Current opinion in lipidology最新文献_第8页

C-reactive protein, pharmacological treatments and diet: how to target your inflammatory burden. C反应蛋白、药物治疗和饮食：如何减轻炎症负担。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-06-01 Epub Date: 2024-01-25 DOI: 10.1097/MOL.0000000000000922

Benjamin Bay, Natalie Arnold, Christoph Waldeyer

{"title":"C-reactive protein, pharmacological treatments and diet: how to target your inflammatory burden.","authors":"Benjamin Bay, Natalie Arnold, Christoph Waldeyer","doi":"10.1097/MOL.0000000000000922","DOIUrl":"10.1097/MOL.0000000000000922","url":null,"abstract":"Purpose of review: This article focuses on pharmacological agents as well as dietary changes aimed at the reduction of the inflammatory burden measured by circulating C-reactive protein concentrations.Recent findings: Over the last years, repurposed as well as new anti-inflammatory agents have been investigated in outcome trials in the cardiovascular field. Currently, a specific inhibition of the inflammatory cascade via the interleukin-6 ligand antibody ziltivekimab is being explored in large-scale outcome trials, after the efficacy of this agent with regard to the reduction of inflammatory biomarkers was proven recently. Next to the investigated pharmacological agents, specific dietary patterns possess the ability to improve the inflammatory burden. This enables patients themselves to unlock a potential health benefit ahead of the initiation of a specific medication targeting the inflammatory pathway.Summary: Both pharmacological agents as well as diet provide the opportunity to improve the inflammatory profile and thereby lower C-reactive protein concentrations. Whilst advances in the field of specific anti-inflammatory treatments have been made over the last years, their broad implementation is currently limited. Therefore, optimization of diet (and other lifestyle factors) could provide a cost effective and side-effect free intervention to target low-grade vascular inflammation.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"141-148"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139562580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid metabolism during pregnancy: consequences for mother and child. 孕期脂质代谢：对母婴的影响。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-06-01 Epub Date: 2024-02-21 DOI: 10.1097/MOL.0000000000000927

Janneke W C M Mulder, D Meeike Kusters, Jeanine E Roeters van Lennep, Barbara A Hutten

{"title":"Lipid metabolism during pregnancy: consequences for mother and child.","authors":"Janneke W C M Mulder, D Meeike Kusters, Jeanine E Roeters van Lennep, Barbara A Hutten","doi":"10.1097/MOL.0000000000000927","DOIUrl":"10.1097/MOL.0000000000000927","url":null,"abstract":"Purpose of review: Accommodating fetal growth and development, women undergo multiple physiological changes during pregnancy. In recent years, several studies contributed to the accumulating evidence about the impact of gestational hyperlipidemia on cardiovascular risk for mother and child. This review aims to provide a comprehensive overview of the current research on lipid profile alterations during pregnancy and its associated (cardiovascular) outcomes for mother and child from a clinical perspective.Recent findings: In a normal pregnancy, total and LDL-cholesterol levels increase by approximately 30-50%, HDL-cholesterol by 20-40%, and triglycerides by 50-100%. In some women, for example, with familial hypercholesterolemia (FH), a more atherogenic lipid profile is observed. Dyslipidemia during pregnancy is found to be associated with adverse (cardiovascular) outcomes for the mother (e.g. preeclampsia, gestational diabetes, metabolic syndrome, unfavorable lipid profile) and for the child (e.g. preterm birth, large for gestational age, preatherosclerotic lesions, unfavorable lipid profile).Summary: The lipid profile of women during pregnancy provides a unique window of opportunity into the potential future cardiovascular risk for mother and child. Better knowledge about adverse outcomes and specific risk groups could lead to better risk assessment and earlier cardiovascular prevention. Future research should investigate implementation of gestational screening possibilities.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"133-140"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11064913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Familial hypercholesterolemia in children and the importance of early treatment. 儿童家族性高胆固醇血症和早期治疗的重要性。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-06-01 Epub Date: 2024-02-14 DOI: 10.1097/MOL.0000000000000926

Sibbeliene E van den Bosch, Barbara A Hutten, Willemijn E Corpeleijn, D Meeike Kusters

引用次数: 0

Basic and translational evidence supporting the role of TM6SF2 in VLDL metabolism. 支持 TM6SF2 在 VLDL 代谢中发挥作用的基础和转化证据。

IF 3.8 3区医学

Current opinion in lipidology Pub Date : 2024-06-01 Epub Date: 2024-03-08 DOI: 10.1097/MOL.0000000000000930

Jing Liu, Henry N Ginsberg, Gissette Reyes-Soffer

{"title":"Basic and translational evidence supporting the role of TM6SF2 in VLDL metabolism.","authors":"Jing Liu, Henry N Ginsberg, Gissette Reyes-Soffer","doi":"10.1097/MOL.0000000000000930","DOIUrl":"10.1097/MOL.0000000000000930","url":null,"abstract":"Purpose of review: Transmembrane 6 superfamily member 2 ( TM6SF2 ) gene was identified through exome-wide studies in 2014. A genetic variant from glutamic acid to lysine substitution at amino acid position 167 (NM_001001524.3:c.499G> A) (p.Gln167Lys/p.E167K, rs58542926) was discovered (p.E167K) to be highly associated with increased hepatic fat content and reduced levels of plasma triglycerides and LDL cholesterol. In this review, we focus on the discovery of TM6SF2 and its role in VLDL secretion pathways. Human data suggest TM6SF2 is linked to hepatic steatosis and cardiovascular disease (CVD), hence understanding its metabolic pathways is of high scientific interest.Recent findings: Since its discovery, completed research studies in cell, rodent and human models have defined the role of TM6SF2 and its links to human disease. TM6SF2 resides in the endoplasmic reticulum (ER) and the ER-Golgi interface and helps with the lipidation of nascent VLDL, the main carrier of triglycerides from the liver to the periphery. Consistent results from cells and rodents indicated that the secretion of triglycerides is reduced in carriers of the p.E167K variant or when hepatic TM6SF2 is deleted. However, data for secretion of APOB, the main protein of VLDL particles responsible for triglycerides transport, are inconsistent.Summary: The identification of genetic variants that are highly associated with human disease presentation should be followed by the validation and investigation into the pathways that regulate disease mechanisms. In this review, we highlight the role of TM6SF2 and its role in processing of liver triglycerides.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"157-161"},"PeriodicalIF":3.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Familial hypercholesterolemia-Plus: is the metabolic syndrome changing the clinical picture of familial hypercholesterolemia? 家族性高胆固醇血症加：代谢综合征是否改变了家族性高胆固醇血症的临床表现？

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-04-22 DOI: 10.1097/mol.0000000000000938

Liam R Brunham

引用次数: 0

APOE and familial hypercholesterolemia. APOE 和家族性高胆固醇血症。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-04-17 DOI: 10.1097/mol.0000000000000937

Fernando Civeira, César Martín, Ana Cenarro

引用次数: 0

Angiopoietin-like protein 8: a multifaceted protein instrumental in regulating triglyceride metabolism. 血管生成素样蛋白8:调节甘油三酯代谢的多方面蛋白。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-04-01 Epub Date: 2023-11-14 DOI: 10.1097/MOL.0000000000000910

Yi Wen, Yan Q Chen, Robert J Konrad

{"title":"Angiopoietin-like protein 8: a multifaceted protein instrumental in regulating triglyceride metabolism.","authors":"Yi Wen, Yan Q Chen, Robert J Konrad","doi":"10.1097/MOL.0000000000000910","DOIUrl":"10.1097/MOL.0000000000000910","url":null,"abstract":"Purpose of review: The angiopoietin-like (ANGPTL) proteins ANGPTL3 and ANGPTL4 are critical lipoprotein lipase (LPL) inhibitors. This review discusses the unique ability of the insulin-responsive protein ANGPTL8 to regulate triglyceride (TG) metabolism by forming ANGPTL3/8 and ANGPTL4/8 complexes that control tissue-specific LPL activities.Recent findings: After feeding, ANGPTL4/8 acts locally in adipose tissue, has decreased LPL-inhibitory activity compared to ANGPTL4, and binds tissue plasminogen activator (tPA) and plasminogen to generate plasmin, which cleaves ANGPTL4/8 and other LPL inhibitors. This enables LPL to be fully active postprandially to promote efficient fatty acid (FA) uptake and minimize ectopic fat deposition. In contrast, liver-derived ANGPTL3/8 acts in an endocrine manner, has markedly increased LPL-inhibitory activity compared to ANGPTL3, and potently inhibits LPL in oxidative tissues to direct TG toward adipose tissue for storage. Circulating ANGPTL3/8 levels are strongly correlated with serum TG, and the ANGPTL3/8 LPL-inhibitory epitope is blocked by the TG-lowering protein apolipoprotein A5 (ApoA5).Summary: ANGPTL8 plays a crucial role in TG metabolism by forming ANGPTL3/8 and ANGPTL4/8 complexes that differentially modulate LPL activities in oxidative and adipose tissues respectively. Selective ANGPTL8 inhibition in the context of the ANGPTL3/8 complex has the potential to be a promising strategy for treating dyslipidemia.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"58-65"},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92153105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction. 编辑介绍。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-04-01 Epub Date: 2024-03-07 DOI: 10.1097/MOL.0000000000000924

引用次数: 0

Editorial introduction. 编辑介绍。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-04-01 Epub Date: 2024-03-07 DOI: 10.1097/MOL.0000000000000924

引用次数: 0

The current state of apolipoprotein E in dyslipidemia. 脂蛋白 E 在血脂异常中的应用现状。

IF 4.6 3区医学

Current opinion in lipidology Pub Date : 2024-04-01 Epub Date: 2023-12-06 DOI: 10.1097/MOL.0000000000000915

Katrine L Rasmussen, Ruth Frikke-Schmidt

{"title":"The current state of apolipoprotein E in dyslipidemia.","authors":"Katrine L Rasmussen, Ruth Frikke-Schmidt","doi":"10.1097/MOL.0000000000000915","DOIUrl":"10.1097/MOL.0000000000000915","url":null,"abstract":"Purpose of review: Apolipoprotein E (apoE) plays a pivotal role in lipid metabolism in the peripheral circulation and in the brain. This has been recognized for decades; however, the importance of the full spectrum of variation in the APOE gene has been less investigated. This review focusses on current progresses in this field with main focus on apoE in dyslipidemia and vascular disease.Recent findings: Whereas ε4 is the risk increasing allele for Alzheimer disease, ε2 is associated with increased risk for age-related macular degeneration. Rare functional ε2-like variants in APOE have previously been reported to have protective associations for Alzheimer disease but recent findings suggest a simultaneous high risk of age-related macular degeneration, in line with observations for the ε2 allele.Summary: ApoE plays an important and well established role in dyslipidemia, vascular disease, and dementia. Recent evidence from large general population studies now also suggests that apoE is involved in age-related macular degeneration. ApoE-targeted therapeutics are being developed for multiple purposes; this heralds a promising change in the approach to disease processes involving apoE. The different risk profile for dementia and age-related macular degeneration should, however, be kept in mind when developing drugs targeting mechanisms resembling these variants.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"78-84"},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138486934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0