酰基辅酶a合成酶中链3的表达与黑色素瘤患者肥胖相关,并与雄激素受体相关

IF 2.3 4区 医学 Q2 DERMATOLOGY
Yuan Zheng, Pingdong Jiang, Liyin Zhang
{"title":"酰基辅酶a合成酶中链3的表达与黑色素瘤患者肥胖相关,并与雄激素受体相关","authors":"Yuan Zheng, Pingdong Jiang, Liyin Zhang","doi":"10.4103/ds.ds-d-22-00141","DOIUrl":null,"url":null,"abstract":"Background: Malignant melanoma is a typical type of cancer that feature the obesity paradox. Objectives: We aim to evaluate the role of acyl-CoA synthetase medium-chain 3 (ACSM3) in obesity paradox in malignant melanoma (MM). Methods: With reproduction of the Cancer Genome Atlas (TCGA) MM dataset and validation using immunohistochemistry, we evaluated correlations of ACSM3 expression with body mass index (BMI), gender, and androgen receptor (AR) expression. Results: ACSM family genes were downregulated in MM and in normal skin exposed to ultraviolet. Higher expression of ACSM3 was associated with improved overall survival in men but not in women. Subgroup analysis showed the best survival outcome in obese patients with high ACSM3 expression. ACSM3 expression was significantly lower in cases with ulceration. NET-GE-based gene enrichment analysis of ACSM-overexpressed cases showed significant enrichment in lipid metabolism and butanoate metabolism. AR stood as the top possible transcription factor of ACSM3 using multiple algorithms. Expressions of ACSM3 and AR were positively correlated in obese men and overweight women. ACSM3 expression was positively correlated with BMI in men and overweight women. Conclusion: ACSM3 expression is associated with obesity in MM patients and correlates with AR. Functional analysis linking the findings to the obesity paradox warrants further study.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"23 1","pages":"87 - 93"},"PeriodicalIF":2.3000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expression of acyl-CoA synthetase medium-chain 3 is associated with obesity in melanoma patients and correlates with androgen receptor\",\"authors\":\"Yuan Zheng, Pingdong Jiang, Liyin Zhang\",\"doi\":\"10.4103/ds.ds-d-22-00141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Malignant melanoma is a typical type of cancer that feature the obesity paradox. Objectives: We aim to evaluate the role of acyl-CoA synthetase medium-chain 3 (ACSM3) in obesity paradox in malignant melanoma (MM). Methods: With reproduction of the Cancer Genome Atlas (TCGA) MM dataset and validation using immunohistochemistry, we evaluated correlations of ACSM3 expression with body mass index (BMI), gender, and androgen receptor (AR) expression. Results: ACSM family genes were downregulated in MM and in normal skin exposed to ultraviolet. Higher expression of ACSM3 was associated with improved overall survival in men but not in women. Subgroup analysis showed the best survival outcome in obese patients with high ACSM3 expression. ACSM3 expression was significantly lower in cases with ulceration. NET-GE-based gene enrichment analysis of ACSM-overexpressed cases showed significant enrichment in lipid metabolism and butanoate metabolism. AR stood as the top possible transcription factor of ACSM3 using multiple algorithms. Expressions of ACSM3 and AR were positively correlated in obese men and overweight women. ACSM3 expression was positively correlated with BMI in men and overweight women. Conclusion: ACSM3 expression is associated with obesity in MM patients and correlates with AR. Functional analysis linking the findings to the obesity paradox warrants further study.\",\"PeriodicalId\":11107,\"journal\":{\"name\":\"Dermatologica Sinica\",\"volume\":\"23 1\",\"pages\":\"87 - 93\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatologica Sinica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/ds.ds-d-22-00141\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatologica Sinica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/ds.ds-d-22-00141","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:恶性黑色素瘤是一种典型的以肥胖悖论为特征的癌症。目的:探讨酰基辅酶a合成酶中链3 (ACSM3)在恶性黑色素瘤(MM)肥胖悖论中的作用。方法:通过复制癌症基因组图谱(TCGA) MM数据集并使用免疫组织化学进行验证,我们评估了ACSM3表达与体重指数(BMI)、性别和雄激素受体(AR)表达的相关性。结果:ACSM家族基因在MM和正常皮肤暴露于紫外线下均下调。在男性中,ACSM3的高表达与总生存率的提高有关,而在女性中则无关。亚组分析显示,ACSM3高表达的肥胖患者生存率最高。溃疡组ACSM3表达明显降低。基于net - ge的基因富集分析显示,acsm过表达病例的脂质代谢和丁酸盐代谢显著富集。在多种算法下,AR被认为是ACSM3最可能的转录因子。在肥胖男性和超重女性中,ACSM3和AR的表达呈正相关。在男性和超重女性中,ACSM3的表达与BMI呈正相关。结论:ACSM3的表达与MM患者的肥胖相关,并与AR相关。将该发现与肥胖悖论联系起来的功能分析值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression of acyl-CoA synthetase medium-chain 3 is associated with obesity in melanoma patients and correlates with androgen receptor
Background: Malignant melanoma is a typical type of cancer that feature the obesity paradox. Objectives: We aim to evaluate the role of acyl-CoA synthetase medium-chain 3 (ACSM3) in obesity paradox in malignant melanoma (MM). Methods: With reproduction of the Cancer Genome Atlas (TCGA) MM dataset and validation using immunohistochemistry, we evaluated correlations of ACSM3 expression with body mass index (BMI), gender, and androgen receptor (AR) expression. Results: ACSM family genes were downregulated in MM and in normal skin exposed to ultraviolet. Higher expression of ACSM3 was associated with improved overall survival in men but not in women. Subgroup analysis showed the best survival outcome in obese patients with high ACSM3 expression. ACSM3 expression was significantly lower in cases with ulceration. NET-GE-based gene enrichment analysis of ACSM-overexpressed cases showed significant enrichment in lipid metabolism and butanoate metabolism. AR stood as the top possible transcription factor of ACSM3 using multiple algorithms. Expressions of ACSM3 and AR were positively correlated in obese men and overweight women. ACSM3 expression was positively correlated with BMI in men and overweight women. Conclusion: ACSM3 expression is associated with obesity in MM patients and correlates with AR. Functional analysis linking the findings to the obesity paradox warrants further study.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Dermatologica Sinica
Dermatologica Sinica DERMATOLOGY-
CiteScore
2.80
自引率
20.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating dermatological-related medical science knowledge to improve global health. Articles on clinical, laboratory, educational, and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, brief reports, case reports and correspondence are accepted.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信