Dermatologica Sinica最新文献

Cutaneous metaplastic synovial cyst in the buttock: A comprehensive analysis of etiologic, clinical, ultrasonic, and pathological aspects 臀部皮肤变性滑膜囊肿：病因、临床、超声波和病理方面的综合分析

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2024-06-27 DOI: 10.4103/ds.ds-d-24-00032

Li-Cheng Tsai, Chih-Jung Hsu

引用次数: 0

Physician visits for psoriasis and reduced risk of adverse pregnancy outcomes: A nationwide study in Taiwan 银屑病就诊与降低不良妊娠结局风险：台湾一项全国性研究

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2024-06-27 DOI: 10.4103/ds.ds-d-23-00163

Li-Ting Kao, Hui-Wen Yang, Yu-Tien Chang, I-Hsun Li, Liang-Hsuan Chen, Ya-Chiao Hu, Yi-Hsien Chen

{"title":"Physician visits for psoriasis and reduced risk of adverse pregnancy outcomes: A nationwide study in Taiwan","authors":"Li-Ting Kao, Hui-Wen Yang, Yu-Tien Chang, I-Hsun Li, Liang-Hsuan Chen, Ya-Chiao Hu, Yi-Hsien Chen","doi":"10.4103/ds.ds-d-23-00163","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00163","url":null,"abstract":"<h3>Background: </h3>\u0000<p>It is unclear whether women with psoriasis who receive adequate management or achieve better control of their psoriasis before and during pregnancy could eliminate the negative effects.</p>\u0000<h3>Objectives: </h3>\u0000<p>The objective of this study was to investigate the association between physician visits for psoriasis and adverse pregnancy outcomes.</p>\u0000<h3>Methods: </h3>\u0000<p>This study used the National Health Insurance database and Birth Certificate Application in Taiwan. This research further categorized the study subjects into mothers with mild/severe psoriasis who visited physicians for psoriasis before delivery, mothers with mild/severe psoriasis who did not visit a physician for psoriasis before delivery, and mothers without psoriasis. Logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the occurrence of adverse pregnancy outcomes, including maternal and neonatal outcomes.</p>\u0000<h3>Results: </h3>\u0000<p>3,339 mothers with severe psoriasis, 41,296 mothers with mild psoriasis, and 2,017,271 mothers without psoriasis were included in this study. The mothers with mild/severe psoriasis demonstrated a significantly higher risk of labor complications and maternal risk factors. After adjusting for confounders, mothers with severe psoriasis who did not visit a physician for psoriasis demonstrated significantly higher odds of labor complications (OR 1.217), maternal risk factors (OR 1.507), having low-birth weight infants (OR 1.236), etc., than mothers without psoriasis.</p>\u0000<h3>Conclusion: </h3>\u0000<p>This study demonstrated that mothers with psoriasis had a higher risk of adverse pregnancy outcomes. In addition, seeking medical care for psoriasis, particularly for women with severe psoriasis, appeared to exert a protective effect against adverse pregnancy outcomes.</p>","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"23 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141546938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fractional CO2 laser as monotherapy or combined with platelet-rich plasma in the treatment of atrophic postacne scars: A narrative review 二氧化碳点阵激光作为单一疗法或结合富血小板血浆治疗萎缩性痤疮后疤痕：综述

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2024-03-29 DOI: 10.4103/ds.ds-d-23-00154

Abeer Attia Tawfik, Mahmoud A. Rageh

{"title":"Fractional CO2 laser as monotherapy or combined with platelet-rich plasma in the treatment of atrophic postacne scars: A narrative review","authors":"Abeer Attia Tawfik, Mahmoud A. Rageh","doi":"10.4103/ds.ds-d-23-00154","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00154","url":null,"abstract":"<p>Acne scars are the unfortunate outcome of acne vulgaris. It is a common problem that faces many young adults and can cause severe distress and impair their quality of life. Different therapeutic modalities have been tried for atrophic acne scars; however, no standard treatment has been identified yet. In this review, we are focusing on fractional CO2 laser (FCL), whether used as monotherapy or combined with platelet-rich plasma (PRP), trying to highlight the efficacy and safety of such modalities in the treatment of atrophic acne scarring. PubMed, Embase, and Cochrane Library databases were used to search for relevant studies that were published in the period from January 2017 to December 2022. We used a combination of the following keywords: “acne scar,” “acne scars,” “modalities for acne scars” in addition to the names of additional therapies studied in this review, such as “laser and acne scars,” “plateletrich plasma,” “platelet-rich plasma,” “PRP,” and “platelet-rich plasma therapy and acne scars”. Twelve studies were found utilizing the use of FCL whether used as monotherapy or combined with PRP in the treatment of atrophic acne scarring. Most of the studies showed that acne scars improved with both treatment modalities, but the combination approach yielded better results with less incidence of side effects.</p>","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"3 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140577694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of adding educational video in patients with atopic dermatitis to facilitate shared decision-making 为特应性皮炎患者添加教育视频以促进共同决策的效果

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2024-03-08 DOI: 10.4103/ds.ds-d-23-00196

Shou-En Wu, Yi-Hsien Chen, Chen-Yeu Soong, Chien-Ping Chiang, Wei-Ming Wang, Chih-Tsung Hung

{"title":"Effectiveness of adding educational video in patients with atopic dermatitis to facilitate shared decision-making","authors":"Shou-En Wu, Yi-Hsien Chen, Chen-Yeu Soong, Chien-Ping Chiang, Wei-Ming Wang, Chih-Tsung Hung","doi":"10.4103/ds.ds-d-23-00196","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00196","url":null,"abstract":"<h3>Background: </h3>\u0000<p>Shared decision-making (SDM) is becoming more popular in various medical specialties as a core component of patient-centered care. However, patients’ lack of sufficient disease knowledge remains a barrier to implementing SDM.</p>\u0000<h3>Objectives: </h3>\u0000<p>This study aims to examine the effectiveness of two educational approaches for atopic dermatitis (AD) patients, a pamphlet and pamphlet plus video, using assessments of knowledge level and satisfaction.</p>\u0000<h3>Methods: </h3>\u0000<p>From August 2021 to February 2023, patients with AD from the dermatology outpatient clinic at Tri-Service General Hospital were included. Educational pamphlets were provided before educational videos, and patients were asked to complete an identical five-question test postpamphlet and postpamphlet plus video, respectively. A questionnaire was used to evaluate patients’ satisfaction. The two test scores were compared, and the satisfaction levels were analyzed.</p>\u0000<h3>Results: </h3>\u0000<p>The mean postpamphlet plus video score (94.84 ± 10.20) was significantly higher than the mean postpamphlet score (77.42 ± 17.17, <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> < 0.001) across 62 eligible samples. Gender and age subgroups showed similar trends. In addition, most patients preferred educational pamphlet plus videos (ranging from 37.5% to 75.0% in different subgroups) compared with educational pamphlets (ranging from 0.0% to 3.85%). The educational pamphlet plus video demonstrated high satisfaction in promoting disease knowledge and treatment options for AD.</p>\u0000<h3>Conclusion: </h3>\u0000<p>Adding educational video is an efficient approach toward reinforcement of patients’ knowledge of AD and further facilitates the implementation of SDM in dermatology practice.</p>","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"59 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140323612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic associations of human leukocyte antigen alleles in cutaneous delayed drug hypersensitivity reactions: An updated review 皮肤迟发性药物超敏反应中人类白细胞抗原等位基因的遗传关联：最新综述

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-12-29 DOI: 10.4103/ds.ds-d-23-00082

Chun-Bing Chen, Chih-Chun Lee, Chuang-Wei Wang, Wei-Kai Hung, Wen-Hung Chung

{"title":"Genetic associations of human leukocyte antigen alleles in cutaneous delayed drug hypersensitivity reactions: An updated review","authors":"Chun-Bing Chen, Chih-Chun Lee, Chuang-Wei Wang, Wei-Kai Hung, Wen-Hung Chung","doi":"10.4103/ds.ds-d-23-00082","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00082","url":null,"abstract":"<p>Cutaneous delayed drug hypersensitivity reactions (DHRs) are common iatrogenic events with potentially life-threatening consequences. Delayed DHRs encompass diverse phenotypes and can be classified by their distinct T-cell responses to drug antigens. Interaction between the immune receptors, human leukocyte antigen (HLA) and T-cell receptor (TCR), and the complementary antigenic peptide is required for the development of delayed DHRs. These idiosyncratic interactions can be elicited by the formation of antigenic drug-protein adducts (hapten hypothesis) or from direct interactions of drugs with the immune receptors (pharmacological interaction of drugs with immune receptors concept, altered peptide repertoire model, and altered TCR model). In addition, viral infections may play a role by providing co-stimulatory signals or enhancing TCR/HLA expression on T-cells. The associations of HLA allele polymorphisms and DHRs are phenotype and ethnicityspecific. The discovery of genetic polymorphisms associated with DHRs has provided a strategy to prevent and diagnose potentially life-threatening reactions. Recently, advances in next-generation sequencing technologies, such as the incorporation of whole-exome or whole-genome sequencing, enabled the comprehensive detection of susceptibility loci. Several HLA associations have shown clinical utility and cost-effectiveness, such as HLA-B*15:02 (carbamazepine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis in Han Chinese), HLA-B*58:01 (allopurinol-induced severe cutaneous adverse reactions in Han Chinese), HLA-B*57:01 (abacavir hypersensitivity reactions in Caucasians), and HLA-B*13:01 (dapsone-induced drug reaction with eosinophilia and systemic symptoms in Han Chinese). Herein, we summarize the current knowledge of the pathogenesis, antigen presentation models, and HLA associations of cutaneous delayed DHRs.</p>","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"1 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139070223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levels of evidence and study designs: A brief introduction to dermato-epidemiologic research methodology 证据等级和研究设计：皮肤流行病学研究方法简介

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-12-15 DOI: 10.4103/ds.ds-d-23-00159

Yen-Ning Chen, Ching-Chi Chi*

引用次数: 0

Membrane-free stem cell components ameliorate atopic dermatitis in 2,4-dinitrochlorobenzene-induced NC/Nga mice 无膜干细胞成分可改善2,4-二硝基氯苯诱导的NC/Nga小鼠的特应性皮炎

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-12-15 DOI: 10.4103/ds.ds-d-23-00070

Nattan Stalin, Dongyup Lee, Amitesh Sharma, Shivani Devi, Jiwon Choi, Yunbhin Hwang, Young Sil Kim, Tae-Sik Park*

{"title":"Membrane-free stem cell components ameliorate atopic dermatitis in 2,4-dinitrochlorobenzene-induced NC/Nga mice","authors":"Nattan Stalin, Dongyup Lee, Amitesh Sharma, Shivani Devi, Jiwon Choi, Yunbhin Hwang, Young Sil Kim, Tae-Sik Park*","doi":"10.4103/ds.ds-d-23-00070","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00070","url":null,"abstract":"\u0000 \u0000 \u0000 Atopic dermatitis (AD) is a prevalent inflammatory skin disorder characterized by skin barrier dysfunction, thymic stromal lymphopoietin (TSLP) production and an imbalance in the Th1/Th2 immune response. While numerous studies have examined the therapeutic potential of adipose-derived stem cells (ADSC) in repairing and regenerating damaged skin tissues caused by AD, the effects of membrane-free stem cell components derived from ADSC extract (ADSCE) on AD have not been investigated.\u0000 \u0000 \u0000 \u0000 The objective of this study was to investigate the alleviating effects of ADSCE on AD in mice and validate the therapeutic application of ADSCE on AD.\u0000 \u0000 \u0000 \u0000 An AD-like lesion was induced by the administration of 2,4-dinitrochlorobenzene (DNCB) on the dorsal skin of NC/Nga mice. Then, ADSCE was administered subcutaneously for 3 weeks. Dermatitis score, epidermal thickness, transepidermal water loss (TEWL), and serum levels of immunoglobulin E (IgE) were measured. Expression of the skin barrier proteins and inflammatory cytokines were measured by western blotting and quantitative real-time polymerase chain reaction.\u0000 \u0000 \u0000 \u0000 The administration of ADSCE demonstrated a significant amelioration in several skin diseases, as indicated by improvements in dermatitis score, epidermal thickness, TEWL, and total blood levels of IgE. ADSCE treatment led to an upregulation in the expression of various skin barrier proteins, including involucrin, loricrin, occludin, and zonula occludens-1. In addition, ADSCE inhibited the infiltration of mast cells and the expression of TSLP. Expression of inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1 β, IL-4, and inducible nitric oxide synthase, was also lowered by ADSCE.\u0000 \u0000 \u0000 \u0000 The use of ADSCE resulted in enhanced skin features and exerted anti-inflammatory properties on AD-like lesions in mice.\u0000","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"309 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A young woman with generalized pustular psoriasis and synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated successfully with upadacitinib 一名患有全身脓疱型银屑病和滑膜炎、痤疮、脓疱病、骨质增生和骨炎综合征的年轻女性，使用达达替尼治疗获得成功

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-12-15 DOI: 10.4103/ds.ds-d-23-00156

M. Ma, Tangliang Qian, Chen Li*

引用次数: 0

Hand eczema and its severity in nonmedical personnel: A study of the use of hand sanitizer on transepidermal water loss and skin capacitance 非医务人员的手部湿疹及其严重程度：使用洗手液对经表皮失水和皮肤电容的影响研究

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-12-15 DOI: 10.4103/ds.ds-d-23-00143

Caroline Oktarina, R. Astriningrum, Aida S. D. Hoemardani, W. Budianti, Sandra Widaty, Dewi Friska

{"title":"Hand eczema and its severity in nonmedical personnel: A study of the use of hand sanitizer on transepidermal water loss and skin capacitance","authors":"Caroline Oktarina, R. Astriningrum, Aida S. D. Hoemardani, W. Budianti, Sandra Widaty, Dewi Friska","doi":"10.4103/ds.ds-d-23-00143","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00143","url":null,"abstract":"\u0000 \u0000 \u0000 An increased frequency of hand sanitizer use and washing hands with soap seems to increase the incidence of hand eczema (HE).\u0000 \u0000 \u0000 \u0000 The aim was to analyze HE in nonmedical personnel, its severity, and the effect of hand sanitizer use on transepidermal water loss (TEWL) and skin capacitance.\u0000 \u0000 \u0000 \u0000 This observational cross-sectional study was conducted from July to September 2022. Subjects were recruited based on the study criteria with cluster random sampling method. Each subject’s identity, data related to hand sanitizer use and handwashing, atopic stigmata, and duration of HE were documented. The severity of HE was assessed with the HE Severity Index (HECSI). TEWL and skin capacitance were measured with the Tewameter® TM 300 and Corneometer® CM 825 instruments.\u0000 \u0000 \u0000 \u0000 Out of 240 subjects who were selected randomly, 24 normal subjects and 24 subjects with HE were recruited. The incidence of HE in nonmedical personnel using hand sanitizer was 10%, with a median disease duration of 22 weeks and a mean HECSI score of 9.25 ± 6.33. There was no significant difference in TEWL and skin capacitance between the groups (P > 0.05). There was no significant correlation between TEWL and skin capacitance with the HECSI score (P > 0.05). Subjects with HE washed their hands more frequently than subjects without HE (6 vs. 4.5 times per day; P 0.005).\u0000 \u0000 \u0000 \u0000 Most nonmedical personnel with HE had a mild form of the condition. There were no significant barrier function and skin hydration differences between the groups.\u0000","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"103 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosacea understanding among Korean patients: A multi-center questionnaire study 韩国患者对红斑痤疮的了解：多中心问卷调查研究

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-12-07 DOI: 10.4103/ds.ds-d-23-00145

Yukari Woo, Suyeun Kim, Sang Hyun Cho, Hei Sung Kim

{"title":"Rosacea understanding among Korean patients: A multi-center questionnaire study","authors":"Yukari Woo, Suyeun Kim, Sang Hyun Cho, Hei Sung Kim","doi":"10.4103/ds.ds-d-23-00145","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00145","url":null,"abstract":"\u0000 \u0000 \u0000 Rosacea is a common chronic skin condition. To manage rosacea long-term and prevent further flare-ups, patients need to be aware of the disease and have sound knowledge of the condition. However, few related studies have been conducted on this subject.\u0000 \u0000 \u0000 \u0000 The aim of this study was to identify rosacea awareness and knowledge among Korean rosacea patients and their means of gathering information on the disease.\u0000 \u0000 \u0000 \u0000 A prospective multicenter cross-sectional study recruited a total of 201 outpatients who were diagnosed with rosacea by a dermatologist. All were asked to complete a questionnaire asking about their demographic characteristics, rosacea awareness, and knowledge.\u0000 \u0000 \u0000 \u0000 Among 201 rosacea patients, 146 (72.6%) were unaware of the disease before their diagnosis. The median number of questions the patients correctly answered was 6 of a total of 13 questions (46%) on rosacea knowledge, implying relatively shallow knowledge on rosacea. Better understanding of rosacea was negatively associated with age (odds ratio [OR] 0.965; 95% confidence interval [CI]: 0.941 – 0.989) and positively associated with a higher education level (OR = 2.896; 95% CI: 1.379–6.082). Individuals with rosacea felt that they were getting reliable information from doctors (n = 189, 94%), followed by the Internet (n = 38, 18.9%).\u0000 \u0000 \u0000 \u0000 Overall, rosacea awareness and knowledge among Korean rosacea patients were relatively low. Detailed education, especially targeting elderly patients and those with low education levels, is necessary for better disease outcomes.\u0000","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"84 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0