Current opinion in pediatrics最新文献_第10页

Semaglutide for management of obesity in adolescents: efficacy, safety, and considerations for clinical practice. 塞马鲁肽治疗青少年肥胖症：疗效、安全性和临床实践中的注意事项。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI: 10.1097/MOP.0000000000001365

Megan O Bensignor, Silva Arslanian, Mary Ellen Vajravelu

{"title":"Semaglutide for management of obesity in adolescents: efficacy, safety, and considerations for clinical practice.","authors":"Megan O Bensignor, Silva Arslanian, Mary Ellen Vajravelu","doi":"10.1097/MOP.0000000000001365","DOIUrl":"10.1097/MOP.0000000000001365","url":null,"abstract":"Purpose of review: The purpose of this review is to describe the existing limited data related to the use of semaglutide in adolescents with obesity, supplementing with findings from adult studies of semaglutide use.Recent findings: Semaglutide, as a once weekly subcutaneous injection for weight management, effectively reduces body mass index (BMI) while improving hyperglycemia, elevated alanine aminotransferase levels, hyperlipidemia, and quality of life in youth with obesity. As of this review, only one large randomized clinical trial of semaglutide in youth has been completed, with a follow-up duration of 68 weeks. Thus, long-term data on the safety in adolescents is limited, particularly regarding the risks of cholelithiasis, pancreatitis, suicidal ideation, and disordered eating. Due to the cost of semaglutide, particularly in the United States, limited cost effectiveness analyses have demonstrated unfavorable incremental cost-effectiveness ratios for semaglutide relative to phentermine-topiramate as an alternative antiobesity medication in adolescents.Summary: Semaglutide represents an important advance in the pediatric obesity management, with clear short-term reductions in BMI and improvement in metabolic parameters. However, its long-term safety and efficacy for youth with obesity remain to be demonstrated. Additional research is needed to assess trends in utilization and adherence to minimize the risk of worsening socioeconomic disparities in pediatric obesity.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"449-455"},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical monitoring of 21-hydroxylase deficiency: a clinical utility of overnight fasting urine pregnanetriol. 21- 羟化酶缺乏症的生化监测：隔夜空腹尿液孕三醇的临床实用性。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI: 10.1097/MOP.0000000000001369

Yukihiro Hasegawa, Tomoyo Itonaga, Tomohiro Ishii, Masako Izawa, Naoko Amano

{"title":"Biochemical monitoring of 21-hydroxylase deficiency: a clinical utility of overnight fasting urine pregnanetriol.","authors":"Yukihiro Hasegawa, Tomoyo Itonaga, Tomohiro Ishii, Masako Izawa, Naoko Amano","doi":"10.1097/MOP.0000000000001369","DOIUrl":"10.1097/MOP.0000000000001369","url":null,"abstract":"Purpose of review: 21-Hydroxylase deficiency (21-OHD), the most common form of congenital adrenal hyperplasia, is an autosomal recessive disorder caused by pathogenic variants in CYP21A2 . Although this disorder has been known for several decades, many challenges related to its monitoring and treatment remain to be addressed. The present review is written to describe an overview of biochemical monitoring of this entity, with particular focus on overnight fasting urine pregnanetriol.Recent findings: We have conducted a decade-long research project to investigate methods of monitoring 21-OHD in children. Our latest studies on this topic have recently been published. One is a review of methods for monitoring 21-OHD. The other was to demonstrate that measuring the first morning PT level may be more practical and useful for biochemical monitoring of 21-OHD. The first morning pregnanetriol (PT), which was previously reported to reflect a long-term auxological data during the prepubertal period, correlated more significantly than the other timing PT in this study, with 17-OHP, before the morning medication.Summary: In conclusion, although the optimal method of monitoring this disease is still uncertain, the use of overnight fasting urine pregnanetriol (P3) as a marker of 21-OHD is scientifically sound and may be clinically practical.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"456-462"},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The increase in diabetes in children from underdeveloped countries. 不发达国家儿童糖尿病发病率上升。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-06-03 DOI: 10.1097/MOP.0000000000001366

Cai Zhang, Xiaoping Luo

{"title":"The increase in diabetes in children from underdeveloped countries.","authors":"Cai Zhang, Xiaoping Luo","doi":"10.1097/MOP.0000000000001366","DOIUrl":"10.1097/MOP.0000000000001366","url":null,"abstract":"Purpose of review: The incidence of type 1 diabetes (T1D) in children and adolescents has been increased over decades worldwide. Recent studies showed that the trend of T1D incidences were different between developed and underdeveloped countries. This review aimed to summarize the changes of childhood T1D incidences in underdeveloped countries over the past decade.Recent findings: Majority of the underdeveloped countries lacked of nationwide population-based studies on childhood T1D. We reviewed the trend of childhood T1D in important underdeveloped countries with available data in recent years. The incidences of childhood T1D in underdeveloped countries were low decades ago, but it increased significantly recently, particularly in the sub-Saharan African, Middle East and North African regions.Summary: The incidences of childhood T1D increased significantly in underdeveloped countries, especially in the sub-Saharan African, Middle East and North African regions. T1D registry and population-based studies are helpful to understand the situation and characteristic of childhood T1D in underdeveloped countries.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"467-472"},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vulvar skin disease in the pediatric population. 儿童外阴皮肤病。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-06-03 DOI: 10.1097/MOP.0000000000001370

Taylor Griffith, Madeline Hunt, Kalyani Marathe

{"title":"Vulvar skin disease in the pediatric population.","authors":"Taylor Griffith, Madeline Hunt, Kalyani Marathe","doi":"10.1097/MOP.0000000000001370","DOIUrl":"10.1097/MOP.0000000000001370","url":null,"abstract":"Purpose of review: Vulvar skin disease is an underrecognized pediatric condition encompassing a wide range of conditions, from isolated vulvar disease to vulvar manifestations of systemic illnesses. This review highlights the most current research discussing clinical features, risk factors, and treatments.Recent findings: Recent studies confirm that labial adhesions resolve more quickly with estrogen treatment. Topical corticosteroids remain first-line for treatment of vulvar lichen sclerosus, and some procedural interventions are showing promising results. Latest evidence shows efficacy of biologic agents in hidradenitis suppurativa and vulvar Crohn's. Vaginal voiding remains an underrecognized cause of irritant vulvovaginitis. Lately vulvar aphthae have been associated with coronavirus disease 2019. Distinguishing between infantile perianal pyramidal protrusion, molluscum, and condyloma can be aided by differences in morphologic features.Summary: Vulvar dermatoses have a high impact on children's health and wellbeing. Clinician familiarity with recognition and latest advancements in vulvar dermatoses can aid in prompt diagnosis, management, and appropriate referrals. Vulvar biopsy and vaginal cultures should be used prudently. Treatments include topicals, behavioral modification, systemic medications, and procedures.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"400-405"},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of sleep and mental health in adolescence: an overview. 睡眠对青少年心理健康的影响：概述。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-05-01 DOI: 10.1097/MOP.0000000000001358

Michelle Woodfield, Nanci Ginty Butler, Michael Tsappis

{"title":"Impact of sleep and mental health in adolescence: an overview.","authors":"Michelle Woodfield, Nanci Ginty Butler, Michael Tsappis","doi":"10.1097/MOP.0000000000001358","DOIUrl":"10.1097/MOP.0000000000001358","url":null,"abstract":"Purpose of review: Sleep deprivation is known to affect multiple aspects of mental health, physical health, and daily functioning. With increasing reports of sleep disturbances and increasing mental health needs in adolescents, it is imperative that healthcare providers have a strong understanding of the relationship between sleep and mental health, the impact of poor sleep on the school experience, and an understanding of behavioral interventions targeting sleep practices.Recent findings: Recent studies have shown that the relationship between sleep and mental health is complex and multifaceted. While mental health diagnoses and symptoms can negatively influence sleep quality and quantity, so too does poor sleep increase the risk of mental health diagnoses, symptom severity, and suicide risk. Sleep likewise affects the school experience, both positively and negatively. Targeted interventions and prevention programs may be effective in treatment of sleep disturbances for adolescents.Summary: Clinicians must be aware of the above associations and their clinical implications. Patients with either mental health or sleep concerns should be screened for potential co-morbid conditions. Improving sleep hygiene practices can improve the sleep experience in adolescents, however, there remains a gap in understanding the best method to improve sleep hygiene practices in this population.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"375-381"},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates on postinfectious skin rashes in pediatric dermatology. 儿科皮肤科感染后皮疹的最新进展。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1097/MOP.0000000000001376

Samantha Shwe Daniel, Caitlin Peterman, Smita Awasthi

{"title":"Updates on postinfectious skin rashes in pediatric dermatology.","authors":"Samantha Shwe Daniel, Caitlin Peterman, Smita Awasthi","doi":"10.1097/MOP.0000000000001376","DOIUrl":"10.1097/MOP.0000000000001376","url":null,"abstract":"Purpose of review: This review provides updates on postinfectious skin rashes in the pediatric population from recently published literature.Recent findings: The COVID-19 pandemic and its sequelae remain a focus of research on pediatric infectious skin rashes. Multisystem inflammatory syndrome in children (MIS-C) and reactive infectious mucocutaneous eruption (RIME) are common complications of infection with SARS-COV-2 in the pediatric population. Most cases of MIS-C show low mortality and suggest mucocutaneous symptoms do not correlate with COVID-19 disease severity. Cases of papular acrodermatitis of childhood, also known as Gianotti-Crosti, have also been reported in association with SARS-COV-2, and can present similarly in reaction to other viral infection like molluscum contagiosum, known as a Gianotti-Crosti syndrome-like reaction (GCLR). Other relevant studies on postinfectious skin rashes include updates on the management of staphylococcal scalded skin syndrome (SSSS), with newer evidence advocating for beta-lactam monotherapy without clindamycin and reduced ancillary testing. Finally, the emergence of antifungal resistance due to Trichophyton indotinae is a growing global health concern emphasizing the need for improved antifungal stewardship.Summary: It is prudent for clinicians to be informed of both common and rare diagnoses that have emerged more recently in association with the COVID-19 pandemic, in addition to other diseases with newer evidence-based recommendations to guide management.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"36 4","pages":"431-435"},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninfectious causes of alopecia in the pediatric population. 儿童脱发的非感染性原因。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-05-29 DOI: 10.1097/MOP.0000000000001374

Elie Saliba, Asghar Shah, Samer Wahood, Remie Chrabieh

引用次数: 0

Strategies to minimize procedure-related pain and anxiety: lessons from pediatric dermatology. 尽量减少手术相关疼痛和焦虑的策略：从儿科皮肤病学中汲取的经验。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1097/MOP.0000000000001371

Nadine Abouchaleh, Cheryl Bayart

引用次数: 0

Update on the use of long-acting growth hormone in children. 儿童使用长效生长激素的最新情况。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-05-07 DOI: 10.1097/MOP.0000000000001362

Margaret Cristina da Silva Boguszewski, Cesar Luiz Boguszewski

{"title":"Update on the use of long-acting growth hormone in children.","authors":"Margaret Cristina da Silva Boguszewski, Cesar Luiz Boguszewski","doi":"10.1097/MOP.0000000000001362","DOIUrl":"10.1097/MOP.0000000000001362","url":null,"abstract":"Purpose of review: After extensive research and many years of waiting, long-acting growth hormone (LAGH) formulations have finally become a reality in clinical practice and emerge as a potential solution to address the challenges of daily injections of recombinant human GH (rhGH). In this review, we present a brief history of the development of LAGH and provide a critical analysis of the existing literature on the five LAGH available and approved to date for treatment in children.Recent findings: In clinical trials, LAGH therapy has shown noninferiority compared with daily rhGH therapy in promoting linear growth in children with GH deficiency, with similar rates of adverse events.Summary: In the real world, many questions still need to be answered, such as whether a specific group of patients will benefit most from the weekly injection, whether compliance will be better compared with daily rhGH, whether long-term efficacy, monitoring and safety profile will be the same for the different LAGH compounds, and whether the cost-effectiveness will justify their use in different settings.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"437-441"},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial. 社论

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2024-08-01 Epub Date: 2024-07-04 DOI: 10.1097/MOP.0000000000001373

Sally Radovick

引用次数: 0