目前对性激素相关毛发疾病的认识和治疗

IF 2.3 4区医学 Q2 DERMATOLOGY

Dermatologica Sinica Pub Date : 2023-04-01 DOI:10.4103/ds.DS-D-22-00162

T. Hsieh, Ling-Ying Tsai, Ming-Ying Wu, Sung-Jan Lin

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引用次数: 1

摘要

毛囊(HF)的生长受局部和全身环境的调节。性激素是一种全身性因素，它矛盾地促进和抑制身体不同部位的毛发生长，导致多毛症、雄激素性脱发和女性型脱发等疾病。在过去的几十年里，性激素相关的头发疾病的治疗取得了进展，但其中一些疾病的发病机制仍然不清楚，甚至存在争议。我们回顾了主要性激素对头发生长的生物学作用，并总结了它们已知的影响。我们讨论了动物和人类HFs对性激素的不同反应，总结了性激素相关毛发疾病的发病机制，并强调了这些疾病目前治疗的益处和争议。最后，我们讨论了性激素与免疫系统的相互作用以及表观遗传学在这些头发疾病中的可能作用等未来的研究方向。

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Current understanding and treatment of sex hormone-related hair diseases

Hair follicle (HF) growth is regulated by local and systemic environments. Sex hormones, a systemic factor, paradoxically promote and suppress hair growth in different sites of the body, leading to diseases such as hirsutism, androgenetic alopecia, and female pattern hair loss. The past decades have seen progress in the treatment of sex hormone-related hair diseases, but the pathogenesis of some of these diseases remains obscure and even controversial. We review the biological effects of major sex hormones on hair growth and summarize their known impacts. We discuss the different responses of animal and human HFs to sex hormones, summarize the pathogenesis of sex hormone-related hair diseases, and highlight the benefits of and controversies in the current management of these diseases. Finally, we discuss future research directions such as interactions between sex hormones and the immune system and the possible role of epigenetics in these hair disorders.

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来源期刊

Dermatologica Sinica DERMATOLOGY-

CiteScore

2.80

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating dermatological-related medical science knowledge to improve global health. Articles on clinical, laboratory, educational, and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, brief reports, case reports and correspondence are accepted.