Journal of Current Medical Research and Practice最新文献

{"title":"Knowledge, attitude, and practice of breastfeeding and weaning among mothers of children under 2 years of age in a village in Assiut Governorate, Egypt","authors":"Wafaa H. Tawfilis, Mohammad Q. Hasan, Eman M. Mohamed, Amira E. El-Gazzar","doi":"10.4103/jcmrp.jcmrp_80_22","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_80_22","url":null,"abstract":"Aim This study aims to assess the knowledge, attitude, and practice of mothers of infants and young children (0–23 months) in a rural area in Upper Egypt regarding breastfeeding (BF), complementary feeding, and weaning and to find the relation between knowledge and attitude of mothers and exclusive breastfeeding (EBF) practice. Subjects and methods A crosssectional study was conducted on 308 rural mothers who attended the Rural Health Unit of Bany-Semaiae village, Abou-Teeg District, Assiut Governorate, seeking health care for themselves or for their children and accompanying a child aged less than 2 years. Results The study revealed that most of the studied mothers knew that BF is the best nutritive source for the baby in the first 6 months and had good knowledge about the benefits of BF for child. Regarding weaning, most of the mothers defined weaning as BF cessation. Most of the mothers agreed that BF protects child from infection, 96.6% agreed that it is the best milk to child's health, 37% agreed that breast milk may alter body shape of the mother, and 31.5% agreed that BF should be stopped during mother's illness. Overall, 39.6% initiated BF immediately after delivery, and 74.4% of the mothers offered prelacteal feeds to baby in the first 3 days after delivery. Regarding knowledge level, 24.4% of mothers had good knowledge. Concerning mother's attitude toward feeding children, 70.1% of mothers had a positive attitude. EBF in the first 6 months was 44.2% and continued BF at 1 year was 60.6% of study children. It was found that mother's attitude level is significantly associated with EBF but not associated with knowledge level. Conclusion The study concluded that mothers' feeding practice of their children was less satisfactory, and there is a need for enhancing EBF through launching health education campaigns targeting the concerned mothers and their families.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115476095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and socioeconomic burden of osteoarthritis","authors":"Eman M. Alkady, Zahraa I. Selim, M. Abdelaziz, Fatma El-Hafeez","doi":"10.4103/jcmrp.jcmrp_99_19","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_99_19","url":null,"abstract":"Osteoarthritis (OA) is one of the most common joint disease worldwide. It can lead to joint disability as it is a slowly progressive disease. It is also the most common reason for total knee and hip replacement. The prevalence of OA varies by site, age, sex, and ethnicity. The rapid increase in the prevalence of OA indicates that it will have an increasing effect on public health systems and future healthcare. The prevalence of OA is increasing owing to the growing age of the population all over the world.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126479201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular and retinal changes in unilateral amblyopia using optical coherence tomography","authors":"Aliaa Y. El-Kabsh, O. Ali, Gamal Rashed, M. Sayed","doi":"10.4103/jcmrp.jcmrp_67_22","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_67_22","url":null,"abstract":"Purpose To identify changes in macular parameters, such as central macular thickness and volume, using optical coherence tomography in cases of unilateral amblyopia and to compare that with their normal fellow eyes. Design A prospective, cross-sectional study was performed. Patients and methods This study included 62 eyes of 31 participants with unilateral amblyopia who were classified into four categories: anisometropic myopic, anisometropic hypermetropic, strabismic esotropic, and stabismic exotropic amblyopia. Comparison was done with their sound fellow eyes by spectral domain optical coherence tomography regarding changes in macular parameter (central macular thickness and macular volume). Results The amblyopic eyes had significantly higher central subfield thickness versus the normal fellow eyes (251.84 ± 44.90 vs. 225.32 ± 53.47 μm; P = 0.03), but both groups had insignificant differences regarding average macular volume (7.84 ± 0.72 vs. 7.94 ± 0.82 mm3; P = 0.58). Conclusion In this study, we had documented significant changes in central macular thickness and insignificant changes regarding macular volume in amblyopic eyes among cases of unilateral amblyopia in comparison with their sound fellow eyes.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121086731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hysteroscopic findings in cases of secondary infertility after cesarean section","authors":"Hazem M. Ibrahim, Ahmad M. Abdelaleem, Ayman A. Askar","doi":"10.4103/jcmrp.jcmrp_179_19","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_179_19","url":null,"abstract":"Background Cesarean section (CS) is a common procedure nowadays. Although being essential in many conditions, CS has short-term and long-term complications. One of the long-term complications is infertility. Presence of a previous CS raises the possibility of uterine factor as a contributing cause of infertility. Hysteroscopy is the gold standard method to assess the uterine cavity. It can identify some abnormalities missed by hysterosalpingography or ultrasound. Patients and methods A prospective observational study was conducted that included 56 women with complaint of secondary infertility after CS. Office hysteroscopy was done for all women to assess the uterine cavity and to find out any subtle abnormalities in these women. The authors excluded women with clear causes of infertility and medical disorders that may preclude the hysteroscope, such as epilepsy, cardiac diseases, and women with active cervical or uterine infection. Results All participating women did not have an apparent cause of infertility. A total of 25 (44.7%) patients had normal hysteroscopic findings and 31 (55.3%) patients were found to have abnormal findings: nine (16.1%) patients with uterine niche, eight (14.3%) patients with endometrial adhesions, seven (12.5%) patients with endometrial polyp, four (7.1%) patients septate uterus, and three (5.4%) patients with submucous myoma. Conclusion The study showed that a high proportion of patients with secondary infertility after CS have uterine cavity abnormalities that warrant hysteroscopic examination, but further study is needed to evaluate the pregnancy outcome of correction of these abnormalities.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126644537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum and synovial fluid 14-3-3η protein in patients with primary knee osteoarthritis compared with rheumatoid arthritis: relation to functional status and radiographic damage","authors":"Mona H. Abd Elsamea, N. Hammam, D. Fouad, E. Kholef, G. Salem","doi":"10.4103/jcmrp.jcmrp_28_22","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_28_22","url":null,"abstract":"Aim of the work The aim of the present work was to examine the association between 14-3-3η protein levels in both serum and synovial fluid (SF) with radiographic damage and physical function in patients with primary knee osteoarthritis (OA) compared with rheumatoid arthritis (RA) patients. Patients and methods This is a cross-sectional study that involved two groups: group 1 included 50 primary knee OA patients, and group 2 included 50 RA patients. All study patients were assessed for serum and SF levels of 14-3-3η protein that was measured through ELISA technique. Functional assessment of OA patients was done using Western Ontario and McMaster Osteoarthritis index (WOMAC). Radiological assessment was evaluated using Kellgren–Lawrence (KL) grading scale. Results The mean age of OA patients was 51.7 ± 10.4 years, disease duration was 24.8 ± 5.2 months, and mean WOMAC and KL grading scores were 18.5 ± 6.5 and 2.0 ± 0.99, respectively. Serum and SF 14-3-3η protein was significantly higher among RA compared with OA (1.5 ± 0.51 and 3.6 ± 1.1 ng/ml vs. 0.24 ± 0.03 and 0.24 ± 0.03, P = 0.004 and 0.018, respectively). There were no significant differences in serum and SF 14-3-3η protein between male and female OA patients (P = 0.99 and 0.87, respectively). A significant correlation was found between serum levels of 14-3-3η and erythrocyte sedimentation rate (r = 0.49, P = 0.014). The correlations between 14-3-3η protein in OA patients with WOMAC and KL grading scale were weak and not significant (P > 0.05). Conclusions 14-3-3η protein levels were significantly lower in OA patients compared with RA patients. Although 14-3-3η levels were significantly correlated with inflammation, there was no correlation with functional status or radiological damage in knee OA patients.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"139 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125826286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum interleukin-21 level in patients with severe adverse cutaneous drug reactions and correlation with disease severity","authors":"H. Morsy, Fathiya Ibrahim, Dalia Negm, Ibrahim M. Mwafey, M. Hanna","doi":"10.4103/jcmrp.jcmrp_133_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_133_21","url":null,"abstract":"Introduction Interleukin-21 (IL-21) is accepted to play a pathogenic part in development of unfavorable cutaneous medicate responses. Adverse cutaneous drug reactions create a wide run of clinical signs such as pruritus, maculopapular ejections, urticaria, angioedema, fixed drug eruption, erythema multiforme, vesiculobullous responses (e.g. Stevens–Johnson syndrome and toxic epidermal necrolysis), and exfoliative dermatitis. Patients and methods Twenty patients (drug-eruption group) and 14 healthy controls (control group) were recruited from Assiut University Hospitals' Dermatology Department and Outpatient Clinic. Data were collected in the period from October 2017 to December 2018. Patients were assessed clinically by percentage of surface area of the body involvement (body surface area %) and score of toxic epidermal necrolysis. At presentation and after 1 month of treatment, blood samples were taken to evaluate serum IL-21 levels using an enzyme-linked immunosorbent assay. Results Inside the study, the cruel serum IL-21 level was considerably greater than in the control group, in drug-eruption group was 575.58 ± 94.67 ng/dl, and in the control group was 128.00 ± 73.94 ng/dl with P value of 0.000. The drug-eruption group had a significantly higher serum level of IL-21 before treatment than after treatment with P value of 0.000. Additionally, there was a critical relationship between IL-21 levels in the blood and the severity of the condition. Before and after therapy, there was a significant positive association between blood IL-21 levels and the proportion of body surface area involvement. Conclusion IL-21 levels in the blood were significantly higher in EM and SJS/TEN patients, suggesting that it may have a role in the etiology of EM and SJS/TEN and it could be employed as a marker for the severity of SJS/TEN and patient prognosis in the future.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126510480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallbladder status among children with chronic hemolytic anemia attending Assiut University Children's Hospital","authors":"Shohanda Mohammed, Abdel A. Moez, S. Galal","doi":"10.4103/jcmrp.jcmrp_24_22","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_24_22","url":null,"abstract":"Background One among the numerous comorbidities of chronic hemolytic anemia (CHA) is bladder stones. The extensive use of abdominal ultrasound in kids documented raised detection rate of gallstones. Aim and objectives To see the frequency of gallbladder diseases among kids with CHA and to see the risk factors of gallbladder diseases among patients with CHA attending Assiut University Children's hospital. Patients and methods This cross-sectional study included 50 kids with CHA aged from 1 to 18 years, who were admitted to the Hematology Unit at Assiut University Children's Hospital (from the start of December 2018 to the end of November 2019). All patients were evaluated by full history, general and abdominal examination, laboratory assessment, and ultrasound findings to find the probable risk factors for gallstones. Results The age of patients ranged from 1 year up to 18 years. The commonest age of bladder diseases detection was at 6 years. Twenty-one (42%) cases had gallbladder diseases. Bladder diseases were symptomatic in –81 with abdominal pain in affected kids. Thalassemia major was recorded more frequently (72%) in the studied group with 20 and 8% reporting sickle cell anemia and spherocytosis, respectively. The frequency of blood transfusion had statistical significance with gallbladder affection. Conclusion From this study, it can be concluded that the type of hemolytic disease, frequency of blood transfusion, history of hydroxy urea intake, and splenomegaly were risk factors for gallbladder affection in children with chronic hemolytic disease.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116835446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual dysfunction in female patients with chronic kidney disease","authors":"D. Attallah, H. Gaber, Essam A. Aziz, A. Hosny, Esraa Mohamed","doi":"10.4103/jcmrp.jcmrp_76_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_76_21","url":null,"abstract":"Aim To evaluate sexual function in female patients with CKD and patients with end-stage renal disease who are on regular dialysis. Background Chronic kidney disease (CKD) affects both sexual function (SF) and quality of life. Method A total of 100 individuals were included in this case-control study. Participants were divided into two groups. The first group included 50 female patients with chronic kidney disease (CKD-V) and the second group included 50 healthy females (control group). All subjects were subjected to a clinical evaluation, were the Female Sexual Function Index (FSFI) was administered. Results In the CKD group, most of patients reported sexual dysfunction, and there was a statistically significant difference between this group and the control group. In the CKD group, all domains of sexual function were affected with variable percentages. There was no statistically significant correlation between any of the FSFI score domains and age or duration of disease in the patient group. Conclusions Sexual dysfunction is common in female patients with CKD, Therefore, we emphasize the need for routine assessment and early treatment of female sexual dysfunction in CKD patient.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"77 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120852172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcome of different forms and regiments of antituberculous drugs in Assiut Governorate","authors":"Maha K. Ghanem, H. Makhlouf, A. Hasan, David S. Kelada","doi":"10.4103/JCMRP.JCMRP_65_20","DOIUrl":"https://doi.org/10.4103/JCMRP.JCMRP_65_20","url":null,"abstract":"Introduction The prescription of effective and well-tolerated antituberculosis (TB) treatment regimen is an important step in the management of TB. Objective To compare the outcome of fixed-dose combination (FDC) therapy versus standard treatment (ST) in treatment of pulmonary tuberculosis (PTB) and extrapulmonary TB in Assiut Governorate. Patients and methods In this prospective cross-sectional analytic study, 120 patients were included. Overall, 60 had PTB based on sputum-positive acid-fast bacilli, and 60 had extrapulmonary TB based on biopsy or culture from the affected sites. Patients were classified into two groups: 80 patients received FDC in the form of four-drug combinations in the intensive phase and the two-drug combination therapy in the continuation phase (group 1) and 40 patients received ST in the form of four separate drugs in the intensive phase and the two separate drugs in the continuation phase (group 2). Follow-up of clinical data, laboratory markers, sputum conversion in PTB during the course of treatment, drug tolerance, compliance, and developing of adverse effect was done in both groups. Results There is no statistically significant difference between both groups regarding improvement of the fever and anorexia and weight loss (P > 0.05 for each). Moreover, there are no statistically significant changes in the sputum conversion between both groups after 2, 4, and 6 months, respectively. There is a statistically significant increase in the percentage of the patients, with increase of alanine aminotransferase, aspartate aminotransferase, and bilirubin level along the course of the treatments in patients receiving FDC and ST (P < 001) but still within normal limits, and there is no need to stop or change the therapy. No significant difference between the two groups regarding the adverse effects such as nausea, vomiting, anorexia, blurred vision, peripheral neuropathy, arthralgia, and skin rash is recorded. Conclusion Both FDC and ST have comparable results, with no superiority of either one over the other.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115115539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and outcome of parapneumonic effusion among children attending Assiut University Pediatric Hospital","authors":"Walaa I. Ahmed, Moustafa M. El-Saied, Y. Abdel-Raheem, Abeer A Mokhtar","doi":"10.4103/jcmrp.jcmrp_141_21","DOIUrl":"https://doi.org/10.4103/jcmrp.jcmrp_141_21","url":null,"abstract":"Background Empyema is the most frequent suppurative complication of bacterial pneumonia in childhood. As parapneumonic effusion (PPE) progresses, fibrin and cellular debris accumulate, the purulent fluid becomes septated, and a thick peel forms over the pleura. Aim To describe and compare clinical, laboratory, microbiological findings in patients with PPE and to verify the prognostic accuracy of pleural fluid C-reactive protein in disease progression. Patients and methods In all, 25 children aged from 1 month to 16 years, with PPE and empyema were enrolled in this prospective study, which was carried out at Assiut University Children Hospital, from January 1, 2019 to June 30, 2019. Results Fever and dyspnea occurred in 88 and 64% of patients, respectively. Right effusion occurred in 64% of patients. Hemoglobin was less than 10 g/dl in 72% of patients. Pleural fluid C-reactive protein after 1 week, decreased significantly (15.21 ± 9.45 vs. 50.70 ± 20.85 mg/dl). Blood culture showed no growth in 11 (44%) patients while six (24%) patients had Staphylococcus aureus. Pleural culture revealed no growth in 13 (52%) patients while S. aureus was found in seven (28%) patients. Conclusion S. aureus is the most common isolated organism in both blood and pleural fluid positive cultures. All children received the recommended antibiotics for the treatment of empyema and empyema drainage with an intercostal tube without using fibrinolytic therapy and only 12% of the children were advised for surgical treatment in the form of open thoracotomy with decortication.","PeriodicalId":110854,"journal":{"name":"Journal of Current Medical Research and Practice","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123791819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}