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Current Opinion in Neurobiology最新文献

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Ferret contributions to the business of sensory neurobiology 雪貂对感觉神经生物学事业的贡献。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-11-01 DOI: 10.1016/j.conb.2024.102929
Rebecca H.C. Norris, Jennifer K. Bizley
{"title":"Ferret contributions to the business of sensory neurobiology","authors":"Rebecca H.C. Norris,&nbsp;Jennifer K. Bizley","doi":"10.1016/j.conb.2024.102929","DOIUrl":"10.1016/j.conb.2024.102929","url":null,"abstract":"<div><div>In this brief review, we will highlight the ferret <em>Mustela putorius furo</em> as an increasingly utilized animal model for sensory systems and cognitive neuroscience research. In particular, the human like hearing range of the ferret, coupled with their amenability to training, make them an especially useful model for auditory and multisensory neuroscience. These factors, combined with the increasing availability of virally mediated circuit dissection methods, mean they occupy a unique niche as a versatile and valuable research model.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102929"},"PeriodicalIF":4.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When the society dictates food search – Neural signalling underlying appetitive motivation in honey bees 当社会决定食物搜寻--蜜蜂食欲动机的神经信号基础
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-10-28 DOI: 10.1016/j.conb.2024.102930
Rafael Carvalho da Silva , Louise Bestea , Gabriela de Brito Sanchez , Martin Giurfa
{"title":"When the society dictates food search – Neural signalling underlying appetitive motivation in honey bees","authors":"Rafael Carvalho da Silva ,&nbsp;Louise Bestea ,&nbsp;Gabriela de Brito Sanchez ,&nbsp;Martin Giurfa","doi":"10.1016/j.conb.2024.102930","DOIUrl":"10.1016/j.conb.2024.102930","url":null,"abstract":"<div><div>In honey bees, appetitive motivation is primarily driven by the needs of the colony rather than individual needs. The regulation of appetitive behavior is achieved through the coordinated action of neuropeptides, hormones and biogenic amines, which integrate multiple signals to ensure appropriate appetitive responses. Dopamine signalling underpins a food-related wanting system that is sensitive to aversive experiences. The short neuropeptide F (sNPF) enhances appetitive responsiveness, food intake and behavioral and neural responsiveness to food-related odorants. Additionally, it facilitates appetitive learning and memory. On the contrary, tachykinin-related peptides (TRPs) inhibit appetitive responses. Physiological changes during the transition to the foraging state lead to distinct patterns of insulin and adipokinetic hormone (AKH) signaling, different from those seen in solitary insects, indicating that social life had significant consequences on the systems controlling appetitive motivation. Overall, studying the neural bases of appetitive behavior in bees reveals unique aspects that arise from their social lifestyle.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102930"},"PeriodicalIF":4.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paper wasps: A model clade for social cognition 纸黄蜂：社会认知的典范支系
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-10-24 DOI: 10.1016/j.conb.2024.102928
Christopher M. Jernigan, Lorenz C.C. Mammen, Ronald D. Brown, Michael J. Sheehan
{"title":"Paper wasps: A model clade for social cognition","authors":"Christopher M. Jernigan,&nbsp;Lorenz C.C. Mammen,&nbsp;Ronald D. Brown,&nbsp;Michael J. Sheehan","doi":"10.1016/j.conb.2024.102928","DOIUrl":"10.1016/j.conb.2024.102928","url":null,"abstract":"<div><div>Paper wasps are a highly intelligent group of socially flexible insects with complex lives and variation in social structures. They engage in sophisticated communication within their small societies using olfaction, vibration, and even visual signals of quality or individual identity in some species. Here we describe the social biology of paper wasps as well as the impressive visual and cognitive abilities seen in this group. We summarize the recent discoveries about where and how social information is processed in the wasp brain and highlight the potential of this clade to further our understanding of the neural underpinnings of complex social cognition, its development, and its evolution.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102928"},"PeriodicalIF":4.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Neural correlates of social signaling in rodents: An acoustic perspective” "啮齿动物社会信号的神经相关性：声学视角"。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-10-18 DOI: 10.1016/j.conb.2024.102927
Dori M. Grijseels , Alena Lemazina , Luciana López-Jury , Alison J. Barker
{"title":"“Neural correlates of social signaling in rodents: An acoustic perspective”","authors":"Dori M. Grijseels ,&nbsp;Alena Lemazina ,&nbsp;Luciana López-Jury ,&nbsp;Alison J. Barker","doi":"10.1016/j.conb.2024.102927","DOIUrl":"10.1016/j.conb.2024.102927","url":null,"abstract":"<div><div>Despite the abundance and variety of rodent species worldwide, historically few have been used to study the neurobiology of social signaling. In recent years, the diversity of rodent behaviors has been leveraged to advance our understanding of neural circuits underlying social behaviors, and in particular those related to acoustic communication. Here we highlight recent work investigating vocal behaviors across social contexts in multiple rodent species and discuss how these studies reveal both shared and distinct neural circuits.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102927"},"PeriodicalIF":4.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The superior colliculus: New insights into an evolutionarily ancient structure 上丘：对古老进化结构的新认识
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-10-09 DOI: 10.1016/j.conb.2024.102926
Teresa Guillamón-Vivancos, Fabrizio Favaloro, Francesco Dori, Guillermina López-Bendito
{"title":"The superior colliculus: New insights into an evolutionarily ancient structure","authors":"Teresa Guillamón-Vivancos,&nbsp;Fabrizio Favaloro,&nbsp;Francesco Dori,&nbsp;Guillermina López-Bendito","doi":"10.1016/j.conb.2024.102926","DOIUrl":"10.1016/j.conb.2024.102926","url":null,"abstract":"<div><div>The superior colliculus is a structure located in the dorsal midbrain with well conserved function and connectivity across species. Essential for survival, the superior colliculus has evolved to trigger rapid orientation and avoidance movements in response to external stimuli. The increasing recognition of the widespread connectivity of the superior colliculus, not only with brainstem and spinal cord, but also with virtually all brain structures, has rekindled the interest on this structure and revealed novel roles in the past few years. In this review, we focus on the most recent advancements in understanding its cellular composition, connectivity and function, with a particular focus on how the cellular diversity and connectivity arises during development, as well as on its recent role in the emergence of sensory circuits.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102926"},"PeriodicalIF":4.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging evidence of a link between inflammation and the neuropathology of prenatal opioid exposure 炎症与产前接触阿片类药物的神经病理学之间存在联系的新证据。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-10-03 DOI: 10.1016/j.conb.2024.102924
Isobel A.R. Williams, Kelly J. Clemens
{"title":"Emerging evidence of a link between inflammation and the neuropathology of prenatal opioid exposure","authors":"Isobel A.R. Williams,&nbsp;Kelly J. Clemens","doi":"10.1016/j.conb.2024.102924","DOIUrl":"10.1016/j.conb.2024.102924","url":null,"abstract":"<div><div>Opioid use continues to increase, particularly among women of reproductive age. As a result, increasing numbers of infants are born with prenatal exposure to opioids, suffering both acute and long-term negative consequences. Studies performed across the past 5 years have highlighted both peripheral and central inflammation as a consistent feature of prenatal opioid exposure. Dysregulated innate and adaptive immunity have been detected in human and rodent studies, highlighting a likely role of inflammation in the neuropathology associated with opioid exposure. Identifying immune changes occurring following prenatal opioid exposure will be critical for developing new therapeutic approaches in this field.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102924"},"PeriodicalIF":4.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte-neuron crosstalk in neurodevelopmental disorders 神经发育障碍中的星形胶质细胞-神经元串扰
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.conb.2024.102925
Gabrielle Séjourné , Cagla Eroglu
{"title":"Astrocyte-neuron crosstalk in neurodevelopmental disorders","authors":"Gabrielle Séjourné ,&nbsp;Cagla Eroglu","doi":"10.1016/j.conb.2024.102925","DOIUrl":"10.1016/j.conb.2024.102925","url":null,"abstract":"<div><div>A fundamental feature shared across neurodevelopmental disorders (NDDs) is the disruption of synaptic circuit formation and homeostasis. During early life, non-neuronal cells called astrocytes tightly regulate the establishment of circuits by controlling formation, remodeling, stabilization, and maturation of synapses. Concurrently, astrocytes mature to meet the evolving needs of the developing brain. Bidirectional astrocyte-neuron communication synchronizes astrocyte maturation with synapse development. An emerging body of evidence supports the hypothesis that in NDDs, deficits in astrocyte-neuron communication underlie errors in synaptic circuit development. Here we will review and discuss these findings, with the aim of inspiring future research and guiding translational studies.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102925"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polygenicity in a box: Copy number variants, neural circuit development, and neurodevelopmental disorders 盒子里的多基因遗传：拷贝数变异、神经回路发育和神经发育障碍。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-09-20 DOI: 10.1016/j.conb.2024.102917
Anthony-Samuel LaMantia
{"title":"Polygenicity in a box: Copy number variants, neural circuit development, and neurodevelopmental disorders","authors":"Anthony-Samuel LaMantia","doi":"10.1016/j.conb.2024.102917","DOIUrl":"10.1016/j.conb.2024.102917","url":null,"abstract":"<div><div>Clinically defined neurodevelopmental disorders (cd-NDDs), including Autistic Spectrum Disorder (ASD) and Schizophrenia (Scz), are primarily polygenic: Multiple risk genes distributed across the genome, in potentially infinite combinations, account for variable pathology. Polygenicity raises a fundamental question: Can “core” cd-NDD pathogenic mechanisms be identified given this genomic complexity? With the right models and analytic targets, a distinct class of polygenic mutations—Copy Number Variants (CNVs): contiguous gene deletions or duplications associated with cd-NDD risk—provide a singular opportunity to define cd-NDD pathology. CNVs orthologous to those that confer cd-NDD risk have been engineered in animals as well as human stem cells. Using these tools, one can determine how altered function of multiple genes cause serial stumbles over cell biological steps typically taken to build optimal “polygenic” neural circuits. Thus, cd-NDD pathology may be a consequence of polygenic deviations—stumbles—that exceed limits of adaptive variation for key developmental steps.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102917"},"PeriodicalIF":4.8,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959438824000795/pdfft?md5=3b02d703f9e903119de2b0c073bc6964&pid=1-s2.0-S0959438824000795-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The power of human stem cell-based systems in the study of neurodevelopmental disorders 基于人类干细胞的系统在神经发育障碍研究中的作用
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-09-17 DOI: 10.1016/j.conb.2024.102916
Megha Jhanji , Elisa M. York , Sofia B. Lizarraga
{"title":"The power of human stem cell-based systems in the study of neurodevelopmental disorders","authors":"Megha Jhanji ,&nbsp;Elisa M. York ,&nbsp;Sofia B. Lizarraga","doi":"10.1016/j.conb.2024.102916","DOIUrl":"10.1016/j.conb.2024.102916","url":null,"abstract":"<div><p>Neurodevelopmental disorders (NDDs) affect 15% of children and are usually associated with intellectual disability, seizures, and autistic behaviors, among other neurological presentations. Mutations in a wide spectrum of gene families alter key stages of human brain development, leading to defects in neural circuits or brain architecture. Studies in animal systems have provided important insights into the pathobiology of several NDDs. Human stem cell technologies provide a complementary system that allows functional manipulation of human brain cells during developmental stages that would otherwise be inaccessible during human fetal brain development. Therefore, stem cell-based models advance our understanding of human brain development by revealing human-specific mechanisms contributing to the broad pathogenesis of NDDs. We provide a comprehensive overview of the latest research on two and three-dimensional human stem cell-based models. First, we discuss convergent cellular and molecular phenotypes across different NDDs that have been revealed by human iPSC systems. Next, we examine the contribution of in vitro human neural systems to the development of promising therapeutic strategies. Finally, we explore the potential of stem cell systems to draw mechanistic insight for the study of sex dimorphism within NDDs.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102916"},"PeriodicalIF":4.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959438824000783/pdfft?md5=69a5fa57e6d1640458ce135c49194de8&pid=1-s2.0-S0959438824000783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics and the timing of neuronal differentiation 表观遗传学与神经元分化的时机
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-09-14 DOI: 10.1016/j.conb.2024.102915
Andrew I. Aldridge, Anne E. West
{"title":"Epigenetics and the timing of neuronal differentiation","authors":"Andrew I. Aldridge,&nbsp;Anne E. West","doi":"10.1016/j.conb.2024.102915","DOIUrl":"10.1016/j.conb.2024.102915","url":null,"abstract":"<div><p>Epigenetic regulation of the genome is required for cell-type differentiation during organismal development and is especially important to generate the panoply of specialized cell types that comprise the brain. Here, we review how progressive changes in the chromatin landscape, both in neural progenitors and in postmitotic neurons, orchestrate the timing of gene expression programs that underlie first neurogenesis and then functional neuronal maturation. We discuss how disease-associated mutations in chromatin regulators can change brain composition by impairing the timing of neurogenesis. Further, we highlight studies that are beginning to show how chromatin modifications are integrated at the level of chromatin architecture to coordinate changing transcriptional programs across developmental including in postmitotic neurons.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102915"},"PeriodicalIF":4.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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