Dermatologic Therapy最新文献

{"title":"Isotretinoin and Thyroid Dysfunction: A Call for Routine Monitoring","authors":"Zoha Iftikhar,&nbsp;Laura Ghanem,&nbsp;Maheen Sheraz,&nbsp;Mansoor Ahmed,&nbsp;Shree Rath,&nbsp;Mustafa Husain","doi":"10.1155/dth/4503927","DOIUrl":"https://doi.org/10.1155/dth/4503927","url":null,"abstract":"<div>\u0000 <p>Isotretinoin is a widely prescribed medication for severe acne and other dermatological conditions. While effective in managing acne, some of its systemic effects were widely discussed. However, its impact particularly on thyroid function remains underexplored. This narrative review highlights current evidence on the relationship between isotretinoin use and thyroid dysfunction, evaluating the need for routine thyroid function testing to help clinicians assess the risk of thyroid dysfunction in their patients. We searched PubMed, Scopus, and Google Scholar from inception to February 2025. Interpretation was guided by a systematic approach emphasizing study relevance, methodological quality, and recency. Inclusion criteria focused on peer-reviewed research addressing isotretinoin’s impact on thyroid function. Study designs, sample sizes, and risk of bias were critically assessed to maintain objectivity and reliability in synthesizing current evidence. Studies consistently report alterations in thyroid hormone levels during isotretinoin therapy, including elevated thyroid-stimulating hormone (TSH) and decreased free triiodothyronine (FT3) and free thyroxine (FT4) levels. Studies suggest that these changes may be mediated through mechanisms involving thyroid cell apoptosis, immunomodulatory effects, or central regulatory disruptions. Females and individuals undergoing prolonged isotretinoin therapy appear to be at higher risk. These findings highlight the importance of routine thyroid function monitoring in patients on isotretinoin, particularly those with a predisposition to autoimmune disorders or prolonged treatment courses. Further research with larger sample sizes and rigorous methodologies is needed to comprehend the underlying mechanisms and refine clinical guidelines. This review emphasizes on the need for a multidisciplinary approach involving dermatologists and endocrinologists to ensure optimal patient care and safety.</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/4503927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Efficacy and Safety of Kinesiology Tape Wrapping as Adjunct Therapy for Epidermal Growth Factor Receptor–Induced Paronychia","authors":"Ying-Hsiang Wang,&nbsp;Shang-Hung Lin,&nbsp;Yu-Wen Cheng,&nbsp;Yi-Chien Yang,&nbsp;Ting-Jung Hsu","doi":"10.1155/dth/7019466","DOIUrl":"https://doi.org/10.1155/dth/7019466","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Current therapies for epidermal growth factor receptor inhibitor (EGFRI)–related paronychia demonstrate effectiveness; however, some patients respond poorly and experience recurrent painful granulation tissue, particularly in weight-bearing areas such as the big toes. Based on promising results from our previous pilot study by Hsu and colleagues, novel kinesiology tape wrapping, which physically shields the inflamed periungual tissue from irritation by the nail plate, has emerged as a potentially effective adjunct therapy.</p>\u0000 <p><b>Objectives:</b> This open-label, randomized-controlled, single-center study was aimed to evaluate the efficacy and safety of kinesiology tape wrapping in cancer patients with EGFRI-related paronychia.</p>\u0000 <p><b>Materials and Methods:</b> Eligible participants were assigned to receive either kinesiology tape wrapping in combination with conventional therapies or conventional therapies alone for 12 weeks. Efficacy outcomes, including the reduction of subjective pain assessed by the numerical rating scale (NRS) and the objective single-digit scoring system for paronychia related to oncologic treatments (single-digit SPOT), as well as adverse events (AEs), were recorded at baseline and at Weeks 1, 2, 4, 8, and 12 postenrollment.</p>\u0000 <p><b>Results:</b> A total of 24 patients were randomized, of which, 22 qualified for analysis. The rate of continuous tape use was 36.3%. At Week 12, pain NRS scores showed no significant differences between groups, while patients treated with continuous or intermittent kinesiology tape wrapping demonstrated notably greater reductions in single-digit SPOT scores compared to those receiving conventional therapy alone (NRS: 3.27 vs. 2.78, <i>p</i> = 0.586; single-digit SPOT: 5.32 vs. 1.52, <i>p</i> = 0.022). No serious AEs were reported.</p>\u0000 <p><b>Conclusion:</b> Kinesiology tape wrapping is an effective and safe adjunct noninvasive therapy that offers additional benefits in managing EGFRI-related paronychia. Further studies with longer follow-ups and improved patient compliance may help fully evaluate its effectiveness in pain reduction.</p>\u0000 <p><b>Trial Registration</b>: ClinicalTrials.gov identifier: NCT06411093</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/7019466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of Effectiveness and Cost-Effectiveness of Treatments for Psoriasis Integrating Clinician- and Patient-Reported Outcomes: A Cohort Study From SPEECH","authors":"Ning Yu,&nbsp;Yu Wang,&nbsp;Lian Cui,&nbsp;Xia Li,&nbsp;Jun Gu,&nbsp;Xinling Bi,&nbsp;Jinhua Xu,&nbsp;Hui Deng,&nbsp;Xin Li,&nbsp;Qiang Wang,&nbsp;Yangfeng Ding,&nbsp;Yuling Shi","doi":"10.1155/dth/9464860","DOIUrl":"https://doi.org/10.1155/dth/9464860","url":null,"abstract":"<div>\u0000 <p>Effective and cost-effective management strategies for psoriasis are crucial for clinical decision-making. In the management of psoriasis, evidence concerning the effectiveness and cost-effectiveness of therapies from both clinicians’ and patients’ perspectives is vital for clinical decision-making. To compare the effectiveness and cost-effectiveness of acitretin, methotrexate, phototherapy, and biologics (adalimumab, ustekinumab, guselkumab, secukinumab, and ixekizumab) in treating chronic plaque psoriasis, we collected the data from the Shanghai Psoriasis Effectiveness Evaluation CoHort (SPEECH), an observational, multicenter, and prospective registry. Integrating both clinician- and patient-reported outcomes allows for a comprehensive evaluation of treatment impacts, capturing clinical disease improvements as well as patient-perceived quality of life enhancements, thereby providing a more complete perspective compared to analyses focusing solely on clinical outcomes. Proportions of patients achieving 75% improvement in Psoriasis Area and Severity Index (PASI 75), PASI 90, PASI 100, minimally important difference in Dermatology Life Quality Index (DLQI MID), DLQI 0/1, and Patient Global Assessment (PtGA) MID at 12 weeks were evaluated. The number needed to treat (NNT) and incremental cost per responder (ICPR) were computed for treatments relative to acitretin. A total of 1916 patients with chronic plaque psoriasis were analyzed, with 240 patients on acitretin, 459 on methotrexate, 391 on phototherapy, 64 on adalimumab, 164 on ustekinumab, 97 on guselkumab, 298 on secukinumab, and 203 on ixekizumab. At 12 weeks, patients on methotrexate (adjusted relative risk [RR], 2.03 [95% CI, 1.66–2.48]), phototherapy (RR, 2.01 [95% CI, 1.64–2.46]), adalimumab (RR, 2.22 [95% CI, 1.66–2.96]), ustekinumab (RR, 2.86 [95% CI, 2.27–3.62]), guselkumab (RR, 3.34 [95% CI, 2.54–4.38]), secukinumab (RR, 3.38 [95% CI, 2.74–4.16]), and ixekizumab (RR, 3.59 [95% CI, 2.88–4.47]) were more likely to achieve PASI 75 versus patients on acitretin. Comparable rankings were observed for PASI 90, PASI 100, DLQI MID, DLQI 0/1, and PtGA MID. Additionally, methotrexate and phototherapy demonstrated numerically lower ICPR values compared to other evaluated treatments, while ixekizumab exhibited the lowest ICPR among the biologics. Overall, our study indicated that ixekizumab, secukinumab, guselkumab, and ustekinumab demonstrated superior effectiveness compared to other therapies at 12 weeks. Methotrexate and phototherapy offered the best cost-effectiveness, while ixekizumab led in cost-effectiveness among biologics.</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/9464860","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum YKL-40 Levels as a Biomarker for Disease Severity and Therapeutic Response in Atopic Dermatitis Patients","authors":"Jiaming Fan,&nbsp;Sijie Zhou,&nbsp;Xinyun Tang,&nbsp;Xuechen Ai,&nbsp;Peimei Zhou","doi":"10.1155/dth/6650241","DOIUrl":"https://doi.org/10.1155/dth/6650241","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease, and the related biomarkers are still under investigation. Chitinase-3-like protein 1 (YKL-40) is implicated in various inflammatory conditions. This study aimed to explore changes in serum YKL-40 levels in patients with AD and evaluate their correlation with disease severity.</p>\u0000 <p><b>Methods:</b> We enrolled 62 patients with AD (16 with mild, 24 with moderate, and 22 with severe AD) and 62 age- and sex-matched healthy controls. No statistically significant difference in the clinical baseline data was observed between the two groups. Peripheral venous blood samples were collected to assess the serum levels of YKL-40, thymus and activation-regulated chemokine (TARC), interleukin (IL)-4, and IL-13. YKL-40 levels were compared between the groups, and correlations with SCORing Atopic Dermatitis (SCORAD) scores and other serum parameters were analyzed. Patients with moderate-to-severe AD received either traditional treatment (cetirizine hydrochloride and compound glycyrrhizin tablets) or dupilumab for 4 weeks, with comparison of therapeutic effects and serum changes.</p>\u0000 <p><b>Results:</b> Patients with AD exhibited significantly increased serum YKL-40 levels (<i>p</i> &lt; 0.001), which was positively correlated with SCORAD scores (<i>R</i>² = 0.603, <i>p</i> &lt; 0.001). Serum YKL-40 levels were significantly higher in moderate-to-severe AD patients compared with healthy controls but not in mild AD patients (<i>p</i> = 0.094). In addition, TARC, IgE, IL-4, and IL-13 levels were increased in patients with AD (<i>p</i> &lt; 0.001), with strong correlations to YKL-40. Dupilumab treatment significantly reduced visual analog scale scores for itching (<i>p</i> = 0.016) and YKL-40, IL-4, and IL-13 levels (<i>p</i> &lt; 0.05).</p>\u0000 <p><b>Conclusions:</b> YKL-40 levels were elevated in patients with AD and are correlated with disease severity and IL-4, IL-13, and TARC levels. Dupilumab effectively lowers YKL-40 and inflammatory markers, showing therapeutic benefit.</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/6650241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Oral Tranexamic Acid on Hair Melanin in Asian Women","authors":"Tingwei Zhang,&nbsp;Jinglai Li,&nbsp;Yuexin Li,&nbsp;Zhenxi Guo,&nbsp;Xiangjie Qi","doi":"10.1155/dth/9071909","DOIUrl":"https://doi.org/10.1155/dth/9071909","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Tranexamic acid (TXA) is widely used to treat melasma, but its potential effects on hair pigmentation remain unexplored. Concerns about hair whitening during TXA treatment have been raised, as it is often perceived as a sign of aging and may elicit negative emotional responses. This study aimed to evaluate the effects of oral TXA on hair melanin content and color.</p>\u0000 <p><b>Methods and Results:</b> Seven middle-aged East Asian women completed a 3-month prospective observational study, taking 500-mg oral TXA daily, excluding menstruation periods. Hair samples were collected from 10 scalp regions before and after treatment. Melanin content was measured using liquid chromatography–tandem mass spectrometry, and hair color changes were assessed with a colorimeter. One participant was excluded due to hair dyeing during the study. After 3 months of TXA treatment, no statistically significant changes in hair melanin content or hair color were observed, even after accounting for individual differences.</p>\u0000 <p><b>Discussion:</b> Oral TXA administered at 500 mg daily for 3 months did not significantly affect hair melanin content or color in middle-aged East Asian women. These findings provide reassurance for patients and clinicians regarding hair pigmentation during TXA treatment. Further research with diverse populations is recommended.</p>\u0000 <p><b>Trial Registration:</b> Chinese Registry of Clinical Trials: ChiCTR2400092219</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/9071909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Standard-Dose Omalizumab Against Chronic Urticaria: A Real-World Study","authors":"Zijing Xiao,&nbsp;Duoqin Wang,&nbsp;Yanyun Shen,&nbsp;Yixin Shao,&nbsp;Lisi Peng,&nbsp;Taiyu Jin,&nbsp;Yiqi Zhu,&nbsp;Hui Tang","doi":"10.1155/dth/8754260","DOIUrl":"https://doi.org/10.1155/dth/8754260","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Omalizumab has been recommended for the treatment of CU. Meanwhile, real-world data are available on the efficacy and safety of omalizumab in patients with CSU, but there is a relative paucity of data on the use of the drug in the treatment of CIndU and CSU combined with CIndU.</p>\u0000 <p><b>Objective:</b> To evaluate the efficacy and safety of omalizumab in Chinese patients with CSU, CholU, SDerm, or both, who had an inadequate response to H1-antihistamine treatment.</p>\u0000 <p><b>Methods:</b> This was an observational, retrospective chart review of patients with CU initiating omalizumab treatment.</p>\u0000 <p><b>Results:</b> In total, 78.4% (<i>n</i> = 80/102) of patients showed a response to omalizumab at the end of the study period, and 36.3% (<i>n</i> = 37/102) showed a complete response. Among patients with different subtypes, 84.8% (<i>n</i> = 38/45) of CSU, 37.5% (<i>n</i> = 3/8) of CholU, 50% (<i>n</i> = 1/2) of SDerm and 80.9% (<i>n</i> = 38/47) of CSU + SDerm comorbidity subgroup patients showed a response. The mean of tIgE levels of responders were significantly higher than nonresponders (649.48 ± 814.69 vs. 264.27 ± 262.49 ng/mL, <i>p</i> = 0.004). Patients with isolated CSU exhibited significantly lower relapse rates compared to the CSU + SDerm comorbidity subgroup (42.9% vs. 57.1%, <i>p</i> = 0.042). In total, 12 patients reinitiated omalizumab treatment after a relapse and all of them showed an early response. The mean response time was 1.33 ± 0.65 months. The response mode was similar with their first treatment.</p>\u0000 <p><b>Conclusion:</b> Omalizumab is effective in difficult-to-treat patients with CSU and CSU + SDerm comorbidity subgroup, but the response rates in patients with isolated CholU or SDerm are unsatisfactory. The mean of tIgE levels of responders were significantly higher than nonresponders at baseline. Patients in the CSU + SDerm comorbidity subgroup demonstrate an elevated risk of relapse. These findings support omalizumab’s role in refractory CSU and comorbid CSU + SDerm, but highlight unmet needs in isolated CIndU subtypes.</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/8754260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy and Safety of Upadacitinib Combined With a 308 nm Excimer Laser in the Treatment of Refractory Vitiligo Complicated With Atopic Dermatitis","authors":"Fangfei Zhou,&nbsp;Weiye Li,&nbsp;Yuhang Liu,&nbsp;Qiuyue Jin,&nbsp;Wenzhao Han,&nbsp;Jiaqi Li,&nbsp;Xiang Liu","doi":"10.1155/dth/9949035","DOIUrl":"https://doi.org/10.1155/dth/9949035","url":null,"abstract":"<div>\u0000 <p>Vitiligo is autoimmune-induced skin depigmentation. Phototherapy is commonly used as the basic treatment for vitiligo; however, its curative effect is limited in some cases of refractory vitiligo. This study aimed to evaluate the clinical efficacy and safety of upadacitinib combined with a 308 nm excimer laser (308 nm EL) for treating refractory vitiligo with moderate-to-severe atopic dermatitis (AD). We analyzed the treatment of 19 Chinese patients with skin diseases and found that sex, disease duration, and skin type did not affect repigmentation, whereas age was negatively correlated with repigmentation. After 4 months of therapy, the overall remission degree of the vitiligo area severity index (VASI) score reached 55.00%, and the last 2 months were better than the first 2 months. The curative effect of vitiligo on the face and neck was better, with an improvement of &gt; 70.00%, followed by the torso, arms, and legs. The VASI scores of the hands and feet were the worst, especially the feet which scored only 28.00%. The average improvement in the SCORing of AD (SCORAD) and dermatology life quality index (DLQI) scores was 41.89% and 49.12%, respectively. No serious adverse events were observed. Overall, upadacitinib combined with 308-nm EL showed promising clinical value for the treatment of refractory vitiligo.</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/9949035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Risk Factors for Poor Efficacy of Adalimumab Treatment in Patients With Crohn’s Disease: Insights From Machine Learning Models","authors":"Xiaojun Li,&nbsp;Maomao Tang,&nbsp;Jie Zhang,&nbsp;Yongjun Wang,&nbsp;Chunlian Wang,&nbsp;Chunhui Ouyang","doi":"10.1155/dth/1996661","DOIUrl":"https://doi.org/10.1155/dth/1996661","url":null,"abstract":"<div>\u0000 <p><b>Aim:</b> Adalimumab (ADA) is an effective treatment for Crohn’s disease (CD); however, some patients still experience adverse reactions and nonresponse. This study aimed to explore the risk factors associated with ADA poor efficacy through machine learning algorithms, which provide promising guidance for the management of ADA in clinical practice.</p>\u0000 <p><b>Methods:</b> This single-center investigation included 114 CD patients treated with ADA in the Department of Gastroenterology from January 2020 to January 2023. Risk factors associated with each poor efficacy event were explored using logistic regression and machine learning algorithms. Shapley additive explanations (SHAP) and partial dependence plot methods were used to analyze the risk factors of each event.</p>\u0000 <p><b>Results:</b> The results showed 8 of these patients experienced primary non-response (PNR), 35 patients developed secondary loss of response (LOR), and 27.2% (31/114) of patients experienced at least one adverse events (AEs). After comparing the fit of the models established by 10 algorithms, the risk factors associated with PNR, LOR, and AEs were analyzed using the logistic regression algorithm, KNN algorithm, and Extra Tree algorithm, respectively. The most important variables related to the PNR, LOR, and AEs events were the history of corticosteroid use, baseline CDAI, and uric acid, respectively.</p>\u0000 <p><b>Conclusions:</b> This study confirmed the efficacy of ADA for clinical practice in the Chinese CD population, and that patients with a history of corticosteroid use, high levels of disease activity, and high inflammatory state before ADA treatment were associated with increased risks of poor efficacy.</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/1996661","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of Cutaneous Immune-Related Adverse Events: A Qualitative Study in Patients With Cancer Receiving Immune Checkpoint Inhibitors","authors":"Zhihui Yang,&nbsp;Ruiqi Lu,&nbsp;Xingwen Li,&nbsp;Suting Liu,&nbsp;Yuanyuan Luo,&nbsp;Ziqi Wang,&nbsp;Yang Zhao,&nbsp;Lili Zhang","doi":"10.1155/dth/7119579","DOIUrl":"https://doi.org/10.1155/dth/7119579","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Cutaneous immune-related adverse events (cirAEs) represent a prevalent manifestation of adverse reactions linked to immune checkpoint inhibitors (ICIs) therapy, substantially affecting patients’ quality of life.</p>\u0000 <p><b>Objective:</b> To describe the symptomatic experience of cirAEs in patients with cancer receiving ICIs.</p>\u0000 <p><b>Design:</b> Qualitative interviews on experiences were conducted from the perspective of patients with cancer.</p>\u0000 <p><b>Methods:</b> A purposive sample of 18 patients with cirAEs participated in this semistructured interview. Transcripts were entered into Nvivo 11.0. Qualitative content analysis was used to analyze the data for significant statements and phrases, which were organized into themes and subthemes.</p>\u0000 <p><b>Results:</b> Three main themes were identified in the data: (i) multiple emotions coexist, affecting the quality of life; (ii) insufficient coping capacity for cirAEs management; and (iii) exploring needs and expectations for management with cirAEs.</p>\u0000 <p><b>Conclusions:</b> The results of this study enable healthcare providers to better understand and empathize with the patient’s experience, to truly practice the essence of patient-centered care, and to provide a basis for the development of standardized symptom management programs in the future.</p>\u0000 <p><b>Implications for Clinical Practice:</b> To strengthen patient education by clarifying knowledge of cirAEs and providing evidence-based coping strategies, formulate personalized management plans supported by multidisciplinary collaboration when necessary, establish standardized symptom management protocols incorporating regular monitoring and dynamic strategy adjustments, and promote patient participation in decision-making while building support networks to enhance self-efficacy, thereby laying the foundation for future standardized management protocols through patient-centered integrated management approaches.</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/7119579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pruritus and Its Association With Cancer and Mortality in Dermatomyositis and Polymyositis: A Nationwide Cohort Study in Taiwan From 2005 to 2022","authors":"Der-Jr Huang,&nbsp;Yu-Hsuan Joni Shao,&nbsp;Yi-Hsien Shih,&nbsp;Woan-Ruoh Lee,&nbsp;Ling-Ya Huang,&nbsp;Yu-Min Kuo,&nbsp;Quoc Thao Trang Pham,&nbsp;Hao-Jui Weng","doi":"10.1155/dth/9963667","DOIUrl":"https://doi.org/10.1155/dth/9963667","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Pruritus is the most common initial symptom reported by patients with dermatomyositis (DM) and polymyositis (PM). However, there is limited data regarding the impact of pruritus on cancer and mortality in patients with DM and PM. In this study, we aimed to investigate how pruritus is associated with cancer and mortality in patients with DM and PM.</p>\u0000 <p><b>Methods:</b> This nationwide, population-based retrospective cohort study included adult DM and PM patients from Taiwan’s National Health Insurance Research Database between 2005 and 2022. Sex- and age-matched pruritic patients, identified by over 6 weeks of antipruritic medication use, and nonpruritic patients were analyzed. The primary outcome was cancer occurrence or all-cause mortality. The association between pruritus and these outcomes was estimated using Cox proportional hazards models.</p>\u0000 <p><b>Results:</b> Among 919 matched pairs of pruritic and nonpruritic patients, cancer was observed in 19.96% in the long-term pruritic group (LPG), 14.63% in the short-term pruritic group (SPG), and 10.34% in the non-pruritic group (NPG) (<i>p</i> &lt; 0.0001). All-cause mortality was documented as 30.37% in the LPG, 29.69% in the SPG, and 37.76% in the NPG (<i>p</i> &lt; 0.0001). After adjusting for sex, age, and other comorbidities, pruritus was associated with an increased risk of cancer (hazard ratio (HR) 1.708, 95% confidence interval (CI) 1.229–2.374) and a lower risk of all-cause mortality (HR 0.483, 95% CI 0.409–0.569).</p>\u0000 <p><b>Conclusion:</b> This population-based study revealed that pruritus appeared to be associated with increased risks of cancer and decreased all-cause mortality. Thus, pruritus may serve as a pragmatic factor for risk stratification and tailored treatment strategies in DM and PM. Cancer screening, particularly for nasopharyngeal and breast cancers in East Asian populations, is recommended for patients with DM or PM, especially those presenting with pruritus. Meanwhile, patients without pruritus may require vigilant management for potentially life-threatening complications and comorbidities.</p>\u0000 </div>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/9963667","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}