Dermatologica Sinica最新文献

{"title":"Upadacitinib for the treatment of alopecia areata – A case report","authors":"Jui-Wen Yeh, Chao-Chun Yang","doi":"10.4103/ds.ds-d-23-00110","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00110","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139199777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of thyroid cancer among patients with vitiligo: A systematic review and meta-analysis","authors":"Yi-Rong Li, Ting-An Chang, Jen-Hung Wang, Li-Yu Chen, Jing-Wun Lu, Ching-Hui Loh, Tai-Li Chen","doi":"10.4103/ds.ds-d-23-00089","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00089","url":null,"abstract":"<h3>Background: </h3>\u0000<p>Whether patients with vitiligo have an increased risk of thyroid cancer remained controversial.</p>\u0000<h3>Objectives: </h3>\u0000<p>To study the risk of developing thyroid cancer among vitiligo patients using meta-analysis.</p>\u0000<h3>Methods: </h3>\u0000<p>This meta-analysis was performed via a literature review of four databases (Web of Science, Embase, PubMed, and Cochrane Library) from their respective inception till February 17, 2023. Relevant reviews and the bibliographies of eligible studies were also scrutinized. During searching in databases, no filter was placed regarding the language or geography of the study. Only observational studies presenting with adjusted risk estimates were eligible for meta-analysis. The random-effects model was employed for performing this meta-analysis.</p>\u0000<h3>Results: </h3>\u0000<p>Four studies with 200,629 vitiligo patients and 404,124 nonvitiligo controls were included in this meta-analysis, and patients with vitiligo were found to have an elevated risk of thyroid cancer (pooled relative risk, 1.341; 95% confidence interval, 1.083–1.661).</p>\u0000<h3>Conclusion: </h3>\u0000<p>Our systematic review and meta-analysis found that vitiligo patients are at a slightly elevated risk of thyroid cancer, although the exact underlying mechanisms remain unclear. Even though the evidence is limited, clinicians should not ignore the possible susceptibility of developing thyroid malignancy among vitiligo patients.</p>","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"1 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139070019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment responses of four different biologics in a patient with recurrent generalized pustular psoriasis harboring IL36RN mutation","authors":"Chang-Yu Hsieh, Tsen-Fang Tsai","doi":"10.4103/ds.ds-d-23-00107","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00107","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"32 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139247218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical distribution of basal cell carcinoma and squamous cell carcinoma in the Taiwanese population","authors":"Hsin-Yu Huang, Chao-Chun Yang","doi":"10.4103/ds.ds-d-23-00075","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00075","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"175 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of cyclosporine in the treatment of patients with possible neurogenic rosacea presenting as persistent facial edema with burning sensation: A case series","authors":"I-Heng Chiu, Tsen-Fang Tsai","doi":"10.4103/ds.ds-d-23-00041","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00041","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":" 1273","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135186557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of alprostadil in chilblain lupus erythematosus","authors":"Wei-En Wang, Chung-Hsing Chang","doi":"10.4103/ds.ds-d-23-00065","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00065","url":null,"abstract":"Dear Editor, A 56-year-old woman presented with chronic pain in her digits. She had worked in the seafood frozen-packaging line of a food factory for many years. Physical examination revealed ulcerations on the pulps and knuckles of her digits, with hyperkeratosis and fissures [Figure 1a-d]. No similar lesions on toes were found. The lesions were worsened by exposure to a cold environment. Raynaud’s phenomenon and sclerodactyly were not observed. In addition, a patch of cicatricial alopecia was observed on the vertex of the scalp [Figure 1e]. Discoid lupus erythematosus was confirmed by skin biopsy.Figure 1: (a-d) Erythematous plaques with fissures and ulceration on the fingers and pulps of the digits. (e) A patch of cicatricial alopecia on the vertex of the scalp. (f and g) Bilateral hand magnetic resonance angiography showed patent distal radial arteries, ulnar to interdigital arteries, and postcontrast enhancement of soft tissue swelling over the 1st to 5th digits.Blood tests revealed high titers of anti-Ro/SSA antibodies (50.1 EliA U/mL) and low C4 levels (18.2 mg/dL). However, she tested negative for antinuclear antibodies (ANA), anticardiolipin antibodies, anti-Scl-70 antibodies, and anti-double-stranded DNA antibodies. The cryoglobulin and cold agglutinin tests were negative. A diagnosis of systemic lupus erythematosus (SLE) was not fulfilled. Bilateral hand magnetic resonance angiography showed patent distal radial arteries, ulnar to interdigital arteries, and postcontrast enhancement of soft-tissue swelling over the 1st to 5th digits [Figure 1f and g]. Based on her clinical symptoms and laboratory results, she was diagnosed with chilblain lupus erythematosus (CHLE). The proposed CHLE diagnostic criteria have not yet been validated, although the Mayo Clinic diagnostic criteria proposed by Su et al. include clinical presentation, laboratory findings, and histopathology.[1] She was treated with oral pentoxifylline and nifedipine for 5 months; however, only mild improvement was seen. We further administrated a 10-day regimen of intravenous alprostadil at a dose of 60 µg/day. Significant improvement in the digital ulcers was observed within 2 weeks [Figure 2a]. Laser Doppler flowmetry revealed increased microvascular perfusion in the digits of the left hand at 30°C and 44°C during the 8-week follow-up [Figure 2b].Figure 2: (a) The digital ulcers showed significant improvement within 2 weeks (left hand). (b) Laser Doppler flowmetry revealed an increase in microvascular perfusion in the middle digit of the left hand both at 30°C and 44°C after alprostadil treatment during an 8-week follow-up.CHLE is a rare form of cutaneous lupus erythematosus; based on previous studies, it coexists with SLE in 33%–88% of patients.[2,3] Moreover, SLE developed in these patients before or after the onset of CHLE.[2,3] CHLE lesions initially present as violaceous-erythematous papules and plaques on the toes, fingers, or face, and they worsen during exposure to co","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"116 24","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135136490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of cutaneous nocardiosis successfully treated with third-generation cephalosporin","authors":"Tzu-Yu Liu, Feng-Ling Lin","doi":"10.4103/ds.ds-d-23-00109","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00109","url":null,"abstract":"Dear Editor, Cutaneous nocardiosis is a type of skin and soft-tissue infection caused by Nocardia species, a kind of bacteria isolated from the environment. Sulfamethoxazole is the priority choice of oral medication,[1] but impaired renal function is a concern. Herein, we present a case successfully treated with oral cefixime as an alternative. An 87-year-old man with diabetes mellitus, congestive heart failure, and stage 4 chronic kidney disease (estimated glomerular filtration rate: 28.5 mL/min/1.73 m²) suffered from painful lesions on the face after falling to the ground. Abrasion wound and ecchymosis developed initially, so he was brought to local clinic for management. The patient did not receive systemic immunosuppressant or glucocorticoids, nor was he diagnosed with malignancy or an autoimmune disease. Topical antibiotic was given, and his wound gradually healed. However, pustular eruptions at the trauma site developed 1 week later. Cellulitis was impressed first, so topical fusidic acid cream and oral doxycycline were applied after obtaining the wound culture. The primary wound culture yielded coagulase-negative Staphylococcus epidermidis, which indicated colonization or contamination of the specimen. His symptoms also did not improve after 1-week oral antibiotic treatment. He then came to the dermatology clinic. Physical examination revealed erythematous firm nodules and pustules with erythematous-based patches on the left cheek [Figure 1a]. The patient was afebrile then.Figure 1: Clinical presentation: (a) before treatment: erythematous nodules and pustules on left cheek; (b) after treatment: erythema and pustules on left cheek resolved.Differential diagnoses included bacterial cellulitis, atypical infection (e.g. sporotrichosis, nocardiosis, tuberculosis, nontuberculous mycobacterium, or leishmaniasis), or Majocchi granuloma. He then received skin biopsy with tissue culture. Pathology report revealed suppurative microabscesses with aggregation of histiocytes [Figure 2a]. Immunohistochemistry stain showed negative for Gram’s stain [Figure 2b], periodic acid–Schiff stain [Figure 2c], or acid-fast stain [Figure 2d]. The tissue culture yielded Nocardiabrasiliensis, so cutaneous nocardiosis was diagnosed. The chest X-ray only showed enlarged heart size without increased infiltration or nodule at the lung field. Considering the impaired renal function of the patient, sulfamethoxazole was not given. We prescribed alternative treatment with oral cefixime 100 mg twice a day. After 4-week treatment, the skin lesion of the patient almost resolved [Figure 1b].Figure 2: Histopathological investigation: (a) Histopathology stain of the skin biopsy revealed suppurative microabscesses with aggregation of histiocytes (H and E, ×200); immunohistochemical stain of skin biopsy revealed negative for (b) Gram’s stain (×200), (c) periodic acid–Schiff stain (×200), and (d) acid-fast stain (×200).Cutaneous nocardiosis is skin and soft-tissue infection from a ki","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"51 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135869199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous mucinosis of infancy: A case report","authors":"Q. Luo, Guoying Wang, Qin He, Xiangang Fang","doi":"10.4103/ds.ds-d-23-00018","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00018","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"62 1","pages":"172 - 173"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91306607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab for patients with photoaggravated dermatoses with skin nodules as main manifestations: A case series","authors":"Rui-Xian Ye, X. Tian, Jingyao Liang, Rujun Xue, Qiongxiao Huang, Yimin Liang, YuMei Liu","doi":"10.4103/ds.ds-d-22-00172","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00172","url":null,"abstract":"Photoaggravated dermatoses (PD) are diseases that occur without ultraviolet (UV) radiation but are sometimes or frequently exacerbated by UV radiation. The clinical manifestations of PD are varied, some patients may present with pruritic nodular lesions at the site of light exposure, which possibly through a light-induced type 2 inflammatory response. Some cases may be difficult to treat, safe and effective treatment methods are constantly being explored. Here, we reported five patients with moderate to severe PD with skin nodules as main manifestations successfully treated with dupilumab, who were previously resistant to conventional treatment. After the 16-week treatment period, dupilumab showed good efficacy and safety in PD mainly characterized by nodules.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"1 1","pages":"166 - 169"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76087574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic bullous pemphigoid presented with figurate erythema: A case report and review of literature","authors":"Yu-Hua Lee, Nai-Wen Kang, P. Cheng","doi":"10.4103/ds.ds-d-22-00210","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00210","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"10 1","pages":"170 - 171"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85998076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}