杜匹单抗用于以皮肤结节为主要表现的光加重性皮肤病患者:一个病例系列

IF 2.3 4区医学 Q2 DERMATOLOGY

Dermatologica Sinica Pub Date : 2023-07-01 DOI:10.4103/ds.ds-d-22-00172

Rui-Xian Ye, X. Tian, Jingyao Liang, Rujun Xue, Qiongxiao Huang, Yimin Liang, YuMei Liu

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引用次数: 1

摘要

光加重性皮肤病(PD)是一种在没有紫外线照射的情况下发生的疾病，但有时或经常因紫外线照射而加重。PD的临床表现多种多样，部分患者可能在光照部位出现瘙痒性结节状病变，这可能是光诱导的2型炎症反应。有些病例可能难以治疗，人们正在不断探索安全有效的治疗方法。在这里，我们报告了5例以皮肤结节为主要表现的中重度PD患者，他们以前对常规治疗有耐药性，但杜匹单抗治疗成功。经过16周的治疗期，dupilumab在以结节为主的PD中显示出良好的疗效和安全性。

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Dupilumab for patients with photoaggravated dermatoses with skin nodules as main manifestations: A case series

Photoaggravated dermatoses (PD) are diseases that occur without ultraviolet (UV) radiation but are sometimes or frequently exacerbated by UV radiation. The clinical manifestations of PD are varied, some patients may present with pruritic nodular lesions at the site of light exposure, which possibly through a light-induced type 2 inflammatory response. Some cases may be difficult to treat, safe and effective treatment methods are constantly being explored. Here, we reported five patients with moderate to severe PD with skin nodules as main manifestations successfully treated with dupilumab, who were previously resistant to conventional treatment. After the 16-week treatment period, dupilumab showed good efficacy and safety in PD mainly characterized by nodules.

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来源期刊

Dermatologica Sinica DERMATOLOGY-

CiteScore

2.80

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating dermatological-related medical science knowledge to improve global health. Articles on clinical, laboratory, educational, and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, brief reports, case reports and correspondence are accepted.