Natural History and Prognostic Factors of Chronic Urticaria in Children Aged < 2 Years: A Single-Centered, Real-World, and Retrospective Study

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2025-04-16 DOI:10.1155/dth/1564070

Chun-Xiao Li, Hua-Guo Li, Bei-Bei Zhang, Yun Huang, Bei-Ming Wang, Yi-Hang Shen, Xiao-Xiao Wang, Wei-Qin Yang, Yan Gu, Yi-Feng Guo, Hui Zhang

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Abstract

Background: To date, a limited number of studies have reported on the natural course and prognostic factors of chronic urticaria (CU) among children aged < 2 years.

Objective: In this study, we delineated the characteristics and natural history of CU in children aged < 2 years, with an additional aim of identifying prognostic factors closely associated with CU.

Methods: This study included children aged < 2 years who had CU between May 2019 and June 2023. The clinical data and laboratory results of these children were retrieved from their medical records or through telephone interviews.

Results: The study population comprised 111 children with a median age of 16.30 (0.3–24) months at onset. Remission rates at 6, 12, and 36 months after the onset of CU were 36.08%, 51.55%, and 77.32%, respectively. After the sex and age at onset were adjusted, multivariate regression analysis revealed that allergic conjunctivitis was a risk factor for CU (OR_adjusted = 5.14 [95% CI, 1.03–28.52]).

Conclusion: The course of CU in children aged < 2 years is relatively short, with most children having a favorable outcome. Allergic conjunctivitis serves as a risk factor for CU in this age group.

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< 2岁儿童慢性荨麻疹的自然病史和预后因素：一项单中心、真实世界和回顾性研究

背景：迄今为止，关于慢性荨麻疹（CU）的自然病程和预后因素的研究报告数量有限。2年。目的：本研究描述了18岁儿童CU的特点和自然病史；2年，另一个目的是确定与CU密切相关的预后因素。方法：本研究纳入年龄为<；在2019年5月至2023年6月期间接受过CU教育的2岁学生。这些儿童的临床资料和实验室结果是从他们的医疗记录或通过电话访谈中检索的。结果：研究人群包括111名儿童，发病时中位年龄为16.30（0.3-24）个月。CU发病后6个月、12个月和36个月的缓解率分别为36.08%、51.55%和77.32%。在调整性别和发病年龄后，多因素回归分析显示过敏性结膜炎是CU的危险因素（or校正= 5.14 [95% CI, 1.03-28.52]）。结论：老年儿童CU病程；2年的时间相对较短，大多数孩子都有良好的结局。过敏性结膜炎是这一年龄组发生CU的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.