Current opinion in lipidology最新文献_第8页

Cardiovascular disease prevention in heterozygous familial hypercholesterolemia: how important is a healthy diet in the era of long-lasting cholesterol-lowering drug therapies? 杂合性家族性高胆固醇血症的心血管疾病预防：在长期降胆固醇药物治疗的时代，健康饮食有多重要？

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-01 DOI: 10.1097/MOL.0000000000000908

Gabrielle Roy, Jean-Philippe Drouin-Chartier

{"title":"Cardiovascular disease prevention in heterozygous familial hypercholesterolemia: how important is a healthy diet in the era of long-lasting cholesterol-lowering drug therapies?","authors":"Gabrielle Roy, Jean-Philippe Drouin-Chartier","doi":"10.1097/MOL.0000000000000908","DOIUrl":"10.1097/MOL.0000000000000908","url":null,"abstract":"Purpose of review: This review aims to provide an in-depth perspective on the importance of diet for cardiovascular disease (CVD) prevention in heterozygous familial hypercholesterolemia (HeFH).Recent findings: Even though data on diet and CVD prevention in HeFH are limited, the currently available evidence supports its cholesterol-lowering effect and its favorable association with CVD risk on the long-term. However, qualitative evidence from individuals with HeFH suggests that there is a common perception that diet is useless compared to medication, and this misconception serves as a barrier to healthy eating. On the other hand, evidence also suggests that individuals with HeFH are at higher risk of eating disorders compared with unaffected individuals. Family history of premature death and the chronic nature of the disease would be in cause.Summary: Emphasizing a healthy diet needs to remain at the foundation of CVD prevention in HeFH. Evidence are limited but supportive of the cholesterol-lowering and cardioprotective potential effects of diet. Engaging in conversations about healthy dieting with individuals in HeFH is likely to help prevent misconceptions about diet. Additionally, it could help reduce the risk of eating disorders, which, altogether, is likely to improve overall CVD prevention.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"1-6"},"PeriodicalIF":4.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipidome and inflammation interplay: the role of diet in this relationship. 脂质和炎症的相互作用：饮食在这种关系中的作用。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-08 DOI: 10.1097/MOL.0000000000000909

Anacristina Rovayo, Estefanía Toledo, Cristina Razquin

{"title":"Lipidome and inflammation interplay: the role of diet in this relationship.","authors":"Anacristina Rovayo, Estefanía Toledo, Cristina Razquin","doi":"10.1097/MOL.0000000000000909","DOIUrl":"10.1097/MOL.0000000000000909","url":null,"abstract":"Purpose of review: The aim of this review was to provide an overview of the role of novel lipid biomarkers from the circulating lipidome in inflammatory processes and the impact that dietary patterns may have on the lipidome.Recent findings: Inflammation is a process that underlies many acute and chronic diseases, contributing to their development and severity. Finding novel molecules which serve as biomarkers and which are involved in inflammation is very useful, since they offer us both preventive or therapeutic targets and reveal mechanisms of action. Recently, several studies have found circulating lipid molecules that are implicated in inflammatory processes of different diseases, such as cardiovascular diseases, type 2 diabetes, COVID-19 or other respiratory infectious diseases. As such, ceramides, triacylglicerides or lysophosphatidylcholines have been associated with inflammation in a different manner depending on the stage of inflammation. The study of dietary patterns, especially healthy ones as the Mediterranean or the Nordic diets, has shown the impact that dietary habits may have on the lipidomic profile of individuals.Conclusions: Healthy dietary patterns have been suggested to exert beneficial effects in the circulating lipid profile. Studying the circulating lipidome could help to find new biomarkers of underlying inflammation, especially in cases of chronic low-grade inflammatory diseases in which it is more difficult to detect.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"20-24"},"PeriodicalIF":4.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary fat, telomere length and cognitive function: unravelling the complex relations. 膳食脂肪、端粒长度与认知功能:揭开复杂关系。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI: 10.1097/MOL.0000000000000900

Hamza Mostafa, Laia Gutierrez-Tordera, Javier Mateu-Fabregat, Christopher Papandreou, Mònica Bulló

{"title":"Dietary fat, telomere length and cognitive function: unravelling the complex relations.","authors":"Hamza Mostafa, Laia Gutierrez-Tordera, Javier Mateu-Fabregat, Christopher Papandreou, Mònica Bulló","doi":"10.1097/MOL.0000000000000900","DOIUrl":"10.1097/MOL.0000000000000900","url":null,"abstract":"Purpose of review: The review aims to explore the recent evidence on the associations between different dietary fat intake and cognitive function, and to understand the role of telomere length in this relationship.Recent findings: Clinical and preclinical studies included in this review suggest that dietary fat intake is associated with cognitive function and telomere length. High intake of saturated fats and trans fats, commonly found in ultra-processed foods, appears to have negative effects on cognitive function and telomere length, while other dietary fats, such as omega-3 polyunsaturated fatty acids and monounsaturated fatty acids are associated with improved cognitive performance and reduced telomere attrition. Controversial results related to omega-6 polyunsaturated fatty acids intake and its impact on cognitive function were found. Dietary fats may affect telomere length and cognition through oxidative stress, inflammation, and insulin resistance.Summary: The current review illustrated the relationship between dietary fat and cognitive function by focusing on the role of telomere length as a potential intermediator. More future studies are required, however, in order to develop targeted interventions aimed at preserving cognitive well-being throughout life.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"33-40"},"PeriodicalIF":4.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy, cardiovascular health, and microchimerism. 怀孕、心血管健康和微嵌合。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-20 DOI: 10.1097/MOL.0000000000000914

Sara Hallum Søndergaard, Mads Kamper-Jørgensen

引用次数: 0

Circulating cell-free DNA and its association with cardiovascular disease: what we know and future perspectives. 循环无细胞DNA及其与心血管疾病的关系：我们所知道的和未来的展望。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-10-06 DOI: 10.1097/MOL.0000000000000907

Steffen Ullitz Thorsen, Kristine Frøsig Moseholm, Frederik Banch Clausen

{"title":"Circulating cell-free DNA and its association with cardiovascular disease: what we know and future perspectives.","authors":"Steffen Ullitz Thorsen, Kristine Frøsig Moseholm, Frederik Banch Clausen","doi":"10.1097/MOL.0000000000000907","DOIUrl":"10.1097/MOL.0000000000000907","url":null,"abstract":"Purpose of review: The aim of this review is to explore a possible link between cell-free DNA (cfDNA) and cardiovascular disease (CVD), which may hold valuable potential for future diagnostics.Recent findings: cfDNA has become topic of high interest across several medical fields. cfDNA is used as a diagnostic biomarker in cancer, prenatal care, and transplantation. In addition, cfDNA may play an unrecognized role in biological processes that are involved in or underlying various disease states, for example, inflammation. Elevated levels of cfDNA are associated with various elements of CVD, cardio-metabolic risk factors, and autoimmune diseases. Mitochondrial cfDNA and neutrophil extracellular traps may play distinct roles. Total circulating cfDNA may reflect the unspecific accumulation of stressors and the organism's susceptibility and resilience to such stressors. As such, cfDNA, in a stressful situation, may provide predictive value for future development of CVD. We suggest exploring such possibility through a large-scale prospective cohort study of pregnant women.Summary: There is no doubt that cfDNA is a valuable biomarker. For CVD, its potential is indicated but less explored. New studies may identify cfDNA as a valuable circulating cardiovascular risk marker to help improve risk stratification.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"14-19"},"PeriodicalIF":4.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introductions. 编辑介绍。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-12-20 DOI: 10.1097/MOL.0000000000000912

引用次数: 0

Genetic variation in apolipoprotein A-V in hypertriglyceridemia. 高甘油三酯血症中载脂蛋白 A-V 的遗传变异。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2023-12-21 DOI: 10.1097/mol.0000000000000916

Shehan D Perera, Robert A Hegele

引用次数: 0

Bempedoic acid: new evidence and recommendations on use. 双鱼藤酸：新证据和使用建议。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2023-12-11 DOI: 10.1097/mol.0000000000000911

Kristina Paponja, Ivan Pećin, Željko Reiner, Maciej Banach

引用次数: 0

Angiopoietin-like 3 inhibition and the liver: less is more? 血管生成素样3抑制与肝脏：少即是多？

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2023-12-01 Epub Date: 2023-10-11 DOI: 10.1097/MOL.0000000000000898

Reindert F Oostveen, G Kees Hovingh, Erik S G Stroes

{"title":"Angiopoietin-like 3 inhibition and the liver: less is more?","authors":"Reindert F Oostveen, G Kees Hovingh, Erik S G Stroes","doi":"10.1097/MOL.0000000000000898","DOIUrl":"10.1097/MOL.0000000000000898","url":null,"abstract":"Purpose of review: The aim of this study was to discuss the potential mechanisms and implications of the opposing liver safety results from recent angiopoietin-like 3 (ANGPTL3) inhibition studies.Recent findings: The clinical development of vupanorsen, a N-acetylgalactosamine (GalNAc) antisense targeting hepatic ANGPTL3, was recently discontinued due to a significant signal of liver transaminase increase. Vupanorsen elicited a dose-dependent increase in hepatic fat fraction up to 75%, whereas the small interfering RNA (siRNA) ARO-ANG3, has reported preliminary evidence of a dose-dependent decrease in hepatic fat fraction up to 30%.Summary: ANGPTL3 inhibition is an attractive therapeutic target to reduce all apoB-containing lipoproteins. The discrepancy in liver signal results between the antisense and siRNA approach may be explained by the level of target inhibition. An alternative explanation may relate to off-target effects of vupanorsen, which have a molecule- and/or platform-specific origin. For intrahepatic strategies, highly potent ANGPTL3 inhibition will for now require special attention for liver safety.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"267-271"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of cardiovascular risk in familial hypercholesterolemia. 家族性高胆固醇血症心血管风险的预测因素。

IF 4.4 3区医学

Current opinion in lipidology Pub Date : 2023-12-01 Epub Date: 2023-09-28 DOI: 10.1097/MOL.0000000000000903

Manuel Jesús Romero-Jiménez, María Elena Mansilla-Rodríguez, Eva Nadiejda Gutiérrez-Cortizo

{"title":"Predictors of cardiovascular risk in familial hypercholesterolemia.","authors":"Manuel Jesús Romero-Jiménez, María Elena Mansilla-Rodríguez, Eva Nadiejda Gutiérrez-Cortizo","doi":"10.1097/MOL.0000000000000903","DOIUrl":"10.1097/MOL.0000000000000903","url":null,"abstract":"Purpose of review: Familial hypercholesterolemia is associated with an increased risk of cardiovascular disease. The current international guidelines of the main scientific societies consider that, all people with Familial Hypercholesterolemia have a high or very high cardiovascular risk. However, the occurrence of atherosclerotic cardiovascular disease is very heterogeneous in this population. Stratifying risk within people with familial hypercholesterolemia is essential to identify individuals who require intensive cholesterol-lowering therapies.Recent findings: In the last year, several studies have been published focusing on the contribution of diabetes to Familial Hypercholesterolemia, the role of stroke, as a manifestation of atherosclerotic disease, and the external validation of the SAFEHEART risk equation in the English population diagnosed with Familial Hypercholesterolemia.Summary: It is necessary the development of a tool that allows us to identify, in a simple, reproducible, and universal way, patients who may have a high risk of suffering a cardiovascular event and who are susceptible to more intensive treatments to reduce cholesterol levels.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"272-277"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0