Current topics in membranes最新文献_第2页

The role of extracellular vesicles in cancer. 细胞外囊泡在癌症中的作用。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-07-22 DOI: 10.1016/bs.ctm.2024.06.010

Elizabeth Cristina Perez Hurtado, Juan Sebastian Henao Agudelo, Rodrigo Augusto Foganholi da Silva, Thiago Albuquerque Viração, Célio Junior da Costa Fernandes

{"title":"The role of extracellular vesicles in cancer.","authors":"Elizabeth Cristina Perez Hurtado, Juan Sebastian Henao Agudelo, Rodrigo Augusto Foganholi da Silva, Thiago Albuquerque Viração, Célio Junior da Costa Fernandes","doi":"10.1016/bs.ctm.2024.06.010","DOIUrl":"https://doi.org/10.1016/bs.ctm.2024.06.010","url":null,"abstract":"Extracellular vesicles (EVs), which include small EVs such as exosomes, play a critical role in intercellular communication and are produced by both cancer and non-cancer cells. Several studies have shown that cancer cells exploit various strategies to regulate the biogenesis, composition, and functions of EVs primarily to promote cancer progression. Given that exosomes originate from major sorting hubs at the limiting membrane of endosomes, they are central to a signaling network that connects external stimuli with intrinsic tumor cell features. Exosomes contain diverse repertoires of molecular cargos, such as proteins, lipids, and nucleic acids, which determine their heterogeneity and functional properties in cancer progression. Therefore, targeting exosome biogenesis will enhance our understanding of tumorigenesis and also promote the discovery of novel approaches for cancer therapy. In this chapter we summarize the machinery of exosome biogenesis and the local, distant, and systemic effects of exosomes released by cancer cells. Furthermore, we explore how these exosomes regulate the anti-tumor immune response and epigenetic mechanisms to sustain cancer progression and their implications in cancer prevention and treatment.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"94 ","pages":"247-285"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles. 细胞外囊泡

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-08-23 DOI: 10.1016/bs.ctm.2024.06.008

Mariana Ottaiano Gonçalves, Juliana Fortes Di Iorio, Gabriela Villa Marin, Paula Meneghetti, Náthani Gabrielly Silva Negreiros, Ana Claudia Torrecilhas

{"title":"Extracellular vesicles.","authors":"Mariana Ottaiano Gonçalves, Juliana Fortes Di Iorio, Gabriela Villa Marin, Paula Meneghetti, Náthani Gabrielly Silva Negreiros, Ana Claudia Torrecilhas","doi":"10.1016/bs.ctm.2024.06.008","DOIUrl":"https://doi.org/10.1016/bs.ctm.2024.06.008","url":null,"abstract":"Cells, pathogens, and other systems release extracellular vesicles (EVs). The particles promote intercellular communication and contain proteins, lipids, RNA and DNA. Initially considered to be cellular waste in the twentieth century, EVs were becoming recognized for their function in biological communication and control. EVs are divided into many subtypes: exosomes, microvesicles, and apoptotic bodies. Exosomes form in the late endosome/multivesicular body and are released when the compartments fuse with the plasma membrane. Microvesicles are generated by direct budding of the plasma membrane, whereas apoptotic bodies are formed after cellular apoptosis. The new guideline for EVs that describes alternate nomenclature for EVs. The particles modulate the immune response by affecting both innate and adaptive immunity, and their specific the structure allows them to be used as biomarkers to diagnose a variety of diseases. EVs have a wide range of applications, for example, delivery systems for medications and genetic therapies because of their ability to convey specific cellular material. In anti-tumor therapy, EVs deliver therapeutic chemicals to tumor cells. The EVs promote transplant compatibility and reduce organ rejection. Host-parasite interactions, therapeutic and diagnostic for cancer, cardiovascular disease, cardiac tissue regeneration, and the treatment of neurological diseases such as Alzheimer's and Parkinson's. The study of EVs keeps on expanding, revealing new functions and beneficial options. EVs have the potential to change drug delivery, diagnostics, and specific therapeutics, creating a new frontier in biomedical.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"94 ","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Receptor-mediated endocytosis in kidney cells during physiological and pathological conditions. 肾脏细胞在生理和病理状态下受体介导的内吞作用。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-06-04 DOI: 10.1016/bs.ctm.2024.05.003

Mariana C Rodrigues, Laura B F Oliveira, Maria Aparecida R Vieira, Celso Caruso-Neves, Diogo B Peruchetti

{"title":"Receptor-mediated endocytosis in kidney cells during physiological and pathological conditions.","authors":"Mariana C Rodrigues, Laura B F Oliveira, Maria Aparecida R Vieira, Celso Caruso-Neves, Diogo B Peruchetti","doi":"10.1016/bs.ctm.2024.05.003","DOIUrl":"https://doi.org/10.1016/bs.ctm.2024.05.003","url":null,"abstract":"Mammalian cell membranes are very dynamic where they respond to several environmental stimuli by rearranging the membrane composition by basic biological processes, including endocytosis. In this context, receptor-mediated endocytosis, either clathrin-dependent or caveolae-dependent, is involved in different physiological and pathological conditions. In the last years, an important amount of evidence has been reported that kidney function involves the modulation of different types of endocytosis, including renal protein handling. In addition, the dysfunction of the endocytic machinery is involved with the development of proteinuria as well as glomerular and tubular injuries observed in kidney diseases associated with hypertension, diabetes, and others. In this present review, we will discuss the mechanisms underlying the receptor-mediated endocytosis in different glomerular cells and proximal tubule epithelial cells as well as their modulation by different factors during physiological and pathological conditions. These findings could help to expand the current understanding regarding renal protein handling as well as identify possible new therapeutic targets to halt the progression of kidney disease.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"93 ","pages":"1-25"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles in malaria: Pathogenesis, diagnosis and therapy. 疟疾中的细胞外囊泡：发病机制、诊断和治疗。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-08-31 DOI: 10.1016/bs.ctm.2024.06.006

Ana Acacia S Pinheiro, Celso Caruso-Neves, Patricia R M Rocco

引用次数: 0

Extracellular vesicles as biomarkers in parasitic disease diagnosis. 细胞外囊泡作为寄生虫病诊断的生物标志物。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-08-12 DOI: 10.1016/bs.ctm.2024.07.003

Berta Barnadas-Carceller, Hernando A Del Portillo, Carmen Fernandez-Becerra

{"title":"Extracellular vesicles as biomarkers in parasitic disease diagnosis.","authors":"Berta Barnadas-Carceller, Hernando A Del Portillo, Carmen Fernandez-Becerra","doi":"10.1016/bs.ctm.2024.07.003","DOIUrl":"https://doi.org/10.1016/bs.ctm.2024.07.003","url":null,"abstract":"Parasitic diseases constitute a major global health problem, affecting millions of people worldwide. Recent advances in the study of extracellular vesicles (EVs) have opened up new strategies for biomarker discovery in protozoan and helminth infections. Analyses of EVs in cultures and biological fluids have identified numerous potential biomarkers that could be useful for early and differential diagnosis, monitoring therapeutic responses, and the overall management and control of these diseases. Despite the potential of these biomarkers, several challenges must be addressed, including limited research, the need for standardized protocols, and the reproducibility of results across studies. In many parasitic infections, EVs have been obtained from various sample types, including plasma from human patients and mouse models, as well as cultures of the parasites at different stages. EVs were isolated by various methods and predominantly characterized through proteomic analysis or RNA sequencing to assess their cargo and identify potential biomarkers. These biomarker candidates were investigated and validated using different assays such as ELISA, Western Blot, and ROC curves. Overall, the use of EVs is considered a promising new diagnostic strategy for parasite infections, but further research with larger cohorts, standardized methods, and additional validation tests are essential for effective diagnosis and management of these diseases.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"94 ","pages":"187-223"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles release from protozoa parasite and animal model. 原生动物寄生虫和动物模型释放的细胞外囊泡。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-08-31 DOI: 10.1016/bs.ctm.2024.06.007

Andrey Sladkevicius Vidal, Rogéria Cristina Zauli, Wagner Luiz Batista, Patricia Xander

引用次数: 0

Exploring bacterial extracellular vesicles: Focus on WHO critical priority pathogens. 探索细菌胞外囊泡：关注世界卫生组织重点关注的病原体。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-07-20 DOI: 10.1016/bs.ctm.2024.06.009

Luciene Andrade da Rocha Minarini

引用次数: 0

Endocytosis in malaria parasites: An ultrastructural perspective of membrane interplay in a unique infection model. 疟原虫的内吞作用：从超微结构角度看独特感染模型中的膜相互作用

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-08-05 DOI: 10.1016/bs.ctm.2024.05.001

Camila Wendt, Kildare Miranda

{"title":"Endocytosis in malaria parasites: An ultrastructural perspective of membrane interplay in a unique infection model.","authors":"Camila Wendt, Kildare Miranda","doi":"10.1016/bs.ctm.2024.05.001","DOIUrl":"https://doi.org/10.1016/bs.ctm.2024.05.001","url":null,"abstract":"Malaria remains a major global threat, representing a severe public health problem worldwide. Annually, it is responsible for a high rate of morbidity and mortality in many tropical developing countries where the disease is endemic. The causative agent of malaria, Plasmodium spp., exhibits a complex life cycle, alternating between an invertebrate vector, which transmits the disease, and the vertebrate host. The disease pathology observed in the vertebrate host is attributed to the asexual development of Plasmodium spp. inside the erythrocyte. Once inside the red blood cell, malaria parasites cause extensive changes in the host cell, increasing membrane rigidity and altering its normal discoid shape. Additionally, during their intraerythrocytic development, malaria parasites incorporate and degrade up to 70 % of host cell hemoglobin. This mechanism is essential for parasite development and represents an important drug target. Blocking the steps related to hemoglobin endocytosis or degradation impairs parasite development and can lead to its death. The ultrastructural analysis of hemoglobin endocytosis on Plasmodium spp. has been broadly explored along the years. However, it is only recently that the proteins involved in this process have started to emerge. Here, we will review the most important features related to hemoglobin endocytosis and catabolism on malaria parasites. A special focus will be given to the recent analysis obtained through 3D visualization approaches and to the molecules involved in these mechanisms.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"93 ","pages":"27-49"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of female sexual hormones on the endothelial glycocalyx. 雌性性激素对内皮糖萼的影响。

4区生物学

Current topics in membranes Pub Date : 2023-01-01 DOI: 10.1016/bs.ctm.2023.02.005

Simone R Potje, Núbia S Martins, Maira N Benatti, Daniel Rodrigues, Vânia L D Bonato, Rita C Tostes

{"title":"The effects of female sexual hormones on the endothelial glycocalyx.","authors":"Simone R Potje, Núbia S Martins, Maira N Benatti, Daniel Rodrigues, Vânia L D Bonato, Rita C Tostes","doi":"10.1016/bs.ctm.2023.02.005","DOIUrl":"https://doi.org/10.1016/bs.ctm.2023.02.005","url":null,"abstract":"The glycocalyx is a layer composed of carbohydrate side chains bound to core proteins that lines the vascular endothelium. The integrity of the glycocalyx is essential for endothelial cells' performance and vascular homeostasis. The neuroendocrine and immune systems influence the composition, maintenance, activity and degradation of the endothelial glycocalyx. The female organism has unique characteristics, and estrogen and progesterone, the main female hormones are essential to the development and physiology of the reproductive system and to the ability to develop a fetus. Female sex hormones also exert a wide variety of effects on other organs, including the vascular endothelium. They upregulate nitric oxide synthase expression and activity, decrease oxidative stress, increase vasodilation, and protect from vascular injury. This review will discuss how female hormones and pregnancy, which prompts to high levels of estrogen and progesterone, modulate the endothelial glycocalyx. Diseases prevalent in women that alter the glycocalyx, and therapeutic forms to prevent glycocalyx degradation and potential treatments that can reconstitute its structure and function will also be discussed.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"91 ","pages":"89-137"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impairment of endothelial glycocalyx in atherosclerosis and obesity. 动脉粥样硬化和肥胖症中的内皮糖萼受损。

4区生物学

Current topics in membranes Pub Date : 2023-01-01 Epub Date: 2023-03-10 DOI: 10.1016/bs.ctm.2023.02.001

Sang Joon Ahn, Elizabeth Le Master, Sara T Granados, Irena Levitan

{"title":"Impairment of endothelial glycocalyx in atherosclerosis and obesity.","authors":"Sang Joon Ahn, Elizabeth Le Master, Sara T Granados, Irena Levitan","doi":"10.1016/bs.ctm.2023.02.001","DOIUrl":"10.1016/bs.ctm.2023.02.001","url":null,"abstract":"Endothelial glycocalyx is a negatively charged gel-like layer located on the apical surface of endothelial cells. It serves as a selective two-way physical barrier between the flowing blood and the endothelium, which regulates the access of macromolecules and of blood cells to the endothelial surface. In addition, endothelial glycocalyx plays a major role in sensing mechanical signals generated by the blood flow and transducing these signals to maintain endothelial functions; Thus, dysfunction or disruption of endothelial glycocalyx in pathological condition leads to endothelial dysfunction and contributes to the development of vascular diseases. In this review, we discuss the impact of atherosclerosis with the following viewpoints: (i) hypercholesterolemic effects on endothelial glycocalyx degradation in animal models and human patients, (ii) disruption of endothelial glycocalyx by atherogenic lipoproteins, (iii) proatherogenic disturbed flow effects on endothelial glycocalyx degradation, (iv) pathological consequences of the loss of glycocalyx integrity in atherogenesis, and (v) therapeutic effect of glycocalyx supplementation on atherosclerosis development. Additionally, we also discuss recent studies in pathological effects of obesity on the disruption of endothelial glycocalyx.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"91 ","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0