The Influence of Different Treatment Intervals on the Efficacy of Hemoporfin-Mediated Photodynamic Therapy in Pediatric Patients With Port-Wine Stain on the Periphery of the Face
Jun Zhou, Jingchen Liang, Lu Cui, Ying Chen, Hongshan Liu, Zhao Wang, Yawen Wang, Shengzhi Mu, Fan Yang, Jing Liu, Weihui Zeng
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Abstract
Background: Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) is considered an effective treatment for Port-wine stain (PWS). However, no studies have explored the effects of different treatment intervals on the efficacy of Hemoporfin-PDT. This study aimed to analyze the impact of different treatment intervals on the efficacy of Hemoporfin-PDT in pediatric facial PWS patients.
Methods: A retrospective analysis was conducted based on the clinical data of 95 pediatric facial PWS patients who received Hemoporfin-PDT treatment from March 2018 to October 2023 in our center. The association between efficacy and sex, age, and treatment interval was analyzed.
Results: After three sessions of Hemoporfin-PDT, 87.37% of patients achieved excellent or good efficacy, 11.58% had fair efficacy, and 1.05% had poor efficacy. The efficacy of patients with a 9-month treatment interval was significantly inferior to those with 3-month and 6-month intervals (OR: 6.99, 95% CI: 1.63–30.02, p = 0.009; OR: 10.92, 95% CI: 2.18–54.76, p = 0.004). However, there was no significant difference between patients with 3-month and 6-month intervals (p = 0.45). Sex and age were not found to be associated with the efficacy of Hemoporfin-PDT.
Conclusion: In pediatric PWS patients with pink-type lesions located on the peripheral face, clinical efficacy is associated with the treatment interval. The efficacy of patients with a 9-month treatment interval is significantly inferior to those with 3-month and 6-month intervals. While the influence of age on the efficacy of Hemoporfin-PDT remains inconclusive, we still believe that early initiation of treatment is beneficial and necessary.
期刊介绍：
Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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