Dermatologica Sinica最新文献_第4页

A case of new-onset palmoplantar pustulosis following mRNA COVID-19 vaccination mRNA - COVID-19疫苗接种后新发掌足底脓疱病1例

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-23-00004

Y. Hsu, T. Tsai

引用次数: 1

The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma 原发性皮肤黏液癌中赖氨酸27处组蛋白H3三甲基化表达的降低

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.DS-D-22-00103

Shu-Hao Li, C. Chiou, Chien-Chin Chen

{"title":"The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma","authors":"Shu-Hao Li, C. Chiou, Chien-Chin Chen","doi":"10.4103/ds.DS-D-22-00103","DOIUrl":"https://doi.org/10.4103/ds.DS-D-22-00103","url":null,"abstract":"Primary cutaneous mucinous carcinoma (PCMC) is rare, and its carcinogenesis is unclear. Trimethylation of histone H3 at lysine 27 (H3K27me3) is a key regulator in chromatin remodeling-controlled transcription. Focusing on the epigenetic mechanism, we aimed to investigate the expression of H3K27me3 in PCMC by immunohistochemistry. A retrospective cohort of PCMC patients from a tertiary hospital in Taiwan was enrolled to evaluate the clinicopathologic features, treatment outcome, and protein expression. Immunohistochemistry for H3K27me3 was performed on all PCMCs and a comparison group of colonic mucinous adenocarcinoma and pure mucinous carcinoma of the breast. The percentage of H3K27me3-negative tumor cells was calculated and analyzed. Three patients with PCMC were recruited. All PCMCs were solitary and slow growing, arising from the head-and-neck region. All PCMCs had tumor excision without local recurrence or metastasis. The loss of H3K27me3 expression was significant in PCMCs (mean ± standard deviation [SD]: 21.0% ± 6.6%) compared to other mucinous carcinomas (mean ± SD: 3.8% ± 1.7%) (P = 0.019). In conclusion, we report a reduction in H3K27me3 expression in PCMC. In contrast, H3K27me3 expression is retained or mildly reduced in other mucinous carcinomas. This is the first study to indicate a possible role of epigenetic events in the pathobiology of PCMC.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88495105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

One case of a rare dermatosis: Lichen myxedematosus 罕见皮肤病:黏性水肿地衣1例

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00072

Ayinuer Maimaisawuti, Palida Abulizi

引用次数: 0

Anti-inflammatory effect of hydrogen sulfide donor sodium-sulfide in an experimental mouse model of contact hypersensitivity 硫化氢供体硫化钠对实验性小鼠接触性过敏模型的抗炎作用

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00173

Nermin Ozlen, Deniz Ercetin, M. Sapmaz-Metin, O. Gunduz

{"title":"Anti-inflammatory effect of hydrogen sulfide donor sodium-sulfide in an experimental mouse model of contact hypersensitivity","authors":"Nermin Ozlen, Deniz Ercetin, M. Sapmaz-Metin, O. Gunduz","doi":"10.4103/ds.ds-d-22-00173","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00173","url":null,"abstract":"Background: Hydrogen sulfide (H2S), synthesized by most immune cells, has been shown to exert anti-inflammatory and antipruritic effects. The effect of H2S on allergic contact dermatitis (ACD), an inflammatory skin disease that negatively affects the quality of life, is unknown. Objectives: We planned to investigate the antipruritic and anti-inflammatory effects of the H2S donor sodium sulfide (Na2S) in the experimental mouse model of contact hypersensitivity (CHS), which is widely used for ACD research. Methods: CHS was created in Balb/c mice using 1-fluoro-2, 4-dinitrobenzene. Na2S was administered systemically (0.2-2-20 mg/kg/i.p.) and locally (1-3-10 nmol/both ear/i.d.) at 3 h and 25 h after the challenge. Ear thickness and the number of scratches were determined at 24 h and 48 h following the challenge. Ear tissue and serum interferon-gamma, interleukin (IL)-2, IL-4, and IL-5 cytokine levels were evaluated by enzyme-linked immunosorbent assay (ELISA). H and E staining was performed for histopathological studies. CD4+ and CD8+ T cells located in the skin were examined by immunohistochemical staining. Results: Locally (1-3-10 nmol/ear/i.d., P < 0.001, P < 0.0001, P < 0.0001, respectively) and systemically (2–20 mg/kg/i.p., P < 0.01, P < 0.0001, respectively), Na2S administration decreased ear thickness dose dependently. Local (1-3-10 nmol/ear/i.d.) Na2S treatment decreased serum IL-2 levels (P < 0.01, P < 0.05, and P < 0.01, respectively). Na2S administered locally (3–10 nmol/ear/i.d., P < 0.05) and systemically (20 mg/kg/i. p., P < 0.05) decreased the number of CD4+ T lymphocytes. Conclusion: Locally and systemically administered Na2S reduces ear thickness, which is one of the symptoms of CHS, probably by preventing CD4+ T lymphocyte infiltration and proliferation and decreasing IL-2 synthesis.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84987251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pemphigus scoring systems and their validation studies – A review of the literature 天疱疮评分系统及其有效性研究-文献综述

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.DS-D-22-00150

Darby Boucher, Anna L. Wilson, Dedee Murrell

引用次数: 1

Current understanding and treatment of sex hormone-related hair diseases 目前对性激素相关毛发疾病的认识和治疗

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.DS-D-22-00162

T. Hsieh, Ling-Ying Tsai, Ming-Ying Wu, Sung-Jan Lin

引用次数: 1

Subcutaneous panniculitis-like T-cell lymphoma and steroid-induced depression successfully treated with prednisolone and cyclosporine 强的松龙和环孢素成功治疗了皮下泛膜炎样t细胞淋巴瘤和类固醇诱导的抑郁症

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00186

Tomoko Oshimo, Ayaki Matsumoto, Hitomi Kaiami, D. Matsumoto, J. Barit, D. Tsuruta

引用次数: 0

Botulinum toxin type A therapy for hidradenitis suppurativa: A case series A型肉毒杆菌毒素治疗化脓性汗腺炎:一个病例系列

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00198

D. Kadylak, W. Barańska-Rybak

引用次数: 0

Transcriptomic profiling and classification of skin melanoma based on ultraviolet response 基于紫外线反应的皮肤黑色素瘤转录组学分析和分类

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-04-01 DOI: 10.4103/ds.ds-d-22-00178

Dongxing Xiao, Zhaozhao Guo, Yuzhen Xiong, Xinqiang He, Chong Zhao, N. Tang

{"title":"Transcriptomic profiling and classification of skin melanoma based on ultraviolet response","authors":"Dongxing Xiao, Zhaozhao Guo, Yuzhen Xiong, Xinqiang He, Chong Zhao, N. Tang","doi":"10.4103/ds.ds-d-22-00178","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00178","url":null,"abstract":"Background: We aimed to explore the therapeutic biomarker for cutaneous melanoma (CM). Objectives: The objective is to provide a novel direction for improving overall survival (OS) for CM. Methods: We obtained the gene sets related to ultraviolet (UV) reaction from MsigDB database and CM HTSeq-FPKM data from The Cancer Genome Atlas (TCGA). Gene set variation analysis was used to calculate the enrichment scores in each sample. DAVID and Gene Set Enrichment Analysis (GSEA) were used to explore the function of differentially expressed genes (DEGs) between cluster 1 and cluster 2. The ssGSEA was used to analyze the degree of immune infiltration in samples. Weighted gene co-expression network analysis (WGCNA), protein–protein interaction (PPI) network, and mutation analysis were performed to screen the DEGs related to UV response. Results: The samples were divided into the high activity of UV response (cluster 1) and low activity of UV response (cluster 2). We found that cluster 2 was related to poorer OS and had a higher reaction to UV response. Function analysis indicated that the DEGs are involved in angiogenesis, epidermal development, and inflammatory reaction. Furthermore, the cluster 2 had a higher degree of immune infiltration. The results of WGCNA indicated that the genes in the MEyellow module were highly related to UV response, which is involved in the process of angiogenesis, cell migration, and skin development. PPI and mutation analysis indicated that COL5A1 was the risk factor for CM. Conclusion: COL5A1 might be an important biomarker and potential therapeutic target of CM.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85745449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bullous vasculitis following COVID-19 vaccination COVID-19疫苗接种后的大疱性血管炎

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00085

Chao-Kuei Juan, Y. Chiu, C. Yen

引用次数: 1