Current topics in membranes最新文献

Structure and molecular composition of Toxoplasma gondii pellicle. 刚地弓形虫膜的结构与分子组成。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2025-07-15 DOI: 10.1016/bs.ctm.2025.06.004

Erica S Martins-Duarte

引用次数: 0

Trypanosoma cruzi surface components: Why so many? Why so polymorphic? 克氏锥虫表面成分：为什么这么多？为什么如此多态？

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2025-07-16 DOI: 10.1016/bs.ctm.2025.06.007

Amanda T S Albanaz, Daniella C Bartholomeu

引用次数: 0

Key proteins of the plasma membrane of Leishmania spp. 利什曼原虫质膜关键蛋白。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2025-07-05 DOI: 10.1016/bs.ctm.2025.06.008

Ramon Vieira Nunes, Bruna Rodrigues de Almeida, Hélida Monteiro de Andrade

{"title":"Key proteins of the plasma membrane of Leishmania spp.","authors":"Ramon Vieira Nunes, Bruna Rodrigues de Almeida, Hélida Monteiro de Andrade","doi":"10.1016/bs.ctm.2025.06.008","DOIUrl":"https://doi.org/10.1016/bs.ctm.2025.06.008","url":null,"abstract":"The initial interaction between host cells and Leishmania infective rforms is dependent on surface proteins from both organisms. Membrane proteins are fundamental molecules that perform a variety of functions, including recognition, adhesion, and host cell penetration, as well as nutrient and enzyme transport and cell signaling. Several Leishmania plasma membrane proteins play critical roles in host interaction, parasite survival, and virulence during the early stages of infection. Among them, the most prominent is GP63, which confers resistance to complement-mediated lysis and induces macrophage phagocytosis. Another important surface protein, prohibitin, has a role in macrophage infection and has demonstrated the ability to generate a humoral response in human patients, making it a potential diagnostic marker. Furthermore, prohibitin is considered a promising target for vaccination against L. infantum. The kinetoplastid membrane protein 11 (KMP11) has also been identified as a potential B- and T-cell immunogen during infection. The analysis of the membrane proteome profile of Leishmania promastigotes could offer a more comprehensive understanding of host-parasite interactions and Leishmania biology. Despite membrane proteins constituting 20-30 % of the proteome in most organisms, there are relatively few proteomic studies on Leishmania parasites that focus on membrane-associated proteins, even though these proteins are potential drug targets. This review provides a survey of the current knowledge regarding the composition of plasma membrane focusing, in alphabetical order, on those proteins that are best characterized in terms of functionality in Leishmania.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"95 ","pages":"249-265"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trypanosoma cruzi membrane proteins and host cell invasion. 克氏锥虫膜蛋白与宿主细胞侵袭。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2025-07-05 DOI: 10.1016/bs.ctm.2025.06.003

Luciana O Andrade

引用次数: 0

Structural and functional aspects of membranes and organelles of Trichomonas vaginalis. 阴道毛滴虫膜和细胞器的结构和功能方面。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2025-08-05 DOI: 10.1016/bs.ctm.2025.06.010

Anna de Freitas, Bruno Vicente, Victor Midlej

{"title":"Structural and functional aspects of membranes and organelles of Trichomonas vaginalis.","authors":"Anna de Freitas, Bruno Vicente, Victor Midlej","doi":"10.1016/bs.ctm.2025.06.010","DOIUrl":"https://doi.org/10.1016/bs.ctm.2025.06.010","url":null,"abstract":"Trichomonas vaginalis is a unicellular, flagellated, microaerophilic protozoan that extracellularly colonizes the human urogenital tract, causing trichomoniasis, a highly prevalent sexually transmitted infection (STI). This chapter explores the parasite's complex membrane structures and compositions, including the undulating membrane and its association with paracostal filaments and the costa. Key organelles such as the Golgi apparatus, lysosomes and hydrogenosomes are presented, detailing their structure, composition and biochemical activities. Unlike most eukaryotes, T. vaginalis lacks mitochondria, and instead, its hydrogenosomes are responsible for ATP synthesis, playing a critical role in the parasite's energy metabolism. The role of the plasma membrane in the endocytosis is addressed, alongside the involvement of the cytoskeleton and associated biochemical changes. Additionally, the chapter cover the parasite's interactions with host cells, focusing on the ameboid form of T. vaginalis. It emphasizes the morphological and structural transformations of the plasma membrane that occur during the transition from the piriform shape. Different types of vesicles associated with the plasma membrane, involved in host-parasite interactions, particularly their roles as adhesion molecules and in vesicular transport, are also discussed. The pseudocyst form of T. vaginalis, found under specific microenvironmental conditions, is also highlighted. In this form, the parasite internalizes its flagella, becoming rounded. The plasma membrane structure, composition and organelle modifications, as well as its relationship with host cells are highlighted. Furthermore, the implications of these transformations for the parasite's survival, immune evasion and pathogenic mechanisms are thoroughly reviewed, providing insights into how these membrane-associated adaptations enhance the parasite's pathogenicity.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"95 ","pages":"89-131"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrient acquisition at the membrane interface: Trypanosomatids subverting host defenses. 膜界面的营养获取：锥虫破坏宿主防御。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2025-07-16 DOI: 10.1016/bs.ctm.2025.06.002

Romário Lopes Boy, Lucas Felipe Almeida Athayde, Nassib Saab Daniel, Maria Fernanda Laranjeira-Silva

{"title":"Nutrient acquisition at the membrane interface: Trypanosomatids subverting host defenses.","authors":"Romário Lopes Boy, Lucas Felipe Almeida Athayde, Nassib Saab Daniel, Maria Fernanda Laranjeira-Silva","doi":"10.1016/bs.ctm.2025.06.002","DOIUrl":"https://doi.org/10.1016/bs.ctm.2025.06.002","url":null,"abstract":"Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. are the trypanosomatid parasites responsible for some of the most significant neglected tropical diseases, such as trypanosomiases and leishmaniases, which impact millions of people globally. Alarmingly, some of these diseases have expanded into previously unaffected regions in recent years. These parasites alternate between invertebrate and vertebrate hosts during their life cycles, adapting to different environments and competing with their hosts for several nutrients. To survive, they have evolved complex strategies to acquire essential nutrients, often subverting host immune defenses and overcoming host-imposed nutritional barriers. This chapter explores the membrane-dependent mechanisms of nutrient sensing and uptake in T. brucei, T. cruzi, and Leishmania spp., with an emphasis on how these parasites adapt to nutrient-limited conditions within their host. Following an overview of the challenges posed by host imposed nutrient restrictions, we examine the parasites' membrane-associated processes and metabolic adaptations that enable their survival. The chapter spans a wide range of micro- and macronutrients-lipids, fatty acids, carbohydrates, amino acids, and metals-discussing the roles of membrane proteins in nutrient scavenging, the metabolic pathways they trigger, and their physiological importance for parasite survival, growth, and infectivity. Special attention is given to the mechanisms by which these parasites evade nutritional immunity, a host defense strategy that limits nutrient availability to pathogens. By shedding light on these nutrient acquisition strategies, this chapter aims to advance our understanding of host-parasite interactions and identify potential targets for therapeutic interventions aimed at the metabolic vulnerabilities of these parasites.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"95 ","pages":"289-325"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 DOI: 10.1016/S1063-5823(25)00028-6

Thiago Castro-Gomes

引用次数: 0

Entamoeba histolytica: Plasma membrane components and virulence factors in the invasive process. 溶组织内阿米巴：侵袭过程中的质膜成分和毒力因子。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2025-07-18 DOI: 10.1016/bs.ctm.2025.06.001

Adriana Oliveira Costa, Maria Aparecida Gomes

{"title":"Entamoeba histolytica: Plasma membrane components and virulence factors in the invasive process.","authors":"Adriana Oliveira Costa, Maria Aparecida Gomes","doi":"10.1016/bs.ctm.2025.06.001","DOIUrl":"https://doi.org/10.1016/bs.ctm.2025.06.001","url":null,"abstract":"Entamoeba histolytica, the etiological agent of amoebiasis, is a parasitic protozoan responsible for severe gastrointestinal complications, including colitis and hepatic abscesses. The parasite primarily colonizes the human large intestine, where the active stages confront a hostile environment. Specialized adaptations in the plasma membrane of E. histolytica are critical for survive in this niche and enable the parasite to persist harmlessly in asymptomatic infection or initiate pathogenic interactions that lead to tissue invasion. Early events in pathogenesis are the breaching of the intestinal mucus layer and the subsequent contact with enteric cell. Thes processes have a link to adhesion, and along with concurrent steps such as host cell killing, immune evasion and immunomodulation, depend on the structural and molecular composition of the parasite´s plasma membrane. Over decades, studies on its diverse plasma membrane´s components have unraveled several mechanisms that guarantee the success of E. histolytica as an intestinal pathogen. This chapter explores how factors associated to plasma membrane contribute to the parasite´s ability to thrive in the intestinal environment, evade host defenses, and thrive disease progression.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"95 ","pages":"1-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membrane dynamics in giardia: Structure, function, and host interactions. 贾第鞭毛虫的膜动力学：结构、功能和宿主相互作用。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2025-07-19 DOI: 10.1016/bs.ctm.2025.06.005

Bruno Vicente, Anna de Freitas, Victor Midlej

{"title":"Membrane dynamics in giardia: Structure, function, and host interactions.","authors":"Bruno Vicente, Anna de Freitas, Victor Midlej","doi":"10.1016/bs.ctm.2025.06.005","DOIUrl":"https://doi.org/10.1016/bs.ctm.2025.06.005","url":null,"abstract":"Giardia intestinalis is an extracellular parasite that inhabits the human intestinal tract, with trophozoite and cyst stages in its life cycle. In this chapter we review basic aspects of structural organization, integrating information of the role of the plasma membrane in various aspects related to its composition, function, and importance at different stages, from the trophozoite form, involvement in encystation, to interactions with the host. Additionally, the membrane's composition, biochemical activities, receptors, and various functions it performs at different stages will be thoroughly explored. The parasite exhibits a unique and fascinating organelle: the peripheral vesicles (PVs). The membranes of these PVs will be explored, foscusing in how they drive endocytic uptake, mediate exocytic release, and carry out lysosomal degradation, all of which are essential for maintaining cellular homeostasis. Additionally, the membranes of the endoplasmic reticulum and their critical role in protein maturation and compartmentalization, both vital for proper cellular functions, will be addressed. Another key role of membranes to be explored is in the encystation process, with the presence of encystation-specific vesicles (ESVs), which are crucial in the life cycle of G. intestinalis, enabling survival in hostile conditions. The transformation of these vesicles and their contribution to protein maturation, ensuring the infectivity and resistance of the parasite, will offer a comprehensive understanding of the mechanisms underlying this parasite's survival and adaptation. The modulation of Giardia's membranes during the adhesion process to host cells will also be addressed, along with the variant surface proteins (VSPs), which are key players in the parasite's immune evasion mechanisms.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"95 ","pages":"35-88"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the condylar volume and skeletal relapse following orthognathic surgery in patients with dentofacial deformity: A retrospective study. 颌面部畸形患者正颌手术后髁突体积的变化和骨骼复发：一项回顾性研究。

4区生物学

Current topics in membranes Pub Date : 2025-01-01 Epub Date: 2022-05-04 DOI: 10.1080/08869634.2022.2070333

Namiaki Takahara, Nobuyoshi Tomomatsu, Atsushi Kimura, Machiko Kosugi, Yasuhiro Kurasawa, Kei-Ichi Morita, Tetsuya Yoda

{"title":"Changes in the condylar volume and skeletal relapse following orthognathic surgery in patients with dentofacial deformity: A retrospective study.","authors":"Namiaki Takahara, Nobuyoshi Tomomatsu, Atsushi Kimura, Machiko Kosugi, Yasuhiro Kurasawa, Kei-Ichi Morita, Tetsuya Yoda","doi":"10.1080/08869634.2022.2070333","DOIUrl":"10.1080/08869634.2022.2070333","url":null,"abstract":"Objective: To evaluate the relationship between the changes in condylar volume and maxillofacial skeletal morphology according to sex as well as the relationship between condylar volume reduction and skeletal relapse in patients who underwent orthognathic surgery.Methods: Ninety-five patients were categorized into skeletal Class III, Class II, and facial asymmetry groups. Computed tomography scans taken preoperatively and at 1 year postoperatively were used for quantitative measurement.Results: Postoperative condylar volume was reduced in both the Class II group and the deviated side of the asymmetry group. Both female and Class II deformity were significant predictors of postoperative reduction in the condylar volume. There was a significant correlation between skeletal relapse and postoperative change in condylar volume in the Class II group.Conclusion: Postoperative condylar resorption may be associated with preoperative maxillofacial skeletal morphology and sex and also with skeletal relapse in the Class II group.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"63 1","pages":"22-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78404377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0