Current opinion in pediatrics最新文献_第4页

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-20 DOI: 10.1097/MOP.0000000000001481

Ruxandra Nicolae, Ruta Navardauskaite, Youn Hee Jee

{"title":"Genetics of short stature.","authors":"Ruxandra Nicolae, Ruta Navardauskaite, Youn Hee Jee","doi":"10.1097/MOP.0000000000001481","DOIUrl":"10.1097/MOP.0000000000001481","url":null,"abstract":"Purpose of review: This review highlights recent genetic discoveries and therapeutic advancements in evaluating and managing children with short stature. With an increasing diagnostic yield from genetic testing and the emergence of genotype-specific treatments, a comprehensive update is necessary for timely application in clinical practice.Recent findings: New pathogenic variants have been identified in genes, including FBN1, IHH, NPR2, ACAN, FGFR3, COMP, MATN3, EXT2, and LZTR1, associated with syndromic and nonsyndromic short stature. Their clinical significance is underscored by sequencing studies showing a diagnostic yield of up to 33% in idiopathic short stature. Concurrently, targeted pharmacologic agents, such as vosoritide or infigratinib, are advanced treatment options for genetically defined achondroplasia. In addition, more data is available on growth hormone responses in children with various genetic short statures.Summary: Incorporating genetic testing into the routine investigation of short stature improves diagnostic accuracy, enables early discussion of prognostic outcomes, and facilitates precision therapy. Timely identification of specific gene variants helps avoid ineffective treatments - such as growth hormone in resistant genotypes - and supports the adoption of personalized medicine interventions.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 4","pages":"380-385"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aisles of health? A pediatrician's guide to vitamins and dietary supplements in pharmacies and supermarkets. 健康通道？儿科医生的维生素和膳食补充剂指南在药店和超市。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-05-21 DOI: 10.1097/MOP.0000000000001475

Mary Lowance, Eric Wang, Mia Graybow, Ruth L Milanaik

{"title":"Aisles of health? A pediatrician's guide to vitamins and dietary supplements in pharmacies and supermarkets.","authors":"Mary Lowance, Eric Wang, Mia Graybow, Ruth L Milanaik","doi":"10.1097/MOP.0000000000001475","DOIUrl":"10.1097/MOP.0000000000001475","url":null,"abstract":"Purpose of review: In recent years, there have been increased discussions among parents about the use of Complementary and Alternative Medicine for kids, specifically dietary supplements and vitamins. While these were originally marketed to supplement nutrient needs, many families have begun to raise questions about the efficacy of vitamins and minerals to treat developmental conditions such as attention-hyperactivity deficit disorder, mood disorders, or sleep disturbances.Recent findings: Research investigating the use of vitamin supplements generally concludes that supplementation may be necessary in cases of deficiency; additional benefits are minimal. Some hormonal and mineral supplements like melatonin, fish oil, and magnesium have been found to reduce symptoms of hyperactivity, sleep disturbance, and conduct disorders in combination with other interventions. However, none of these therapies rival the efficacy of first-line treatment plans for these conditions. Additionally, overuse may lead to toxicity and adverse effects.Summary: While many parents may have concerns about their child's nutrient intake, much is still unknown about the dosing, safety, and efficacy of dietary supplements. For deficient children or patients resistant to eating certain food groups, mineral and vitamin supplements may be an effective way to meet nutritional needs. It is important to note that there is little evidence supporting the efficacy of dietary supplement use to treat other conditions nor any benefit for healthy children with a balanced diet.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"408-417"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental factors trigger pubertal development. 环境因素引发青春期发育。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-02-27 DOI: 10.1097/MOP.0000000000001451

Sofia Malave-Ortiz, Cameron Grant, Natalie D Shaw

引用次数: 0

IUDs and pain control for adolescents and young adults. 宫内节育器和青少年疼痛控制。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-03-19 DOI: 10.1097/MOP.0000000000001457

Sydney M Hartman-Munick, Grace Jhe, Anne Powell

引用次数: 0

Recent updates on the screening, diagnosis, and management of lipids disorders in children and adolescents. 关于儿童和青少年血脂紊乱的筛查、诊断和管理的最新进展。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1097/MOP.0000000000001460

Meghan Sara Drastal, Sarah de Ferranti, Holly Gooding

{"title":"Recent updates on the screening, diagnosis, and management of lipids disorders in children and adolescents.","authors":"Meghan Sara Drastal, Sarah de Ferranti, Holly Gooding","doi":"10.1097/MOP.0000000000001460","DOIUrl":"10.1097/MOP.0000000000001460","url":null,"abstract":"Purpose of review: The purpose of this review is to provide an update on screening, diagnosis, and treatment of lipid disorders in the pediatric patient.Recent findings: Apart from the United States Preventive Services Task Force (USPSTF), the majority of medical societies recommend universal screening for lipid disorders in children and adolescents 21 years or younger. Recent population studies confirm lipid abnormalities are prevalent in children, affecting at least one in five children aged 6-19 years. A systematic review and network meta-analysis of lipid-lowering therapies in children and adolescents with familial hypercholesterolemia found that statins reduced LDL-C by 33.61% and adding ezetimibe reduced LDL-C by an additional 15.85%.Summary: Nearly all major medical societies recommend universal lipid screening in children aged 9-11 and 17-21. Lipid abnormalities are common, and diagnosis is generally made by confirming abnormal lipid results with fasting lipid studies. Lifestyle modifications and statins are the mainstay for treatment of dyslipidemia. However, most research on lipid-lowering therapies is in familial hypercholesterolemia.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"325-332"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eating disorders in Latino boys and young men: the role of sociocultural context in identification, assessment, and treatment. 拉丁裔男孩和年轻男性的饮食失调：社会文化背景在识别、评估和治疗中的作用。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-04 DOI: 10.1097/MOP.0000000000001477

Adrian J Hernandez, Carlos Melendez-Garcia, Emily Pluhar

{"title":"Eating disorders in Latino boys and young men: the role of sociocultural context in identification, assessment, and treatment.","authors":"Adrian J Hernandez, Carlos Melendez-Garcia, Emily Pluhar","doi":"10.1097/MOP.0000000000001477","DOIUrl":"10.1097/MOP.0000000000001477","url":null,"abstract":"Purpose of review: Existing research on eating disorders has predominantly centered on affluent, young White cisgender women, limiting providers' understanding of how sociocultural context influences the identification, assessment, and treatment of eating disorders among racial and ethnic minorities. Latino boys and young men remain a particularly understudied group in eating disorder studies, despite growing recognition of the prevalence of eating disorders within Latino populations. This review integrates a synthesis of current literature, epidemiological data, and multidisciplinary perspectives on sex and culture to outline how sociocultural factors, including cultural beliefs such as machismo, acculturation, and family dynamics, impact the development and expression of eating disorders in Latinos.Recent findings: Findings underscore that Latino boys and young men often present with atypical eating disorder symptoms, such as extreme dietary restrictions and excessive exercise aimed at achieving muscularity. Sociocultural factors (i.e., machismo, acculturative stress, and familial pressures) influence the manifestation and progression of these disorders. These influences are compounded by systemic barriers, such as limited access to culturally responsive care and a lack of awareness among providers regarding diverse eating disorder presentations.Summary: This review highlights the urgent need for culturally informed diagnostic frameworks and interventions to address the eating disorder experiences of Latino boys and young men.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"333-341"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric topical steroid withdrawal syndrome: facts, misconceptions and communicating with patients and families. 儿科局部类固醇戒断综合征：事实，误解和沟通与患者和家属。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-05 DOI: 10.1097/MOP.0000000000001479

Kathleen L Miao, Hsi Yen, Minnelly Luu

{"title":"Pediatric topical steroid withdrawal syndrome: facts, misconceptions and communicating with patients and families.","authors":"Kathleen L Miao, Hsi Yen, Minnelly Luu","doi":"10.1097/MOP.0000000000001479","DOIUrl":"10.1097/MOP.0000000000001479","url":null,"abstract":"Purpose of review: Topical corticosteroids (TCS) have long been a mainstay in treating pediatric atopic dermatitis (AD). Topical steroid withdrawal syndrome (TSWS) has garnered increasing public attention, driven largely by social media discourse. This review aims to provide guidance for clinicians to effectively address concerns about pediatric TSWS in order to optimally manage AD in children.Recent findings: An examination of the literature reveals several misconceptions surrounding TSWS. Research highlights the importance of standardized diagnostic criteria, caution with high- or inappropriate potency TCS, particularly in sensitive areas, and the need for provider-patient communication to improve therapeutic alliance.Summary: TSWS is gaining recognition, and the lack of consensus on diagnostic standards and similarities with AD flares can result in misdiagnosis. This review highlights practical, evidence-based clinical approaches to discuss TSWS with patients/parents. Strategies to prevent adverse effects from TCS include appropriate potency selection and duration of treatment, utilizing gradual tapering protocols with proactive maintenance therapy, and addition of nonsteroidal anti-inflammatory therapies. Moreover, fostering an open, empathetic doctor-patient relationship can reduce unwarranted phobia around corticosteroids and ensure that TCS continue to be used optimally to treat AD and other inflammatory skin conditions. Thorough clinical guidance is essential to address patient/parent concerns about TSWS while working together toward an effective treatment plan for skin disease.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"366-372"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contraception updates for adolescents. 青少年避孕更新。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-04-01 DOI: 10.1097/MOP.0000000000001463

Anna Carleen, Ashley Ebersole

{"title":"Contraception updates for adolescents.","authors":"Anna Carleen, Ashley Ebersole","doi":"10.1097/MOP.0000000000001463","DOIUrl":"10.1097/MOP.0000000000001463","url":null,"abstract":"Purpose of review: To discuss updated guidelines for the provision of contraception to adolescents, review several contraceptive methods that have entered the market in recent years, and summarize insights from the literature that can assist clinicians in providing accurate, destigmatized contraceptive counseling to patients of all sizes.Recent findings: The 2024 United States Selected Practice Recommendations (US SPR) and United States Medical Eligibility for Contraceptive Use (US MEC) guidelines include changes to recommendations for contraception use in persons with various health conditions, and new advice for management of implant-associated breakthrough bleeding, pain control for intrauterine device (IUD) insertions, and counseling for patients who take testosterone. Subcutaneous Depo-Provera usage increased during the COVID-19 pandemic, and multiple studies demonstrate favorable patient experiences with it. Annovera, Miudella, Opill, Phexxi, Slynd, and Twirla are newer contraceptives which have distinct features that may make them attractive options for some patients. Contraception-related weight changes continue to be an active area of research. With the Food and Drug Administration (FDA) recommending broader BMI inclusion criteria, providers can expect more information about safety and efficacy of new contraceptives in individuals across the weight spectrum.Summary: Updated evidence-based guidelines and several new contraceptive options should empower providers to provide patient-centered contraception counseling to patients with a variety of health conditions and contraceptive preferences.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"318-324"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid-induced osteoporosis in children: emerging vascular and molecular targets. 糖皮质激素诱导的儿童骨质疏松症：新出现的血管和分子靶点。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI: 10.1097/MOP.0000000000001476

Sisir Kumar Barik, Janet L Crane

{"title":"Glucocorticoid-induced osteoporosis in children: emerging vascular and molecular targets.","authors":"Sisir Kumar Barik, Janet L Crane","doi":"10.1097/MOP.0000000000001476","DOIUrl":"10.1097/MOP.0000000000001476","url":null,"abstract":"Purpose of review: Glucocorticoid-induced osteoporosis (GIO) poses a significant risk to pediatric patients undergoing chronic glucocorticoid therapy for inflammatory, autoimmune, and genetic conditions. This review highlights the pathophysiology of GIO in children and emerging insights into the role of bone vasculature in skeletal health during growth.Recent findings: GIO arises from a dual mechanism of increased bone resorption and decreased bone formation, leading to rapid declines in bone mineral density. Recent studies emphasize the importance of angiogenic-osteogenic coupling, particularly in the growing skeleton. Endothelial cells are now recognized as active participants in bone health and regeneration. Advances in the understanding of signaling pathways regulating skeletal angiogenesis could predict skeletal side effects during drug development. Therapies enhancing endothelial cell function or promoting skeletal angiogenesis could mitigate glucocorticoid-induced damage. Key signaling pathways, such as platelet-derived growth factor type BB and nuclear factor (NF)-κB play critical roles in recruiting osteoprogenitors and establishing a vascular niche for skeletal angiogenesis.Summary: GIO is uniquely concerning in children due to its impact on peak bone mass and lifelong fracture risk. Understanding how glucocorticoids impair bone vasculature and skeletal remodeling may reveal new therapeutic targets to preserve bone health and mitigate the osteotoxic effects of long-term glucocorticoid use in the growing skeleton.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"390-397"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral JAK inhibitors for pediatric inflammatory skin disease. 口服JAK抑制剂治疗儿童炎症性皮肤病。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1097/MOP.0000000000001474

Erica B Lee, Kelly M Cordoro

{"title":"Oral JAK inhibitors for pediatric inflammatory skin disease.","authors":"Erica B Lee, Kelly M Cordoro","doi":"10.1097/MOP.0000000000001474","DOIUrl":"10.1097/MOP.0000000000001474","url":null,"abstract":"Purpose of review: JAK inhibitors have emerged as a promising new therapy for inflammatory skin disease, including in pediatric populations. However, due to their boxed warnings and lack of long-term safety and efficacy data, their specific role in the treatment ladder for various conditions remains to be determined.Recent findings: JAK inhibitors are currently approved for pediatric atopic dermatitis and alopecia areata with evidence of both efficacy and safety. They are currently being investigated for use in children with vitiligo, psoriasis, juvenile dermatomyositis, and hidradenitis suppurativa. So far, no significant safety concerns, especially regarding the FDA-mandated black box warnings, have been observed in pediatric patients being treated for inflammatory skin disease.Summary: JAK inhibitors provide clinicians and patients with another tool to consider when faced with challenging inflammatory skin diseases. Place in therapy amid the current armamentarium of available treatments for select skin conditions is evolving, as efficacy and safety data accumulates in trials and clinicians develop more real-world experience. As of now, use of JAK inhibitors should be considered on a case-by-case basis after a comprehensive assessment of the benefits and potential risks.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"373-379"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0