Current topics in microbiology and immunology最新文献_第2页

Gastric Carcinoma. 胃癌。

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-28 DOI: 10.1007/82_2025_303

Young-Sik Kim

{"title":"Gastric Carcinoma.","authors":"Young-Sik Kim","doi":"10.1007/82_2025_303","DOIUrl":"https://doi.org/10.1007/82_2025_303","url":null,"abstract":"Epstein-Barr virus (EBV)-associated gastric cancers (EBVaGCs) account for about 10% of gastric cancers globally, with higher prevalence in East Asia and Latin America. These cancers develop through a \"gastritis-infection-cancer sequence\" and are characterized by unique molecular signatures, including CpG island methylator phenotype and mutations in ARID1A and PIK3CA genes. EBVaGCs typically present in the proximal stomach with diffuse-type histology and dense lymphocytic infiltration. Key viral proteins EBNA1 and LMP2A drive oncogenesis by altering cellular processes and immune responses. The IFN-γ signature and extensive epigenetic modifications contribute to their distinct profile. Despite often presenting at advanced stages, EBVaGCs generally have a more favorable prognosis. EBV employs sophisticated strategies to evade immune detection, utilizing latent proteins and noncoding RNAs. Paradoxically, despite an immune-hot environment, EBVaGCs demonstrate effective immune evasion, partly due to the expression of immune checkpoint molecules like PD-L1 and LAG3. Treatment approaches vary based on disease stage, from endoscopic resection for early-stage cancers to systemic therapies for advanced cases. Immunotherapy, particularly PD-1/PD-L1 inhibitors, shows promising results. Emerging research suggests combining these with LAG3 inhibitors may enhance efficacy. Ongoing research and advanced genomic techniques continue to reveal new insights, paving the way for personalized therapies and novel diagnostic approaches.","PeriodicalId":11102,"journal":{"name":"Current topics in microbiology and immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of EBV in the Pathogenesis of Diffuse Large B-Cell Lymphoma. EBV在弥漫性大b细胞淋巴瘤发病中的作用。

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-22 DOI: 10.1007/82_2025_296

Niklas Gebauer, Sophia S Wang

引用次数: 0

EBV: The Viral Genome. EBV：病毒基因组

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-22 DOI: 10.1007/82_2025_298

Paul J Farrell

引用次数: 0

EBNA1.

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-22 DOI: 10.1007/82_2025_299

Lori Frappier

引用次数: 0

Innate Immune Recognition of EBV. EBV的先天免疫识别。

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-22 DOI: 10.1007/82_2025_297

Jessica Stewart, Blossom Damania

引用次数: 0

Horizons of the Future: Preparedness and Response. 未来的视野：准备和应对。

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-21 DOI: 10.1007/82_2025_292

Luísa Maria Inácio da Silva, Rafael Maciel-de-Freitas, Marcelo Henrique Santos Paiva, Gabriel da Luz Wallau

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Viral Entry. 病毒进入。

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-15 DOI: 10.1007/82_2025_300

Samantha Hardy, Crystal B Chhan, Amelia R Davis, Andrew T McGuire

引用次数: 0

Dengue Dilemma: Navigating Cross-Reactivity and Immune Challenges. 登革热困境：导航交叉反应性和免疫挑战。

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-14 DOI: 10.1007/82_2025_294

Cristina R de Barros Cardoso, Thiago Cerqueira-Silva, Manoel Barral-Netto, Viviane S Boaventura

{"title":"Dengue Dilemma: Navigating Cross-Reactivity and Immune Challenges.","authors":"Cristina R de Barros Cardoso, Thiago Cerqueira-Silva, Manoel Barral-Netto, Viviane S Boaventura","doi":"10.1007/82_2025_294","DOIUrl":"https://doi.org/10.1007/82_2025_294","url":null,"abstract":"This chapter examines the immunological mechanisms underlying the cross-reactivity and immune enhancement in dengue and how they influence the clinical outcomes. The four DENV serotypes (DENV-1 to DENV-4) share high genetic and antigenic similarity, leading to antibodies and T cells that can recognize multiple serotypes. While this cross-reactive immunity can confer partial or transient protection, it can also result in antibody-dependent enhancement (ADE), wherein non-neutralizing antibodies facilitate viral entry into immune cells, increasing the likelihood of severe disease in secondary infections and in infants carrying maternal anti-DENV antibodies. Furthermore, cross-reactivity with other flaviviruses, such as ZIKV, complicates serological diagnosis by producing false-positive results and uncertain prior exposure histories. These complexities extend to vaccine design, which must induce effective immunity against all four DENV serotypes while minimizing ADE risk. Epidemiological studies confirm that secondary infections, especially when antibody levels have waned, carry an elevated risk of severe clinical manifestations. However, the timing between infections and the specific serotype involved can modulate these outcomes. A thorough understanding of cross-reactivity and immune enhancement is therefore pivotal for advancing diagnostic accuracy, guiding patient care, and informing vaccine strategies and public health policies to better control dengue globally.","PeriodicalId":11102,"journal":{"name":"Current topics in microbiology and immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: A Brief History of Polyclonal Antibody Therapies Against Bacterial and Viral Diseases Before COVID-19. 更正：COVID-19之前针对细菌和病毒疾病的多克隆抗体治疗简史。

3区医学

Current topics in microbiology and immunology Pub Date : 2025-05-10 DOI: 10.1007/82_2025_295

Nigel Paneth, Madison Walsh, Breanna Kornatowski, Arturo Casadevall

引用次数: 0

Dengue: Historical Aspects. 登革热：历史方面。

3区医学

Current topics in microbiology and immunology Pub Date : 2025-04-30 DOI: 10.1007/82_2025_289

Myrna Cristina Bonaldo, Samuel Goldenberg, Ricardo Galler, Claudia Nunes Duarte Dos Santos

{"title":"Dengue: Historical Aspects.","authors":"Myrna Cristina Bonaldo, Samuel Goldenberg, Ricardo Galler, Claudia Nunes Duarte Dos Santos","doi":"10.1007/82_2025_289","DOIUrl":"https://doi.org/10.1007/82_2025_289","url":null,"abstract":"To write about dengue retrospective epidemiology is a challenging subject because until laboratory diagnosis tests were developed to confirm human infections by dengue virus (DENV) between 1940 and 1950, all reports about disease or epidemics referred to a generic \"dengue/break bone fever/contagious fever/bilious remitting fever.\" These nomenclatures employed in past times had perspectives based on medical reports, letters and diaries of people living in the affected areas at the time, and local newspaper reports. As Packard (Bull Hist Med 90(2):193-221) highlighted, the difficulty of using historical sources and \"the ambiguous nature\" of eighteenth-century disease categories turns the analysis puzzling. Nevertheless, if judiciously used, it can illuminate the history of dengue epidemics over time.In this chapter, we will focus on three periods that were pivotal to shaping our current understanding of dengue disease and epidemiology: (1) First reports of a dengue-like disease and the impact of the infection during the seventeenth and eighteenth centuries; (2) The impact of the II World War (II WW) on the spread of the DENV and its vector worldwide; and (3) The re-introduction of dengue in the Americas and the challenge of Public Health services to control the dramatic escalation of cases and the introduction of new serotypes/genotypes. It is worth mentioning that in the last years, South and Central America and Caribe account for more than 80% of dengue cases in the world (PAHO).","PeriodicalId":11102,"journal":{"name":"Current topics in microbiology and immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0