Dermatologica Sinica最新文献_第3页

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103//DS.V41-1_Editorial

C. Hsu

引用次数: 0

Platelet-rich plasma in the treatment of alopecia areata: A retrospective evaluation of 17 patients 富血小板血浆治疗斑秃:17例患者的回顾性评价

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00205

Yusuf Kelleci, F. Aydın, Gokhan Sahin, E. Yuksel

{"title":"Platelet-rich plasma in the treatment of alopecia areata: A retrospective evaluation of 17 patients","authors":"Yusuf Kelleci, F. Aydın, Gokhan Sahin, E. Yuksel","doi":"10.4103/ds.ds-d-22-00205","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00205","url":null,"abstract":"Background: Alopecia areata (AA) is a disease of unknown etiology which is thought to be autoimmune, that presents challenges in terms of treatment. Platelet-rich plasma (PRP) can induce the development of new hair follicles through various growth factors it contains. PRP could be a treatment option for patients with AA. Objectives: We aim to evaluate the effectiveness and safety of PRP treatment in patients with patch-type AA. Methods: The study included 17 patients diagnosed with patch-type AA who received PRP treatment at least 3 sessions every 4 weeks. Treatment response was evaluated by calculating the severity of alopecia tool (SALT) scores. Results: The mean age of patients was 29.70 ± 10.09, and the mean disease duration was 18.17 ± 39.46 months. The mean SALT score of 17 patients was 6.82 ± 4.96 and 4.35 ± 4.58 before treatment and at the end of the 3rd month, respectively. The reduction in SALT scores was statistically significant (P = 0.01). At the end of the 3rd month, six patients (35.3%) had an excellent response, one patient (5.9%) had a good response, one patient (5.9%) had a partial response, and nine patients (52.9%) showed no response. The mean SALT scores of four patients who received six sessions of PRP of treatment were 6.00 ± 2.94 and 1.75 ± 2.06 at the end of the 6th month. No serious side effects were noted. Relapse was observed in one patient within 1 year of follow-up. Conclusion: As a result of our study, PRP treatment was found to be an effective and reliable treatment method in patients with mild AA.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"85 1","pages":"111 - 115"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77850899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression of acyl-CoA synthetase medium-chain 3 is associated with obesity in melanoma patients and correlates with androgen receptor 酰基辅酶a合成酶中链3的表达与黑色素瘤患者肥胖相关，并与雄激素受体相关

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00141

Yuan Zheng, Pingdong Jiang, Liyin Zhang

{"title":"Expression of acyl-CoA synthetase medium-chain 3 is associated with obesity in melanoma patients and correlates with androgen receptor","authors":"Yuan Zheng, Pingdong Jiang, Liyin Zhang","doi":"10.4103/ds.ds-d-22-00141","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00141","url":null,"abstract":"Background: Malignant melanoma is a typical type of cancer that feature the obesity paradox. Objectives: We aim to evaluate the role of acyl-CoA synthetase medium-chain 3 (ACSM3) in obesity paradox in malignant melanoma (MM). Methods: With reproduction of the Cancer Genome Atlas (TCGA) MM dataset and validation using immunohistochemistry, we evaluated correlations of ACSM3 expression with body mass index (BMI), gender, and androgen receptor (AR) expression. Results: ACSM family genes were downregulated in MM and in normal skin exposed to ultraviolet. Higher expression of ACSM3 was associated with improved overall survival in men but not in women. Subgroup analysis showed the best survival outcome in obese patients with high ACSM3 expression. ACSM3 expression was significantly lower in cases with ulceration. NET-GE-based gene enrichment analysis of ACSM-overexpressed cases showed significant enrichment in lipid metabolism and butanoate metabolism. AR stood as the top possible transcription factor of ACSM3 using multiple algorithms. Expressions of ACSM3 and AR were positively correlated in obese men and overweight women. ACSM3 expression was positively correlated with BMI in men and overweight women. Conclusion: ACSM3 expression is associated with obesity in MM patients and correlates with AR. Functional analysis linking the findings to the obesity paradox warrants further study.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"23 1","pages":"87 - 93"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76551356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of new-onset palmoplantar pustulosis following mRNA COVID-19 vaccination mRNA - COVID-19疫苗接种后新发掌足底脓疱病1例

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-23-00004

Y. Hsu, T. Tsai

引用次数: 1

Giant perforating pilomatricoma: A case report 巨大穿孔性毛囊基质瘤1例

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-23-00001

W. Nho, Junyoung Kim, S. Kee, Dong-Jin Kim, K. Yoon

引用次数: 0

The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma 原发性皮肤黏液癌中赖氨酸27处组蛋白H3三甲基化表达的降低

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.DS-D-22-00103

Shu-Hao Li, C. Chiou, Chien-Chin Chen

{"title":"The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma","authors":"Shu-Hao Li, C. Chiou, Chien-Chin Chen","doi":"10.4103/ds.DS-D-22-00103","DOIUrl":"https://doi.org/10.4103/ds.DS-D-22-00103","url":null,"abstract":"Primary cutaneous mucinous carcinoma (PCMC) is rare, and its carcinogenesis is unclear. Trimethylation of histone H3 at lysine 27 (H3K27me3) is a key regulator in chromatin remodeling-controlled transcription. Focusing on the epigenetic mechanism, we aimed to investigate the expression of H3K27me3 in PCMC by immunohistochemistry. A retrospective cohort of PCMC patients from a tertiary hospital in Taiwan was enrolled to evaluate the clinicopathologic features, treatment outcome, and protein expression. Immunohistochemistry for H3K27me3 was performed on all PCMCs and a comparison group of colonic mucinous adenocarcinoma and pure mucinous carcinoma of the breast. The percentage of H3K27me3-negative tumor cells was calculated and analyzed. Three patients with PCMC were recruited. All PCMCs were solitary and slow growing, arising from the head-and-neck region. All PCMCs had tumor excision without local recurrence or metastasis. The loss of H3K27me3 expression was significant in PCMCs (mean ± standard deviation [SD]: 21.0% ± 6.6%) compared to other mucinous carcinomas (mean ± SD: 3.8% ± 1.7%) (P = 0.019). In conclusion, we report a reduction in H3K27me3 expression in PCMC. In contrast, H3K27me3 expression is retained or mildly reduced in other mucinous carcinomas. This is the first study to indicate a possible role of epigenetic events in the pathobiology of PCMC.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"84 1","pages":"116 - 120"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88495105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

One case of a rare dermatosis: Lichen myxedematosus 罕见皮肤病:黏性水肿地衣1例

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00072

Ayinuer Maimaisawuti, Palida Abulizi

引用次数: 0

Anti-inflammatory effect of hydrogen sulfide donor sodium-sulfide in an experimental mouse model of contact hypersensitivity 硫化氢供体硫化钠对实验性小鼠接触性过敏模型的抗炎作用

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00173

Nermin Ozlen, Deniz Ercetin, M. Sapmaz-Metin, O. Gunduz

{"title":"Anti-inflammatory effect of hydrogen sulfide donor sodium-sulfide in an experimental mouse model of contact hypersensitivity","authors":"Nermin Ozlen, Deniz Ercetin, M. Sapmaz-Metin, O. Gunduz","doi":"10.4103/ds.ds-d-22-00173","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00173","url":null,"abstract":"Background: Hydrogen sulfide (H2S), synthesized by most immune cells, has been shown to exert anti-inflammatory and antipruritic effects. The effect of H2S on allergic contact dermatitis (ACD), an inflammatory skin disease that negatively affects the quality of life, is unknown. Objectives: We planned to investigate the antipruritic and anti-inflammatory effects of the H2S donor sodium sulfide (Na2S) in the experimental mouse model of contact hypersensitivity (CHS), which is widely used for ACD research. Methods: CHS was created in Balb/c mice using 1-fluoro-2, 4-dinitrobenzene. Na2S was administered systemically (0.2-2-20 mg/kg/i.p.) and locally (1-3-10 nmol/both ear/i.d.) at 3 h and 25 h after the challenge. Ear thickness and the number of scratches were determined at 24 h and 48 h following the challenge. Ear tissue and serum interferon-gamma, interleukin (IL)-2, IL-4, and IL-5 cytokine levels were evaluated by enzyme-linked immunosorbent assay (ELISA). H and E staining was performed for histopathological studies. CD4+ and CD8+ T cells located in the skin were examined by immunohistochemical staining. Results: Locally (1-3-10 nmol/ear/i.d., P < 0.001, P < 0.0001, P < 0.0001, respectively) and systemically (2–20 mg/kg/i.p., P < 0.01, P < 0.0001, respectively), Na2S administration decreased ear thickness dose dependently. Local (1-3-10 nmol/ear/i.d.) Na2S treatment decreased serum IL-2 levels (P < 0.01, P < 0.05, and P < 0.01, respectively). Na2S administered locally (3–10 nmol/ear/i.d., P < 0.05) and systemically (20 mg/kg/i. p., P < 0.05) decreased the number of CD4+ T lymphocytes. Conclusion: Locally and systemically administered Na2S reduces ear thickness, which is one of the symptoms of CHS, probably by preventing CD4+ T lymphocyte infiltration and proliferation and decreasing IL-2 synthesis.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"31 1","pages":"94 - 102"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84987251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pemphigus scoring systems and their validation studies – A review of the literature 天疱疮评分系统及其有效性研究-文献综述

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.DS-D-22-00150

Darby Boucher, Anna L. Wilson, Dedee Murrell

引用次数: 1

Transcriptomic profiling and classification of skin melanoma based on ultraviolet response 基于紫外线反应的皮肤黑色素瘤转录组学分析和分类

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00178

Dongxing Xiao, Zhaozhao Guo, Yuzhen Xiong, Xinqiang He, Chong Zhao, N. Tang

{"title":"Transcriptomic profiling and classification of skin melanoma based on ultraviolet response","authors":"Dongxing Xiao, Zhaozhao Guo, Yuzhen Xiong, Xinqiang He, Chong Zhao, N. Tang","doi":"10.4103/ds.ds-d-22-00178","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00178","url":null,"abstract":"Background: We aimed to explore the therapeutic biomarker for cutaneous melanoma (CM). Objectives: The objective is to provide a novel direction for improving overall survival (OS) for CM. Methods: We obtained the gene sets related to ultraviolet (UV) reaction from MsigDB database and CM HTSeq-FPKM data from The Cancer Genome Atlas (TCGA). Gene set variation analysis was used to calculate the enrichment scores in each sample. DAVID and Gene Set Enrichment Analysis (GSEA) were used to explore the function of differentially expressed genes (DEGs) between cluster 1 and cluster 2. The ssGSEA was used to analyze the degree of immune infiltration in samples. Weighted gene co-expression network analysis (WGCNA), protein–protein interaction (PPI) network, and mutation analysis were performed to screen the DEGs related to UV response. Results: The samples were divided into the high activity of UV response (cluster 1) and low activity of UV response (cluster 2). We found that cluster 2 was related to poorer OS and had a higher reaction to UV response. Function analysis indicated that the DEGs are involved in angiogenesis, epidermal development, and inflammatory reaction. Furthermore, the cluster 2 had a higher degree of immune infiltration. The results of WGCNA indicated that the genes in the MEyellow module were highly related to UV response, which is involved in the process of angiogenesis, cell migration, and skin development. PPI and mutation analysis indicated that COL5A1 was the risk factor for CM. Conclusion: COL5A1 might be an important biomarker and potential therapeutic target of CM.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"40 1","pages":"103 - 110"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85745449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0