Pregnancy, cardiovascular health, and microchimerism.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-20 DOI:10.1097/MOL.0000000000000914

Sara Hallum Søndergaard, Mads Kamper-Jørgensen

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引用次数: 0

Abstract

Purpose of review: To provide an updated review of scientific literature concerning associations between pregnancy and cardiovascular health among women, and to discuss a possible impact of microchimerism on the association.

Recent findings: In most studies, pregnancy and childbirth is associated with increased risk of cardiovascular disease in women. Some ascribe the association mainly to lifestyle, whereas others suggest that pregnancy itself negatively affects women's cardiovascular health. Pregnancy is a natural source of microchimerism, which in turn markedly affects female health. The only study published in the area surprisingly shows that among middle-aged women, male-origin microchimerism (MOM) is associated with half the risk of developing ischemic heart disease (IHD). No similar association is found between MOM and ischemic stroke.

Summary: The sparse evidence published suggests reduced risk of developing IHD among MOM-positive women. Despite the association being biologically plausible, replication of the findings is warranted to support that this is not a chance finding.

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怀孕、心血管健康和微嵌合。

综述的目的:提供有关怀孕与女性心血管健康之间关系的科学文献的最新综述，并讨论微嵌合在这种关系中的可能影响。最新发现:在大多数研究中，怀孕和分娩与女性患心血管疾病的风险增加有关。一些人将这种联系主要归因于生活方式，而另一些人则认为怀孕本身会对女性的心血管健康产生负面影响。怀孕是微嵌合的自然来源，这反过来又显著影响女性的健康。在该领域发表的唯一一项令人惊讶的研究表明，在中年妇女中，男性来源的微嵌合(MOM)与患缺血性心脏病(IHD)的风险有一半相关。在MOM和缺血性中风之间没有发现类似的关联。摘要:已发表的少量证据表明，妈妈阳性妇女患IHD的风险降低。尽管这种联系在生物学上是合理的，但研究结果的重复证明，这不是一个偶然的发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.