Physicians' Controversies Towards Fertility Preservation in Young Patients with Gynecological Cancer: An MITO Survey.

IF 3.4 4区 医学 Q2 ONCOLOGY
Giacomo Corrado, Inge Peters, Erica Silvestris, Raffaella Cioffi, Marcello Iacobelli, Emanuela Mancini, Riccardo Vizza, Sofia Thiella, Gennaro Cormio, Sandro Pignata, Giorgia Mangili
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Abstract

Guidelines on fertility preservation (FP) have been developed to help young women preserve their fertility, which may have been impaired due to cancer. Nevertheless, the correct management of oncological patients of childbearing age remains controversial, especially regarding gynecological malignancies. For this reason, we explored the current knowledge, attitudes, and clinical practices of physicians towards the challenges of FP in this population. A specially developed questionnaire on fertility-related issues in patients with gynecological cancer was administered via email to 167 people, representing 167 centers of the Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) group. A total of 56 physicians, who represented 56 out of these 167 centers, responded to our survey (response rate: 33.5%). Approximately half of these physicians stated that they had adequate knowledge about the use of gonadotropin-releasing analog (GnRHa) injections (n = 30; 53.6%), the cryopreservation of oocytes (n = 25; 44.6%), and the cryopreservation of ovarian tissue (n = 27; 48.2%) in patients with gynecological tumors. Meanwhile, regarding (borderline) ovarian tumors, endometrial or cervical cancer, and genetic mutation carriers, attitudes varied substantially. In conclusion, the results of our survey highlight the different perspectives on controversial topics among physicians directly involved in the treatment of these tumors. These findings also demonstrate the lack of evidence on these issues to adequately counsel this specific patient population.

医师对年轻妇科癌症患者保留生育能力的争议:一项MITO调查。
制定了保留生育能力的指导方针,以帮助年轻妇女保留可能因癌症而受损的生育能力。然而,育龄肿瘤患者的正确管理仍然存在争议,特别是关于妇科恶性肿瘤。出于这个原因,我们探讨了目前的知识,态度和临床实践的医生对计划生育的挑战,在这一人群。一份关于妇科癌症患者生育相关问题的特别调查问卷通过电子邮件发给167人,这些人代表了意大利卵巢癌和妇科恶性肿瘤多中心试验(MITO)组的167个中心。共有56名医生,他们代表167个中心中的56个,回应了我们的调查(回复率:33.5%)。大约一半的医生表示,他们对妇科肿瘤患者使用促性腺激素释放类似物(GnRHa)注射剂(n = 30; 53.6%)、卵母细胞冷冻保存(n = 25; 44.6%)和卵巢组织冷冻保存(n = 27; 48.2%)有足够的了解。同时,对于(交界性)卵巢肿瘤、子宫内膜癌或宫颈癌以及基因突变携带者,态度差异很大。总之,我们的调查结果突出了直接参与这些肿瘤治疗的医生对有争议话题的不同观点。这些发现也表明,在这些问题上缺乏足够的证据来充分咨询这一特定的患者群体。
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来源期刊
Current oncology
Current oncology ONCOLOGY-
CiteScore
3.30
自引率
7.70%
发文量
664
审稿时长
1 months
期刊介绍: Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.
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