Clinico-Epidemiological Study on Neoadjuvant Chemotherapy Followed by Chemoradiotherapy in Muscle-Invasive Bladder Cancer at Assiut University Hospital

Abstract

Background: Radical cystectomy is reference management of muscle-invasive bladder cancer (MIBC), with a reduced quality of life after cystectomy. Our study aimed to assess the efficacy of neoadjuvant chemotherapy (NAC) followed by concurrent chemoradiotherapy (CCRTH). Patients and Methods: Our study was conducted at Assiut University Hospital's Clinical Oncology Department from 2015 to 2019. The study was approved by the Ethical Committee at the Faculty of Medicine, Assiut University (IRB17101267). Data were extracted from the medical records of 36 patients with pathologically confirmed MIBC (cT2-T4a N0M0) treated by 3 cycles of NAC (cisplatin/gemcitabine); responders underwent maximum transurethral resection of the bladder tumor (MTURBT) followed by chemoradiotherapy (60-66 Gy) over 6-weeks with concurrent weekly cisplatin at 40 mg/m2. Results: