Current opinion in pediatrics最新文献_第5页

Current progress in international pediatric emergency medicine: Erratum. 国际儿科急诊医学的最新进展：勘误。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1097/MOP.0000000000001433

引用次数: 0

Should healthcare organizations be accountable for child community health indicators at the community level? 保健组织是否应对社区一级的儿童社区健康指标负责？

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-12-02 DOI: 10.1097/MOP.0000000000001430

Kelly J Kelleher, Rose Hardy

{"title":"Should healthcare organizations be accountable for child community health indicators at the community level?","authors":"Kelly J Kelleher, Rose Hardy","doi":"10.1097/MOP.0000000000001430","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001430","url":null,"abstract":"Purpose of review: This paper reviews options for including community health accountability metrics for child healthcare systems, international and regional experience with such metrics, and some specific candidates for metric consideration.Recent findings: The inclusion of community metrics in child health accountability systems requires expanded accountability frameworks and re-education of clinicians. Most of the experience with use of community metrics in accountability systems comes from international settings. Lessons learned in these settings include the importance of linking the metrics to various policy and practice implementation measures while balancing the incentives for such 'horizontal' or communitywide indicators with current incentives. The Accountable Communities for Health movement may be the best-known example of US community health indicators for accountability. Four new papers suggest specific child metrics for consideration as child metrics, but only infant mortality rates and high school graduation rates are sufficiently standardized and nationally reported to be useful for such efforts.Summary: Healthcare accountability for child community health is an important next step, but the coordination with existing accountability systems, data collection systems, and financial incentives require more research to be effective in helping children. Infant mortality rates and high school graduation rates have the most potential as cross system accountability metrics.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in cellular therapies for children and young adults with solid tumors. 儿童和青少年实体瘤的细胞治疗进展。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-20 DOI: 10.1097/MOP.0000000000001423

Michelle Choe, Matthew Campbell, Catherine M Albert

{"title":"Advances in cellular therapies for children and young adults with solid tumors.","authors":"Michelle Choe, Matthew Campbell, Catherine M Albert","doi":"10.1097/MOP.0000000000001423","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001423","url":null,"abstract":"Purpose of review: Adoptive immunotherapy brings hope to children and young adults diagnosed with high-risk solid tumors. Cellular (cell) therapies such as chimeric antigen receptor (CAR) T cell, CAR natural killer (NK) cell, and T cell receptor (TCR) T cell therapy are potential avenues of targeted therapy with limited long-term toxicities. However, development of cell therapies for solid tumors is in its nascent stages. Here, we will review the current clinical experience, barriers to efficacy, and strategies to improve clinical response and patient access.Recent findings: Cell therapies are shown to be generally safe and well tolerated. Strategies to optimize antitumor activity have now moved into early-phase trials. The immunosuppressive tumor microenvironment remains a major barrier to efficacy, and efforts are underway to gain better understanding. This will inform future treatment strategies to enhance the antitumor activity of cell therapies.Summary: Clinical experiences to date provide important insights on how to leverage cell therapies against solid tumors. Key factors in advancing the field include a better understanding of immune cell biology, tumor cell behavior, and the tumor microenvironment. Lastly, improving access to novel cell therapies remains an important consideration in the conduct of clinical trials and for future implementation into standard practice.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"67-74"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatrics leading the way: co-enrollment as the next step in health-related social needs screening and referral. 儿科引领潮流：共同登记作为健康相关社会需求筛查和转诊的下一步。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-12 DOI: 10.1097/MOP.0000000000001416

Stephanie Ettinger de Cuba, Carley Ruemmele, Ana Poblacion

{"title":"Pediatrics leading the way: co-enrollment as the next step in health-related social needs screening and referral.","authors":"Stephanie Ettinger de Cuba, Carley Ruemmele, Ana Poblacion","doi":"10.1097/MOP.0000000000001416","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001416","url":null,"abstract":"Purpose of review: To contextualize how pediatrics led the field in developing and implementing tools to screen for social determinants of health in clinical care as well as in creating innovative interventions to mitigate them, and to summarize where the evidence points as the next frontier.Recent findings: The evidence showed that health-related social needs (HRSN), like food insecurity, energy insecurity, and housing instability, continue to drive poor health outcomes across the lifespan; patients and healthcare providers are open to discussing HRSN in clinical settings, though some providers feel ill-equipped to do so; to mitigate HRSN, healthcare plays a unique role in ensuring patients' HRSN are understood, referring to effective resources through building strong, lasting relationships with community partners, embedding services in the healthcare setting across all departments, and empowering patient families to participate in programs and services; and administrative burden hinders families from getting all the benefits to which they are entitled, which streamlined co-enrollment processes can address.Summary: Pediatric providers can add a unique and credible voice to seeking changes to the safety-net, including co-enrollment, that could reduce administrative burden, address patients' HRSN, and improve health starting in the prenatal period through later adulthood.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"19-26"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pleuropulmonary blastoma and DICER1-related tumor predisposition: from clinicopathologic observations to clinical trial. 胸膜肺母细胞瘤与dicer1相关的肿瘤易感性：从临床病理观察到临床试验

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-12-06 DOI: 10.1097/MOP.0000000000001431

Alexander T Nelson, Kenneth S Chen, Kris Ann P Schultz

{"title":"Pleuropulmonary blastoma and DICER1-related tumor predisposition: from clinicopathologic observations to clinical trial.","authors":"Alexander T Nelson, Kenneth S Chen, Kris Ann P Schultz","doi":"10.1097/MOP.0000000000001431","DOIUrl":"10.1097/MOP.0000000000001431","url":null,"abstract":"Purpose of review: Pleuropulmonary blastoma (PPB) is a rare primary lung neoplasm of infancy and childhood. The purpose of this review is to highlight recent developments in our understanding of PPB and research strategies to facilitate future rare cancer research.Recent findings: The International PPB/DICER1 Registry has recently assembled the largest-ever cohorts of type I and Ir PPB and type II and III PPB. These analyses were strengthened by robust histologic, genetic and longitudinal data made possible by systematic data collection and abstraction and dedicated central pathology review. These cohorts have laid the groundwork for a prospective consortium-based clinical trial to assess response to camptothecins in type II and III PPB and standardize the use of chemotherapy in type I PPB.Summary: Significant strides in the study of PPB have been made through clinical, laboratory and translational research, multidisciplinary collaborations and the generous contributions of patients, families and referring physicians. Ongoing advancements will continue to depend on multidisciplinary, multiperspective global collaborations.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"48-55"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introductions. 编辑介绍。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1097/MOP.0000000000001424

引用次数: 0

Food as medicine through the lenses of Food Access, Justice, and Sovereignty. 从食物获取、正义和主权的角度看食物作为药物。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-21 DOI: 10.1097/MOP.0000000000001417

Norma Gonzalez, Ismail Samad, Olivia Thomas, Jenna Rice, Rebecca Valdez, Katherine Burt

{"title":"Food as medicine through the lenses of Food Access, Justice, and Sovereignty.","authors":"Norma Gonzalez, Ismail Samad, Olivia Thomas, Jenna Rice, Rebecca Valdez, Katherine Burt","doi":"10.1097/MOP.0000000000001417","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001417","url":null,"abstract":"Purpose of review: Food as Medicine (FAM) and supplemental nutrition programs like supplemental nutrition assistance program (SNAP), women, infants, and children (WIC), and school meals aim to combat rising diet-related chronic diseases and healthcare costs by addressing poor diet and food insecurity. However, their effectiveness is limited by a lack of community integration in planning, implementation, and evaluation. We introduce the Food Access, Justice, and Sovereignty (FAJS) framework, which expands FAM efforts to address acute food disparity through community-based strategies grounded in justice and sovereignty.Recent findings: FAM interventions on adult populations have demonstrated a positive impact on food insecurity and its related chronic illness and shows promise for pediatric populations. However, community-driven solutions are essential for shifting power toward greater integration of the lived experiences of community, which can enhance positive behavioral changes needed for greater prevention and management of chronic illness.Summary: Using community driven approaches through the lens of access, justice, and sovereignty address the effects of food insecurity and diet-related chronic diseases for adults and pediatric populations. Through the FAJS Framework, interventionalists can develop sustainable nutrition programs that engender community health, control, and lasting impact.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"13-18"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observational gait analysis. 观察步态分析。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-28 DOI: 10.1097/MOP.0000000000001426

Leo Donnan

引用次数: 0

Detection and treatment of developmental dysplasia of the hip in infants: updates and recommendations. 婴儿髋关节发育不良的检测和治疗：最新进展和建议。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-28 DOI: 10.1097/MOP.0000000000001420

Aidan P Cosgrove, Claudia Maizen

{"title":"Detection and treatment of developmental dysplasia of the hip in infants: updates and recommendations.","authors":"Aidan P Cosgrove, Claudia Maizen","doi":"10.1097/MOP.0000000000001420","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001420","url":null,"abstract":"Purpose of review: Developmental dysplasia of the hip (DDH) is common and is a source of potentially avoidable morbidity through childhood and adult life. Despite progress over the past century, there is a wide variation in policy, practice and outcomes between countries. This review considers information from a geographically wide range of locations to evaluate the impact of these variations and understand how these variations arise. The aim is to help clinicians and policymakers adopt the best practices for their population.Recent findings: There is a lack of randomized controlled trials to guide decisions on screening. Given the large numbers to treat and preexisting practices, it is unlikely that such trials of sufficient statistical power will be performed. However, many whole population studies are becoming available from different countries that allow an assessment and comparison of the impact of their strategies.Summary: Standardizing metrics in studies and defining late diagnosis would improve comparisons across studies. The general trend appears to favour universal screening to reduce the risk of late diagnosis, the need for surgery and the subsequent poorer outcomes. Notably, resource-constrained countries like Mongolia have successfully implemented universal screening, showing that effective strategies can be adopted regardless of resources.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"88-93"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The childhood cancer data initiative: enabling data sharing to drive research advances and transform pediatric cancer diagnosis and treatment. 儿童癌症数据倡议：使数据共享能够推动研究进展并改变儿童癌症的诊断和治疗。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI: 10.1097/MOP.0000000000001422

Subhashini Jagu, Jaime M Guidry Auvil, Gregory Reaman

{"title":"The childhood cancer data initiative: enabling data sharing to drive research advances and transform pediatric cancer diagnosis and treatment.","authors":"Subhashini Jagu, Jaime M Guidry Auvil, Gregory Reaman","doi":"10.1097/MOP.0000000000001422","DOIUrl":"10.1097/MOP.0000000000001422","url":null,"abstract":"Purpose of review: With growing emphasis on data-driven research in pediatric oncology, particularly in the context of advances in molecular characterization and precision medicine, there is an urgent need for comprehensive data-sharing initiatives. This review explores how the Childhood Cancer Data Initiative (CCDI) addresses this critical need.Recent findings: CCDI plays a key role in enhancing pediatric cancer research by improving data integration, sharing, and collaboration. Its Molecular Characterization Initiative advances the field by leveraging detailed molecular data to inform clinical trials and therapeutic strategies. For small patient populations, such as those with rhabdomyosarcoma, CCDI's efforts in integrating data across institutions are vital for advancing risk-based treatment strategies to achieve meaningful clinical outcomes.Summary: CCDI's advancements in data sharing have profound implications for both clinical practice and research. By enabling precise diagnoses, tailoring treatments based on individual genetic profiles, and addressing the challenges associated with small patient populations, CCDI is driving transformative changes in pediatric oncology. Continued support and expansion of such initiatives are crucial to fully realizing their potential in improving outcomes for children with cancer.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"42-47"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0