Current opinion in lipidology最新文献_第9页

Intracellular lipase and regulation of the lipid droplet. 细胞内脂肪酶和脂滴的调节。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-04-01 Epub Date: 2024-02-15 DOI: 10.1097/MOL.0000000000000918

Ainara G Cabodevilla, Ni Son, Ira J Goldberg

{"title":"Intracellular lipase and regulation of the lipid droplet.","authors":"Ainara G Cabodevilla, Ni Son, Ira J Goldberg","doi":"10.1097/MOL.0000000000000918","DOIUrl":"10.1097/MOL.0000000000000918","url":null,"abstract":"Purpose of review: Lipid droplets are increasingly recognized as distinct intracellular organelles that have functions exclusive to the storage of energetic lipids. Lipid droplets modulate macrophage inflammatory phenotype, control the availability of energy for muscle function, store excess lipid, sequester toxic lipids, modulate mitochondrial activity, and allow transfer of fatty acids between tissues.Recent findings: There have been several major advances in our understanding of the formation, dissolution, and function of this organelle during the past two years. These include new information on movement and partition of amphipathic proteins between the cytosol and lipid droplet surface, molecular determinants of lipid droplet formation, and pathways leading to lipid droplet hydrophobic lipid formation. Rapid advances in mitochondrial biology have also begun to define differences in their function and partnering with lipid droplets to modulate lipid storage versus oxidation.Summary: This relationship of lipid droplets biology and cellular function provides new understanding of an important cellular organelle that influences muscle function, adipose lipid storage, and diseases of lipotoxicity.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":"35 2","pages":"85-92"},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic testing for familial hypercholesterolemia. 家族性高胆固醇血症基因检测。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-04-01 Epub Date: 2024-01-31 DOI: 10.1097/MOL.0000000000000925

Yiyi Zhang, Sarah D de Ferranti, Andrew E Moran

{"title":"Genetic testing for familial hypercholesterolemia.","authors":"Yiyi Zhang, Sarah D de Ferranti, Andrew E Moran","doi":"10.1097/MOL.0000000000000925","DOIUrl":"10.1097/MOL.0000000000000925","url":null,"abstract":"Purpose of review: Despite familial hypercholesterolemia (FH) being the most common genetic cause of cardiovascular disease (CVD), genetic testing is rarely utilized in the US. This review summarizes what is known about the clinical utility of genetic testing and its role in the diagnosis and screening of FH.Recent findings: The presence of an FH-causative variant is associated with a substantially higher risk of CVD, even when low-density lipoprotein cholesterol (LDL-C) levels are only modestly elevated. Genetic testing can facilitate the identification of FH cases who may be missed by clinical diagnostic criteria, improve risk stratification beyond LDL-C and family history, guide treatment decisions, and improve treatment initiation and adherence. Genetic testing can be incorporated into FH screening and diagnosis algorithms, including cascade, targeted, and universal screening. Integrating genetic testing into cascade screening can enhance the effectiveness of the process. Several models of universal FH screening with coordinated genetic and lipid testing are feasible and effective.Summary: More systematic integration of genetic testing into FH diagnosis and screening can significantly reduce the burden of this condition through early detection and treatment. Further pragmatic implementation studies are needed to determine how to more effectively and affordably integrate genetic testing into clinical lipid screening programs.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"93-100"},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel functions of Tribbles-homolog 1 in liver, adipocytes and atherosclerosis. Tribbles-homolog 1 在肝脏、脂肪细胞和动脉粥样硬化中的新功能。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-04-01 Epub Date: 2024-01-17 DOI: 10.1097/MOL.0000000000000917

Ileana Hernandez-Resendiz, Ralph Burkhardt

{"title":"Novel functions of Tribbles-homolog 1 in liver, adipocytes and atherosclerosis.","authors":"Ileana Hernandez-Resendiz, Ralph Burkhardt","doi":"10.1097/MOL.0000000000000917","DOIUrl":"10.1097/MOL.0000000000000917","url":null,"abstract":"Purpose of review: Human genetics studies have sparked great interest in the pseudokinase Tribbles homolog 1, as variant at the TRIB1 gene locus were robustly linked to several cardiometabolic traits, including plasma lipids and coronary artery disease. In this review, we summarize recent findings from mouse models that investigated the function of hepatic and adipocyte Trib1 in lipid metabolism and its role in atherosclerosis.Recent findings: Studies in atherosclerosis prone low-density lipoprotein (LDL)-receptor knockout mice suggested that systemic Trib1 -deficiency promotes atherosclerotic lesion formation through the modulation of plasma lipids and inflammation. Further, investigations in mice with hepatocyte specific deletion of Trib1 identified a novel role in the catabolism of apoB-containing lipoproteins via regulation of the LDL-receptor. Moreover, recent studies on Trib1 in adipocytes uncovered critical functions in adipose tissue biology, including the regulation of plasma lipid and adiponectin levels and the response to β3-adrenergic receptor activation.Summary: Functional studies in mice have expanded our understanding of how Trib1 contributes to various aspects of cardiometabolic diseases. They support the notion that Trib1 exerts tissue-specific effects, which can result in opposing effects on cardiometabolic traits. Additional studies are required to fully elucidate the molecular mechanisms underlying the cellular and systemic effects of Trib1 .","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"51-57"},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139489957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-density lipoprotein functionality, cardiovascular health, and patterns of alcohol consumption: new insights and future perspectives. 高密度脂蛋白功能、心血管健康和饮酒模式：新见解和未来展望。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-10-03 DOI: 10.1097/MOL.0000000000000906

Marta Trius-Soler, Kenneth J Mukamal, Marta Guasch-Ferré

{"title":"High-density lipoprotein functionality, cardiovascular health, and patterns of alcohol consumption: new insights and future perspectives.","authors":"Marta Trius-Soler, Kenneth J Mukamal, Marta Guasch-Ferré","doi":"10.1097/MOL.0000000000000906","DOIUrl":"10.1097/MOL.0000000000000906","url":null,"abstract":"Purpose of review: Cardiovascular diseases (CVD) pose a significant public health challenge, contributing to 422 million disability-adjusted life years in 2021. The role of high-density lipoproteins (HDL) and alcohol consumption, one of their major modifiable determinants, remains controversial. The objective of this review is to provide a comprehensive narrative overview of HDL functionality and its predictive value for CVD in relation to patterns of alcohol consumption.Recent findings: HDL phenotypes beyond HDL-cholesterol (HDL-c) such as distribution of HDL subspecies, HDL particle abundance, and reverse cholesterol transport capacity are promising indicators of atherosclerotic CVD risk. Low-to-moderate alcohol consumption seems to improve HDL functionality and reduce the incidence of CVD among primarily middle-aged men and postmenopausal women. Advancements in our understanding of HDL biogenesis, structure, and function hold promise for improving HDL-related measures and their predictive value for cardiovascular health.Summary: Low-to-moderate alcohol consumption appears to not only increase HDL-c concentration found in the HDL fraction of plasma but also enhance HDL functionality, providing insights into the underlying mechanisms linking alcohol exposure and cardiovascular health benefits. However, rigorous, well designed intervention trials of alcohol consumption on hard cardiovascular outcomes are needed to identify robust causal associations of HDL phenotypes and alcohol consumption with cardiovascular risk.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"25-32"},"PeriodicalIF":4.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41106770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular disease prevention in heterozygous familial hypercholesterolemia: how important is a healthy diet in the era of long-lasting cholesterol-lowering drug therapies? 杂合性家族性高胆固醇血症的心血管疾病预防：在长期降胆固醇药物治疗的时代，健康饮食有多重要？

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-01 DOI: 10.1097/MOL.0000000000000908

Gabrielle Roy, Jean-Philippe Drouin-Chartier

{"title":"Cardiovascular disease prevention in heterozygous familial hypercholesterolemia: how important is a healthy diet in the era of long-lasting cholesterol-lowering drug therapies?","authors":"Gabrielle Roy, Jean-Philippe Drouin-Chartier","doi":"10.1097/MOL.0000000000000908","DOIUrl":"10.1097/MOL.0000000000000908","url":null,"abstract":"Purpose of review: This review aims to provide an in-depth perspective on the importance of diet for cardiovascular disease (CVD) prevention in heterozygous familial hypercholesterolemia (HeFH).Recent findings: Even though data on diet and CVD prevention in HeFH are limited, the currently available evidence supports its cholesterol-lowering effect and its favorable association with CVD risk on the long-term. However, qualitative evidence from individuals with HeFH suggests that there is a common perception that diet is useless compared to medication, and this misconception serves as a barrier to healthy eating. On the other hand, evidence also suggests that individuals with HeFH are at higher risk of eating disorders compared with unaffected individuals. Family history of premature death and the chronic nature of the disease would be in cause.Summary: Emphasizing a healthy diet needs to remain at the foundation of CVD prevention in HeFH. Evidence are limited but supportive of the cholesterol-lowering and cardioprotective potential effects of diet. Engaging in conversations about healthy dieting with individuals in HeFH is likely to help prevent misconceptions about diet. Additionally, it could help reduce the risk of eating disorders, which, altogether, is likely to improve overall CVD prevention.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"1-6"},"PeriodicalIF":4.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipidome and inflammation interplay: the role of diet in this relationship. 脂质和炎症的相互作用：饮食在这种关系中的作用。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-08 DOI: 10.1097/MOL.0000000000000909

Anacristina Rovayo, Estefanía Toledo, Cristina Razquin

{"title":"Lipidome and inflammation interplay: the role of diet in this relationship.","authors":"Anacristina Rovayo, Estefanía Toledo, Cristina Razquin","doi":"10.1097/MOL.0000000000000909","DOIUrl":"10.1097/MOL.0000000000000909","url":null,"abstract":"Purpose of review: The aim of this review was to provide an overview of the role of novel lipid biomarkers from the circulating lipidome in inflammatory processes and the impact that dietary patterns may have on the lipidome.Recent findings: Inflammation is a process that underlies many acute and chronic diseases, contributing to their development and severity. Finding novel molecules which serve as biomarkers and which are involved in inflammation is very useful, since they offer us both preventive or therapeutic targets and reveal mechanisms of action. Recently, several studies have found circulating lipid molecules that are implicated in inflammatory processes of different diseases, such as cardiovascular diseases, type 2 diabetes, COVID-19 or other respiratory infectious diseases. As such, ceramides, triacylglicerides or lysophosphatidylcholines have been associated with inflammation in a different manner depending on the stage of inflammation. The study of dietary patterns, especially healthy ones as the Mediterranean or the Nordic diets, has shown the impact that dietary habits may have on the lipidomic profile of individuals.Conclusions: Healthy dietary patterns have been suggested to exert beneficial effects in the circulating lipid profile. Studying the circulating lipidome could help to find new biomarkers of underlying inflammation, especially in cases of chronic low-grade inflammatory diseases in which it is more difficult to detect.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"20-24"},"PeriodicalIF":4.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary fat, telomere length and cognitive function: unravelling the complex relations. 膳食脂肪、端粒长度与认知功能:揭开复杂关系。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI: 10.1097/MOL.0000000000000900

Hamza Mostafa, Laia Gutierrez-Tordera, Javier Mateu-Fabregat, Christopher Papandreou, Mònica Bulló

{"title":"Dietary fat, telomere length and cognitive function: unravelling the complex relations.","authors":"Hamza Mostafa, Laia Gutierrez-Tordera, Javier Mateu-Fabregat, Christopher Papandreou, Mònica Bulló","doi":"10.1097/MOL.0000000000000900","DOIUrl":"10.1097/MOL.0000000000000900","url":null,"abstract":"Purpose of review: The review aims to explore the recent evidence on the associations between different dietary fat intake and cognitive function, and to understand the role of telomere length in this relationship.Recent findings: Clinical and preclinical studies included in this review suggest that dietary fat intake is associated with cognitive function and telomere length. High intake of saturated fats and trans fats, commonly found in ultra-processed foods, appears to have negative effects on cognitive function and telomere length, while other dietary fats, such as omega-3 polyunsaturated fatty acids and monounsaturated fatty acids are associated with improved cognitive performance and reduced telomere attrition. Controversial results related to omega-6 polyunsaturated fatty acids intake and its impact on cognitive function were found. Dietary fats may affect telomere length and cognition through oxidative stress, inflammation, and insulin resistance.Summary: The current review illustrated the relationship between dietary fat and cognitive function by focusing on the role of telomere length as a potential intermediator. More future studies are required, however, in order to develop targeted interventions aimed at preserving cognitive well-being throughout life.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"33-40"},"PeriodicalIF":4.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating cell-free DNA and its association with cardiovascular disease: what we know and future perspectives. 循环无细胞DNA及其与心血管疾病的关系：我们所知道的和未来的展望。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-10-06 DOI: 10.1097/MOL.0000000000000907

Steffen Ullitz Thorsen, Kristine Frøsig Moseholm, Frederik Banch Clausen

{"title":"Circulating cell-free DNA and its association with cardiovascular disease: what we know and future perspectives.","authors":"Steffen Ullitz Thorsen, Kristine Frøsig Moseholm, Frederik Banch Clausen","doi":"10.1097/MOL.0000000000000907","DOIUrl":"10.1097/MOL.0000000000000907","url":null,"abstract":"Purpose of review: The aim of this review is to explore a possible link between cell-free DNA (cfDNA) and cardiovascular disease (CVD), which may hold valuable potential for future diagnostics.Recent findings: cfDNA has become topic of high interest across several medical fields. cfDNA is used as a diagnostic biomarker in cancer, prenatal care, and transplantation. In addition, cfDNA may play an unrecognized role in biological processes that are involved in or underlying various disease states, for example, inflammation. Elevated levels of cfDNA are associated with various elements of CVD, cardio-metabolic risk factors, and autoimmune diseases. Mitochondrial cfDNA and neutrophil extracellular traps may play distinct roles. Total circulating cfDNA may reflect the unspecific accumulation of stressors and the organism's susceptibility and resilience to such stressors. As such, cfDNA, in a stressful situation, may provide predictive value for future development of CVD. We suggest exploring such possibility through a large-scale prospective cohort study of pregnant women.Summary: There is no doubt that cfDNA is a valuable biomarker. For CVD, its potential is indicated but less explored. New studies may identify cfDNA as a valuable circulating cardiovascular risk marker to help improve risk stratification.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"14-19"},"PeriodicalIF":4.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy, cardiovascular health, and microchimerism. 怀孕、心血管健康和微嵌合。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-20 DOI: 10.1097/MOL.0000000000000914

Sara Hallum Søndergaard, Mads Kamper-Jørgensen

引用次数: 0

Editorial introductions. 编辑介绍。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-12-20 DOI: 10.1097/MOL.0000000000000912

引用次数: 0