Journal of Current Medical Research and Practice最新文献

{"title":"Assessment of Cognitive Functions in Bipolar Disorder Patients","authors":"A. ElBeh, Hossam Khalifa, Marwa Salama","doi":"10.21608/jcmrp.2024.346793","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346793","url":null,"abstract":": Bipolar disorders are chronic disorders with a high relapse rate; the lifetime prevalence is approximately 4%. Bipolar patients may experience cognitive impairment at various phases of the illness, even during the euthymic phase of the disease. Aims: To assess cognitive abilities in individuals with bipolar 1 disorder during remission and to investigate the correlation between cognitive functions and the clinical profile and demographic characteristics of the patients. Setting and Design: This is a case-control study involving patients diagnosed with bipolar 1 disorder in the euthymic phase, as per DSM-5 diagnostic criteria. Patients and methods: This study included 36 bipolar 1 disorder patients in the euthymic phase diagnosed according to DSM-5 diagnostic criteria. Also, it included 36 cross-matched healthy individuals as control subjects. Results: Patients with bipolar1 disorder demonstrated considerably lesser cognitive functions during remission than the control group. The bipolr1 disorder severity and recurrence are significantly inversely correlated to cognitive function. Conclusion: Bipolar1 disorder patients frequently have cognitive impairment at all phases of the illness, even during euthymia. Cognitive impairment is frequently seen as a fundamental feature of bipolar disorder. The severity and recurrence of the illness appear to play a key influence in cognitive impairments.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"6 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140519176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Acne Severity in Adult Female Acne Patients in Relation to BMI","authors":"Reham Maher, Abdel Gaber, Emad Abdelraheem Taha, Randa Ahmed El Zohne, Diana Gamal-Esmat, Fouad Botros, Radwa M. Bakr","doi":"10.21608/jcmrp.2024.346791","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346791","url":null,"abstract":"Background: Acne stands as one of the most prevalent disorders in dermatology. Acne and weight gain are thought to be clinical indicators of h yperandrogenism, and it appears that obesity is linked to increased sensitivity to androgenic hormones and more severe acne. To better manage acne sufferers, this research may help uncover any connections between the severity of acne and Body Mass Index (BMI) in adult female patients. Objectives: To determine the relation between BMI and acne severity in adult female acne patients. Methods : This is a one-year case-control study. Informed written consent was taken from 103 females who attended the dermatology, venereology, and andrology outpatient clinic at Assiut University in Assiut, Egypt, between the 1 st of April, 2022, and the 31 st of March, 2023. The case group comprised 53 adult females with acne, whereas 50 age-matched females without acne comprised the control group. The Global Acne Grading System (GAGS) was used to determine the severity of acne. Results: The BMIs of both study groups were comparable. According to the GAGS scale, 19 cases (35.8%) had mild, 18 cases (34.0%) had moderate, 14 cases (26.4%) had severe, and two cases (3.8%) had very severe acne vulgaries. BMI and acne severity showed a significant positive correlation (r=0.542, p<0.001). Conclusions : This study showed that acne severity and BMI are related. Thus, BMI may be related to acne pathogenesis and severity in adult female patients.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"25 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140522726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-Epidemiological Study on Neoadjuvant Chemotherapy Followed by Chemoradiotherapy in Muscle-Invasive Bladder Cancer at Assiut University Hospital","authors":"MD. Hoda Abeer Amin, MD Rehab Essa, M.Sc Samar Abd-Elmaboud, El-Morshedy","doi":"10.21608/jcmrp.2024.346792","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346792","url":null,"abstract":"Background: Radical cystectomy is reference management of muscle-invasive bladder cancer (MIBC), with a reduced quality of life after cystectomy. Our study aimed to assess the efficacy of neoadjuvant chemotherapy (NAC) followed by concurrent chemoradiotherapy (CCRTH). Patients and Methods: Our study was conducted at Assiut University Hospital's Clinical Oncology Department from 2015 to 2019. The study was approved by the Ethical Committee at the Faculty of Medicine, Assiut University (IRB17101267). Data were extracted from the medical records of 36 patients with pathologically confirmed MIBC (cT2-T4a N0M0) treated by 3 cycles of NAC (cisplatin/gemcitabine); responders underwent maximum transurethral resection of the bladder tumor (MTURBT) followed by chemoradiotherapy (60-66 Gy) over 6-weeks with concurrent weekly cisplatin at 40 mg/m2. Results:","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"28 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140525835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD 11b and CD56 As Prognostic Markers in Acute Myeloid Leukemia","authors":"Shaaban R. Helal, Eman M.Salah Eldin, Zeinab A.Kamel","doi":"10.21608/jcmrp.2024.346794","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346794","url":null,"abstract":". Abstract Background: Acute myeloid leukemia (AML) is a common adult leukemia and is characterized by a differentiation block and aberrant clonal growth of hematopoietic blasts. Aim: This study aims:","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Intra-operative and Early Post-operative Complications of Laser in–situ Keratomileusis","authors":"Tarek Abdelrahman Mohamed Saad, Ahmed Mohamed, Khaled Abdelazeem, D. El-Sebaity","doi":"10.21608/jcmrp.2024.346796","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346796","url":null,"abstract":"Several Laser in-situ keratomileusis (LASIK) complications have been identified over the years. Reporting complications of LASIK surgery will help refine the approach to their management. LASIK was introduced in the late 1980s with the development of the ophthalmic excimer laser [1, 2]. To avoid the disadvantages of photorefractive keratectomy (PRK), LASIK was introduced [3]. LASIK rapidly increased in popularity and became the predominant form of refractive surgery in the late 1990s and continues till today [4]. Correcting different refractive errors, including myopia, hyperopia, and astigmatism, is the main aim of all laser refractive procedures. LASIK has been used to treat many degrees of myopia with promising results, and there are great expectations for treating farsightedness. Compared to PRK, LASIK is advantageous in causing minimal postoperative discomfort, rapid restoration of visual clarity and stability of refractive changes, less frequent opacification, and better ability to correct high levels of myopia. Intraoperative complications, although infrequent, include Microkeratome-related flap complications (flap buttonhole, free cap, and incomplete, short, or irregular flaps), corneal perforation, corneal epithelial defect, conjunctival bleeding, subconjunctival hemorrhage, and interface debris [6]. Post-operative Complications include inaccurate correction, visual aberrations, flap striae (macrostriae -microstriae) [6], flap dislocation, dry eye, diffuse lamellar keratitis (DLK), pressure-induced stromal keratitis (PISK), infectious keratitis [7","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140526839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study Between the Efficacy of Oral Verapamil and Bisoprolol on Reduction of Intraoperative Bleeding during Endoscopic Sinus Surgery under General Anesthesia","authors":"Ahmed Talaat, Ahmed Ali, Mohammed Ali Hassan, Refaat Al-Quossi, Mohammed Sayed Hassanein, Ahmed Antar, Saleh M. Badran","doi":"10.21608/jcmrp.2024.346799","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346799","url":null,"abstract":"Background","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"104 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140515773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis A Virus Antibodies in Patients with Chronic Hepatitis B and C; A Cross-Sectional Study in Egyptian Patients.","authors":"Lobna Abd El, Wahed Ahmed, Essam El-Deen Abdelmohsen, Wael Ahmed Abbas, Kerollos Latif, Labib Garas, Enas Ahmed, Reda Alkareemy","doi":"10.21608/jcmrp.2024.346795","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346795","url":null,"abstract":"Background: Acute viral hepatitis A has a wide range of presentation; it may result in mild symptoms and self-limited disease or lead to fulminant liver cell failure. It infects 1.4 million people worldwide annually. Super-infection of HAV on top of chronic viral infections, including HBV, HCV, HIV, and dengue virus, or even chronic non-viral liver disease may affect the natural course of the basic disease and lead to fulminant liver failure and higher mortality rate. Aim of the work: To detect the seroprevalence of previous HAV infection in chronic hepatitis B and C patients in Assiut to clarify its effect on these patients and the different impacts of HAV infection on hepatitis B and hepatitis C patients. Results : 235 patients (94 %) were HAV IgG positive, and 15 (6%) were negative. The Child-Pugh score showed more deterioration in HAV IgG-positive patients than negative patients. Of 235 HAV IgG-positive patients, 160 (68%) were HCV antibody-positive, and 75 (32%) were HBsAg positive. Patients with HAV/HCV have more impaired liver functions and lower Child-Pugh scores than HAV/HBV patients. Conclusion : Our study showed that the prevalence of HAV infection in chronic liver disease patients is very high, as (94%) of them were positive for HAV IgG antibody. This high prevalence was associated with a significant deterioration in liver functions in chronic liver disease patients, leading to a worse prognosis. Also, we found that HAV/HCV patients showed more deteriorated liver functions than HAV/HBV patients, lower Child-Pugh","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"25 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140526889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of Pediatric Seizures at Al-Arish Central Hospital - North Sinai","authors":"Ehsan Mohammed Saied, Elsayed Khalil, Abdel Karim, Eman Fathalla Gad, Taghreed Abdul-Aziz, M.Ismail","doi":"10.21608/jcmrp.2024.346797","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346797","url":null,"abstract":"Background: Seizures represent a prevalent etiology for pediatric hospitalization, resulting in notable morbidity and mortality. Seizures are temporary manifestations arising from an atypical, heightened, or synchronized neural activity within the cerebral cortex. Approximately 2% of emergency department visits are attributed to them. Aim of the Study : This study was to delineate the seizure presentation among patients admitted to the Pediatric department at Al-Arish Central Hospital in North Sinai and to contrast the findings with those of comparable studies conducted nationally and internationally. Furthermore, it provides descriptive information essential for planning future research. Patients and Methods: The present study comprised a cohort of 125 pediatric patients diagnosed with seizures who were admitted to the Pediatric department at Al-Arish Central Hospital in North Sinai for one year, from June 2019 to May 2020. The age range of the individuals was from two months to eighteen years. Results: The etiological analysis conducted indicated that epilepsy was the most prevalent cause of seizures in children, accounting for 45 cases (36.0%). Febrile convulsion was identified as the second most common cause, with 39 cases (31.2%) observed. Valproic acid (62.5%) and Levetiracetam (45.0%) were the prevalent antiepileptic drugs employed. Conclusions: Seizure is a prevalent reason for hospitalization among children, particularly those under the age of five, at the pediatric department of Al Arish Central Hospital in North Sinai. Generalized tonic-clonic seizures are more frequent and have diverse etiologies. Epilepsy was identified as the predominant etiology for seizures, with febrile seizures following as the subsequent cause. The most prevalent types of symptomatic seizures associated with infectious causes of the central nervous system were those attributed to viral encephalitis.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"107 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140526363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Intrathecal Dexamethasone on Intra-operative Hemodynamics in Elderly Patients Undergoing Urologic Endoscopic Surgery","authors":"A. Mandour, Fatma Ahmed, Abd El-Aal, Ahmed Dalia Mohamed, Ayman Abdel-Khalek Abbas, Mohammed Abou-Glalah","doi":"10.21608/jcmrp.2024.346798","DOIUrl":"https://doi.org/10.21608/jcmrp.2024.346798","url":null,"abstract":"Background: An adjuvant of local anesthetics (LA) with spinal anesthesia (SA) increases the SA length. Aim: This study investigates the impact of intrathecal addition of dexamethasone to bupivacaine on improving post-spinal anesthesia hypotension (PSAH) in elderly patients.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140525164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical audit on umbilical venous catheterization at NICU of Assiut University Children Hospital","authors":"Beshoy Emad, Ghada El.Sedfy, Amira Shalaby","doi":"10.4103/jcmrp.jcmrp_23_23","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_23_23","url":null,"abstract":"Introduction It is known that neonates have a friable Peripheral blood vessels and it is difficult to access, particularly in preterm so we use umbilical arterial catheters (UACs) and umbilical venous catheters (UVCs) to provide easy and rapid access during resuscitation, administration of fluids and parenteral nutrition, frequent blood sampling and blood transfusion in unstable neonates who need urgent intervention. Objectives To check the adherence of the physician to the accepted guidelines for umbilical venous catheterization at Neonatal Intensive Care unit of Assiut University Children Hospital, educate healthcare personnel about the proper method of insertion and maintenance of this line and educate them how to prevent intravascular catheter-related infections. Patient and methods This was prospective Clinical audit study, From the 1st of April 2020 up to the end of December 2020, included All newborn admitted to NICU, at Assiut University Children Hospital during the study period and in need for central lines. We applied Checklist Steps of Umbilical Catheterization (UVC) and determined the percentage of achievement of each step. Results The mean gestational age of the studied cases was 32.61 ± 2.68 weeks, The median birth weight (gram) of the studied cases was 1720, Out of 94 studied cases, 42 (44.7%) were males and 52 (55.3%) were females. and Regarding maturity; the vast majority of the studied cases were preterm (92.6%) and only seven cases (7.4%) were full-term. Concerning the steps of UVC insertion; those steps were done in 100% of cases (washing the cord with an antiseptic tincture, Insertion a sterile umbilical catheter into the vessel, detect a good blood flow through the catheter and adding Tape Bridge for further stability.followed by determining the length of catheter, Cutting the cord in a horizontal way with a scalpel to a length of 1 cm from skin, putting a sterile gloves, a mask and gown, Positioning of the catheter were verified by x-ray and Scrubbing hands to elbow was done in 90 (95.7%) 87 (92.6%), 84 (89.4%),77 (81.9%), 59 (62.8%) of the studied cases respectively. but other steps were done in lower percentages. Conclusion Those steps were done in 100% of cases (washing the cord with an antiseptic solution, Insertion a sterile umbilical catheter into the vessel, detecting a good blood flow through the catheter and Adding Tape Bridge for further stability, but there were defects in all other steps with different percentages.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"258 1","pages":"154 - 158"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}