Efficacy of Diluted Calcium Hydroxyapatite Filler for Neck Rejuvenation: A Pilot Study on Single-Session, Short-Term Outcomes

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2025-04-24 DOI:10.1155/dth/1621113

Kui Young Park

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引用次数: 0

Abstract

Background: Calcium hydroxyapatite (CaHA) fillers are widely used in esthetic medicine for skin rejuvenation; however, their efficacy and safety for neck rejuvenation remain underexplored.

Objective: To evaluate the clinical efficacy and safety of a diluted CaHA filler for improving skin barrier function, hydration, elasticity, and wrinkle severity in the neck.

Methods: This 4-week prospective, single-center pilot study involved 10 volunteers aged 19–70 years with a horizontal neck wrinkle severity (HNWS) score of 2 or higher. A total of 4.8 mL of CaHA filler (VoLassom) mixed with normal saline (1:2 ratio) was injected into the subdermal layer of the neck using a 28-gauge needle across 24 points (three horizontal lines and eight points per line). Clinical outcomes, including transepidermal water loss (TEWL), skin hydration, elasticity, and HNWS, were assessed at baseline and at 2 and 4 weeks after treatment.

Results: Nine participants completed the study. TEWL decreased significantly from 8.07 ± 1.53 g/m²/h at the baseline to 6.11 ± 2.17 g/m²/h at week four (p = 0.001), reflecting improved skin barrier function. Skin hydration increased from 57.72 ± 7.17 AU at the baseline to 64.78 ± 4.27 AU at week 4 (p = 0.01), and elasticity parameters (R2, R5, and R7) showed significant improvements (p < 0.05). The HNWS score decreased from 2.44 ± 0.53 at the baseline to 1.00 ± 0.00 at week 4. No significant adverse events were observed.

Conclusion: Diluted CaHA filler is a safe and effective option for neck rejuvenation, significantly improving skin barrier function, hydration, elasticity, and wrinkle severity within a short observational period.

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稀释羟基磷灰石钙填充剂对颈部年轻化的疗效：一项单期短期结果的试点研究

背景：羟基磷灰石钙（CaHA）填料广泛应用于皮肤嫩肤美容医学；然而，它们对颈部年轻化的有效性和安全性仍未得到充分研究。目的：评价稀释CaHA填充剂改善颈部皮肤屏障功能、水合作用、弹性和皱纹严重程度的临床疗效和安全性。方法：这项为期4周的前瞻性单中心试点研究纳入了10名年龄在19-70岁之间、水平颈部皱纹严重程度（HNWS）评分为2分或更高的志愿者。用28号针穿过24个点（3条水行线，每条线8个点），将4.8 mL CaHA填充剂（VoLassom）与生理盐水（1:2比例）混合注入颈部真皮下层。临床结果，包括经皮失水（TEWL）、皮肤水化、弹性和HNWS，在基线和治疗后2周和4周进行评估。结果：9名参与者完成了研究。TEWL从基线的8.07±1.53 g/m2/h显著下降到第四周的6.11±2.17 g/m2/h (p = 0.001)，反映了皮肤屏障功能的改善。皮肤水合度从基线时的57.72±7.17 AU增加到第4周时的64.78±4.27 AU (p = 0.01)，弹性参数（R2、R5和R7）有显著改善(p <；0.05)。HNWS评分从基线时的2.44±0.53降至第4周时的1.00±0.00。未观察到明显的不良事件。结论：稀释的CaHA填充剂是安全有效的颈部年轻化选择，在短期观察期内显著改善皮肤屏障功能，水合作用，弹性和皱纹严重程度。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.