke Viberg, Jonas Askø Andersen, Claus Varnum, Per Hviid Gundtoft, Kai Henrik Wiborg Lange, Lars Hyldborg Lundstrøm, Anders Kehlet Nørskov","doi":"10.61409/A08250653","DOIUrl":"10.61409/A08250653","url":null,"abstract":"Introduction: Distal radius fractures (DRFs) are common, with over 14,000 annual cases in Denmark. Most cases are treated non-surgically and may require closed reduction prior to casting. National guidelines for anaesthesia and reduction technique for closed reduction of DRFs are lacking, impacting clinical practices and potentially optimal care. This survey aimed to describe Danish clinical practice for initial treatment and closed reduction of DRFs.Methods: Between January and April 2025, the survey was distributed online to the 23 physicians responsible for all 44 emergency departments and minor injury units treating DRFs in Denmark. The survey examined the clinical practices used for anaesthesia, reduction technique and post-reduction follow-up for patients with DRFs.Results: The response rate was 100% (23/23). All departments used haematoma block as anaesthetic method. Manual reduction followed by induced muscle fatigue was reported as the preferred reduction technique (87%, 20/23). Among these, 80% (16/20) mentioned that finger-trap-traction was used as a muscle-fatiguing method. All sites used X-ray imaging to assess the reduction result. Surgery was offered when reduction was unsatisfactory, depending on various criteria, e.g. Clinical Frailty Scale, age or clinical assessment.Conclusions: In Denmark, haematoma block is the standard anaesthetic method for the closed reduction procedure of DRFs. Mostly finger-trap traction is used to induce muscle relaxation before manual reduction. Clinical practice is generally well-aligned with minor variation in surgical intervention criteria.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 3","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose S-ketamine for prehospital pain relief. 低剂量s -氯胺酮用于院前止痛。

IF 1.1 4区医学

Danish medical journal Pub Date : 2026-02-18 DOI: 10.61409/A08250694

Daniel Wittrock, Lars-Gustav Rahbek Nielsen, Henning Morthorst Lassesen, Poul Fredslund Pedersen, Jonas Emdal, Christian Nyby Bergholdt, Lars Bak Nielsen, Jakob Oxlund, Søren Mikkelsen

{"title":"Low-dose S-ketamine for prehospital pain relief.","authors":"Daniel Wittrock, Lars-Gustav Rahbek Nielsen, Henning Morthorst Lassesen, Poul Fredslund Pedersen, Jonas Emdal, Christian Nyby Bergholdt, Lars Bak Nielsen, Jakob Oxlund, Søren Mikkelsen","doi":"10.61409/A08250694","DOIUrl":"10.61409/A08250694","url":null,"abstract":"Introduction: S-ketamine is increasingly used as an adjunct to opioids for prehospital traumatic pain, but data on patient experience and safety in civilian paramedic practice remain limited. We evaluated low-dose S-ketamine, alone or with fentanyl, in a Danish prehospital setting.Methods: This was a prospective observational study including adult prehospital patients with pain from significant trauma, suspected fractures of long bones, spine or pelvis, or joint dislocations. Paramedics administered intravenous S-ketamine, usually after fentanyl, and recorded pain using a numerical rating scale (NRS) and an electronic questionnaire on efficacy, side effects and patient experience. Data completeness was ensured by twice-weekly electronic record searches and follow-up.Results: Among 348 patients, 320 (92.0%) reported effective pain relief, with a median NRS reduction of five points. In the combination group, the median fentanyl dose was 150 µg (IQR: 100-200 µg), and the median ketamine dose was 10 mg (IQR: 10-20 mg). In the monotherapy group, the median ketamine dose was 15 mg (IQR: 10-20 mg). Hallucinations occurred in 30.0% (23.9% positive, 6.0% negative) and diplopia in 9.2%. Blood pressure changes > 20 mmHg occurred in 10.1% and tachycardia in 8.0%, with no serious adverse events. Overall, 93.2% stated they would accept S-ketamine again.Conclusions: In this prospective observational cohort, low-dose S-ketamine, administered alone or in combination with fentanyl, was associated with effective prehospital analgesia, infrequent and predominantly benign side effects and high patient satisfaction.Funding: None.Trial registration: Not relevant.","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"73 3","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0