Cell biology of astrocytic adhesive interactions and signaling pathways in regulating neuronal circuits

IF 5.2 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2025-05-06 DOI:10.1016/j.conb.2025.103037

Vasileios Glykos, Maria Vazquez Pavon, Yukiko Goda

引用次数: 0

Abstract

Astrocytes have attracted attention for their crucial roles in various brain functions. Yet a gap remains in our understanding. The cellular and molecular basis by which astrocytes interact with neuronal circuits are not clear, and how astrocytes leverage their hallmark morphology dominated by intricate processes in implementing their functions require consideration. This review highlights insights into these outstanding questions gained from recent studies featuring mediators and regulators of cell–cell interactions between astrocytes and neurons, focusing on cell adhesion proteins such as cadherins and neuroligins, among others, as well as cell-extracellular matrix interactions, including astrocytic interactions with the perineuronal network.

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星形胶质细胞粘附相互作用的细胞生物学和调节神经元回路的信号通路

星形胶质细胞因其在各种脑功能中的重要作用而受到关注。然而，我们的理解仍有差距。星形胶质细胞与神经元回路相互作用的细胞和分子基础尚不清楚，星形胶质细胞如何利用其由复杂过程主导的标志形态来实现其功能需要考虑。这篇综述强调了对星形胶质细胞和神经元之间细胞间相互作用的介质和调节因子的最新研究所获得的这些突出问题的见解，重点是细胞粘附蛋白如钙粘蛋白和神经素等，以及细胞外基质相互作用，包括星形胶质细胞与神经周围网络的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience