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Caenorhabditis elegans for opioid addiction research 用于阿片类药物成瘾研究的秀丽隐杆线虫
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-09-05 DOI: 10.1016/j.conb.2024.102914
Soichiro Ide , Kazutaka Ikeda
{"title":"Caenorhabditis elegans for opioid addiction research","authors":"Soichiro Ide ,&nbsp;Kazutaka Ikeda","doi":"10.1016/j.conb.2024.102914","DOIUrl":"10.1016/j.conb.2024.102914","url":null,"abstract":"<div><p>The problem of drug addiction has become a profound societal problem worldwide. A better understanding of the neurobiological basis of addiction and the discovery of more effective treatments are needed. Recent studies have shown that many mechanisms that underlie addiction exist in more primitive organisms, including the nematode <em>Caenorhabditis elegans</em> (<em>C. elegans</em>). <em>C. elegans</em> is also hypothesized to possess a functional opioid-like system, including the endogenous opioid-like peptide NLP-24 and opioid-like receptor NPR-17. Opioids, such as morphine, are thought to cause addiction-like behavior by activating dopamine nerves in <em>C. elegans</em> via the opioid-like system. Accumulating evidence suggests that <em>C. elegans</em> is an excellent animal model for identifying molecular mechanisms of addiction.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"88 ","pages":"Article 102914"},"PeriodicalIF":4.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The big mixup: Neural representation during natural modes of primate visual behavior 大混淆灵长类视觉行为自然模式中的神经表征
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-08-29 DOI: 10.1016/j.conb.2024.102913
David A. Leopold
{"title":"The big mixup: Neural representation during natural modes of primate visual behavior","authors":"David A. Leopold","doi":"10.1016/j.conb.2024.102913","DOIUrl":"10.1016/j.conb.2024.102913","url":null,"abstract":"<div><p>The primate brain has evolved specialized visual capacities to navigate complex physical and social environments. Researchers studying cortical circuits underlying these capacities have traditionally favored the use of simplified tasks and brief stimulus presentations in order to isolate cognitive variables with tight experimental control. As a result, operational theories about visual brain function have come to emphasize feature detection, hierarchical stimulus encoding, top-down task modulation, and functional segregation in distinct cortical areas. Recently, however, experimental paradigms combining natural behavior with electrophysiological recordings have begun to offer a distinctly different portrait of how the brain takes in and analyzes its visual surroundings. The present article reviews recent work in this area, highlighting some of the more surprising findings in domains of social vision and spatial navigation along with shifts in thinking that have begun to emanate from this approach.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"88 ","pages":"Article 102913"},"PeriodicalIF":4.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959438824000758/pdfft?md5=cb7e44f49e638e6a53bf545a022d9bab&pid=1-s2.0-S0959438824000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging X-linked genes associated with neurodevelopmental disorders in females 新出现的与女性神经发育障碍有关的 X 连锁基因
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-08-20 DOI: 10.1016/j.conb.2024.102902
Jeronimo Lukin , Corinne M. Smith , Silvia De Rubeis
{"title":"Emerging X-linked genes associated with neurodevelopmental disorders in females","authors":"Jeronimo Lukin ,&nbsp;Corinne M. Smith ,&nbsp;Silvia De Rubeis","doi":"10.1016/j.conb.2024.102902","DOIUrl":"10.1016/j.conb.2024.102902","url":null,"abstract":"<div><p>A significant source of risk for neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism spectrum disorder (ASD), lies in genes located on the X chromosome. Males can be particularly vulnerable to X-linked variation because of hemizygosity, and male-specific segregation in pedigrees has guided earlier gene discovery for X-linked recessive conditions. More recently, X-linked disorders disproportionally affecting females, with complex inheritance patterns and/or presenting with sex differences, have surfaced. Here, we discuss the genetics and neurobiology of X-linked genes that are paradigmatic to understand NDDs in females. Integrating genetic, clinical, and functional data will be key to understand how X-linked variation contributes to the risk architecture of NDDs.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"88 ","pages":"Article 102902"},"PeriodicalIF":4.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jellyfish for the study of nervous system evolution and function 用于研究神经系统进化和功能的水母
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-08-20 DOI: 10.1016/j.conb.2024.102903
Karen Cunningham , David J. Anderson , Brandon Weissbourd
{"title":"Jellyfish for the study of nervous system evolution and function","authors":"Karen Cunningham ,&nbsp;David J. Anderson ,&nbsp;Brandon Weissbourd","doi":"10.1016/j.conb.2024.102903","DOIUrl":"10.1016/j.conb.2024.102903","url":null,"abstract":"<div><p>Jellyfish comprise a diverse clade of free-swimming predators that arose prior to the Cambrian explosion. They play major roles in ocean ecosystems via a suite of complex foraging, reproductive, and defensive behaviors. These behaviors arise from decentralized, regenerative nervous systems composed of body parts that generate the appropriate part-specific behaviors autonomously following excision. Here, we discuss the organization of jellyfish nervous systems and opportunities afforded by the recent development of a genetically tractable jellyfish model for systems and evolutionary neuroscience.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"88 ","pages":"Article 102903"},"PeriodicalIF":4.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959438824000655/pdfft?md5=89ec717cf9e4642b7f17b93b5e6407e7&pid=1-s2.0-S0959438824000655-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of ovarian hormones on the putative mechanisms that promote female nicotine use 卵巢激素对促进女性使用尼古丁的假定机制的影响
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-08-16 DOI: 10.1016/j.conb.2024.102900
Priscilla Giner , Sebastian Ortegon , Deniz Bagdas , Laura E. O'Dell
{"title":"The influence of ovarian hormones on the putative mechanisms that promote female nicotine use","authors":"Priscilla Giner ,&nbsp;Sebastian Ortegon ,&nbsp;Deniz Bagdas ,&nbsp;Laura E. O'Dell","doi":"10.1016/j.conb.2024.102900","DOIUrl":"10.1016/j.conb.2024.102900","url":null,"abstract":"<div><p>Nicotine use is driven by pleasurable effects, but following chronic exposure, nicotine use becomes largely driven by the desire need to avoid withdrawal symptoms. Current cessation strategies focusing on alleviating withdrawal, but current cessation interventions are less effective for women than men. Also, hormone fluctuations across the menstrual cycle appear to impact use patterns, withdrawal severity, and treatment efficacy. This raises important questions regarding optimal quit dates and the application of hormone interventions to alleviate withdrawal in women. This review surveys the existing literature assessing the impact of ovarian hormones on nicotine withdrawal severity. This is an important issue because women seeking cessation treatments may be using hormone-based contraceptives or hormone replacement post-menopause. Hormone interventions may also offer a novel treatment avenue that is more effective than current cessation approaches. Future work in this area is important for reducing health disparities produced by excessive nicotine use in women.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"88 ","pages":"Article 102900"},"PeriodicalIF":4.8,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Midbrain KCC2 downregulation: Implications for stress-related and substance use behaviors 中脑 KCC2 下调：对压力相关行为和药物使用行为的影响
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-08-13 DOI: 10.1016/j.conb.2024.102901
Anna C. Pearson, Alexey Ostroumov
{"title":"Midbrain KCC2 downregulation: Implications for stress-related and substance use behaviors","authors":"Anna C. Pearson,&nbsp;Alexey Ostroumov","doi":"10.1016/j.conb.2024.102901","DOIUrl":"10.1016/j.conb.2024.102901","url":null,"abstract":"<div><p>Stress-related and substance use disorders are both characterized by disruptions in reward-related behaviors, and these disorders are often comorbid with one another. Recent investigations have identified a novel mechanism of inhibitory plasticity induced by both stress and substance use within the ventral tegmental area (VTA), a key region in reward processing. This mechanism involves the neuron-specific potassium chloride cotransporter isoform 2 (KCC2), which is essential in modulating inhibitory signaling through the regulation of intracellular chloride (Cl<sup>−</sup>) in VTA GABA neurons. Experiences, such as exposure to stress or substance use, diminish KCC2 expression in VTA GABA neurons, leading to abnormal reward-related behaviors. Here, we review literature suggesting that KCC2 downregulation contributes to irregular dopamine (DA) transmission, impacting multiple reward circuits and promoting maladaptive behaviors. Activating KCC2 restores canonical GABA functioning and reduces behavioral deficits in preclinical models, leading us to advocate for KCC2 as a target for therapies aimed at alleviating and mitigating various stress-related and substance use disorders.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"88 ","pages":"Article 102901"},"PeriodicalIF":4.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal UBE3A substrates hold therapeutic potential for Angelman syndrome 神经元 UBE3A 底物具有治疗安杰曼综合征的潜力。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-08-09 DOI: 10.1016/j.conb.2024.102899
Joseph C. Krzeski , Matthew C. Judson , Benjamin D. Philpot
{"title":"Neuronal UBE3A substrates hold therapeutic potential for Angelman syndrome","authors":"Joseph C. Krzeski ,&nbsp;Matthew C. Judson ,&nbsp;Benjamin D. Philpot","doi":"10.1016/j.conb.2024.102899","DOIUrl":"10.1016/j.conb.2024.102899","url":null,"abstract":"<div><p>Emerging therapies for Angelman syndrome, a severe neurodevelopmental disorder, are focused on restoring <em>UBE3A</em> gene expression in the brain. Further therapeutic opportunities may arise from a better understanding of how <em>UBE3A</em> gene products—both long and short isoforms of the ubiquitin ligase E3A (UBE3A)—function in neurons. Great strides have been made recently toward identifying ubiquitin substrates of UBE3A <em>in vitro</em> and in heterologous expression systems. From this work, a particularly close relationship between UBE3A and subunits of the 19S regulatory particle of the proteasome has become evident. We propose that further research cognizant of isoform-specific UBE3A functional roles will be instrumental in elucidating key UBE3A/substrate relationships within distinct neuronal compartments, lending to the discovery of novel therapeutic targets and valuable clinical biomarkers for the treatment of Angelman syndrome.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"88 ","pages":"Article 102899"},"PeriodicalIF":4.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel therapeutics in development for the treatment of stimulant-use disorder 正在开发治疗兴奋剂使用障碍的新型疗法。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-08-01 DOI: 10.1016/j.conb.2024.102898
Erica J. Young , Laszlo Radnai , Victor Prikhodko , Courtney A. Miller
{"title":"Novel therapeutics in development for the treatment of stimulant-use disorder","authors":"Erica J. Young ,&nbsp;Laszlo Radnai ,&nbsp;Victor Prikhodko ,&nbsp;Courtney A. Miller","doi":"10.1016/j.conb.2024.102898","DOIUrl":"10.1016/j.conb.2024.102898","url":null,"abstract":"<div><p>Misuse and accidental overdoses attributed to stimulants are escalating rapidly. These stimulants include methamphetamine, cocaine, amphetamine, ecstasy-type drugs, and prescription stimulants such as methylphenidate. Unlike opioids and alcohol, there are no therapies approved by the US Food and Drug Administration (FDA) to treat stimulant-use disorder. The high rate of relapse among this population highlights the insufficiency of current treatment options, which are limited to abstinence support programs and behavioral modification therapies. Here, we briefly outline recent regulatory actions taken by FDA to help support the development of new stimulant use disorder treatments and highlight several new therapeutics in the clinical development pipeline.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"87 ","pages":"Article 102898"},"PeriodicalIF":4.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959438824000606/pdfft?md5=9645fde3049a3b948c0398d0ad218e3d&pid=1-s2.0-S0959438824000606-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mosquitoes as a model for understanding the neural basis of natural behaviors 以蚊子为模型，了解自然行为的神经基础。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-07-12 DOI: 10.1016/j.conb.2024.102897
Lukas Weiss , Carolyn S. McBride
{"title":"Mosquitoes as a model for understanding the neural basis of natural behaviors","authors":"Lukas Weiss ,&nbsp;Carolyn S. McBride","doi":"10.1016/j.conb.2024.102897","DOIUrl":"10.1016/j.conb.2024.102897","url":null,"abstract":"<div><p>Mosquito behaviors have been the subject of extensive research for over a century due to their role in the spread of human disease. However, these behaviors are also beginning to be appreciated as excellent models for neurobiological research in their own right. Many of the same behaviors and sensory abilities that help mosquitoes survive and reproduce alongside humans represent striking examples of generalizable phenomena of longstanding neurobiological interest. In this review, we highlight four prominent examples that promise new insight into (1) precise circadian tuning of sensory systems, (2) processing of complex natural odors, (3) multisensory integration, and (4) modulation of behavior by internal states.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"87 ","pages":"Article 102897"},"PeriodicalIF":4.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging GPCR targets for AUD: Insights from preclinical studies 治疗 AUD 的新兴 GPCR 靶点：临床前研究的启示
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2024-07-05 DOI: 10.1016/j.conb.2024.102896
Roberta Goncalves Anversa , Maiya L. Barron , Leigh C. Walker , Andrew J. Lawrence
{"title":"Emerging GPCR targets for AUD: Insights from preclinical studies","authors":"Roberta Goncalves Anversa ,&nbsp;Maiya L. Barron ,&nbsp;Leigh C. Walker ,&nbsp;Andrew J. Lawrence","doi":"10.1016/j.conb.2024.102896","DOIUrl":"https://doi.org/10.1016/j.conb.2024.102896","url":null,"abstract":"<div><p>G protein-coupled receptors (GPCRs) are the largest group of membrane receptors in the central nervous system and one of the key proteins for signal transduction between cells. Currently, many drugs available on the market act via GPCRs and these receptors remain attractive targets for the treatment of brain disorders, including alcohol use disorder (AUD). Here, we describe the most recent literature, with a primary focus on the past 5 years, on GPCR targets with the potential for reducing behaviours associated with excessive alcohol intake. Specifically, we focus on preclinical evidence of compounds with attractive pharmacological profiles and potential for future clinical investigation for the treatment of AUD.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"87 ","pages":"Article 102896"},"PeriodicalIF":4.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959438824000588/pdfft?md5=5139ba1cd93ee7638bb8e551a9d0e5c3&pid=1-s2.0-S0959438824000588-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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