Current topics in membranes最新文献

How has the evolution of our understanding of the compartmentalization of sphingolipid biosynthesis over the past 30 years altered our view of the evolution of the pathway? 在过去 30 年中，我们对鞘脂生物合成的分区的理解发生了怎样的变化，从而改变了我们对该途径进化的看法？

4区生物学

Current topics in membranes Pub Date : 2024-06-24 DOI: 10.1016/bs.ctm.2024.06.001

Assaf Biran, Tamir Dingjan, Anthony H Futerman

{"title":"How has the evolution of our understanding of the compartmentalization of sphingolipid biosynthesis over the past 30 years altered our view of the evolution of the pathway?","authors":"Assaf Biran, Tamir Dingjan, Anthony H Futerman","doi":"10.1016/bs.ctm.2024.06.001","DOIUrl":"https://doi.org/10.1016/bs.ctm.2024.06.001","url":null,"abstract":"Sphingolipids are unique among cellular lipids inasmuch as their biosynthesis is compartmentalized between the endoplasmic reticulum (ER) and the Golgi apparatus. This compartmentalization was first recognized about thirty years ago, and the current review not only updates studies on the compartmentalization of sphingolipid biosynthesis, but also discusses the ramifications of this feature for our understanding of how the pathway could have evolved. Thus, we augment some of our recent studies by inclusion of two further molecular pathways that need to be considered when analyzing the evolutionary requirements for generation of sphingolipids, namely contact sites between the ER and the Golgi apparatus, and the mechanism(s) of vesicular transport between these two organelles. Along with evolution of the individual enzymes of the pathway, their subcellular localization, and the supply of essential metabolites via the anteome, it becomes apparent that current models to describe evolution of the sphingolipid biosynthetic pathway may need substantial refinement.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysosomal membrane contact sites: Integrative hubs for cellular communication and homeostasis. 溶酶体膜接触点：细胞通讯和平衡的整合枢纽。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI: 10.1016/bs.ctm.2024.07.001

Sumit Bandyopadhyay, Daniel Adebayo, Eseiwi Obaseki, Hanaa Hariri

引用次数: 0

Extracellular vesicles in parasitic protozoa: Impact of Leishmania exosomes containing Leishmania RNA virus 1 (LRV1) on Leishmania infectivity and disease progression. 寄生原生动物的胞外囊泡：含有利什曼病RNA病毒1（LRV1）的利什曼病外泌体对利什曼病感染性和疾病进展的影响。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-07-16 DOI: 10.1016/bs.ctm.2024.07.002

Marine Leroux, Andrea Lafleur, Carlos Villalba-Guerrero, Myriam Beaulieu, Andressa Brito Lira, Martin Olivier

{"title":"Extracellular vesicles in parasitic protozoa: Impact of Leishmania exosomes containing Leishmania RNA virus 1 (LRV1) on Leishmania infectivity and disease progression.","authors":"Marine Leroux, Andrea Lafleur, Carlos Villalba-Guerrero, Myriam Beaulieu, Andressa Brito Lira, Martin Olivier","doi":"10.1016/bs.ctm.2024.07.002","DOIUrl":"10.1016/bs.ctm.2024.07.002","url":null,"abstract":"This chapter focuses on the interplay between Leishmania parasites and their host, particularly on Leishmania RNA virus (LRVs) and extracellular vesicles (EVs) in modulating host-pathogen interactions. Leishmania EVs have been shown to facilitate gene transfer, including drug-resistance genes, enhancing the parasites' survival and resistance to antileishmanial therapeutics. These EVs also play a significant role in host immune modulation by altering cytokine production in macrophages and promoting an anti-inflammatory environment that favours parasitic persistence. The presence of virulence factors such as GP63 within these EVs further underscores their role in the parasite's immunopathogenesis. Over the last few decades, LRVs have been established as drivers of the severity and persistence of leishmaniasis by exacerbating inflammatory responses and potentially influencing treatment outcomes. This chapter discusses the evolutionary origins and classification of these viruses, and explores their role in parasitic pathogenicity, highlighting their ubiquity across protozoan parasites and their impact on disease progression.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of extracellular vesicles in the interaction of hosts and Toxoplasma gondii. 细胞外囊泡参与宿主与弓形虫的相互作用。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-08-29 DOI: 10.1016/bs.ctm.2024.06.003

Letícia Pereira Pedrini Vicentini, Vera Lucia Pereira-Chioccola, Blima Fux

引用次数: 0

Impact of coat protein on evolution of ilarviruses. 衣壳蛋白对伊拉病毒进化的影响。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-06-04 DOI: 10.1016/bs.ctm.2024.05.002

Ali Çelik, Adyatma Irawan Santosa

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Preface. 序言

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Current topics in membranes Pub Date : 2024-01-01 DOI: 10.1016/S1063-5823(24)00031-0

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Biogenesis of EVs in Trypanosomatids. 锥虫体内 EVs 的生物生成。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-09-07 DOI: 10.1016/bs.ctm.2024.06.004

Nadjania Saraiva De Lira Silva, Sergio Schenkman

{"title":"Biogenesis of EVs in Trypanosomatids.","authors":"Nadjania Saraiva De Lira Silva, Sergio Schenkman","doi":"10.1016/bs.ctm.2024.06.004","DOIUrl":"https://doi.org/10.1016/bs.ctm.2024.06.004","url":null,"abstract":"Trypanosomes are protozoan parasites responsible for human diseases such as Chagas disease, African trypanosomiasis, and leishmaniasis. These organisms' growth in various environments and exhibit multiple morphological stages, while adapting their surface components. They acquire and release materials extensively to get nutrients and manage interactions with the extracellular environment. They acquire and utilize proteins, lipids, and carbohydrates for growth via using membrane transport and endocytosis. Endocytosis takes place through distinct membrane areas known as the flagellar pocket and cytostome, depending on the parasite species and its developmental stage. Some forms establish a complex endocytic system to either store or break down the absorbed materials. In contrast, membrane transport facilitates the uptake of small molecules like amino acids, carbohydrates, and iron via particular receptors on the plasma membrane. Concurrently, these parasites secrete various molecules such as proteins, enzymes, nucleic acids, and glycoconjugates either in soluble form or enclosed in extracellular vesicles, which significantly contribute to their parasitic behavior. These activities require exocytosis through a secretory pathway in certain membrane domains such as the flagellum, flagellar pocket, and plasma membrane, which are controlled at various developmental stages. The main features of the endocytic and exocytic mechanisms, as well as the organelles involved, are discussed in this chapter along with their connection to the formation of exosomes and extracellular vesicles in the Tritryp species.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Extracellular vesicles in neurodegenerative, mental, and other neurological disorders: Perspectives into mechanisms, biomarker potential, and therapeutic implications. 神经退行性疾病、精神疾病和其他神经系统疾病中的细胞外囊泡：对机制、生物标志物潜力和治疗意义的展望。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-08-31 DOI: 10.1016/bs.ctm.2024.06.002

Gustavo Satoru Kajitani, Gabriela Xavier, Beatriz Enguidanos Villena-Rueda, Bruno Takao Real Karia, Marcos Leite Santoro

{"title":"Extracellular vesicles in neurodegenerative, mental, and other neurological disorders: Perspectives into mechanisms, biomarker potential, and therapeutic implications.","authors":"Gustavo Satoru Kajitani, Gabriela Xavier, Beatriz Enguidanos Villena-Rueda, Bruno Takao Real Karia, Marcos Leite Santoro","doi":"10.1016/bs.ctm.2024.06.002","DOIUrl":"https://doi.org/10.1016/bs.ctm.2024.06.002","url":null,"abstract":"Extracellular vesicles (EVs) are produced, secreted, and targeted by most human cells, including cells that compose nervous system tissues. EVs carry several types of biomolecules, such as lipids, proteins and microRNA, and can function as signaling agents in physiological and pathological processes. In this chapter, we will focus on EVs and their cargo secreted by brain cells, especially neurons and glia, and how these aspects are affected in pathological conditions. The chapter covers neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, as well as several psychiatric disorders, namely schizophrenia, autism spectrum disorder and major depressive disorder. This chapter also addresses other types of neurological dysfunctions, epilepsy and traumatic brain injury. EVs can cross the blood brain barrier, and thus brain EVs may be detected in more accessible peripheral tissue, such as circulating blood. Alterations in EV composition and contents can therefore impart valuable clues into the molecular etiology of these disorders, and serve biomarkers regarding disease prevalence, progression and treatment. EVs can also be used to carry drugs and biomolecules into brain tissue, considered as a promising drug delivery agent for neurological diseases. Therefore, although this area of research is still in its early development, it offers great potential in further elucidating and in treating neurological disorders.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles and sleep deprivation. 细胞外囊泡和睡眠不足

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Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-09-14 DOI: 10.1016/bs.ctm.2024.06.011

Ronni Rômulo Novaes E Brito

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Extracellular vesicles: Methods for purification and characterization. 细胞外囊泡：纯化和表征方法。

4区生物学

Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-08-23 DOI: 10.1016/bs.ctm.2024.06.005

Paula Meneghetti, Mariana Ottaiano Gonçalves, Gabriela Villa Marin, Juliana Fortes Di Iorio, Náthani Gabrielly Silva Negreiros, Ana Claudia Torrecilhas

引用次数: 0