Omar Mohammed Makhlouf, Gamal A. Eid, Ragai Sobhi Hanna
{"title":"Management and complications of intraoperative spillage of bile and gallstones during laparoscopic cholecystectomy: a single-center experience","authors":"Omar Mohammed Makhlouf, Gamal A. Eid, Ragai Sobhi Hanna","doi":"10.4103/jcmrp.jcmrp_41_22","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_41_22","url":null,"abstract":"Background For symptomatic gallstones, laparoscopic cholecystectomy is the recommended surgical procedure. Aim and objectives This study's primary objectives were to identify the proper management of intraoperative spillage of bile and gallstones from the gallbladder throughout laparoscopic cholecystectomy, and to clarify the most common complications and how to deal with it. Patients and methods A total of 200 consecutive laparoscopic cholecystectomy cases from Assiut University Hospitals between August 2019 and August 2021 were included in the research. Results Gallbladder perforation was significantly occurring in acute cholecystitis. None of the patients underwent open procedure due to gallbladder perforation. Postoperative hospital stays in patients with gallbladder perforation ranges between 2 and 5 days with a mean value of 3.5 day. A follow-up was conducted after 1 week, 3 months, and 6 months. Conclusion Stones that have been dropped may cause morbidity. Even though they are very uncommon, serious consequences may happen and can complicate diagnoses. Gallstones that have spilled should be recovered as soon as feasible using a laparoscope. Because the risk of infective problems in such individuals may be significant, conversion to an open surgery should be taken into consideration if there are many gallstones that cannot be removed in the presence of bacteria.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127459951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Abdel Hammed, Mohammed Tohammy, S. Mohammed, Walaa Ibrahim, Mostafaei Mohammad
{"title":"Predictors of erythropoietin response in nondiabetic end-stage renal-disease patients on hemodialysis","authors":"Muhammad Abdel Hammed, Mohammed Tohammy, S. Mohammed, Walaa Ibrahim, Mostafaei Mohammad","doi":"10.4103/jcmrp.jcmrp_61_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_61_21","url":null,"abstract":"Background Erythropoietin (EPO) resistance is an essential health problem in end-stage renal-disease patients as it is associated with increased mortality. Despite combined intravenous iron usage, anemia exists substantially in the majority of patients, indicating the presence of other pathophysiological mechanisms such as inflammation that could lead to EPO resistance. Objectives To evaluate neutrophil-lymphocytic ratio (NLR) and platelet-lymphocytic ratio (PLR) as possible predictors of EPO resistance in nondiabetic patients on hemodialysis (HD). Patients and methods Fifty patients aged from 18 to 70 years old were diagnosed as end-stage renal disease and on HD regularly for more than 6 months and are receiving EPO therapy for at least more than 2 months. EPO dosing and intravenous iron supplementations given to HD patients and response assessment were following the 2012 Kidney Disease Improving Global Outcome guidelines. EPO resistance was assessed using EPO-stimulating agent (ESA) hyporesponsiveness index (EHRI), calculated as EPO weekly dose divided by body weight (kg) divided by hemoglobin level (Hb) and correlation with NLR, PLR, and C-reactive protein (CRP) was analyzed. EPO hyporesponsiveness (nonresponders) was diagnosed when we need to increase ESA doses up to 50% higher than the dose at which they were stable to maintain a steady Hb concentration after the first month of EPO treatment on weight-based dosing or after treatment with continuous EPO doses. Results Nonresponders to EPO had significantly higher EHRI, NLR, PLR, and CRP in comparison with responders. EHRI had a weak positive correlation with NLR (r = 0.18, P = 0.20), whereas it had a strong positive correlation with PLR (r = 0.65, P = 0.001). PLR at the cutoff point <116.5 has 90% sensitivity and 70% specificity for prediction of response to EPO therapy with overall accuracy that was 82% (area under curve [AUC]=0.79). Conclusion Inflammation is a major contributor in EPO resistance. CRP and PLR could represent cheap and simple parameters to predict response to EPO therapy in nondiabetic HD patients.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122328538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Functional and morphological cardiac changes in myeloproliferative neoplasms","authors":"O. Ibrahiem, A. E. Ahmed, A. Ali","doi":"10.4103/jcmrp.jcmrp_115_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_115_21","url":null,"abstract":"Background Myeloprolifer ative neoplasms (MPNs) are hematopoietic stem cell neoplasms caused by a clonal expansion in one or more myeloid lineages. The greatest obstacles for these neoplasms are cardiovascular consequences such as vascular thrombosis, myocardial infarction, and pulmonary hypertension (PH), which can lead to mortality. Aim This work aimed to understand the relationship between MPN and cardiovascular complications profoundly by transthoracic echocardiography. Patients and methods A prospective clinical study included 30 MPN patients recruited from the Clinical Haematology Unit in Assiut University Hospital from September 2017 to August 2018 to detect morphological and functional cardiac changes by the use the transthoracic echocardiography and two control groups, one group included 30 patients with other hematological disorders and the other group included 30 healthy persons. Results The left atrial diameter, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, posterior-wall diameter, and pulmonary arterial systolic pressure were significantly higher in MPN patients. The frequency of MR (40.7%) and tricuspid-regurgitation (50%) was significantly higher among the study group and 40% had PH. Conclusions Left atrial dilatation, left ventricular hypertrophy, PH, TR, and MR were the most prominent cardiovascular changes in MPN patients.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"213 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115975737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Various phenotypic techniques for detection of beta-lactam resistance in Pseudomonas species and Acinetobacter species: a single-center experience","authors":"A. Ahmed, Hanan Abdellatif, A. M. Abdallah","doi":"10.4103/jcmrp.jcmrp_99_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_99_21","url":null,"abstract":"Background The World Health Organization has emphasized that the risk of antibiotic resistance of Pseudomonas aeruginosa (PSA) and Acinetobacter baumannii (ACB) is due to the extended-spectrum β-lactamase (ESBL) and carbapenemase activity. Objectives The study was designed to describe the rates of different β-lactamases, and to assess the best phenotypic method for detection of these resistances. Methodology This cross-sectional study included 124 isolates obtained from the patients of Assiut University Hospital. Screening and phenotypic confirmatory tests for resistance were done. The study was approved and monitored by the Medical Ethics Committee, Assiut Faculty of Medicine, IRB 17101464. The antimicrobial-susceptibility tests were done by the Kirby–Bauer disk-diffusion method according to the CLSI 2019 guidelines and by automated Vitek2 Compact 15 system. Also, different phenotypic methods were used. Results The highest percentages of β-lactamase enzymes in 52 Pseudomonas isolates (53.8%) were due to both ESBL and carbapenemases (CARBA), whereas isolates with solo ESBL were 19.2% of the total isolates and the least percentages were due to CARBA. The highest percentages of β-lactamase enzymes in 72 Acinetobacter isolates (33.3%) were due to CARBA alone, whereas isolates with both ESBL and CARBA were 16.7% of the total isolates and the least percentages (5.6%) were due to ESBL. The combined-disk test had a high sensitivity and specificity in detection of ESBL and metallo-beta-lactamase (MBL) in PSA, whereas in ACB showed high sensitivity only. Conclusion The ESBL and MBL showed the highest percentage among Pseudomonas isolates, whereas among Acinetobacter isolates, the MBL showed the highest percentage. The phenotypic confirmatory tests showed high sensitivity and specificity and proved to be reliable approaches for identification of the β-lactamase resistance.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116380191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Mawgoud Fawaz, Amal ElAziz Mahmoud, Effat ElHady Touny, M. Mahmoud
{"title":"Role of kidney injury molecule 1 and nephrin as biomarkers for diagnosis of nephropathy in type 2 diabetes mellitus","authors":"Sara Mawgoud Fawaz, Amal ElAziz Mahmoud, Effat ElHady Touny, M. Mahmoud","doi":"10.4103/jcmrp.jcmrp_52_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_52_21","url":null,"abstract":"Background Diabetic nephropathy (DN) is a significant complication of diabetes caused by alterations within the structure and function of the kidneys. This increases the need for novel biomarkers that might predict nephropathy. Kidney injury molecule 1 (KIM-1) is a type 1 membrane protein present on the apical membrane of proximal tubules. It has a possible role in predicting long-term renal outcome. Thus, it serves as a selected and sensitive biomarker for proximal tubule damage. Nephrin is a transmembrane protein in the structure of the slit diaphragm. The study aimed to assess the levels of urinary KIM-1 and nephrin to detect early changes of renal functions in patients with type 2 diabetes mellitus (T2DM) and to assist in the prevention. Patients and methods This is a prospective study comprising 60 patients with T2DM. Patients were divided into three groups by their urinary albumin/creatinine ratio. Peripheral hemogram, liver and renal functions, lipogram, glycosylated hemoglobin (HbA1C), urine albumin/creatinine ratio, urinary KIM-1, and nephrin were done. Patients with type 1 DM, fever, infection, gestational diabetes, as well as evidence of systemic disease were excluded. Moreover, 28 volunteers were included. Results In this study, urinary nephrin and KIM-1 were significantly higher in those with macroalbuminuria, microalbuminuria, and those with normoalbuminuria compared with the control group. Both nephrin and KIM-1 had a significant positive correlation with creatinine in patients with macroalbuminuria and patients with microalbuminuria. Multivariate logistic regression analysis showed that the odds ratio for the presence of DN in the highest KIM-1 was 3.01 (95% confidence interval = 2.11–5.60; P < 0.001), nephrin was 2.9 (95% confidence interval = 1.10–4.65; P < 0.001), and HbA1C was 2.23 (95% confidence interval = 1.94–4.11; P < 0.001). By using receiver operating characteristic, it was noticed that the level of nephrin with cutoff value of more than 10 μg/ml was able to detect the diagnosis and prognosis of DN in our patients with sensitivity of 95%, specificity of 94%, and positive predictive value of 98.2%. Conclusion Urinary KIM-1 and nephrin levels appear to increase in kidney injury secondary to DN in the early period regardless of albuminuria, as urinary KIM-1 and nephrin were increased, even though there was normal urinary albumin excretion in the normoalbuminuric group. The study revealed that KIM-1, nephrin, and HBA1C were independent predictors of DN.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124220586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadia A. Elwahab, S. Sayed, Eman H. Elhakeim, Aisha A. Elraheem
{"title":"Anti-carbamylated protein antibodies in rheumatoid arthritis: their relationship to joint damage and disease activity","authors":"Nadia A. Elwahab, S. Sayed, Eman H. Elhakeim, Aisha A. Elraheem","doi":"10.4103/jcmrp.jcmrp_146_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_146_21","url":null,"abstract":"Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, autoantibody production, and cartilage and bone destruction. The cause of RA is still unknown. Identification of disease-related biomarkers would be helpful in diagnosing and classifying RA. The two autoantibody systems most commonly used are rheumatoid factor and anticitrullinated protein antibodies (ACPA). Several RA-associated autoantibody systems have been identified such as anti-carbamylated protein antibodies (anti-CarP Ab), anti-acetylated protein antibodies, and others. Anti-CarP Abs are the second most vigorously researched anti-modified protein antibodies following ACPA. Research on anti-CarP Ab may provide novel insights into the pathology and etiology of RA. Aim To detect the sensitivity and specificity of serum anti-CarP in diagnosis of RA especially in seronegative ACPA. Patients and method This study included 60 patients with RA fulfilling the ACR/EULAR 2010 criteria. A total of 20 apparently healthy participants were taken as controls. Written consents were taken from the patients before enrollment in this study. IRB of Assiut Faculty of Medicine approved the study. IRB local approval number is 17100085. Result There was a statistically significant increase in the level of anti-CarP among patients with RA in comparison with the control group, but there is an insignificant increased level of anti-CarP in the ACPA seropositive group in comparison with the seronegative ACPA group. Conclusion The level of anti-CarP was significantly higher among patients with RA in comparison with the control group. Five (25%) patients from the healthy control group gave anti-CarP-positive result; this can be explained by that anti-CarP Abs may exist in healthy participants many years earlier than the onset of manifestation of RA.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132088112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mostafa M. Embaby, Kotb Abbass Metwalley, Rania Riad
{"title":"Febrile neutropenia in nonmalignant conditions: tertiary center experience","authors":"Mostafa M. Embaby, Kotb Abbass Metwalley, Rania Riad","doi":"10.4103/jcmrp.jcmrp_30_22","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_30_22","url":null,"abstract":"Background Neutrophils play an important role in immunity of the body because they attack and kill the invading microorganisms. The clinical sequelae of neutropenia usually manifest as infections, most commonly of the mucous membranes. The risk of serious infection increases as the absolute neutrophililc count falls to the severely neutropenic range (<500/μl). Patients and methods A retrospective study was conducted on patients admitted to Haematology Unit and Intermediate Care Unit at Assiut University Children Hospital during the period from April 1, 2018 to March 31, 2019 (1-year study). Data were collected and compared with guidelines. Results Among 50 patients, males were 44% and females were 56%. All patients enrolled in this study were neutropenic and had fever. Patients having neutropenia due to aplastic anemia were 92%, patients having oral mucosal lesions were 56%, and patients having fever of unknown origin were 44%. Conclusion Aplastic anemia is the most common cause of nonmalignant febrile neutropenia. Neutropenia leads to severe infections. Granulocyte colony-stimulating factor can be used in treatment of neutropenia. Bone marrow transplant can cure this disorder.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127912413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Effat E. Tony, Yousryeia R. Ahmed, A. Mahmoud, Walaa Hussein, M. Khairallah
{"title":"The relationship between mean platelet volume and neutrophil/lymphocyte ratio with inflammation and proteinuria in chronic kidney disease","authors":"Effat E. Tony, Yousryeia R. Ahmed, A. Mahmoud, Walaa Hussein, M. Khairallah","doi":"10.4103/jcmrp.jcmrp_98_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_98_21","url":null,"abstract":"Background Mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) are particularly useful as inflammatory markers. The goal of this study was to see if there was a correlation of MPV and NLR with inflammatory markers in patients with chronic kidney disease (CKD) stages II, III, IV, and V. Patients and methods We conducted a case–control study with patients with established CKD who were recruited from the Internal Medicine Department's nephrology unit. The participants in this study comprised 120 patients with CKD at various stages and 30 healthy volunteers. Results Patients with CKD had a significantly higher NLR than the control group (2.94 ± 0.62 vs. 1.76 ± 0.13, respectively, P = 0.001). The average MPV, on the contrary, did not change significantly between the groups (P = 0.18). There was no statistically significant difference between stages in terms of MPV, although NLR was much lower in stage II patients than in other stages. NLR had a positive relationship with fibrinogen (r = 0.23; P = 0.001), C-reactive protein (r = 0.28; P = 0.001), creatinine (r = 0.24; P = 0.001), urea (r = 0.21; P = 0.001), uric acid (r = 0.11; P = 0.05), and proteinuria (r = 0.31; P = 0.004). Conclusion NLR (rather than MPV) may be employed as a biomarker of inflammation, a risk factor for proteinuria, and a practical predictor of CKD prognosis.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"371 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126708616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A clinical audit on the management of children with hepatorenal syndrome admitted to Assiut University Children Hospital","authors":"S. Fahmy, A. Ahmad, E. Hashem","doi":"10.4103/jcmrp.jcmrp_29_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_29_21","url":null,"abstract":"Introduction Hepatorenal syndrome (HRS) is defined as worsening kidney function in patients with advanced cirrhosis. Aim The study aimed to evaluate the management of children with HRS, who were admitted to the Pediatric Hepatology and Nephrology Units, Assiut University Children Hospital, according to published international guidelines, searching for defects, obstacles, or needs to improve the management of such cases. Patients and methods Medical records of children with advanced liver disease accompanied by renal manifestations during the period from the March 1, 2017 to the February 28, 2018 were collected and reviewed to choose the cases that fulfilled the inclusion criteria of the present study. A structured data collection form was designed according to the adopted published guidelines. The collected data were tabulated, statistically analyzed, and discussed. Results Out of 158 collected records, only 11 fulfilled the inclusion criteria of the present study. Their data revealed a severe defect in recording the admission and follow-up historical data, registered data about the clinical examination, important investigations, and management. Finally, the outcome data revealed that recovery with improvement of acute kidney injury had occurred in only two cases; they had early acute kidney injury diagnosis and proper management. Conclusion The study revealed that management of cases with HRS in the present study was not following any well-known published guidelines for management of such cases. Recommendations Management of children with HRS must follow the published international guidelines to improve both management and outcome of such cases.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128946481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanaa A. Mohammad, Duaa Rafat, M. Samy, Mohammad Ata Abdel-Gawad
{"title":"Causes of goiter in children attending Assiut University Children Hospital","authors":"Hanaa A. Mohammad, Duaa Rafat, M. Samy, Mohammad Ata Abdel-Gawad","doi":"10.4103/jcmrp.jcmrp_80_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_80_21","url":null,"abstract":"Introduction Goiter accompanies almost all thyroid diseases in children. It may be of congenital or acquired causes. Neck ultrasound (US) combined with color Doppler US on thyroid vasculature is useful in adjunct to clinical assessment and assessment of thyroid function in the diagnosis of goiter and its cause. In this study, we aimed to assess the causes of goiter in children attending Assiut University Children Hospital. Patients and methods This cross-sectional observational study included 28 patients with goiter. Each child was subjected to full clinical history and systemic examination and thyroid gland examination. The following investigations were done: neck US, thyroid-stimulating hormone and free T4, and thyroid autoantibodies in the indicated cases. Results Goiter in children is more prevalent in females by about three-fold than males. Acquired goiter is more prevalent than congenital goiter, constituting 82% of the studied cases of goiter. Family history of thyroid disorders was positive in all patients with congenital goiter and in six out of 23 patients with acquired goiter. Goiter with hyperthyroidism (mostly Grave's disease) is the most common cause of acquired goiter in children, followed by goiter with hypothyroidism (mostly Hashimoto's disease), then goiter with euthyroidism (mostly simple goiter). Neck US on thyroid gland with color Doppler US on thyroid vasculature is useful in cases with goiter for the diagnosis of goiter and its cause. Conclusion Acquired goiter is more prevalent than congenital goiter. Goiter with hyperthyroidism is the most common cause of acquired goiter in children. Neck US on thyroid gland with color Doppler US on thyroid vasculature is useful for the diagnosis of goiter and its cause.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"148 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114174215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}