Current oncology最新文献

Physicians' Controversies Towards Fertility Preservation in Young Patients with Gynecological Cancer: An MITO Survey. 医师对年轻妇科癌症患者保留生育能力的争议：一项MITO调查。

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-21 DOI: 10.3390/curroncol32090527

Giacomo Corrado, Inge Peters, Erica Silvestris, Raffaella Cioffi, Marcello Iacobelli, Emanuela Mancini, Riccardo Vizza, Sofia Thiella, Gennaro Cormio, Sandro Pignata, Giorgia Mangili

{"title":"Physicians' Controversies Towards Fertility Preservation in Young Patients with Gynecological Cancer: An MITO Survey.","authors":"Giacomo Corrado, Inge Peters, Erica Silvestris, Raffaella Cioffi, Marcello Iacobelli, Emanuela Mancini, Riccardo Vizza, Sofia Thiella, Gennaro Cormio, Sandro Pignata, Giorgia Mangili","doi":"10.3390/curroncol32090527","DOIUrl":"10.3390/curroncol32090527","url":null,"abstract":"Guidelines on fertility preservation (FP) have been developed to help young women preserve their fertility, which may have been impaired due to cancer. Nevertheless, the correct management of oncological patients of childbearing age remains controversial, especially regarding gynecological malignancies. For this reason, we explored the current knowledge, attitudes, and clinical practices of physicians towards the challenges of FP in this population. A specially developed questionnaire on fertility-related issues in patients with gynecological cancer was administered via email to 167 people, representing 167 centers of the Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) group. A total of 56 physicians, who represented 56 out of these 167 centers, responded to our survey (response rate: 33.5%). Approximately half of these physicians stated that they had adequate knowledge about the use of gonadotropin-releasing analog (GnRHa) injections (n = 30; 53.6%), the cryopreservation of oocytes (n = 25; 44.6%), and the cryopreservation of ovarian tissue (n = 27; 48.2%) in patients with gynecological tumors. Meanwhile, regarding (borderline) ovarian tumors, endometrial or cervical cancer, and genetic mutation carriers, attitudes varied substantially. In conclusion, the results of our survey highlight the different perspectives on controversial topics among physicians directly involved in the treatment of these tumors. These findings also demonstrate the lack of evidence on these issues to adequately counsel this specific patient population.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxicity of Esculetin Compared with Vinblastine and Paclitaxel in PC-3 Prostate Cancer Cells. 紫杉醇与长春花碱、紫杉醇对PC-3型前列腺癌细胞的细胞毒性比较

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-20 DOI: 10.3390/curroncol32090526

Ana I García-Pérez, Virginia Rubio, Angel Herráez, Lilian Puebla, José C Diez

{"title":"Cytotoxicity of Esculetin Compared with Vinblastine and Paclitaxel in PC-3 Prostate Cancer Cells.","authors":"Ana I García-Pérez, Virginia Rubio, Angel Herráez, Lilian Puebla, José C Diez","doi":"10.3390/curroncol32090526","DOIUrl":"10.3390/curroncol32090526","url":null,"abstract":"Background/objectives: Metastatic prostate cancer is among the therapy-resistant human neoplasms. PC-3 is a commonly used experimental cell line that does not express androgen receptors. We compared the cytotoxicity of esculetin with that of vinblastine and paclitaxel on prostatic tumour PC-3 cells.Methods: Cells were treated with either esculetin (100 or 250 μM), vinblastine (50 μM) or paclitaxel (100 or 200 μM) for 19 to 72 h. Cells were assessed for metabolic viability, membrane integrity, DNA fragmentation and cell cycle analysis. Apoptosis was checked with annexin and propidium iodide.Results: Esculetin decreased the metabolic activity of PC-3 cells in a time- and concentration-dependent way. The metabolic activity of vinblastine- and paclitaxel-treated cells did not show time-dependence. Cells treated with 250 µM esculetin for 48 or 72 h showed apoptosis levels similar to those produced by 50 µM vinblastine at these incubation times or by 200 µM paclitaxel at 19 h. Vinblastine and paclitaxel produced cell cycle arrest in the G2/M phase after incubation for 19 h. In contrast, esculetin did not significantly affect the cell cycle.Conclusions: A differential action of esculetin on PC-3 prostate cells may be inferred. This may be relevant for novel therapies against resistant prostate cancer.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measles Outbreaks and Implications for Patients Receiving Stem Cell or Cellular Therapies in Canada: Cell Therapy Transplant Canada (CTTC) Infectious Diseases Working Committee. 麻疹暴发和对加拿大接受干细胞或细胞治疗的患者的影响：加拿大细胞治疗移植（CTTC）传染病工作委员会。

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-19 DOI: 10.3390/curroncol32090525

Simon F Dufresne, Mohammadreza R Shahmirzadi, Uday Deotare, Dima Kabbani, Shahid Husain, Coleman Rotstein, Seyed M Hosseini-Moghaddam

{"title":"Measles Outbreaks and Implications for Patients Receiving Stem Cell or Cellular Therapies in Canada: Cell Therapy Transplant Canada (CTTC) Infectious Diseases Working Committee.","authors":"Simon F Dufresne, Mohammadreza R Shahmirzadi, Uday Deotare, Dima Kabbani, Shahid Husain, Coleman Rotstein, Seyed M Hosseini-Moghaddam","doi":"10.3390/curroncol32090525","DOIUrl":"10.3390/curroncol32090525","url":null,"abstract":"Measles exposures have historically been rare since the introduction of routine vaccination programs, resulting in a lack of attention from cancer patients, hematopoietic stem cell transplant (HCT) recipients, patients receiving cellular therapy (CT) and their healthcare providers. It is essential to acknowledge the importance of vigilance in these situations. Measles herd immunity has declined significantly in North America due to rising vaccine hesitancy, resulting in outbreaks. Measles can result in severe outcomes, and its reemergence has raised alarm among patients and healthcare professionals caring for HCT/CT recipients. Patients with severe immunocompromising conditions cannot receive live-attenuated vaccines, such as the measles vaccine. The lack of data on measles prevention in this vulnerable group presents significant clinical challenges. In response, Cell Therapy Transplant Canada (CTTC) Infectious Diseases Working Committee has developed a set of frequently asked questions to provide expert guidance to HCT and CT recipients, acknowledging the limited evidence base.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Embolism Associated with Olaparib in BRCA2-Mutated Prostate Cancer: A Case Report. 与奥拉帕尼相关的brca2突变前列腺癌肺栓塞：1例报告。

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-19 DOI: 10.3390/curroncol32090523

Shuhei Ishii, Shigekatsu Maekawa, Fumiko Amano, Daichi Kikuchi, Daiki Ikarashi, Renpei Kato, Mitsugu Kanehira, Ryo Takata, Jun Sugimura, Wataru Obara

{"title":"Pulmonary Embolism Associated with Olaparib in BRCA2-Mutated Prostate Cancer: A Case Report.","authors":"Shuhei Ishii, Shigekatsu Maekawa, Fumiko Amano, Daichi Kikuchi, Daiki Ikarashi, Renpei Kato, Mitsugu Kanehira, Ryo Takata, Jun Sugimura, Wataru Obara","doi":"10.3390/curroncol32090523","DOIUrl":"10.3390/curroncol32090523","url":null,"abstract":"Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor approved for treating metastatic castration-resistant prostate cancer (mCRPC) with BRCA mutations, has significant clinical benefits. However, evidence suggests an increased risk of venous thromboembolism, including pulmonary embolism (PE), particularly in patients with PC. However, no case reports of olaparib-associated PE in mCRPC have been published. Here, we report the case of a 70-year-old man with mCRPC harboring a BRCA2 mutation, who developed PE during olaparib therapy. Diagnostic evaluations included contrast-enhanced computed tomography and serum D-dimer level measurement. Clinical decision tools, such as the Wells score and the Khorana score, were used to support the diagnosis and risk assessment. The patient developed acute dyspnea and chest pain 7 months after olaparib initiation. Imaging confirmed multiple pulmonary emboli; laboratory testing revealed markedly elevated D-dimer levels. Anticoagulation therapy with apixaban led to rapid clinical and radiological improvement. However, mCRPC eventually progressed after olaparib discontinuation, and the patient died 15 months after olaparib initiation. This is the first reported case of olaparib-associated PE in mCRPC. It underscores the importance of vigilance for thromboembolic complications during PARP inhibitor therapy. The integration of clinical scoring systems and biomarkers may facilitate timely PE diagnosis and management, potentially improving patient outcomes.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unmet Supportive Care Needs in Cancer Survivors in Spain: A Multicentre Cross-Sectional Study on Prevalence and Sociodemographic and Disease-Related Risk Factors. 西班牙癌症幸存者未满足的支持性护理需求：一项关于患病率、社会人口统计学和疾病相关危险因素的多中心横断面研究

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-19 DOI: 10.3390/curroncol32090524

Yolanda Andreu, Beatriz Gil-Juliá, Carmen Picazo, Ana García-Conde, Ana Soto-Rubio

{"title":"Unmet Supportive Care Needs in Cancer Survivors in Spain: A Multicentre Cross-Sectional Study on Prevalence and Sociodemographic and Disease-Related Risk Factors.","authors":"Yolanda Andreu, Beatriz Gil-Juliá, Carmen Picazo, Ana García-Conde, Ana Soto-Rubio","doi":"10.3390/curroncol32090524","DOIUrl":"10.3390/curroncol32090524","url":null,"abstract":"Objective: This multicentre study investigates unmet supportive care needs (SCNs) among cancer survivors in Spain and analyses sociodemographic and cancer-related risk factors.Methods: A cross-sectional design was used with 1862 cancer survivors aged 18-92 years who had completed primary treatment with curative intent and were disease-free. Participants responded to the Cancer Survivors' Unmet Needs (CaSUN) questionnaire. Descriptive and multivariate analyses explored SCNs in the total sample and subgroups, as well as differences according to sociodemographic and cancer-related variables.Results: At least 20% of participants reported 18 needs out of a total of 35 identified by the CaSUN questionnaire. One-third to half reported needs in the comprehensive care and information domain. Risk factors for reporting more needs included younger age; female sex; not having a partner; being on sick leave or unemployed; having a diagnosis of haematological, breast or gynaecological cancer; receiving systemic treatment (chemotherapy and/or hormone therapy); and being at an earlier stage of survival.Conclusions: The study highlights significant unmet care needs among cancer survivors in Spain and the urgency of improving management of the physical and psychosocial effects of cancer and its treatment. Special attention should be given to those at greatest risk through personalised and comprehensive care strategies integrated into survivorship programs.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Tumor Recurrence with Early 18F-FDG PET-CT After Thermal and Non-Thermal Ablation. 热消融和非热消融后早期18F-FDG PET-CT预测肿瘤复发。

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-18 DOI: 10.3390/curroncol32090521

Govindarajan Narayanan, Nicole T Gentile, Brian J Schiro, Ripal T Gandhi, Constantino S Peña, Susan van der Lei, Madelon Dijkstra

{"title":"Predicting Tumor Recurrence with Early 18F-FDG PET-CT After Thermal and Non-Thermal Ablation.","authors":"Govindarajan Narayanan, Nicole T Gentile, Brian J Schiro, Ripal T Gandhi, Constantino S Peña, Susan van der Lei, Madelon Dijkstra","doi":"10.3390/curroncol32090521","DOIUrl":"10.3390/curroncol32090521","url":null,"abstract":"The purpose was to determine the ability of 18-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) scans performed within 24 h of percutaneous image-guided ablation of primary and metastatic malignancies to predict ablation effectiveness and local tumor progression (LTP). This single-center retrospective review included patients who underwent image guided ablation (microwave ablation (MWA), cryoablation, or irreversible electroporation (IRE)) between August 2018 and February 2024 for primary and metastatic malignancies. The primary outcome measure encompassed correlating post-ablation 18F-FDG PET-CT findings with LTP development per tumor, assessed using the chi-square test. The secondary outcome measure was local tumor progression-free survival (LTPFS) per tumor, evaluated using the Kaplan-Meier survival curves, and potential confounders were identified in multivariable analysis utilizing Cox proportional hazards regression models. A total of 132 patients, who underwent 159 procedures for 224 tumors, were included. During follow-up, LTP developed in 120 out of 224 tumors (53.6%). The presence of residual nodular 18F-FDG avidity on PET-CT within 24 h after the ablation significantly correlated with the development of LTP at follow-up imaging (p < 0.001). The positive predictive value of nodular 18F-FDG avidity was 86.7%. In multivariable analysis, the hazard ratio (HR) for 18F-FDG avidity was 2.355 (95% CI 1.614-2.647; p < 0.001). The presence of 18F-FDG avidity on PET-CT within 24 h after the ablation was highly correlated with development of LTP and decreased LTPFS. The detection of residual tumor tissue may allow early re-treatments, especially in tumors with nodular uptake, contributing to increased LTPFS.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma in Primary Care: A Narrative Review of Training Interventions and the Role of Telemedicine in Medical Education. 初级保健中的黑色素瘤：培训干预和远程医疗在医学教育中的作用的叙述性回顾。

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-18 DOI: 10.3390/curroncol32090522

Ignazio Stanganelli, Edoardo Mora, Debora Cantagalli, Serena Magi, Laura Mazzoni, Matelda Medri, Cesare Massone, Davide Melandri, Federica Zamagni, Ines Zanna, Gianluca Pistore, Saverio Caini, Salvatore Amato, Vincenzo De Giorgi, Pietro Quaglino, Maria Antonietta Pizzichetta, Giovanni Luigi Tripepi, Giorgia Ravaglia, Sofia Spagnolini

{"title":"Melanoma in Primary Care: A Narrative Review of Training Interventions and the Role of Telemedicine in Medical Education.","authors":"Ignazio Stanganelli, Edoardo Mora, Debora Cantagalli, Serena Magi, Laura Mazzoni, Matelda Medri, Cesare Massone, Davide Melandri, Federica Zamagni, Ines Zanna, Gianluca Pistore, Saverio Caini, Salvatore Amato, Vincenzo De Giorgi, Pietro Quaglino, Maria Antonietta Pizzichetta, Giovanni Luigi Tripepi, Giorgia Ravaglia, Sofia Spagnolini","doi":"10.3390/curroncol32090522","DOIUrl":"10.3390/curroncol32090522","url":null,"abstract":"General practitioners play a crucial role in the early detection and prevention of cutaneous melanoma. However, structured training on skin cancer diagnosis and management is often lacking. This narrative review aims to map the current educational interventions for general practitioners focused on melanoma, assess their methodological approaches and outcomes, and explore the contribution of e-learning and telemedicine in medical education. A comprehensive literature search identified 54 relevant studies published between 1 January 1995 and 31 December 2024. Data were extracted and categorized by topics covered, training methodology, interactivity, and clinical outcomes. Training programs varied widely in duration, delivery, and content. Interventions that integrated dermoscopy and interactive methodologies demonstrated improved diagnostic accuracy and clinical impact. E-learning, particularly asynchronous models, emerged as a flexible and effective modality, although few studies evaluated long-term retention or clinical practice changes. Educational programs tailored to general practitioners and enriched with dermoscopy and telemedicine tools show promise in improving melanoma detection and care. Structured, interactive, and blended/hybrid learning models should be prioritized to support effective primary and secondary prevention.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on Pang et al. Ablative Techniques for Lung Metastases: Patient Selection and Outcomes Following Treatment with Stereotactic Radiotherapy or Radiofrequency Ablation. Curr. Oncol. 2025, 32, 303. 对Pang等人的评论。肺转移的消融技术：立体定向放疗或射频消融治疗后的患者选择和结果。咕咕叫。生物学报，2025,32,303。

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-17 DOI: 10.3390/curroncol32090517

Fergus Macbeth, Tom Treasure

引用次数: 0

Reply to Macbeth, F.; Treasure, T. Comment on "Pang et al. Ablative Techniques for Lung Metastases: Patient Selection and Outcomes Following Treatment with Stereotactic Radiotherapy or Radiofrequency Ablation. Curr. Oncol. 2025, 32, 303". 回答麦克白，f；对“庞等人”的评论。肺转移的消融技术：立体定向放疗或射频消融治疗后的患者选择和结果。咕咕叫。生物学报，2025,32,303”。

IF 3.4 4区医学

Current oncology Pub Date : 2025-09-17 DOI: 10.3390/curroncol32090518

Nicos Fotiadis, Daniel Tong, Jennifer W S Pang, Merina Ahmed

引用次数: 0

Nutritional Status and Chemotherapy Completion in Resectable Pancreatic Cancer: A Narrative Review. 可切除胰腺癌的营养状况和化疗完成：一项叙述性综述。